| Year |
Title |
Altmetric |
| 2023
|
Next-generation retinoid X receptor agonists increase ATRA signaling in organotypic epithelium cultures and have distinct effects on receptor dynamics.
Journal of Biological Chemistry.
299.
2023
|
|
| 2022
|
Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers.
Journal of Medicinal Chemistry.
65:14409-14423.
2022
|
|
| 2021
|
Stability of the Retinoid X Receptor-α Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide.
Biochemistry.
60:1165-1177.
2021
|
|
| 2020
|
A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disorders.
Diabetes.
69:2003-2016.
2020
|
|
| 2019
|
A randomized, placebo-controlled, double-blind, dose escalation, single dose, and steady-state pharmacokinetic study of 9cuab30 in healthy volunteers.
Cancer Prevention Research.
12:903-912.
2019
|
|
| 2018
|
A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.
Journal of Surgical Research.
228:54-62.
2018
|
|
| 2018
|
The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis.
Journal of Dermatological Science.
90:343-356.
2018
|
|
| 2016
|
Translation of a tissue-selective rexinoid, UAB30, to the clinic for breast cancer prevention.
Current Topics in Medicinal Chemistry.
16.
2016
|
|
| 2016
|
Preclinical evaluation of UAB30 in pediatric renal and hepatic malignancies.
Molecular Cancer Therapeutics.
15:911-921.
2016
|
|
| 2016
|
Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermis.
PLoS One.
11.
2016
|
|
| 2015
|
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Journal of Medicinal Chemistry.
58:7763-7774.
2015
|
|
| 2015
|
Preclinical evaluation of a novel RXR agonist for the treatment of neuroblastoma.
Molecular Cancer Therapeutics.
14:1559-1569.
2015
|
|
| 2014
|
Global molecular changes in rat livers treated with RXR agonists: a comparison using transcriptomics and proteomics
2014
|
|
| 2014
|
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.
Journal of Medicinal Chemistry.
57:5370-5380.
2014
|
|
| 2014
|
Defining the communication between agonist and coactivator binding in the retinoid x receptor α ligand binding domain.
Journal of Biological Chemistry.
289:814-826.
2014
|
|
| 2014
|
Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.
Bioorganic and Medicinal Chemistry.
22:178-185.
2014
|
|
| 2013
|
Conformational analysis of retinoic acids: Effects of steric interactions on nonplanar conjugated polyenes.
Computational and Theoretical Chemistry.
1011:11-20.
2013
|
|
| 2013
|
Effects on gene expression in rat liver after administration of RXR Agonists: UAB30, 4-Methyl-UAB30, and Targretin (Bexarotene)s.
Molecular Pharmacology.
83:698-708.
2013
|
|
| 2012
|
The CDK4/6 inhibitor PD0332991 reverses epithelial dysplasia associated with abnormal activation of the cyclin-CDK-Rb pathway.
Cancer Prevention Research.
5:810-821.
2012
|
|
| 2012
|
The impact of novel retinoids in combination with platinum chemotherapy on ovarian cancer stem cells.
Gynecologic Oncology.
125:226-230.
2012
|
|
| 2012
|
The use of retinoids in ovarian cancer: A review of the literature.
International Journal of Gynecological Cancer.
22:191-198.
2012
|
|
| 2011
|
A CXCL8 receptor antagonist based on the structure of N-acetyl-proline- glycine-proline.
European Journal of Pharmacology.
668:435-442.
2011
|
|
| 2011
|
Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9- cis -retinoic acid.
Biochemistry.
50:93-105.
2011
|
|
| 2010
|
A pilot, first-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers.
Cancer Prevention Research.
3:1565-1570.
2010
|
|
| 2009
|
Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.
Cancer Biology and Therapy.
8:285-294.
2009
|
|
| 2009
|
Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.
Cancer Biology and Therapy.
8:289-298.
2009
|
|
| 2008
|
The novel retinoid, 9cUAB30, inhibits telomerase and induces apoptosis in HL60 cells.
Translational Oncology.
1:148-152.
2008
|
|
| 2007
|
Conformation of 3′CMP bound to RNase A using TrNOESY.
Molecular cell biology research communications : MCBRC.
463:37-46.
2007
|
|
| 2007
|
In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid.
Drug Metabolism and Disposition.
35:1157-1164.
2007
|
|
| 2006
|
Expression of crustacean (Callinectes sapidus) molt-inhibiting hormone in Escherichia coli: Characterization of the recombinant peptide and assessment of its effects on cellular signaling pathways in Y-organs.
Molecular and Cellular Endocrinology.
253:96-104.
2006
|
|
| 2006
|
Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers.
Carcinogenesis.
27:1232-1239.
2006
|
|
| 2004
|
Biochemical characterization and crystallization of recombinant 3-phosphoglycerate kinase of Plasmodium falciparum
2004
|
|
| 2004
|
Rescuing cystic fibrosis transmembrane conductance regulator (CHR)-processing mutants by transcomplementation
2004
|
|
| 2003
|
9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers.
Cancer Letters.
201:17-24.
2003
|
|
| 2003
|
Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3′,4′-dihydro-1′(2′H) -naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30).
Journal of Medicinal Chemistry.
46:3766-3769.
2003
|
|
| 2002
|
Determination of RNase A/2′-cytidine monophosphate binding affinity and enthalpy by a global fit of thermal unfolding curves.
Analytical Biochemistry.
302:184-190.
2002
|
|
| 2002
|
Bromination, Chlorination, and Nitration of Isoflavonoids.
ACS Symposium Series.
807:251-261.
2002
|
|
| 2001
|
Structural studies on conformationally defined 6-s-trans UAB retinoids.
Computational and Theoretical Chemistry.
549:39-45.
2001
|
|
| 2001
|
Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.
Acta crystallographica. Section D, Structural biology.
57:806-812.
2001
|
|
| 2001
|
NMR conformational analysis of cis and trans proline isomers in the neutrophil chemoattractant, N-acetyl-proline-glycine-proline.
Biospectroscopy.
58:548-561.
2001
|
|
| 2000
|
Structure - Function relationship in the antifreeze activity of synthetic alanine - Lysine antifreeze polypeptides.
Biomacromolecules.
1:268-274.
2000
|
|
| 1999
|
Chlorination and nitration of soy isoflavones.
Molecular cell biology research communications : MCBRC.
368:265-275.
1999
|
|
| 1999
|
Peptide inhibition of ENaC.
Biochemistry.
38:354-363.
1999
|
|
| 1999
|
1H and 13C NMR assignments of conformationally defined 6-s-cis-retinoids.
Magnetic Resonance in Chemistry.
37:82-85.
1999
|
|
| 1999
|
Bioactivity of peptide analogs of the neutrophil chemoattractant, N- acetyl-proline-glycine-proline
1999
|
|
| 1998
|
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Journal of Medicinal Chemistry.
41:1679-1687.
1998
|
|
| 1997
|
Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids.
Molecular cell biology research communications : MCBRC.
344:220-227.
1997
|
|
| 1997
|
A structural model for a new class of conformationally constrained retinoid: (2Z,4E)-4-[3',4'-dihydro-1'(2'H)-naphthalene-1'-ylidene]-2-butenoic acid.
Journal of Chemical Crystallography.
27:231-235.
1997
|
|
| 1996
|
Natural and synthetic retinoids induce hepatic lecithin: Retinol acyltransferase (LRAT) activity in vitamin A-deficient rats
1996
|
|
| 1996
|
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure- activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.
Journal of Medicinal Chemistry.
39:3625-3635.
1996
|
|
| 1996
|
Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acid.
Toxicology and Applied Pharmacology.
139:310-316.
1996
|
|
| 1995
|
Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 2. Selective Agonists for Nuclear Receptor Binding and Transcriptional Activity.
Journal of Medicinal Chemistry.
38:2302-2310.
1995
|
|
| 1995
|
Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configuration.
Bioorganic and Medicinal Chemistry Letters.
5:953-958.
1995
|
|
| 1995
|
13C NMR assignments of conforma‐tionally defined 6‐s‐trans‐retinoids.
Magnetic Resonance in Chemistry.
33:497-499.
1995
|
|
| 1994
|
A Conformationally Defined 6-s-trans-Retinoic Acid Isomer: Synthesis, Chemopreventive Activity, and Toxicity.
Journal of Medicinal Chemistry.
37:4499-4507.
1994
|
|
| 1994
|
Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding.
Journal of Clinical Investigation.
94:228-236.
1994
|
|
| 1992
|
Analysis of the Two-State Behavior of the Thermal Unfolding of Serum Retinol Binding Protein Containing a Single Retinol Ligand.
Biochemistry.
31:5560-5567.
1992
|
|
| 1992
|
Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product.
Journal of Biological Chemistry.
267:6455-6458.
1992
|
|
| 1990
|
1H and 13C NMR studies on the self‐association of retinoic acid.
Magnetic Resonance in Chemistry.
28:223-226.
1990
|
|
| 1989
|
Reactions of Vinylogous Phosphonate Carbanions and Reformatsky Reagents with a Sterically Hindered Ketone and Enone.
Journal of Organic Chemistry.
54:1992-1997.
1989
|
|
| 1987
|
13C and 15N NMR pH Titration of Poly(vinylamine): A Two-Stage Process Sensitive to Polymer Tacticity.
Macromolecules.
20:621-625.
1987
|
|
| 1987
|
13C NMR assignments of the isoprenoid chain carbons of retinoids from empirical chemical shift differences.
Magnetic Resonance in Chemistry.
25:1040-1045.
1987
|
|
| 1987
|
Preparation of the 9-cis, 13-cis-, and all trans-isomers of α- and β2-retinal.
Organic Preparations and Procedures International: the new journal for organic synthesis.
19:187-195.
1987
|
|
| 1987
|
pH Dependence of Bacteriorhodopsin Thermal Unfolding.
Biochemistry.
26:7431-7438.
1987
|
|
| 1986
|
A Configurational Study of Poly(vinylamine) by Multinuclear Nuclear Magnetic Resonance.
Macromolecules.
19:913-916.
1986
|
|
| 1986
|
DETERMINATION OF THE SEQUENCE DISTRIBUTION AND IONIZATION CONSTANT OF POLY(ACRYLIC ACID-CO-VINYLAMINE) BY C-13 NMR..
Journal of Polymer Science: Polymer Symposia.
17-30.
1986
|
|
| 1985
|
Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5β-cholanoic acid.
Journal of Lipid Research.
26:1068-1078.
1985
|
|
| 1985
|
Isolation of detergent-solubilized monomers of bacteriorhodopsin by size-exclusion high-performance liquid chromatography.
Journal of Chromatography A.
326:243-250.
1985
|
|
| 1985
|
Determination of the Tacticity and Analysis of the pH Titration of Poly(acrylic acid) by 1H and 13C NMR.
Macromolecules.
18:2154-2157.
1985
|
|
| 1985
|
Heteronuclear Correlated Two-Dimensional NMR Spectroscopy Applied to the Diad Assignment of Vinyl Polymers.
Macromolecules.
18:2334-2337.
1985
|
|
| 1985
|
Synthesis of 13C single and double labelled retinals, precursors for NMR studies of visual pigments and related systems.
Journal of Labelled Compounds and Radiopharmaceuticals.
22:807-817.
1985
|
|
| 1984
|
Purification of bovine rhodopsin by high-performance size-exclusion chromatography.
Journal of Chromatography A.
296:121-128.
1984
|
|
| 1984
|
15N and 13C NMR study of the effects of hydrogen bonding and protonation in linear schiff bases: Models for structural studies of rhodopsin and bacteriorhodopsin.
Magnetic Resonance in Chemistry.
22:121-124.
1984
|
|
| 1984
|
Synthesis and carbon-13 nmr of an unusual tricyclic barbituric acid derivativet.
Journal of Organic Chemistry.
49:3227-3230.
1984
|
|
| 1983
|
Multiple isolectric forms of detergent-solubilized bovine rhodopsin. II. Spectral analysis
1983
|
|
| 1981
|
Nuclear magnetic resonance studies of rhodopsin and bacteriorhodopsin.
Journal of Photochemistry.
17:63.
1981
|
|
| 1979
|
Interpretations of the effects of pH on the spectra of purple membrane.
Journal of Molecular Biology.
135:595-609.
1979
|
|
| 1979
|
Interpretation of the absorption and circular dichroic spectra of oriented purple membrane films.
Biophysical Journal.
26:427-440.
1979
|
|
| 1978
|
Comparative studies on the fine structure of purple membrane from Halobacterium cutirubrum and Halobacterium halobium
1978
|
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