Positions

Overview

  • After earning an MD at the Cornell School of Medicine in New York, Dr. Morris completed residency at Vanderbilt University School of Medicine in Nashville, Tennessee, followed by fellowships in Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center in Nashville. Prior to his arrival at UK Healthcare, Dr. Morris served as the Inaugural Director of the Critical Illness and Injury Research Center at Wake Forest.

    He has been involved in ICU Clinical Trial design and administration for over 20 years and has been the first author on several single- and multi-center studies regarding ARDS, sepsis, and early ICU rehabilitation. Funding sources for early ICU rehabilitation have been the NIH's National Institute of Nursing Research and the National Heart Lung and Blood Institute, the US Department of Defense, and the Claude D. Pepper Older American Independence Centers (OAICS). He remains active in early ICU Rehabilitation research.

    Dr. Morris has served as a member of the FDA's Pulmonary and Allergy Advisory Committee and was a Co-editor of the American Journal of Critical Care.

    He is certified by the American Board of Internal Medicine in Internal Medicine, Pulmonary Disease and Critical Care Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Patients Surviving Critical COVID-19 have Impairments in Dual-task Performance Related to Post-intensive Care SyndromeJournal of Intensive Care Medicine.  37:890-898. 2022
    2022 Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement TherapyClinical Journal of the American Society of Nephrology.  17:634-642. 2022
    2022 Mobility Levels With Physical Rehabilitation Delivered During and After Extracorporeal Membrane Oxygenation: A Marker of Illness Severity or an Indication of Recovery?Physical Therapy.  102. 2022
    2022 Association of Phosphate Containing Solutions with Incident Hypophosphatemia in Critically Ill Patients Requiring Continuous Renal Replacement TherapyBlood Purification.  51:122-129. 2022
    2022 Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: Secondary analysis of SAILS-ALTOS trialThorax.  77:22-30. 2022
    2021 A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failureScientific Reports.  11. 2021
    2021 Mechanical Power: A New Concept in Mechanical VentilationAmerican Journal of the Medical Sciences.  362:537-545. 2021
    2021 Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort StudyJournal of Intensive Care Medicine.  36:1466-1474. 2021
    2021 Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence StudyChest.  160:1304-1315. 2021
    2021 Muscle Power is Related to Physical Function in Patients Surviving Acute Respiratory Failure: A Prospective Observational StudyAmerican Journal of the Medical Sciences.  361:310-318. 2021
    2021 Efficacy and safety of vancomycin loading doses in critically ill patients with methicillin-resistant Staphylococcus aureus infectionTherapeutic Advances in Infectious Disease.  8. 2021
    2021 Physical Function Measured Prior to Lung Transplantation Is Associated With Posttransplant Patient OutcomesTransplantation Proceedings.  53:288-295. 2021
    2020 Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illnessCritical Care (UK).  24. 2020
    2020 Safety and Feasibility of Physical Rehabilitation and Active Mobilization in Patients Requiring Continuous Renal Replacement Therapy: A Systematic ReviewCritical Care Medicine.  48:E1112-E1120. 2020
    2020 A narrative review of pharmacologic de-resuscitation in the critically illJournal of Critical Care.  59:156-162. 2020
    2020 Evaluating Physical Functioning in Survivors of Critical Illness: Development of a New Continuum Measure for Acute CareCritical Care Medicine.  48:1427-1435. 2020
    2020 Recovery from COVID-19 and acute respiratory distress syndrome: The potential role of an intensive care unit recovery clinic: A case reportJournal of Medical Case Reports.  14. 2020
    2020 Interrater Reliability of Muscle Ultrasonography Image Acquisition by Physical Therapists in Patients Who Have or Who Survived Critical IllnessPhysical Therapy.  100:1701-1711. 2020
    2020 Risk factors for and prediction of postintubation hypotension in critically ill adults: A multicenter prospective cohort studyPLoS One.  15. 2020
    2020 Response to physical rehabilitation and recovery trajectories following critical illness: Individual participant data meta-analysis protocolBMJ Open.  10. 2020
    2020 The fear and risk of community falls in patients following an intensive care admission: An exploratory cohort studyAustralian Critical Care.  33:144-150. 2020
    2020 Impact of protocolized diuresis for de-resuscitation in the intensive care unitCritical Care (UK).  24. 2020
    2020 A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failureNitric Oxide: Biology and Chemistry.  94:63-68. 2020
    2020 Continuous Versus Intermittent Infusion of Vancomycin and the Risk of Acute Kidney Injury in Critically Ill Adults: A Systematic Review and Meta-Analysis∗Critical Care Medicine.  912-918. 2020
    2020 Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU: Cardiovascular, endocrine, hematologic, pulmonary and renal considerations: Executive summaryCritical Care Medicine.  415-419. 2020
    2020 Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU: Cardiovascular, endocrine, hematologic, pulmonary, and renal considerationsCritical Care Medicine.  48:E173-E191. 2020
    2020 Safety, Feasibility, and Efficacy of Early Rehabilitation in Patients Requiring Continuous Renal Replacement: A Quality Improvement StudyKidney International Reports.  5:39-47. 2020
    2019 Early therapeutic mobility and changes in scores for pain and fatigueCritical Care Nurse.  39:30-37. 2019
    2019 Multidisciplinary Prerounding Meeting as a Continuous Quality Improvement Tool: Leveraging to Reduce Continuous Benzodiazepine Use at an Academic Medical CenterJournal of Intensive Care Medicine.  34:707-713. 2019
    2019 The relationship between self-report and performance-based measures of physical function following an ICU stayJournal of Critical Care.  51:19-23. 2019
    2019 Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized TrialJournal of Parenteral and Enteral Nutrition.  43:471-480. 2019
    2019 Echogenicity Is Related to Skeletal Muscle Strength in Patients with Acute Respiratory FailureJournal of Cardiopulmonary Rehabilitation and Prevention.  39:E17-E20. 2019
    2019 Editorial by US Food and Drug Administration Attorney Fails to Address Core and Ongoing Issues Seen With Vasopressin MarketAnesthesia and Analgesia.  128:E55-E56. 2019
    2019 Physical function trajectories in survivors of acute respiratory failureAnnals of the American Thoracic Society.  16:471-477. 2019
    2019 A Multidisciplinary Approach for the Management of Severe Hyponatremia in Patients Requiring Continuous Renal Replacement TherapyKidney International Reports.  4:59-66. 2019
    2019 Fluid overload associates with major adverse kidney events in critically ill patients with acute kidney injury requiring continuous renal replacement therapyCritical Care Medicine.  47:E753-E760. 2019
    2018 Assessing skeletal muscle dysfunction in sepsis utilizing muscle ultrasound in search for pathways to improve ICU survivor's functional outcomesJournal of Critical Care.  47:322-323. 2018
    2018 Dose of Early Therapeutic Mobility: Does Frequency or Intensity Matter?Biological Research for Nursing.  20:522-530. 2018
    2018 Physical function impairment in survivors of critical illness in an ICU Recovery ClinicJournal of Critical Care.  45:163-169. 2018
    2018 Reply to Smith et al.American Journal of Respiratory and Critical Care Medicine.  197:1505-1506. 2018
    2018 Diaphragm Dysfunction in Critical IllnessChest.  153:1040-1051. 2018
    2018 Upper arm anthropometrics versus DXA scan in survivors of acute respiratory distress syndromeEuropean Journal of Clinical Nutrition.  72:613-617. 2018
    2018 Influence of Prehospital Function and Strength on Outcomes of Critically Ill Older AdultsJournal of the American Geriatrics Society.  66:525-531. 2018
    2018 Characterizing hospitalist practice and perceptions of critical care deliveryJournal of Hospital Medicine.  13:6-12. 2018
    2018 Effect of thiamine administration on lactate clearance and mortality in patients with septic shockCritical Care Medicine.  46:1747-1752. 2018
    2018 Evaluating muscle mass in survivors of acute respiratory distress syndrome: A 1-year multicenter longitudinal studyCritical Care Medicine.  46:1238-1246. 2018
    2018 Insidious Harm of Medication Diluents as a Contributor to Cumulative Volume and Hyperchloremia: A Prospective, Open-Label, Sequential Period Pilot StudyCritical Care Medicine.  46:1217-1223. 2018
    2018 US food and drug administration disruption of generic drug market increases hospital costsAnesthesia and Analgesia.  127:1414-1420. 2018
    2017 Timing and amount of physical therapy treatment are associated with length of stay in the cardiothoracic icuScientific Reports.  7. 2017
    2017 Are physical measures related to patient-centred outcomes in ARDS survivors?Thorax.  72:884-892. 2017
    2017 Time of admission to the PICU and mortalityPediatric Critical Care Medicine.  18:915-923. 2017
    2017 Effect of ganciclovir on IL-6 levels among cytomegalovirus-seropositive adults with critical illness: A randomized clinical trialJAMA: Journal of the American Medical Association.  318:731-740. 2017
    2017 Mastering the design for rehabilitation strategies in ICU survivorsThorax.  72:594-595. 2017
    2017 Factors influencing physical activity and rehabilitation in survivors of critical illness: a systematic review of quantitative and qualitative studiesIntensive Care Medicine.  43:531-542. 2017
    2017 What factors affect implementation of early rehabilitation into intensive care unit practice? A qualitative study with cliniciansJournal of Critical Care.  38:137-143. 2017
    2017 Liberation from mechanical ventilation in critically Ill adults: An official ATS/ACCP clinical practice guidelineAnnals of the American Thoracic Society.  14:441-443. 2017
    2017 Point prevalence study of mobilization practices for acute respiratory failure patients in the United StatesCritical Care Medicine.  45:205-215. 2017
    2017 An Official American Thoracic Society/American College of Chest Physicians Clinical Practice Guideline: Liberation from mechanical ventilation in critically ill adults rehabilitation protocols, ventilator liberation protocols, and cuff leak testsAmerican Journal of Respiratory and Critical Care Medicine.  195:120-133. 2017
    2017 Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline: Inspiratory Pressure Augmentation During Spontaneous Breathing Trials, Protocols Minimizing Sedation, and Noninvasive Ventilation Immediately After ExtubationChest.  151:166-180. 2017
    2017 Liberation From Mechanical Ventilation in Critically Ill Adults: Executive Summary of an Official American College of Chest Physicians/American Thoracic Society Clinical Practice GuidelineChest.  151:160-165. 2017
    2017 Official executive summary of an American Thoracic Society/American College of Chest Physicians clinical practice guideline: Liberation from mechanical ventilation in critically ill adultsAmerican Journal of Respiratory and Critical Care Medicine.  195:115-119. 2017
    2016 Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States HospitalsChest.  150:1260-1268. 2016
    2016 Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issuesClinical Nutrition.  35:1196-1206. 2016
    2016 Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure a randomized clinical trialJAMA: Journal of the American Medical Association.  315:2694-2702. 2016
    2016 Evaluating physical outcomes in acute respiratory distress syndrome survivors: Validity, responsiveness, and minimal important difference of 4-meter gait speed testCritical Care Medicine.  44:859-868. 2016
    2016 One-year outcomes of rosuvastatin versus placebo in sepsis-associated acute respiratory distress syndrome: Prospective follow-up of SAILS randomised trialThorax.  71:401-410. 2016
    2016 Decision conflict and regret among surrogate decision makers in the medical intensive care unitJournal of Critical Care.  32:79-84. 2016
    2016 Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: An ancillary study to a randomised controlled trialThe Lancet Respiratory Medicine.  4:203-212. 2016
    2016 Adapting the ABCDEF Bundle to Meet the Needs of Patients Requiring Prolonged Mechanical Ventilation in the Long-Term Acute Care Hospital Setting: Historical Perspectives and Practical ImplicationsSeminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections.  37:119-135. 2016
    2016 Authors' response to commentaries on rosuvastatin for delirium and cognitive impairment in sepsis-associated acute respiratory distress syndromeJournal of Thoracic Disease.  8:E1534-E1536. 2016
    2015 Ultrasonography in the intensive care setting can be used to detect changes in the quality and quantity of muscle and is related to muscle strength and functionJournal of Critical Care.  30:1151.e9-1151.e14. 2015
    2015 Sonography for assessing dynamic diaphragm dysfunction in acute respiratory distressJournal of Ultrasound in Medicine.  34:1704-1706. 2015
    2015 A conceptual framework: The early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndromeCritical Care (UK).  19. 2015
    2015 Interobserver reliability of quantitative muscle sonographic analysis in the critically ill populationJournal of Ultrasound in Medicine.  34:1191-1200. 2015
    2015 Cognitive screening among acute respiratory failure survivors: A cross-sectional evaluation of the Mini-Mental State ExaminationCritical Care (UK).  19. 2015
    2015 Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wastingScience Translational Medicine.  7. 2015
    2014 Off-hours admission to pediatric intensive care and mortalityPediatrics.  134:e1345-e1353. 2014
    2014 Risk factors for physical impairment after acute lung injury in a national, multicenter studyAmerican Journal of Respiratory and Critical Care Medicine.  189:1214-1224. 2014
    2014 The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injuryPLoS One.  9. 2014
    2014 Erratum: A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsisCritical Care Medicine.  42. 2014
    2013 High resource utilization does not affect mortality in acute respiratory failure patients managed with tracheostomyRespiratory Care: a monthly science journal.  58:1863-1872. 2013
    2013 Early exercise rehabilitation of muscle weakness in acute respiratory failure patientsExercise and Sport Sciences Reviews.  41:208-215. 2013
    2013 ICU early mobilization: From recommendation to implementation at three medical centersCritical Care Medicine.  41. 2013
    2013 Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding EDEN Trial follow-upAmerican Journal of Respiratory and Critical Care Medicine.  188:567-576. 2013
    2013 The authors replyCritical Care Medicine.  41. 2013
    2013 A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsisCritical Care Medicine.  41:706-716. 2013
    2013 The authors replyCritical Care Medicine.  41. 2013
    2013 Quantitative neuromuscular ultrasound in the intensive care unitMuscle and Nerve.  47:255-259. 2013
    2013 United States critical illness and injury trials groupChest.  143:808-813. 2013
    2012 Tracheostomy practice in adults with acute respiratory failureCritical Care Medicine.  40:2890-2896. 2012
    2012 Does U.S. health care need a national institute of critical care?Critical Care Medicine.  40:1337-1338. 2012
    2012 A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shockCritical Care (UK).  16. 2012
    2012 A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distress syndromeBMC Pulmonary Medicine.  12. 2012
    2012 Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndromeAmerican Journal of the Medical Sciences.  343:446-451. 2012
    2011 High-dose vitamin d interventional trials: Is there reason to pause?Minerva Anestesiologica.  77:1139-1140. 2011
    2011 Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failureAmerican Journal of the Medical Sciences.  341:373-377. 2011
    2010 Safety and barriers to careCritical Care Nurse.  30. 2010
    2010 Influence of an institution-specific sepsis protocol on the adequacy of empiric antimicrobial therapyHospital Pharmacy.  45:538-544. 2010
    2010 A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adultsCritical Care (UK).  14. 2010
    2009 Will comparative effectiveness research increase patient safety in intensive care units?American Journal of Critical Care.  18:504-506. 2009
    2009 One is never enough: ResponseAmerican Journal of Critical Care.  18:400-401. 2009
    2009 Seasonal influenza: Protect your patients by protecting yourselfAmerican Journal of Critical Care.  18:396-398. 2009
    2009 All ICUs are not created equal: Evaluating pilot studies performed in different environmentsAmerican Journal of Critical Care.  18:294-297. 2009
    2009 Time for critical care to join the CDC's universal HIV screening initiative?American Journal of Critical Care.  18:96-98. 2009
    2009 Assessing ICU transfers at night: A call to reduce mortality and readmission riskAmerican Journal of Critical Care.  18:6-8. 2009
    2008 How will they learn?American Journal of Critical Care.  17:306-309. 2008
    2008 Time for a tool to measure moral distress?American Journal of Critical Care.  17:398-401. 2008
    2008 Passing the torch: The challenge of handoffsAmerican Journal of Critical Care.  17:95-97. 2008
    2008 A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndromeCritical Care Medicine.  36:782-788. 2008
    2008 Could multicenter trials optimize the cost of prolonged mechanical ventilation?American Journal of Critical Care.  17:8-10. 2008
    2008 Early intensive care unit mobility therapy in the treatment of acute respiratory failureCritical Care Medicine.  36:2238-2243. 2008
    2008 Foundations of evidence-based practice: Critical care trial networksAmerican Journal of Critical Care.  17:190-193. 2008
    2007 Global Poverty: a Challenge for Critical CareAmerican Journal of Critical Care.  16:528-530. 2007
    2007 Quality improvement or research? The ethics of hospital project oversightAmerican Journal of Critical Care.  16:424-426. 2007
    2007 Nurse residency programs: Preparing for the next shiftAmerican Journal of Critical Care.  16:328-330. 2007
    2007 Critical care professionalism in the age of pay-for-performance: From ICUs to outpatient critical care clinicsAmerican Journal of Critical Care.  16:200-203. 2007
    2007 Early Intensive Care Unit Mobility: Future DirectionsCritical Care Clinics.  23:97-110. 2007
    2007 Moving Our Critically Ill Patients: Mobility Barriers and BenefitsCritical Care Clinics.  23:1-20. 2007
    2007 PrefaceCritical Care Clinics.  23. 2007
    2006 Safety and efficacy of affinity-purified, anti-tumor necrosis factor-α, ovine fab for injection (CytoFab) in severe sepsisCritical Care Medicine.  34:2271-2281. 2006
    2004 Drotrecogin alfaDrugs of Today.  40:517-538. 2004
    2004 Comparison of 3 methods of detecting acute respiratory distress syndrome: Clinical screening, chart review, and diagnostic codingAmerican Journal of Critical Care.  13:59-64. 2004
    2003 The author replies [2]American Journal of Critical Care.  12:398. 2003
    2003 The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): Role, methodology, and resultsCritical Care Medicine.  31:2291-2301. 2003
    2003 Meeting unmet needs in patients with sepsis: The role of drotrecogin alfa (activated)American Journal of Critical Care.  12:94-97. 2003
    2003 The ARDS support centerCritical Care (UK).  7:266-267. 2003
    2002 Identifying patients with severe sepsis who should not be treated with drotrecogin alfa (activated)The American Journal of Surgery.  184:S19-S24. 2002
    2002 Relationship between the inflammation and coagulation pathways in patients with severe sepsis: Implications for therapy with activated protein CBioDrugs: clinical immunotherapeutics, biopharmaceuticals and gene therapy.  16:403-417. 2002
    2002 Fatal asbestosis 50 years after brief high intensity exposure in a vermiculite expansion plantAmerican Journal of Respiratory and Critical Care Medicine.  165:1145-1149. 2002
    2001 Acute respiratory distress syndrome: Pharmacological treatment options in developmentDrugs.  61:897-907. 2001
    2001 Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsisCritical Care Medicine.  29:2051-2059. 2001
    2000 Oxidative stress and NF-κB activation: Correlation in patients following allogeneic bone marrow transplantationAntioxidants and Redox Signaling.  2:93-102. 2000
    1999 In vitro and in vivo effects of genistein on murine alveolar macrophage TNFα productionInflammation.  23:231-239. 1999
    1999 A pilot study of estrogen's effects on bronchial myocyte adhesion molecule expressionPharmacotherapy.  19:1426-1431. 1999
    1999 Choosing the appropriate control [2] (multiple letters)Chest.  115:1214-1215. 1999
    1998 A trial of antioxidants N-acetylcysteine and procysteine in ARDSPneumologie.  52:66-67. 1998
    1998 The phytoestrogen genistein reduces bone loss in short-term ovariectomized ratsOsteoporosis International.  8:274-281. 1998
    1998 Cyclosporine-induced β-adrenergic receptor down-regulation in bovine pulmonary artery smooth muscle cells: A pilot studyPharmacotherapy.  18:341-344. 1998
    1998 Idiopathic pneumonia syndrome in mice after allogeneic bone marrow transplantationAmerican Journal of Respiratory Cell and Molecular Biology.  18:235-242. 1998
    1997 Role of T-Lymphocytes in the resolution of endotoxin-induced lung injuryInflammation.  21:269-278. 1997
    1997 A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.Chest.  112:164-172. 1997
    1997 A trial of antioxidants N-acetylcysteine and procysteine in ARDSChest.  112:164-172. 1997
    1995 Escherichia coli endotoxin-mediated endothelial injury is modulated by glutathione ethyl esterJournal of Infectious Diseases.  172:1119-1122. 1995
    1994 Significance of glutathione in lung disease and implications for therapyAmerican Journal of the Medical Sciences.  307:119-127. 1994
    1991 Adult respiratory distress syndrome: Strategies to provide support and enhance oxygen deliveryPostgraduate medicine.  90. 1991

    Research Overview

  • ARDS, sepsis, and early ICU rehabilitation
  • Education And Training

  • Vanderbilt University Medical Center Pulmonary and Critical Care Medicine, Postdoctoral Fellowship
  • Doctor of Medicine, Cornell University 1985
  • Bachelor's Degree in Biology, St. John's University 1981
  • Full Name

  • Peter Morris