Environmental exposures and neoplastic changes modulate DNA damage response and repair pathways in cells. These changes leave mutagenic lesions within the DNA, resulting in mutations and chromosomal damage. The Gassman lab has two primary research areas that examine the modulation of DNA damage response and repair pathways. The first focus area is examining how environmental agents like bisphenol A or dihydroxyacetone, a combustion product from electronic cigarettes, induce DNA damage and alter the response of repair pathways. The second focus area examines the impact of dysregulated DNA repair in cancer development and its treatment. The Gassman lab has developed techniques to measure altered DNA repair in normal and tumor cells to determine defects in DNA repair pathways that may not be identified by mutation or gene expression changes. By measuring the lesions remaining within the genome, DNA repair defects can be identified and interactions within DNA repair pathways better understanding. Using this knowledge, the Gassman lab hopes to improve therapeutic selection and patient outcomes by mapping the modified DNA repair landscape in cancer. Their current focus areas are breast, ovarian, and prostate cancers. The long-term goal of the lab is to understand gene-environment interactions and their impact on genomic stability and human disease.