Electrocardiographic characteristics of ventricular arrhythmias originating from the junction of the left and right coronary sinuses of Valsalva in the aorta: The activation pattern as a rationale for the electrocardiographic characteristics

Academic Article


  • Background: Ventricular arrhythmias (VAs) may arise from the aortic sinuses and have electrocardiographic and electrophysiological characteristics that suggest a left (LCC) or right coronary cusp (RCC) origin. However, VAs that arise near the junction of those two cusps (L-RCC) may have unusual features. Objectives: The purpose of this study was to examine the electrocardiographic and electrophysiological characteristics of VAs arising from the L-RCC. Methods: We studied 155 patients with idiopathic VAs with either left or right bundle branch block and an inferior QRS axis morphology and five control subjects undergoing a pacing study. Results: For 146 of the 155 patients, the origin determined by the successful ablation site was at the L-RCC in five, LCC in 13, RCC in six, non-coronary cusp in two, right ventricular outflow tract in 108, left ventricular outflow tract in five, left ventricular epicardium in four, and pulmonary artery in three. A qrS pattern in leads V1-V3 was observed only in the VAs with an L-RCC origin. The propagation map revealed that the direction of the propagating wave front from the L-RCC origin produced a vector compatible with a q wave and that the anterior activation to the right ventricular outflow tract via the LCC or RCC formed the r wave. Pacing performed at multiple sites in the aortic root in the control subjects demonstrated that only pacing from the L-RCC could reproduce a qrS pattern in leads V1-V3. Conclusions: This study revealed that a qrS pattern in leads V1-V3 suggests a site of origin at the L-RCC. © 2008 Heart Rhythm Society.
  • Published In

  • Heart Rhythm  Journal
  • Digital Object Identifier (doi)

    Author List

  • Yamada T; Yoshida N; Murakami Y; Okada T; Muto M; Murohara T; McElderry HT; Kay GN
  • Start Page

  • 184
  • End Page

  • 192
  • Volume

  • 5
  • Issue

  • 2