Associations of properdin factor B with melanoma

Academic Article


  • We investigated 98 melanoma patients and 135 normal controls for differences in phenotype and genotype frequencies at the properdin factor B locus. A significant negative association with the Bf-F allele and melanoma was found, resulting in an estimated relative risk of 0.5. The estimated relative risk for developing melanoma among people with the Bf-FF genotype is 0.07. The Bf-S phenotype was significantly increased among the melanoma sample, with an estimated risk of 6.5. The data suggest association of the Bf locus with a melanoma protection and/or susceptibility gene(s). © 1982.
  • Authors

    Published In

  • Cancer Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Budowle B; Barger BO; Balch CM; Go RCP; Roseman JM; Acton RT
  • Start Page

  • 247
  • End Page

  • 251
  • Volume

  • 5
  • Issue

  • 3