Combination versus sequential five drug chemotherapy in metastatic carcinoma of the breast

Academic Article


  • Patients with metastatic or recurrent adenocarcinoma of the breast were randomized to weekly combination chemotherapy, intermittent combination chemotherapy, or single drug chemotherapy administered sequentially. Patients receiving weekly combination therapy were more likely to respond than those receiving a single drug therapy (5 fluorouracil). The median survival for either group treated with combination therapy was double that of patients on sequential therapy. One fourth of the patients had a prolonged survival (>75 weeks) regardless of therapy.
  • Published In

  • Cancer Research  Journal
  • Author List

  • Smalley RV; Murphy S; Huguley CM; Bartolucci AA
  • Volume

  • 36
  • Issue

  • 11