Selected Publications

Academic Article

Year Title Altmetric
2023 Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamicsJournal of Biological Chemistry.  299. 2023
2022 Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin CancersJournal of Medicinal Chemistry.  65:14409-14423. 2022
2022 Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substratesJournal of Biological Chemistry.  298. 2022
2021 A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cellsCommunications Biology.  4. 2021
2021 Characterization of subunit interactions in the hetero-oligomeric retinoid oxidoreductase complexBiochemical Journal.  478:3597-3611. 2021
2021 17-Beta Hydroxysteroid Dehydrogenase 13 Deficiency Does Not Protect Mice From Obesogenic Diet InjuryHepatology.  73:1701-1716. 2021
2021 Dietary Vitamin A Impacts Refractory TelogenFrontiers in Cell and Developmental Biology.  9. 2021
2021 Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetesJournal of Biological Chemistry.  296. 2021
2020 Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activityJournal of Lipid Research.  61:1400-1409. 2020
2020 Generation of retinaldehyde for retinoic acid biosynthesisBiomolecules.  10. 2020
2019 Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glandsJournal of Biological Chemistry.  294:17060-17074. 2019
2019 17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver DiseaseHepatology.  69:1504-1519. 2019
2019 Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient damsChemico-Biological Interactions.  302:117-122. 2019
2019 Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complexJournal of Biological Chemistry.  294:838-851. 2019
2018 Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in miceJournal of Biological Chemistry.  293:6996-7007. 2018
2017 Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10Chemico-Biological Interactions.  276:88-94. 2017
2017 The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasisJournal of Biological Chemistry.  292:5884-5897. 2017
2016 Retinoic acid synthesis and degradationSub-cellular biochemistry.  81:127-161. 2016
2016 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a ChordateMolecular Biology and Evolution.  33:2401-2416. 2016
2016 Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermisPLoS One.  11. 2016
2015 Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary CancersJournal of Medicinal Chemistry.  58:7763-7774. 2015
2015 Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C familyChemico-Biological Interactions.  234:135-143. 2015
2014 The retinaldehyde reductase activity of dhrs3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasisJournal of Biological Chemistry.  289:14868-14880. 2014
2013 Enzymology of retinoic acid biosynthesis and degradationJournal of Lipid Research.  54:1744-1760. 2013
2013 IntroductionChemico-Biological Interactions.  202:1. 2013
2013 Chemico-Biological Interactions. Enzymology and molecular biology of carbonyl metabolism 16. Introduction.Chemico-Biological Interactions.  202:1. 2013
2012 Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic developmentJournal of Biological Chemistry.  287:9061-9071. 2012
2011 Chemico-Biological Interactions: IntroductionChemico-Biological Interactions.  191:1. 2011
2011 Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49MChemico-Biological Interactions.  191:55-59. 2011
2011 Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft cultureJournal of Biological Chemistry.  286:13550-13560. 2011
2010 Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific ratesFEBS Letters.  584:507-510. 2010
2009 Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster 2009
2009 Biochemical characterization of human epidermal retinol dehydrogenase 2Chemico-Biological Interactions.  178:182-187. 2009
2009 The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiativeChemico-Biological Interactions.  178:94-98. 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profile 2009
2008 Medium- and short-chain dehydrogenase/reductase gene and protein families: Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolismCellular and Molecular Life Sciences.  65:3936-3949. 2008
2008 Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenaseJournal of Biological Chemistry.  283:20299-20308. 2008
2008 Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolism 2008
2008 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity 2008
2007 Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12Journal of Biological Chemistry.  282:35621-35628. 2007
2007 Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissues 2007
2006 Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificityGenomics.  88:820-830. 2006
2006 Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoidsBiochemical Journal.  399:101-109. 2006
2005 Biochemical properties of purified human retinol dehydrogenase 12 (RDH 12): Catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoidsBiochemistry.  44:7035-7047. 2005
2005 Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: A role of RDH11 in visual processes in vivoJournal of Biological Chemistry.  280:8694-8704. 2005
2004 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1Journal of Pharmacology and Experimental Therapeutics.  310:469-476. 2004
2003 Properties of Short-Chain Dehydrogenase/Reductase RalR1: Characterization of Purified Enzyme, Its Orientation in the Microsomal Membrane, and Distribution in Human Tissues and Cell LinesBiochemistry.  42:14838-14845. 2003
2003 13-cis-retinoic acid competitively inhibits 3α-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: A mechanism for its anti-androgenic effects in sebaceous glands?Biochemical and Biophysical Research Communications.  303:273-278. 2003
2003 Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4Chemico-Biological Interactions.  143-144:279-287. 2003
2003 Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: Characterization of the holo-CRBP dehydrogenase activity of RoDH-4Biochemistry.  42:776-784. 2003
2002 Multifunctional nature of human retinol dehydrogenasesCurrent Organic Chemistry.  6:1247-1257. 2002
2002 Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissuesFEBS Letters.  531:489-493. 2002
2002 Evidence that the human gene for prostate short-chain dehydrogenase/ reductase (PSDR1) encodes a novel retinal reductase (RalR1)Journal of Biological Chemistry.  277:28909-28915. 2002
2001 Characterization of a novel type of human microsomal 3α -hydroxysteroid dehydrogenase. Unique tissue distribution and catalytic propertiesJournal of Biological Chemistry.  276:22278-22286. 2001
2001 Further characterization of human microsomal 3α-hydroxysteroid dehydrogenaseMolecular cell biology research communications : MCBRC.  386:1-10. 2001
2001 Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structureChemico-Biological Interactions.  130-132:457-467. 2001
2000 Mammalian methylmalonate-semialdehyde dehydrogenaseMethods in Enzymology.  324:207-218. 2000
1998 Effect of cellular retinol-binding protein on retinol oxidation by human class IV retinol/alcohol dehydrogenase and inhibition by ethanolBiochemical and Biophysical Research Communications.  249:191-196. 1998
1998 cDNA cloning and characterization of a new human microsomal NAD+- dependent dehydrogenase that oxidizes all-trans-retinol and 3α- hydroxysteroidsJournal of Biological Chemistry.  273:19778-19785. 1998
1997 Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroinJournal of Biological Chemistry.  272:14769-14775. 1997
1997 cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3β,5α-hydroxysteroidsJournal of Biological Chemistry.  272:7494-7500. 1997
1996 Erratum: Diversity of the pyruvate dehydrogenase kinase gene family in humans (Journal of Biological Chemistry (1995) 270 (28989-28994))Journal of Biological Chemistry.  271:1250. 1996
1995 Cimetidine Inhibition of Human Gastric and Liver Alcohol Dehydrogenase Isoenzymes: Identification of Inhibitor Complexes by Kinetics and Molecular ModelingBiochemistry.  34:4008-4014. 1995
1995 Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase: Active-site amino acid sequence explains substrate specificity compared with liver isozymesJournal of Biological Chemistry.  270:3625-3630. 1995
1995 A new family of protein kinases- The mitochondrial protein kinasesAdvances in Biological Regulation.  35. 1995
1995 Dietary control and tissue specific expression of branched-chain α-ketoacid dehydrogenase KinaseMolecular cell biology research communications : MCBRC.  316:148-154. 1995
1995 Diversity of the pyruvate dehydrogenase kinase gene family in humansJournal of Biological Chemistry.  270:28989-28994. 1995
1994 Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinaseJournal of Biological Chemistry.  269:29720-29724. 1994
1994 Coordinated expression of valine catabolic enzymes during adipogenesis: Analysis of activity, mRNA, protein levels, and metabolic consequencesMolecular cell biology research communications : MCBRC.  315:317-322. 1994
1994 Effect of dietary protein on the liver content and subunit composition of the branched-chain α-ketoacid dehydrogenase complexMolecular cell biology research communications : MCBRC.  308:446-453. 1994
1993 Evolutionary relationships of branched chain and non-specific alcohol and aldehyde dehydrogenasesAdvances in Experimental Medicine and Biology.  328:523-532. 1993
1993 Molecular cloning of the branched-chain α-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenaseAdvances in Biological Regulation.  33:255-258. 1993
1993 Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinasesJournal of Biological Chemistry.  268:26602-26606. 1993
1992 Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenase 1992
1992 CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distributionJournal of Biological Chemistry.  267:19724-19729. 1992
1991 The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenaseMolecular cell biology research communications : MCBRC.  290:21-26. 1991


Year Title Altmetric
2020 Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids.  493-512. 2020
2020 Generation and isolation of recombinant retinoid oxidoreductase complex.  77-93. 2020

Principal Investigator On

Education And Training

  • Doctor of Philosophy in Mathematics, Moscow State University named after M.V. Lomonosov 1987
  • Master of Science in Biological and Biomedical Sciences, Moscow State University named after M.V. Lomonosov 1982
  • Full Name

  • Natalia Kedishvili