Imaging manifestations of progressive multifocal leukoencephalopathy

Academic Article


  • Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested on imaging and confirmed by cerebrospinal fluid polymerase chain reaction (PCR) for JC virus DNA. In this article, we review the imaging manifestations of PML on computed tomography (CT), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), MR spectroscopy, single photon-emission computed tomography (SPECT) and positron-emission tomography (PET), and outline the role of imaging in follow-up and prognostication. © 2010 The Royal College of Radiologists.
  • Published In

  • Clinical Radiology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Shah R; Bag AK; Chapman PR; Curé JK
  • Start Page

  • 431
  • End Page

  • 439
  • Volume

  • 65
  • Issue

  • 6