Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity

Academic Article


  • The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(α-D-arabinofuranosyl)-α-D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity. © 2001 Elsevier Science Ltd. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Pathak AK; Pathak V; Maddry JA; Suling WJ; Gurcha SS; Besra GS; Reynolds RC
  • Start Page

  • 3145
  • End Page

  • 3151
  • Volume

  • 9
  • Issue

  • 12