Prenatal differentiation of ventral abdominal wall defects: Are amniotic fluid markers useful adjuncts?

Academic Article


  • We retrospectively reviewed 29 cases of ventral abdominal wall defects to evaluate the usefulness of amniotic fluid markers in the prenatal assessment of those disorders. Amniotic fluid α-fetoprotein (AF-AFP) values were available in 17 cases diagnosed prior to 22 weeks' gestation and acetylcholinesterase (AF-ACE) values, in 21 cases. All 7 fetuses with a gastroschisis had an elevated AF-AFP, while only 2 of the 10 fetuses with an omphalocele had elevated values (P = .002). ACE was present in 80% of the cases of gastroschisis versus 27.3% of the cases of omphalocele (P = .03). With equivocal sonographic findings, a normal AF-AFP and negative AF-ACE may be more compatible with an omphalocele.
  • Author List

  • Tucker JM; Brumfield CG; Davis RO; Winkler CL; Boots LR; Krassikoff NE; Hauth JC
  • Start Page

  • 445
  • End Page

  • 448
  • Volume

  • 37
  • Issue

  • 5