Cell wall-mediated neuronal damage in early sepsis

Academic Article


  • Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr -/- mice but was partially mitigated in mice lacking cell wall recognition proteins TLR2 and Nod2 and in mice overexpressing interleukin-10 (IL-10) in macrophages. Thus, cell wall drives SAND through IL-10-repressible inflammatory events. Treatment with CDP-choline ameliorated SAND, suggesting that it may be an effective adjunctive therapy to increase survival and reduce organ damage in sepsis. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Orihuela CJ; Fillon S; Smith-Sielicki SH; El Kasmi KC; Gao G; Soulis K; Patil A; Murray PJ; Tuomanen EI
  • Start Page

  • 3783
  • End Page

  • 3789
  • Volume

  • 74
  • Issue

  • 7