Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia: A prospective observational study

Academic Article


  • Background Fluid bolus administration is a standard treatment for hypotension. However, the effectiveness of the traditional prophylactic bolus in parturients undergoing spinal anesthesia for cesarean delivery has been questioned. One potential mechanism for the failure of a prophylactic fluid bolus to prevent hypotension is hypervolemia-induced destruction of the endothelial glycocalyx, a structure that plays a vital role in regulating intravascular fluid shifts.
  • Digital Object Identifier (doi)

    Author List

  • Powell M; Mathru M; Brandon A; Patel R; Frölich M
  • Start Page

  • 330
  • End Page

  • 334
  • Volume

  • 23
  • Issue

  • 4