Synthesis of carbocyclic orotidine analogs as potential orotidinedecarboxylase inhibitors

Academic Article

Abstract

  • An asymmetric synthesis of carbocyclic orotidine 15 and its monophosphate 16 were accomplished via the key intermediate cyclopentanone 4, which was prepared from D-γ-ribonolactone in steps. None of synthesized the compounds inhibited orotidine 5′-monophosphate decarboxylase (EC 4.1.1.23) or orotate phosphoribosyltransferase (EC 2.4.2.10).
  • Digital Object Identifier (doi)

    Author List

  • Song GY; Naguib FNM; El Kouni MH; Chu CK
  • Start Page

  • 1915
  • End Page

  • 1925
  • Volume

  • 20
  • Issue

  • 12