5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity

Academic Article


  • A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4- imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener–Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μ. © 1992, American Chemical Society. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Comber RN; Reynolds RC; Friedrich JD; Manguikian RA; Buckheit RW; Truss JW; Shannon WM; Secrist JA
  • Start Page

  • 3567
  • End Page

  • 3572
  • Volume

  • 35
  • Issue

  • 19