Ir gene control of immune responses to insulins. II. Phenotypic differences in T cell activity among nonresponder strains of mice

Academic Article


  • Immune responses by mice to heterologous insulins are controlled by H-2 linked Ir genes. In studies to determine the mechanisms responsible for nonresponsiveness, we found that although pork insulin failed to stimulate antibody or proliferative responses in H-2b mice, it did prime T cells that can express helper activity in adoptive recipient mice. This helper activity was insulin-specific in both elicitation and expression. In studies presented in this paper, we have extended this analysis to the response patterns of helper T cells stimulated by sheep, horse, and rat insulins in mice bearing different H-2 haplotypes. The results demonstrate that nonresponder forms of insulin, including rat insulin, prime T cells in H-2b and H-2(d), but not H-2(k), mice. These results suggest that regulation of nonresponsiveness to insulin appears to be through different pathways in mice bearing different H-2 haplotypes.
  • Published In

    Author List

  • Bucy RP; Kapp JA
  • Start Page

  • 2062
  • End Page

  • 2066
  • Volume

  • 130
  • Issue

  • 5