Cortical DNA methylation maintains remote memory

Academic Article


  • A behavioral memory's lifetime represents multiple molecular lifetimes, suggesting the necessity for a self-perpetuating signal. One candidate is DNA methylation, a transcriptional repression mechanism that maintains cellular memory throughout development. We found that persistent, gene-specific cortical hypermethylation was induced in rats by a single, hippocampus-dependent associative learning experience and pharmacologic inhibition of methylation 1 month after learning disrupted remote memory. We propose that the adult brain utilizes DNA methylation to preserve long-lasting memories. © 2010 Nature America, Inc. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Miller CA; Gavin CF; White JA; Parrish RR; Honasoge A; Yancey CR; Rivera IM; Rubio MD; Rumbaugh G; Sweatt JD
  • Start Page

  • 664
  • End Page

  • 666
  • Volume

  • 13
  • Issue

  • 6