Precluding uracil from DNA

Academic Article


  • Two enzymes, dUTP pyrophosphatase and uracil-DNA glycosylase, prevent the misincorporation of uracil into the genome in distinct manners. The atomic structures of these proteins complexed with substrate analogs reveal the structural basis for uracil recognition and suggest a novel mechanism of DNA repair.
  • Published In

  • Structure  Journal
  • Digital Object Identifier (doi)

    Author List

  • Vassylyev DG; Morikawa K
  • Start Page

  • 1381
  • End Page

  • 1385
  • Volume

  • 4
  • Issue

  • 12