We explore the usefulness of a new drying gel containing miconazole nitrate 2% in a unique vehicle for the treatment of chronic intertrigo. Eleven patients with intertrigo were enrolled in the study and instructed to use the gel twice daily. All patients were followed for at least 12 weeks. At follow-up visits, they were asked subjective questions to assess the tolerability and effectiveness of the product. All patients (11/11) reported improvement of their intertrigo and a decrease in new areas of maceration. In addition, all patients were very satisfied with the cosmetic elegance of the product; they had previously used a currently marketed powder containing miconazole 2% but preferred the new gel product. No skin irritation was reported. This regimen is a useful addition to the currently available treatment options for chronic intertrigo.