Selected Publications

Academic Article

Year Title Altmetric
2022 Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cellsPLoS One.  17. 2022
2022 Impact of Bisphenol A on Structure and Function of Mitochondria: A Critical ReviewReviews of Environmental Contamination and Toxicology.  260. 2022
2022 Solution Chemistry of Dihydroxyacetone and Synthesis of Monomeric DihydroxyacetoneChemical Research in Toxicology.  35:616-625. 2022
2022 Glucose Increases STAT3 Activation, Promoting Sustained XRCC1 Expression and Increasing DNA RepairInternational Journal of Molecular Sciences.  23. 2022
2022 Repair-Assisted Damage Detection Reveals Biological Disparities in Prostate Cancer between African Americans and European AmericansCancers.  14. 2022
2021 From single-molecule to genome-wide mapping of DNA lesions: repair-assisted damage detection sequencingBiophysical Reports.  1. 2021
2021 Resolving the Rules of Robustness and Resilience in Biology Across ScalesIntegrative and Comparative Biology.  61:2163-2179. 2021
2021 Cytoprotective effect of vitamin d on doxorubicin-induced cardiac toxicity in triple negative breast cancerInternational Journal of Molecular Sciences.  22. 2021
2021 Activated stat3 is a novel regulator of the xrcc1 promoter and selectively increases xrcc1 protein levels in triple negative breast cancerInternational Journal of Molecular Sciences.  22. 2021
2021 Associations between dna damage and pd-l1 expression in ovarian cancer, a potential biomarker for clinical responseBiology.  10. 2021
2021 Chemical and Biochemical Reactivity of the Reduced Forms of Nicotinamide RibosideACS Chemical Biology.  16:604-614. 2021
2021 Exogenous exposure to dihydroxyacetone mimics high fructose induced oxidative stress and mitochondrial dysfunctionEnvironmental and Molecular Mutagenesis.  62:185-202. 2021
2021 The biochemical pathways of nicotinamide-derived pyridonesInternational Journal of Molecular Sciences.  22:1-27. 2021
2020 Dihydronicotinamide riboside promotes cellspecific cytotoxicity by tipping the balance between metabolic regulation and oxidative stressPLoS One.  15. 2020
2020 Transcriptional dysregulation of base excision repair proteins in breast cancerDNA Repair.  93. 2020
2020 A cancer amidst us: The plexiform lesion in pulmonary arterial hypertension 2020
2020 EGFR signaling promotes resistance to CHK1 inhibitor prexasertib in triple negative breast cancer 2020
2020 Exploiting DNA repair defects in triple negative breast cancer to improve cell killingTherapeutic Advances in Medical Oncology.  12. 2020
2019 DNA damage measurements within tissue samples with Repair Assisted Damage Detection (RADD)Current Research in Biotechnology.  1:78-86. 2019
2019 Defective base excision repair in the response to DNA damaging agents in triple negative breast cancerPLoS One.  14. 2019
2019 Dihydroxyacetone Exposure Alters NAD(P)H and Induces Mitochondrial Stress and Autophagy in HEK293T CellsChemical Research in Toxicology.  32:1722-1731. 2019
2019 Bisphenol A co-exposure effects: a key factor in understanding BPA’s complex mechanism and health outcomesCritical Reviews in Toxicology.  49:371-386. 2019
2019 Targets for repair: detecting and quantifying DNA damage with fluorescence-based methodologiesCurrent Opinion in Biotechnology.  55:30-35. 2019
2019 Simultaneous detection of multiple DNA damage types by multi-colour fluorescent labellingChemical Communications.  55:11414-11417. 2019
2018 Analysis of single, cisplatin-induced DNA bends by atomic force microscopy and simulationsJournal of Molecular Recognition.  31. 2018
2018 Variations in nuclear localization strategies among pol X family enzymesTraffic.  19:723-735. 2018
2018 Significant Engagement in Tanning Behaviors by Men at a U.S. UniversityJournal of Community Health.  43:656-659. 2018
2018 A truly safer alternative? Sunless tanning products and the unknownPreventive Medicine.  112:45-46. 2018
2018 Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic FibroblastsChemical Research in Toxicology.  31:510-519. 2018
2018 Broad spectrum detection of DNA damage by Repair Assisted Damage Detection (RADD)DNA Repair.  66-67:42-49. 2018
2018 Intentional tanning behaviors among undergraduates on the United States' Gulf CoastBMC Public Health.  18. 2018
2018 XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activityDNA Repair.  64:26-33. 2018
2018 Dihydroxyacetone induces G2/M arrest and apoptotic cell death in A375P melanoma cellsEnvironmental toxicology and water quality.  33:333-342. 2018
2018 DNA Polymerase β Mediates Robust Base Lesion Repair in Mammalian Mitochondria 2018
2017 PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1Nucleic Acids Research.  45:12834-12847. 2017
2017 College tanning behaviors, attitudes, beliefs, and intentions: A systematic review of the literaturePreventive Medicine.  105:77-87. 2017
2017 DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondriaDNA Repair.  60:77-88. 2017
2017 XRCC1-mediated repair of strand breaks independent of PNKP bindingDNA Repair.  60:52-63. 2017
2017 High prevalence of combination tanning among undergraduates: Survey at a southeastern US universityJournal of the American Academy of Dermatology.  77:968-970. 2017
2017 Application of laser micro-irradiation for examination of single and double strand break repair in mammalian cellsJournal of Visualized Experiments.  2017. 2017
2017 Role of the oxidized form of XRCC1 in protection against extreme oxidative stressFree Radical Biology and Medicine.  107:292-300. 2017
2017 Induction of oxidative stress by bisphenol A and its pleiotropic effectsEnvironmental and Molecular Mutagenesis.  58:60-71. 2017
2017 DNA polymerase β contains a functional nuclear localization signal at its N-terminusNucleic Acids Research.  45:1958-1970. 2017
2016 Combined effects of high-dose bisphenol A and oxidizing agent (KBrO3) on cellular microenvironment, gene expression, and chromatin structure of Ku70-deficient mouse embryonic fibroblastsEnvironmental Health Perspectives.  124:1241-1252. 2016
2015 Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLSScientific Reports.  5. 2015
2015 Micro-irradiation tools to visualize base excision repair and single-strand break repairDNA Repair.  31:52-63. 2015
2015 Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblastsPLoS One.  10. 2015
2015 DNA polymerase β-dependent cell survival independent of XRCC1 expressionDNA Repair.  26:23-29. 2015
2014 Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repairNucleic Acids Research.  42:6337-6351. 2014
2014 Toward single-molecule optical mapping of the epigenomeACS Nano.  8:14-26. 2014
2014 Base excision repair defects invoke hypersensitivity to PARP inhibitionMolecular Cancer Research.  12:1128-1139. 2014
2013 Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responsesDNA Repair.  12:774-785. 2013
2013 Interaction between DNA Polymerase β and BRCA1PLoS One.  8. 2013
2012 Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse FibroblastsPLoS One.  7. 2012
2012 HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblastsJournal of Biological Chemistry.  287:27648-27658. 2012
2011 Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6PLoS One.  6. 2011
2010 Selection of bead-displayed, PNA-encoded chemicalsJournal of Molecular Recognition.  23:414-422. 2010
2009 Combining atomic force and fluorescence microscopy for analysis of quantum-dot labeled protein-DNA complexesJournal of Molecular Recognition.  22:397-402. 2009
2009 In vivo multimotor force-velocity curves by tracking and sizing sub-diffraction limited vesiclesCellular and Molecular Bioengineering.  2:190-199. 2009
2009 In vivo assembly and single-molecule characterization of the transcription machinery from Shewanella oneidensis MR-1Protein Expression and Purification.  65:66-76. 2009
2009 Lighting up individual DNA binding proteins with quantum dots 2009
2008 Efficient site-specific labeling of proteins via cysteinesBioconjugate Chemistry.  19:786-791. 2008
2007 Three-color alternating-laser excitation of single molecules: Monitoring multiple interactions and distancesBiophysical Journal.  92:303-312. 2007


Year Title Altmetric
2022 Preface.  Ed. 2022-January.  2022
2006 The Global Technology Revolution 2020, Executive Summary: Bio/Nano/Materials/Information Trends, Drivers, Barriers, and Social Implications 2006


Year Title Altmetric
2016 Bisphenol A and Nongenotoxic Drivers of Cancer.  415-438. 2016
2010 Mapping transcription factors on extended dna: A single molecule approach.  203-216. 2010

Research Overview

  • Environmental exposures and neoplastic changes modulate cells' DNA damage response and repair pathways. These changes leave mutagenic lesions within the DNA, resulting in mutations and chromosomal damage. The Gassman lab has two primary research areas that examine the modulation of DNA damage response and repair pathways. The first focus area is examining how environmental agents like bisphenol A or dihydroxyacetone, a combustion product from electronic cigarettes, induce DNA damage and alter the response of repair pathways. The second focus area examines the impact of dysregulated DNA repair on cancer development and its treatment. The Gassman lab has developed techniques to measure altered DNA repair in normal and tumor cells to determine defects in DNA repair pathways that mutation or gene expression changes may not identify. DNA repair defects can be identified by measuring the lesions remaining within the genome, providing a better understanding of interactions within DNA repair pathways. Using this knowledge, the Gassman lab hopes to improve therapeutic selection and patient outcomes by mapping the modified DNA repair landscape in cancer. Their current focus areas are breast, ovarian, and prostate cancers. The lab's long-term goal is to understand gene-environment interactions and their impact on genomic stability and human disease.
  • Education And Training

  • Doctor of Philosophy in Physical Chemistry, University of California Los Angeles 2008
  • Full Name

  • Natalie Gassman