Biodegradable microspheres: vaccine delivery system for oral immunization.

Academic Article


  • The potential of biocompatible and biodegradable microspheres as a controlled release oral vaccine delivery system has been examined. Orally-administered 1-10 micron microspheres composed of poly (DL-lactide-co-glycolide) were specifically taken up into the Peyer's patch lymphoid tissue of the gut, where those greater than or equal to 5 micron remained for up to 35 days. Microspheres less than 5 micron disseminated within macrophages to the mesenteric lymph nodes and spleen. In contrast to soluble staphylococcal enterotoxin B toxoid, oral immunization with enterotoxoid in microspheres induced circulating toxin-specific antibodies and a concurrent secretory IgA anti-toxin response in saliva and gut fluid.
  • Digital Object Identifier (doi)

    Author List

  • Eldridge JH; Gilley RM; Staas JK; Moldoveanu Z; Meulbroek JA; Tice TR
  • Start Page

  • 59
  • End Page

  • 66
  • Volume

  • 146