Inhibition of melanogenesis as an adjuvant strategy in the treatment of melanotic melanomas: selective review and hypothesis.

Academic Article

Abstract

  • Melanogenesis generates immunosuppressive and mutagenic environment and alters cellular metabolism. Melanin can protect malignant melanocytes against chemo-, radio-, and photodynamic therapy. Therefore, we propose to inhibit melanogenesis as an adjuvant treatment modality during immuno-, radio-, chemo- and photodynamic therapy, and as a measure of reducing the probability of melanoma progression.
  • Keywords

  • Antimetabolites, Antineoplastic, Bromodeoxyuridine, Chemotherapy, Adjuvant, Humans, Melanins, Melanocytes, Melanoma, Photochemotherapy, Protective Agents
  • Author List

  • Slominski A; Paus R; Mihm MC
  • Start Page

  • 3709
  • End Page

  • 3715
  • Volume

  • 18
  • Issue

  • 5B