Pathological ventricular remodeling: Mechanisms: Part 1 of 2

Academic Article


  • Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling. © 2013 American Heart Association, Inc.
  • Authors

    Published In

  • Circulation  Journal
  • Digital Object Identifier (doi)

    Author List

  • Burchfield JS; Xie M; Hill JA
  • Start Page

  • 388
  • End Page

  • 400
  • Volume

  • 128
  • Issue

  • 4