• Pi-Ling Chang, PhD is an Associate Professor of Nutrition Sciences at the University of Alabama at Birmingham (UAB). Dr. Chang received her baccalaureate degree in Natural Sciences and Master’s degree in Biochemistry from the University of Chicago. After serving as an instructor in the Department of Biochemistry at the King Saud University, Scientific College for Girls in Saudi Arabia for 5 years, she returned to the United States and earned her doctorate degree in Nutrition Sciences under the mentorship of Dr. Charles Prince at UAB. Dr. Chang’s major research interest focuses on understand how a normal cell develops into a tumor cells in the context of alteration in the cellular microenvironment triggered by external stresses. Specifically, how an elevation of a matricellular protein promote or facilitate a normal cells exposed to carcinogens, tumor promoters or ultraviolet radiation) transform into benign and subsequently, malignant tumors. More recently, Dr. Chang is also investigating novel rexinoids, RXR agonists, in collaboration with UAB chemists and physicians, for the potential treatment of cutaneous T-cell lymphomas, a rare disease with increasing incidence. Besides on-going research, Dr. Chang is teaching several courses in the department of Nutrition Sciences.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Assessing SPP1/Osteopontin (OPN) Splice Variants and Their Association to Nonmelanoma Skin Cancer by Absolute Quantification: Identification of OPN-5 Subvariants and Their Protein Coding PotentialCancer Investigation.  39:559-570. 2021
    2018 The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axisJournal of Dermatological Science.  90:343-356. 2018
    2015 Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axisMolecular Carcinogenesis.  54:379-392. 2015
    2014 Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma developmentJournal of Dermatological Science.  75:121-132. 2014
    2012 Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cellsInternational Journal of Cancer.  131:322-333. 2012
    2011 Reduced mitogenicity of sera following weight loss in premenopausal women 2011
    2010 Establishment and characterization of an osteopontin-null cutaneous squamous cell carcinoma cell line 2010
    2008 Osteopontin expression in normal skin and non-melanoma skin tumors 2008
    2006 Papilloma development is delayed in osteopontin-null mice: Implicating an antiapoptosis role for osteopontinCancer Research.  66:7119-7127. 2006
    2006 Comparison of fetal and adult marrow stromal cells in osteogenesis with and without glucocorticoidsConnective Tissue Research.  47:67-76. 2006
    2006 Production of chemokine CXCL1/KC by okadaic acid through the nuclear factor-κB pathwayCarcinogenesis.  27:43-52. 2006
    2005 Erratum: Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite (Journal of Biomedical Materials Research - Part A (2004) 68A, 2 (273-285) DOI: 10.1002/jbm.a.20043)Journal of Biomedical Materials Research Part A.  73:254. 2005
    2004 Erratum: Osteopontin induction is required for tumor promoter-induced transformation of preneoplastic mouse cells (Carcinogenesis (2003) vol. 24 (1749-1758))Carcinogenesis.  25:463. 2004
    2004 Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatiteJournal of Biomedical Materials Research Part A.  68:273-285. 2004
    2003 Differential expression of mammalian or viral promoter-driven gene in adherent versus suspension cells 2003
    2003 Osteopontin induction is required for tumor promoter-induced transformation of preneoplastic mouse cellsCarcinogenesis.  24:1749-1758. 2003
    2002 Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain: Differences in integrin signaling during cell adhesion to osteopontin versus vitronectinCancer Research.  62:5336-5343. 2002
    2002 Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression 2002
    2001 Hydroxylapatite binds more serum proteins, purified integrins, and osteoblast precursor cells than titanium or steelJournal of Applied Biomaterials.  57:258-267. 2001
    2001 Omega-3 fatty acids decrease protein kinase expression in human breast cancer cellsBreast Cancer Research and Treatment.  67:279-283. 2001
    2000 Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: Effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblastsArthritis and Rheumatism.  43:1597-1605. 2000
    2000 Attachment of primary neonatal rat astrocytes to vitronectin is mediated by integrins αvβ5 and α8β1: Modulation by the type 1 plasminogen activator inhibitorNeuroscience Letters.  283:157-161. 2000
    2000 Transforming JB6 cells exhibit enhanced integrin-mediated adhesion to osteopontinJournal of Cellular Biochemistry.  78:8-23. 2000
    1998 Osteopontin stimulates a subpopulation of quiescent human prostate epithelial cells with high proliferative potential to divide in vitro 1998
    1998 TPA-mediated regulation of osteopontin in human malignant glioma cells 1998
    1998 Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cellsCirculation Research.  82:139-146. 1998
    1997 Phosphorylation of osteopontin by Golgi apparatus casein kinaseBiochemical and Biophysical Research Communications.  240:602-605. 1997
    1997 Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathwaysClinical and Experimental Metastasis.  15:580-592. 1997
    1997 Human osteosarcoma MG-63 cells plus or minus calcitriol treatment do not secrete osteopontin 1997
    1996 Effects of calcitriol and its analogs on osteopontin expression in rat osteosarcoma (ROS 17/2.8) and mouse osteoblast (MC3T3-E1) cells 1996
    1996 Isolation of phosphorated and non-phosphorylated osteopontin by immobilized metal (Fe+ ) affinity chromatography 1996
    1996 Osteopontin stimulates proliferation of a population of progenitors of prostate epithelial cells.Molecular Biology of the Cell.  7:1421-1421. 1996
    1995 Effects of Okadaic Acid on Calcitriol‐and Phorbol Ester‐Induced Expression and Phosphorylation of Osteopontin in Mouse JB6 Epidermal CellsAnnals of the New York Academy of Sciences.  760:24-34. 1995
    1994 Calcitriol regulation of osteopontin expression in mouse epidermal cells 1994
    1993 Calcium-binding properties of osteopontin derived from non-osteogenic sourcesJournal of Biochemistry.  114:702-707. 1993
    1993 la,25-Dihydroxyvitamin D3 Enhances 12-0-Tetradecanoylphorbol-13-acetate-induced Tumorigenic Transformation and Osteopontin Expression in Mouse JB6 Epidermal Cells1Cancer Research.  53:2217-2220. 1993
    1991 1α,25-Dihydroxyvitamin D3 Stimulates Synthesis and Secretion of Nonphosphorylated Osteopontin (Secreted Phosphoprotein 1) in Mouse JB6 Epidermal CellsCancer Research.  51:2144-2150. 1991

    Research Overview

  • Project 1. Determining the function and regulation of matricellular protein, osteopontin, in normal and pathological conditions.
    Project 2. Assessing the therapeutic efficacy of novel RXR agonists for the treatment of cutaneous T-cell lymphoma (CTCL)
  • Teaching Overview

  • Dr. Chang has more than 20 years of teaching experience through mentoring graduate students in research laboratory, in class, and on-line. She was awarded the Dean's Excellence in Mentorship Award in 2017. She is presently serving as the course director for 3 courses: NTR 747 Molecular Biology and Nutrition Sciences, NTR 637 Applied Research in Nutrition Sciences, and NTR 690 Seminar.
  • Teaching Activities

  • NTR618 - Nutritional Biochemistry (Fall Term 2014)
  • NTR618 - Nutritional Biochemistry (Summer Term 2016)
  • NTR618 - Nutritional Biochemistry (Summer Term 2017)
  • NTR618 - Nutritional Biochemistry (Summer Term 2018)
  • NTR618 - Nutritional Biochemistry (Summer Term 2019)
  • NTR618 - Nutritional Biochemistry (Summer Term 2020)
  • NTR618 - Nutritional Biochemistry (Summer Term 2021)
  • NTR618 - Nutritional Biochemistry (Summer Term 2022)
  • NTR637 - App Res in Nutrition Sciences (Spring Term 2017)
  • NTR637 - App Res in Nutrition Sciences (Spring Term 2017)
  • NTR637 - App Res in Nutrition Sciences (Spring Term 2019)
  • NTR637 - App Res in Nutrition Sciences (Spring Term 2020)
  • NTR637 - App Res in Nutrition Sciences (Spring Term 2021)
  • NTR690 - Seminar (Fall Term 2019)
  • NTR690 - Seminar (Fall Term 2020)
  • NTR690 - Seminar (Fall Term 2021)
  • NTR718 - Nutritional Biochemistry (Fall Term 2014)
  • NTR718 - Nutritional Biochemistry (Summer Term 2016)
  • NTR718 - Nutritional Biochemistry (Summer Term 2017)
  • NTR718 - Nutritional Biochemistry (Summer Term 2018)
  • NTR718 - Nutritional Biochemistry (Summer Term 2019)
  • NTR733 - Lab Instr and Method Nutri Res (Fall Term 2009)
  • NTR745 - Origin of Cancer: Microenviron (Spring Term 2013)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2007)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2008)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2010)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2012)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2014)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2016)
  • NTR747 - Molecular Bio/Nutrition Sci (Fall Term 2022)
  • NTR747 - Molecular Bio/Nutrition Sci (Spring Term 2018)
  • NTR747 - Molecular Bio/Nutrition Sci (Spring Term 2020)
  • Full Name

  • Pi-Ling Chang