Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 An American Physiological Society cross-journal Call for Papers on “Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models” 2020
2020 Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease. 2020
2019 Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct 2019
2019 Truncating PKHD1 and PKD2 mutations alter energy metabolism 2019
2018 Announcement 2018
2017 TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicityFree Radical Biology and Medicine.  102:260-273. 2017
2016 Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model 2016
2015 Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegenerationProteomics.  15:4051-4063. 2015
2015 The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate 2015
2015 Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage 2015
2015 Perspectives: From bedside to bench 2015
2015 Fibrosis--A Common Pathway to Organ Injury and FailureNew England Journal of Medicine.  373:96. 2015
2015 Fibrosis-a common pathway to organ injury and failureNew England Journal of Medicine.  372:1138-1149. 2015
2015 Centrobin-mediated regulation of the centrosomal protein 4.1-associated protein (CPAP) level limits centriole length during elongation stageJournal of Biological Chemistry.  290:6890-6902. 2015
2015 Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney diseasePhysiological Reports.  3. 2015
2015 Molecular pathways and therapies in autosomal-dominant polycystic kidney diseasePhysiology.  30:195-207. 2015
2014 Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger 2014
2014 ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease 2014
2014 Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy 2014
2014 Characterization of renal toxicity in mice administered the marine biotoxin domoic acidJournal of the American Society of Nephrology.  25:1187-1197. 2014
2014 Measurement of three-dimensional anisotropic diffusion by multiphoton fluorescence recovery after photobleachingJournal of bioengineering.  42:555-565. 2014
2014 Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways 2014
2013 TRPP2 and TRPV4 Form an EGF-Activated Calcium Permeable Channel at the Apical Membrane of Renal Collecting Duct CellsPLoS One.  8. 2013
2013 An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissueCilia.  2. 2013
2013 Meet your new AJP-Renal Physiology editors 2013
2012 A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma 2012
2012 Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors 2012
2011 Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesisJournal of the American Society of Nephrology.  22:839-848. 2011
2011 The exocyst protein sec10 interacts with polycystin-2 and knockdown causes PKD-phenotypesPLoS Genetics.  7. 2011
2011 Cilia movement regulates expression of the Raf-1 kinase inhibitor protein 2011
2011 Determination of problematic ICD-9-CM subcategories for further study of coding performance: Delphi method.Perspectives in health information management / AHIMA, American Health Information Management Association.  8. 2011
2011 N-methyl-d-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct 2011
2010 Anisotropic solute diffusion tensor in porcine TMJ discs measured by FRAP with spatial fourier analysisJournal of bioengineering.  38:3398-3408. 2010
2010 Editors' note 2010
2010 Telomerase immortalization of principal cells from mouse collecting duct 2010
2009 A true champion of Hungarian kidney research and nephrology education--tribute to László Rosivall.Physiology International.  96:375-382. 2009
2009 ATP as a mediator of macula densa cell signallingPurinergic Signalling.  5:461-471. 2009
2009 Tubuloglomerular feedback mechanisms in nephron segments beyond the macula densaCurrent Opinion in Nephrology and Hypertension.  18:57-62. 2009
2008 Oscillating cortical thick ascending limb cells at the juxtaglomerular apparatusJournal of the American Society of Nephrology.  19:1940-1946. 2008
2008 Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signalsPurinergic Signalling.  4:155-170. 2008
2008 Investigation of protein kinase C activity in a polycystic kidney disease model 2008
2007 Altered pHi regulation and Na+/HCO-3 transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse 2007
2006 Unraveling the relationship between macula densa cell volume and luminal solute concentration/osmolalityKidney International.  70:865-871. 2006
2006 Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubuleKidney International.  69:2116-2118. 2006
2006 Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia 2006
2006 Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells 2006
2005 Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus 2005
2005 Improvement of blood pressure with inhibition of the epithelial sodium channel in blacks with hypertensionHypertension.  46:469-470. 2005
2005 Changes in intracellular Ca2+ and pH in response to thapsigargin in human glioblastoma cells and normal astrocytes 2005
2005 Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+ 2005
2005 Amyloid beta peptide 1-40 stimulates the Na+/Ca2+ exchange activity of SNCXCurrent Neurovascular Research.  2:3-12. 2005
2005 Characterization of basolateral chloride/bicarbonate exchange in macula densa cells 2005
2005 Renal cell-to-cell communication via extracellular ATPPhysiology.  20:86-90. 2005
2004 Current mechanisms of macula densa cell signallingActa Physiologica.  181:463-469. 2004
2004 Regulation of Mesangial Cell Na+/Ca2+ Exchanger IsoformsJournal of Cellular Physiology.  199:181-193. 2004
2004 Extracellular Zinc and ATP Restore Chloride Secretion across Cystic Fibrosis Airway Epithelia by Triggering Calcium EntryJournal of Biological Chemistry.  279:10720-10729. 2004
2004 Macula densa basolateral ATP release is regulated by luminal [NaCl] and dietary salt intake 2004
2004 Romancing the macula densa at UABKidney international. Supplement.  66. 2004
2003 Macula Densa Cell SignalingAnnual Review of Physiology.  65:481-500. 2003
2003 Neuronal nitric oxide synthase: Its role and regulation in macula densa cellsJournal of the American Society of Nephrology.  14:2475-2483. 2003
2003 Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney 2003
2003 Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney. 2003
2003 Na+/Ca2+ exchanger: Target for oxidative stress in salt-sensitive hypertensionHypertension.  42:363-368. 2003
2003 Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transportHypertension.  42:195-199. 2003
2003 Calcium-activated nonselective cationic channel in macula densa cells 2003
2003 Calcium-activated nonselective cationic channel in macula densa cells. 2003
2003 Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cellsJournal of Clinical Investigation.  112:76-82. 2003
2003 Impaired ability of the Na+/Ca2+ exchanger from the Dahl/Rapp salt-sensitive rat to regulate cytosolic calcium. 2003
2003 Impaired ability of the Na+/Ca2+ exchanger from the Dahl/Rapp salt-sensitive rat to regulate cytosolic calcium 2003
2003 Sustained calcium entry through P2X nucleotide receptor channels in human airway epithelial cellsJournal of Biological Chemistry.  278:13398-13408. 2003
2003 Macula densa cell signaling involves ATP release through a maxi anion channel 2003
2003 Confocal and two-photon microscopy.Methods in Molecular Medicine.  86:129-138. 2003
2002 Erratum: Two-photon fluorescence imaging of the living glomerular apparatus (American Journal of Physiology - Renal Physiology (July 2002) 283 (F197-F201)) 2002
2002 Two-photon excitation fluorescence imaging of the living juxtaglomerular apparatus. 2002
2002 Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT1 receptorsJournal of the American Society of Nephrology.  13:1131-1135. 2002
2002 Purinergic receptor signaling at the basolateral membrane of macula densa cellsJournal of the American Society of Nephrology.  13:1145-1151. 2002
2002 Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. 2002
2002 Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT(1) receptors. 2002
2002 Novel regulation of cell [Na(+)] in macula densa cells: apical Na(+) recycling by H-K-ATPase. 2002
2002 Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT1 receptors 2002
2002 Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys 2002
2002 Dysregulation of [Ca2+]i in OK-PTH cells expressing a mesangial cell Na+/Ca2+ exchanger isoform from Dahl/Rapp salt-sensitive ratsAnnals of the New York Academy of Sciences.  976:338-341. 2002
2002 Enhanced susceptibility of a Na+/Ca2+ exchanger isoform from mesangial cells of salt-sensitive Dahl/Rapp rats to oxidative stress inactivationAnnals of the New York Academy of Sciences.  976:342-344. 2002
2002 Erratum: Two-photon fluorescence imaging of the living glomerular apparatus (American Journal of Physiology Renal Physiology (July 2002) 283 (F197-F201)) 2002
2002 Novel regulation of cell [Na+] in macula densa cells: Apical Na+ recycling by H-K-ATPase 2002
2002 Real-time imaging of the living kidney juxtaglomerular apparatus with multiphoton microscopyProceedings of SPIE.  4620:259-266. 2002
2002 Two-photon excitation fluorescence imaging of the living juxtaglomerular apparatus 2002
2000 Macula densa Na+/H+ exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms 2000
2000 Cloning of mesangial cell Na(+)/Ca(2+) exchangers from Dahl/Rapp salt-sensitive/resistant rats. 2000
2000 Renal sodium/calcium exchange; A vasodilator that is defective in salt-sensitive hypertensionActa Physiologica.  168:209-214. 2000
2000 Cloning of mesangial cell Na+/Ca2+ exchangers from Dahl/Rapp salt-sensitive/resistant rats 2000
2000 Macula densa Na+/H+ exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms 2000
1999 6 calcium imaging in macula densa cells. 1999
1999 Altered protein kinase C activation of Na+/Ca2+ exchange in mesangial cells from salt-sensitive ratsAmerican Journal of Physiology.  276. 1999
1999 Cytosolic [Ca2+] signaling pathway in macula densa cells.American Journal of Physiology.  277:F472-F476. 1999
1999 Altered protein kinase C activation of Na+/Ca2+ exchange in mesangial cells from salt-sensitive rats.American Journal of Physiology.  276:F574-F580. 1999
1999 Renal arteriolar Na+/Ca2+ exchange in salt-sensitive hypertension.American Journal of Physiology.  276:F567-F573. 1999
1999 Altered protein kinase C activation of Na+/Ca2+ exchange in mesangial cells from salt-sensitive rats 1999
1999 Angiotensin II stimulates macula densa basolateral sodium/hydrogen exchange via type 1 angiotensin II receptorsJournal of the American Society of Nephrology.  10. 1999
1999 Cytosolic [Ca2+] signaling pathway in macula densa cells 1999
1999 Renal arteriolar Na+/Ca2+ exchange in salt-sensitive hypertension 1999
1998 Transport and regulatory properties of the apical Na-K-2Cl cotransporter of macula densa cells.American Journal of Physiology.  275:F703-F709. 1998
1998 NHE isoforms in macula densa cells 1998
1998 Regulation of the Na+:Ca2+ exchanger by angiotensin II-PKC in mesangial cells from salt Resistant (R) and salt Sensitive (S) rats 1998
1998 Ionic transport in macula densa cellsKidney International.  54. 1998
1998 Regulation of macula densa Na:H exchange by angiotensin IIKidney International.  54:2021-2028. 1998
1998 Transport and regulatory properties of the apical Na-K-2Cl cotransporter of macula densa cells 1998
1997 'Oxidation inhibits substrate proteolysis by calpain I but not autolysisJournal of Biological Chemistry.  272:2005-2012. 1997
1997 Characteristics of membrane transport processes of macula densa cellsClinical and Experimental Pharmacology and Physiology.  24:541-547. 1997
1996 Altered sodium-calcium exchange in afferent arterioles of the spontaneously hypertensive ratKidney International.  50:1889-1896. 1996
1996 Characterization of sodium-calcium exchange in rabbit renal arteriolesKidney International.  50:1856-1862. 1996
1995 A non-radioactive fluorescent method for measuring protein kinase C activityLife Sciences.  57:1701-1707. 1995
1995 Activation of Na:2Cl:K cotransport by luminal chloride in macula densa cellsKidney International.  47:752-757. 1995
1995 Evidence for apical sodium proton exchange in macula densa cellsKidney International.  47:746-751. 1995
1994 Basic properties and potential regulators of the apical K+ channel in macula densa cellsJournal of General Physiology.  103:1055-1070. 1994
1993 Segmentally distinct effects of depolarization on intracellular [Ca2+] in renal arterioles.American Journal of Physiology.  265:F677-F685. 1993
1993 Segmentally distinct effects of depolarization on intracellular [Ca2+] in renal arterioles 1993
1993 Intracellular Ca2+ and PKC activation do not inhibit Na+ and water transport in rat CCDAmerican Journal of Physiology.  265. 1993
1993 Intracellular Ca2+ and PKC activation do not inhibit Na+ and water transport in rat CCD.American Journal of Physiology.  265:F569-F577. 1993
1993 Intracellular Ca2+ and PKC activation do not inhibit Na+ and water transport in rat CCDAmerican Journal of Physiology.  265. 1993
1993 Segmentally distinct effects of depolarization on intracellular [Ca2+] in renal arteriolesAmerican Journal of Physiology.  265. 1993
1993 Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes 1993
1992 Permeability of the macula densa basement membrane area to high molecular weight moleculesKidney and Blood Pressure Research.  15:89-98. 1992
1991 Basolateral ionic permeabilities of macula densa cells.American Journal of Physiology.  260:F856-F860. 1991
1991 Role of cytosolic Ca in renal tubule damage induced by anoxia.American Journal of Physiology.  260:C545-C554. 1991
1991 Basolateral ionic permeabilities of macula densa cellsAmerican Journal of Physiology.  260. 1991
1991 Role of cytosolic Ca in renal tubule damage induced by anoxiaAmerican Journal of Physiology.  260. 1991
1991 Transport pathways in macula densa cellsKidney international. Supplement1991
1990 Direct evidence for apical Na+:2Cl-:K+ cotransport in macula densa cells.American Journal of Physiology.  258:F1466-F1469. 1990
1990 Membrane crosstalk in the mammalian proximal tubule during alterations in transepithelial sodium transport.American Journal of Physiology.  258:F339-F345. 1990
1990 Direct evidence for apical Na+:2Cl-:K+ cotransport in macula densa cellsAmerican Journal of Physiology.  258. 1990
1990 Membrane crosstalk in the mammalian proximal tubule during alterations in transepithelial sodium transportAmerican Journal of Physiology.  258. 1990
1989 Direct measurement of basolateral membrane potentials from cells of the macula densa.American Journal of Physiology.  257:F463-F468. 1989
1989 Effect of adenosine A1 analogue on tubuloglomerular feedback mechanism.American Journal of Physiology.  257. 1989
1989 Direct measurement of basolateral membrane potentials from cells of the macula densaAmerican Journal of Physiology.  257. 1989
1989 Effect of adenosine A1 analogue on tubuloglomerular feedback mechanismAmerican Journal of Physiology.  257. 1989
1988 Evaluation of prostaglandins as mediators of tubuloglomerular feedback.American Journal of Physiology.  254:F642-F649. 1988
1988 Angiotensin influences on tubuloglomerular feedback mechanism in hypertensive ratsKidney International.  34:631-637. 1988
1988 Cellular mechanisms for tubuloglomerular feedback signaling 1988
1988 Evaluation of prostaglandins as mediators of tubuloglomerular feedbackAmerican Journal of Physiology.  254. 1988
1988 Functional evidence for intraluminal adenosine A1 receptors participating in tubuloglomerular signal transmission 1988
1987 Calcium antagonists and intrarenal regulation of glomerular filtration rateAmerican Journal of Nephrology.  7:24-31. 1987
1987 Calcium as a mediator of tubuloglomerular feedbackAnnual Review of Physiology.  Vol. 49:275-293. 1987
1987 Myocardial cell growth and blood pressure development in neonatal spontaneously hypertensive ratsLaboratory Investigation.  56. 1987
1986 Tubuloglomerular feedback responses in the rat during calmodulin inhibition.American Journal of Physiology.  250:F715-F719. 1986
1986 Tubuloglomerular feedback responses in the rat during calmodulin inhibition 1986
1985 Direct visualization of the isolated and perfused macula densa 1985
1985 Cyclic AMP-calcium interaction in the transmission of tubuloglomerular feedback signalsKidney International.  28:728-732. 1985
1985 Direct visualization of the isolated and perfused macula densaAmerican Journal of Physiology.  17. 1985
1985 Prostaglandins in the sodium excretory response to altered renal arterial pressure in dogs 1985
1985 Prostaglandins in the sodium excretory response to altered renal arterial pressure in dogs.American Journal of Physiology.  248. 1985
1984 Tubuloglomerular feedback-mediated decreases in glomerular pressure in Munich-Wistar rats 1984
1984 Participation of prostaglandins in the mediation of tubuloglomerular feedback responses 1984
1984 Tubuloglomerular feedback-mediated decreases in glomerular pressure in Munich-Wistar ratsAmerican Journal of Physiology.  16. 1984
1983 Glomerular filtration dynamics during renal vasodilation with acetylcholine in the dogAmerican Journal of Physiology.  13. 1983
1983 Glomerular filtration dynamics during renal vasodilation with acetylcholine in the dog 1983
1983 Intracellular calcium in the transmission of tubuloglomerular feedback signalsAmerican Journal of Physiology.  14. 1983
1983 Intracellular calcium in the transmission of tubuloglomerular feedback signals 1983
1982 Macula densa feedback control of glomerular filtration: Role of cytosolic calciumMineral and electrolyte metabolism.  8:61-77. 1982
1982 Cytoplasmic calcium in the mediation of macula densa tubulo-glomerular feedback responsesScience.  215:670-673. 1982
1982 Influence of bradykinin and papaverine on renal and glomerular hemodynamics in dogsRenal physiology.  5:197-205. 1982
1982 Influence of converting enzyme inhibition on renal hemodynamics and glomerular dynamics in sodium-restricted dogsHypertension.  4:58-68. 1982
1982 Intrarenal feedback control of glomerular filtration rateSeminars in Nephrology.  2:289-301. 1982
1982 Luminal and cellular mechanisms for the mediation of tubuloglomerular feedback responsesKidney international. Supplement.  22. 1982
1982 Relationship between tubulo-glomerular feedback responses and perfusate hypotonicityKidney International.  22:234-239. 1982
1982 Role of a macula densa feedback mechanism as a mediator of renal autoregulationKidney international. Supplement.  22. 1982
1981 Bilateral renal function responses to converting enzyme inhibitor (SQ 20,881) in two-kidney, one clip goldblatt hypertensive ratsHypertension.  3:285-293. 1981
1981 Dissociation of tubuloglomerular feedback responses from distal tubular chloride concentration in the ratAmerican Journal of Physiology.  9. 1981
1981 Dissociation of tubuloglomerular feedback responses from distal tubular chloride concentration in the rat 1981
1981 Role of feedback mechanism in renal autoregulation and sensing step in feedback pathway. 1981
1980 Distal tubular feedback control of renal hemodynamics and autoregulation.Annual Review of Physiology.  42:557-571. 1980
1980 Effects of converting enzyme inhibitor (CE1. SQ 14,225) on renal hemodynamics and glomerular filtration rate (GFR) at reduced renal arterial pressurePhysiologist.  23. 1980
1980 Impaired renal blood flow autoregulation in ischemic acute renal failureKidney International.  18:68-76. 1980
1980 THE EFFICACY OF THIOPHANATE IN NATURAL NEMATODE INFESTATIONS OF SHEEP AND CATTLEAustralian Veterinary Journal.  56:350-351. 1980
1980 Tubuloglomerular feedback responses during perfusion with nonelectrolyte solutions in the ratKidney International.  18:460-471. 1980
1980 Tubuloglomerular feedback responses during retrograde distal tubular microperfusion with low chloride isotonic and hypotonic solutionsPhysiologist.  23. 1980
1979 Stop-flow pressure feedback responses during reduced renal vascular resistance in the dog.American Journal of Physiology.  237. 1979
1979 Glomerular and renal hemodynamics during converting enzyme inhibition (SQ20,881) in the dogHypertension.  1:371-377. 1979
1979 Glomerular filtration dynamics in the dog during elevated plasma colloid osmotic pressureKidney International.  15:502-512. 1979
1979 Stop-flow pressure feedback responses during reduced renal vascular resistance in the dog 1979
1978 Filtration rate and stop-flow pressure feedback responses to nephron perfusion in the dog.American Journal of Physiology.  234. 1978
1978 Distal tubule glomerular feedback responses during nephron perfusion with an isotonic mannitol solution in the ratPhysiologist.  21:7. 1978
1978 Filtration rate and stop-flow pressure feedback responses to nephron perfusion in the dog 1978
1978 Influence of perfusate osmolality on stop-flow pressure feedback responses in the dogAmerican Journal of Physiology.  4. 1978
1978 Influence of perfusate osmolality on stop-flow pressure feedback responses in the dog 1978
1978 Influence of vasodilators on glomerular filtration dynamics in the dogKidney International.  14:772. 1978
1977 Autoregulatory responses of superficial nephrons and their association with sodium excretion during arterial pressure alterations in the dogCirculation Research.  41:487-496. 1977
1977 Effects of alterations in distal nephron perfusate composition on stop flow pressure in the dog 1977
1977 Effects of angiotensin II blockade on single nephron filtration dynamics in the dogPhysiologist.  20:54. 1977
1977 Evaluation of the single nephron glomerular filtration coefficient in the dogKidney International.  12:137-149. 1977
1977 Possible role of osmolality in the mediation of the distal tubular-glomerular feedback responses in the dogKidney International.  12:568. 1977
1977 Renal hemodynamic and autoregulatory responses to acute hypercalcemiaAmerican Journal of Physiology.  232. 1977
1975 Absence of estimated glomerular pressure autoregulation during interrupted distal deliveryAmerican Journal of Physiology.  229:1596-1603. 1975
1974 Elevated glomerular pressure during proximal blockade and reduced distal delivery in the dogClinical research.  22. 1974

Chapter

Year Title Altmetric
2008 The Renal Microcirculation.  550-683. 2008

Education And Training

  • Doctor of Philosophy in Physiology, University of Alabama at Birmingham 1980
  • Bachelor of Science or Mathematics in Biology, Millsaps College 1974
  • Full Name

  • P. Darwin Bell