Ultraviolet B stimulus production of corticotropin releasing factor (CRF) by human melanocytes

Academic Article


  • Here we show that human melanocytes express the corticotropin releasing factor (CRF) gene and produce CRF peptide. The CRP production and secretion is markedly stimulated by ultraviolet B (UVB) radiation. This is the first demonstration that cutaneous melanocytes respond to environmental stress (UVB) through the production of CRF.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Slominski A; Baker J; Ermak G; Chakraborty A; Pawelek J
  • Start Page

  • 175
  • End Page

  • 176
  • Volume

  • 399
  • Issue

  • 1-2