Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy

Academic Article


  • Hyperbaric oxygen therapy promoted brain cell proliferation. Wnt-3 is closely associated with the proliferation of neural stem cells. We examined whether hyperbaric oxygen promoted neural stem cells to proliferate and its correlation with Wnt-3 protein in hypoxic-ischemic neonate rats. Hyperbaric oxygen therapy was administered 3 h after hypoxia ischemia daily for 7 days. The proliferating stem cells and Wnt-3 protein were examined dynamically in the subventricular zone. Results showed that stem cells proliferated and peaked 7 days after hyperbaric oxygen therapy. Wnt-3 protein increased to the higher levels 3 days after therapy. Linear regression analysis showed that nestin protein correlated with Wnt-3 protein. We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein. © 2007 Lippincott Williams & Wilkins, Inc.
  • Authors

    Published In

  • NeuroReport  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wang XL; Yang YJ; Xie M; Yu XH; Liu CT; Wang X
  • Start Page

  • 1753
  • End Page

  • 1756
  • Volume

  • 18
  • Issue

  • 16