Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells

Academic Article


  • We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel. © 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Slominski A; Semak I; Pisarchik A; Sweatman T; Szczesniewski A; Wortsman J
  • Start Page

  • 102
  • End Page

  • 106
  • Volume

  • 511
  • Issue

  • 1-3