5-Fluorouracil in the treatment of scleroderma: A randomised, double blind, placebo controlled international collaborative study

Academic Article


  • A six month controlled study of 5-fluorouracil in the treatment of scieroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually responded to dose reduction. Two patients receiving 5-fluorouracil died from causes seemingly unrelated to treatment. Significant clinical improvement in scleroderma was not noted in the first six months of treatment with 5-fluorouracil.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Casas JA; Saway PA; Villarreal I; Nolte C; Menajovsky BL; Escudero EE; Blackburn WD; Alarcon GS; Subauste CP
  • Start Page

  • 926
  • End Page

  • 928
  • Volume

  • 49
  • Issue

  • 11