Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

Academic Article

Abstract

  • We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone. Copyright (C) 1999 Federation of European Biochemical Societies.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Slominski A; Gomez-Sanchez CE; Foecking MF; Wortsman J
  • Start Page

  • 364
  • End Page

  • 366
  • Volume

  • 455
  • Issue

  • 3