O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonicalwntsignaling

Academic Article


  • Background: The molecular mechanisms by which Groucho/TLEs repress canonical Wnt signaling are incompletely understood. Results: OGT interacts with TLEs and facilitates TLE-mediated transcriptional repression. Removal of O-GlcNAc is essential for gene activation from Wnt-responsive promoters. Conclusion: OGT plays a vital role in TLE-mediated repression of Wnt signaling. Significance: O-GlcNAc modification has a profound influence on diverse signaling pathways. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Wu J; Bowe DB; Sadlonova A; Whisenhunt TR; Hu Y; Rustgi AK; Nie Y; Paterson AJ; Yang X
  • Start Page

  • 12168
  • End Page

  • 12176
  • Volume

  • 289
  • Issue

  • 17