Selected Publications

Academic Article

Year Title Altmetric
2017 Pilus biogenesis of Gram-positive bacteria: Roles of sortases and implications for assemblyProtein Science.  26:1458-1473. 2017
2013 Secreted proteases control autolysin-mediated biofilm growth of staphylococcus aureusJournal of Biological Chemistry.  288:29440-29452. 2013
2013 Structure of Streptococcus agalactiae tip pilin GBS104: A model for GBS pili assembly and host interactionsActa Crystallographica Section D: Biological Crystallography.  69:1073-1089. 2013
2013 Purification, crystallization and preliminary X-ray diffraction analysis of the Staphylococcus epidermidis extracellular serine protease Esp 2013
2011 The crystal structure analysis of group B streptococcus sortase C1: A model for the "lid" movement upon substrate bindingJournal of Molecular Biology.  414:563-577. 2011
2011 Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1PLoS ONE.  6. 2011
2011 Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development 2011
2011 Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactionsJournal of Biological Chemistry.  286:25963-25972. 2011
2011 Crystallography of gram-positive bacterial adhesinsAdvances in Experimental Medicine and Biology.  715:175-195. 2011
2011 Structural biology of Gram-positive bacterial adhesinsProtein Science.  20:759-772. 2011
2011 A model for group B Streptococcus pilus type 1: The structure of a 35-kDa C-terminal fragment of the major pilin GBS80Journal of Molecular Biology.  407:731-743. 2011
2010 Purification, crystallization and halide phasing of a Streptococcus agalactiae backbone pilin GBS80 fragment 2010
2010 Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1 2010
2009 The Crystal Structure of Cobra Venom Factor, a Cofactor for C3- and C5-Convertase CVFBbStructure.  17:611-619. 2009
2009 The structure of C2b, a fragment of complement component C2 produced during C3 convertase formationActa Crystallographica Section D: Biological Crystallography.  65:266-274. 2009
2008 Evidence for the "dock, lock, and latch" ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrGJournal of Biological Chemistry.  283:638-647. 2008
2008 Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase ABioorganic and Medicinal Chemistry Letters.  18:380-385. 2008
2007 Crystal structure of ACE19, the collagen binding subdomain of Enterococus Faecalis surface protein ACE 2007
2007 Deciphering complement mechanisms: The contributions of structural biologyMolecular Immunology.  44:3809-3822. 2007
2007 An IgG-like Domain in the Minor Pilin GBS52 of Streptococcus agalactiae Mediates Lung Epithelial Cell AdhesionStructure.  15:893-903. 2007
2007 The Enterococcus faecalis MSCRAMM ace binds its ligand by the collagen hug modelJournal of Biological Chemistry.  282:19629-19637. 2007
2007 The Crystal Structure of C2a, the Catalytic Fragment of Classical Pathway C3 and C5 Convertase of Human ComplementJournal of Molecular Biology.  367:224-233. 2007
2007 Crystal structure of C2a, the catalytic subunit of classical pathway C3-convertaseMolecular Immunology.  44:199-199. 2007
2005 A 'Collagen Hug' Model for Staphylococcus aureus CNA binding to collagen 2005
2004 Anchoring of surface proteins to the cell wall of Staphylococcus aureus: A conserved arginine residue is required for efficient catalysis of sortase AJournal of Biological Chemistry.  279:37763-37770. 2004
2004 Crystal structures of Staphylococcus aureus Sortase A and its substrate complexJournal of Biological Chemistry.  279:31383-31389. 2004
2004 Structural analysis of engineered Bb fragment of complement factor B: Insights into the activation mechanism of the alternative pathway C3-convertaseMolecular Cell.  14:17-28. 2004
2004 The Structure of Sortase B, a Cysteine Transpeptidase that Tethers Surface Protein to the Staphylococcus aureus Cell WallStructure.  12:105-112. 2004
2003 A "dock, lock, and latch" structural model for a staphylococcal adhesin binding to fibrinogenCell.  115:217-228. 2003
2003 A structural model for the inhibition of calpain by calpastatin: Crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitorJournal of Molecular Biology.  328:131-146. 2003
2002 A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: Crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A 2002
2002 Crystallization and preliminary X-ray crystallographic analysis of Ace: A collagen-binding MSCRAMM from Enterococcus faecalis 2002
2001 Structural Organization of the Fibrinogen-binding Region of the Clumping Factor B MSCRAMM of Staphylococcus aureusJournal of Biological Chemistry.  276:44721-44728. 2001
2001 Structural biology of the alternative pathway convertaseImmunological Reviews.  180:123-135. 2001
2000 Structure of FKBP12.6 in complex with rapamycinActa Crystallographica Section D: Biological Crystallography.  56:266-271. 2000
2000 New structural motifs on the chymotrypsin fold and their potential roles in complement factor B 2000
2000 Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp226 is a major structural determinant for P1-Arg bindingJournal of Biological Chemistry.  275:378-385. 2000
2000 Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface proteinStructure.  8:67-78. 2000
1999 Erratum: Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, α1β1 integrin and Staphylococcus aureus Cna MSCRAMM (Journal of Biological Chemistry (1999) 274 (24906-24913))Journal of Biological Chemistry.  274:28836. 1999
1999 Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus Cna MSCRAMM. (vol 274, pg 24906, 1999)Journal of Biological Chemistry.  274:28836-28836. 1999
1999 Ace is a collagen-binding MSCRAMM from Enterococcus faecalisJournal of Biological Chemistry.  274:26939-26945. 1999
1999 Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, α1β1 integrin and Staphylococcus aureus Cna MSCRAMMJournal of Biological Chemistry.  274:24906-24913. 1999
1999 Structural basis of profactor D activation: From a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D 1999
1999 Crystallization and preliminary X-ray analysis of B-domain fragments of a Staphylococcus aureus collagen-binding proteinActa Crystallographica Section D: Biological Crystallography.  55:525-527. 1999
1999 Crystallization of ClfA and ClfB fragments: The fibrinogen-binding surface proteins of Staphylococcus aureusActa Crystallographica Section D: Biological Crystallography.  55:554-556. 1999
1999 Expression, purification, crystallization and preliminary x-ray diffraction analysis of uracil phosphoribosyltransferase of Toxoplasma gondiiActa Crystallographica Section D: Biological Crystallography.  55:347-349. 1999
1998 Domain structure of the Staphylococcus aureus collagen adhesinBiochemistry.  37:15423-15433. 1998
1998 Structures of native and complexed complement factor D: Implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activityJournal of Molecular Biology.  282:1061-1081. 1998
1998 Crystallization and preliminary crystallographic investigation of porcine quinolinate phosphoribosyltransferaseActa Crystallographica Section D: Biological Crystallography.  54:119-120. 1998
1998 The atypical serine proteases of the complement systemAdvances in Immunology.  69:249-307. 1998
1997 A growing family of the Ca2+-binding proteins with five EF-hand motifs.Biochemical Journal.  328. 1997
1997 Structure of the collagen-binding domain from a Staphylococcus aureus adhesin 1997
1997 Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding 1997
1997 Preliminary crystallographic study on a low molecular weight form of bacterial plasminogen activator staphylokinaseActa Crystallographica Section D: Biological Crystallography.  53:480-481. 1997
1997 Purification, crystallization and preliminary X-ray diffraction studies of recombinant calcium-binding domain of the small subunit of porcine calpainActa Crystallographica Section D: Biological Crystallography.  53:474-476. 1997
1997 Refined structure of purine nucleoside phosphorylase at 2.75 Å ResolutionActa Crystallographica Section D: Biological Crystallography.  53:131-142. 1997
1997 Site-Directed Mutagenesis of the Phosphocholine-Binding Site of Human C-Reactive Protein: Role of Thr76 and Trp67Journal of Immunology.  158:345-350. 1997
1997 Structure of diisopropyl fluorophosphate-inhibited factor DActa Crystallographica Section D: Biological Crystallography.  53:143-150. 1997
1996 Mutational analysis of the phosphocholine (pch)-binding site of human c-reactive protein (crp)The FASEB Journal.  10. 1996
1996 Complement factor D, a novel serine proteaseProtein Science.  5:553-564. 1996
1995 Erratum: Crystal structure of a complement factor D mutant expressing enhanced catalytic activity (Journal of Biological Chemistry (1995) 270 (24399-24405))Journal of Biological Chemistry.  270:31414. 1995
1995 Catalytic role of a surface loop of the complement serine protease factor DJournal of Immunology.  154:6073-6079. 1995
1995 Crystal structure of a complement factor D mutant expressing enhanced catalytic activityJournal of Biological Chemistry.  270:24399-24405. 1995
1994 Mutational Analysis of the Substrate Binding Site of Human Complement Factor DBiochemistry.  33:14393-14399. 1994
1994 Preliminary crystallographic studies on human complement pro-factor DJournal of Molecular Biology.  235:1144-1146. 1994
1994 Comparison of homology models with experimental structure of a novel serine proteaseActa Crystallographica Section D: Biological Crystallography.  50:889-899. 1994
1994 Error detection in crystallographic modelsActa Crystallographica Section D: Biological Crystallography.  50:900-909. 1994
1994 Recent results and new hardware developments for protein crystal growth in microgravityJournal of Crystal Growth.  135:183-195. 1994
1994 Structure of Human Factor DJournal of Molecular Biology.  235:695-708. 1994
1994 Structure of human factor D: A complement system protein at 2.0 Å resolutionJournal of Molecular Biology.  235:695-708. 1994
1994 Structures of human and porcine aldehyde reductase: An enzyme implicated in diabetic complicationsActa Crystallographica Section D: Biological Crystallography.  50:859-868. 1994
1993 Crystallization and preliminary structure determination of porcine aldehyde reductase from two crystal forms.Acta Crystallographica Section D: Biological Crystallography.  49:490-496. 1993
1991 Crystallization and preliminary X-ray investigation of factor D of human complementJournal of Molecular Biology.  219:1-3. 1991
1991 Purification, crystallization and preliminary crystallographic analysis of porcine aldose reductaseJournal of Molecular Biology.  218:695-698. 1991
1987 Crystallization and preliminary X-ray investigation of uridine phosphorylase from Escherichia coli.Journal of Biological Chemistry.  262:2852-2853. 1987
1986 The integrase family of site-specific recombinases: regional similarities and global diversity. 1986
1985 Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetaseJournal of Biological Chemistry.  260:3350-3354. 1985
1985 Primary structural comparison of the preprohormones cholecystokinin and gastrinFEBS Letters.  182:135-138. 1985
1985 Structural similarity between legumin and vicilin storage proteins from legumes. 1985
1984 Residue contacts in protein structures and implications for protein foldingInternational journal of peptide and protein research.  24:25-39. 1984
1980 Crystal and molecular structure of 2α-bromo-α-tetrahydrosantoninPerkin 2.  1116-1118. 1980
1977 Reaction of selenium sulphide with triphenyl compounds of group V elements 1977


Year Title Altmetric
2018 C2.  127-134. 2018

Education And Training

  • Doctor of Philosophy in Chemistry, 1980
  • Full Name

  • Narayana Sthanam