• While pursuing basic medical research training, he realized how strong his desire was to couple clinical practice with fundamental and translational research. It is for that reason that he matched at UT Southwestern for clinical training and was pleased that his performance there led to being accepted into the prestigious cardiology fellowship at UT Southwestern started in July 2010. During his three years of research, he worked on the cardioprotective effects of histone deacetylase inhibitor (HDAC inhibitor) on ischemia/reperfusion (I/R) injury. He found that SAHA, an FDA-approved anti-cancer HDAC inhibitor, reduced infarct size by 40% when given at the time of reperfusion in a rabbit I/R model (large animal model). Mechanistically, SAHA induces autophagy in the infarct border zone to prevent cardiomyocyte death. This work has been presented at AHA, ACC, HFSA and Northwestern Cardiovascular Young Investigators' Forum and has won two awards. This study has led to a Circulation publication. Aside of the published work, he has also done pilot studies with novel autophagy-inducing agents, Tat-Beclin peptides, and also with cardiac-specific knockout mice of essential autophagy genes, ATG7 an ATG5, which led to a K08, mentored physician-scientist award.
    After graduation from his cardiology fellowship, he joined the faculty at the University of Alabama at Birmingham (UAB). His studies supported by K08 led to an NHLBI R03 award studying ketone bodies function in cardiac I/R injury.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Perimyocarditis following first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine in a healthy young male: a case reportBMC Cardiovascular Disorders.  21. 2021
    2021 Branched chain amino acids selectively promote cardiac growth at the end of the awake periodJournal of Molecular and Cellular Cardiology.  157:31-44. 2021
    2021 Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury.Circulation Research.  129:435-450. 2021
    2021 Beta-Hydroxybutyrate, Friend or Foe for Stressed Hearts 2021
    2021 Natural Killer Cell-Derived Extracellular Vesicles: Novel Players in Cancer ImmunotherapyFrontiers in Immunology.  12. 2021
    2021 Immunoregulatory Effects of Mitochondria Transferred by Extracellular VesiclesFrontiers in Immunology.  11. 2021
    2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy.  17:1-382. 2021
    2020 Analysis of Risk Factors Associated With Poor Outcome in Posterior Reversible Encephalopathy Syndrome After Treatment in Children: Systematic Review and Meta-AnalysisFrontiers in Neurology.  11. 2020
    2020 TMEM173 Drives Lethal Coagulation in SepsisCell Host and Microbe.  27:556-570.e6. 2020
    2020 Immunoregulatory Effects of Stem Cell-Derived Extracellular Vesicles on Immune CellsFrontiers in Immunology.  11. 2020
    2020 Cyclin d2 overexpression enhances the efficacy of human induced pluripotent stem cell-derived cardiomyocytes for myocardial repair in a swine model of myocardial infarctionCirculation.  210-228. 2020
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In VivoCell Stem Cell.  24:579-591.e12. 2019
    2019 Extracellular HMGB1 prevents necroptosis in acute myeloid leukemia cellsBiomedicine and Pharmacotherapy.  112. 2019
    2019 HDAC inhibition as a therapeutic strategy in myocardial ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  129:188-192. 2019
    2018 AMPK regulates immunometabolism in sepsisBrain, Behavior, and Immunity.  72:89-100. 2018
    2018 The Circadian Clock Controls Immune Checkpoint Pathway in SepsisCell Reports.  24:366-378. 2018
    2016 The receptor for advanced glycation end products activates the AIM2 inflammasome in acute pancreatitisJournal of Immunology.  196:4331-4337. 2016
    2016 Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCirculation.  133:1668-1687. 2016
    2015 Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagyAutophagy.  11:214-224. 2015
    2014 Microtubules Regulate Focal Adhesion Dynamics through MAP4K4Developmental Cell.  31:572-585. 2014
    2014 Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagyCirculation.  129:1139-1151. 2014
    2014 MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cellAutophagy.  10:442-452. 2014
    2013 Pathological ventricular remodeling: Therapies: Part 2 of 2Circulation.  128:1021-1030. 2013
    2013 Pathological ventricular remodeling: Mechanisms: Part 1 of 2Circulation.  128:388-400. 2013
    2013 Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsisBiochemical Pharmacology.  86:410-418. 2013
    2012 Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells 2012
    2012 HMGB1 promotes drug resistance in osteosarcomaCancer Research.  72:230-238. 2012
    2012 S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagyInternational Journal of Molecular Medicine.  29:65-72. 2012
    2012 Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcomaAutophagy.  8:275-277. 2012
    2011 HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cellsBMB Reports.  44:601-606. 2011
    2011 UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activationEMBO Reports.  12:727-734. 2011
    2011 TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney 2011
    2011 Tuning flux: Autophagy as a target of heart disease therapyCurrent Opinion in Cardiology.  26:216-222. 2011
    2011 A critical role for UVRAG in apoptosisAutophagy.  7:1242-1244. 2011
    2011 Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoproteinAutophagy.  7:401-411. 2011
    2011 DAMP-mediated autophagy contributes to drug resistanceAutophagy.  7:112-114. 2011
    2011 HMGB1-induced autophagy promotes chemotherapy resistance in leukemia cellsLeukemia.  25:23-31. 2011
    2010 The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in miceJournal of Clinical Investigation.  120:2457-2473. 2010
    2010 Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor α- and interleukin-1 β-induced IKK/NF-κB and JNK/AP-1 activationJournal of Biological Chemistry.  285:5347-5360. 2010
    2008 Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFκB and AP-1 activation as well as IL-6 gene expressionJournal of Biological Chemistry.  283:24497-24505. 2008
    2008 Therapeutic window of hyperbaric oxygen therapy for hypoxic-ischemic brain damage in newborn ratsBrain Research.  1222:87-94. 2008
    2008 Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cellsChinese Journal of Cancer.  27:929-933. 2008
    2007 The best site of transplantation of neural stem cells into brain in treatment of hypoxic-ishemic damage: Experiment with newborn ratsChinese Medical Journal.  87:847-850. 2007
    2007 Ménage-à-Trois 1 Is Critical for the Transcriptional Function of PPARγ Coactivator 1Cell Metabolism.  5:129-142. 2007
    2006 The immunobiological development of human bone marrow mesenchymal stem cells in the course of neuronal differentiationCellular Immunology.  244:19-32. 2006

    Education And Training

  • UT Southwestern Medical Center, Internship
  • UT Southwestern Medical Center, Residency
  • UT Southwestern Medical Center, Postdoctoral Fellowship
  • Doctor of Philosophy in Cardiovascular Science, Baylor College of Medicine 2004
  • Doctor of Medicine, Shandong University 1995
  • Full Name

  • Min Xie