• Prof. Banaszak Holl joined the School of Engineering at UAB in 2022. He serves as Associate Dean for Research and has secondary appointments in the Heersink School of Medicine's Division of Pulmonology, Allergy, and Critical Care Medicine and the Department of Orthopaedic Surgery. He is passionate about engineering education, sustainable design, and the interface of engineering with social justice and human rights.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 Applications of AFM-IR for drug delivery vector characterization: infrared, thermal, and mechanical characterization at the nanoscale.Advanced Drug Delivery Reviews.  192:114646. 2023
    2022 Morphology and Viscosity Changes after Reactive Uptake of Isoprene Epoxydiols in Submicrometer Phase Separated Particles with Secondary Organic Aerosol Formed from Different Volatile Organic CompoundsACS Earth and Space Chemistry.  6:871-882. 2022
    2022 Column Agglutination Assay Using Polystyrene Microbeads for Rapid Detection of Antibodies against SARS-CoV-2ACS Applied Materials and Interfaces.  14:2501-2509. 2022
    2022 Glass Transition Temperatures of Individual Submicrometer Atmospheric Particles: Direct Measurement via Heated Atomic Force Microscopy ProbeAnalytical Chemistry2022
    2021 Visible-Light-Sensitive Triazine-Coated Silica Nanoparticles: A Dual Role Approach to Polymer Nanocomposite Materials with Enhanced PropertiesACS Applied Materials and Interfaces.  13:46033-46042. 2021
    2021 Polymerization-Induced Hierarchical Self-Assembly: From Monomer to Complex Colloidal Molecules and beyondACS Nano.  15:13721-13731. 2021
    2021 Engineering laminated paper for SARS-CoV-2 medical gowns 2021
    2021 Hierarchical Nature of Nanoscale Porosity in Bone Revealed by Positron Annihilation Lifetime SpectroscopyACS Nano.  15:4321-4334. 2021
    2021 Thermally regenerable metal-organic framework with high monovalent metal ion selectivityChemical Engineering Journal.  405. 2021
    2021 Photocatalytic Degradation of 1,4-Dioxane and Malachite Green over Zinc Oxide/Cellulose Nanofiber Using UVA/B from Direct Sunlight and a Continuous Flow Reactor 2021
    2020 ZnO/cellulose nanofiber composites for sustainable sunlight-driven dye degradationACS Applied Nano Materials.  3:10284-10295. 2020
    2020 Microwave-Assisted Hydrothermal Decomposition of Super Absorbent PolymersACS Sustainable Chemistry and Engineering.  8:14504-14510. 2020
    2020 Bulk to Nanometer-Scale Infrared Spectroscopy of Pharmaceutical Dry Powder AerosolsAnalytical Chemistry.  92:8323-8332. 2020
    2020 Uptake and Retention of Nanoplastics in Quagga Mussels.Global Challenges.  4:1800104. 2020
    2020 Rapid Gel Card Agglutination Assays for Serological Analysis following SARS-CoV-2 Infection in HumansACS sensors2020
    2019 Bicomponent poly(ethylene)/poly(propylene) fiber bonding using dielectric inksColloids and Surfaces A: Physicochemical and Engineering Aspects.  582. 2019
    2019 An Anterior Cruciate Ligament Failure MechanismAmerican Journal of Sports Medicine.  47:2067-2076. 2019
    2018 Cathepsin K inhibition preserves compressive load in lumbar vertebrae of osteoporotic monkeysBone Reports.  9:159-164. 2018
    2018 Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction ModelAnnals of Plastic Surgery.  81:604-608. 2018
    2018 Distributions: The Importance of the Chemist's Molecular View for Biological MaterialsBiomacromolecules.  19:1469-1484. 2018
    2017 The Relationship of Collagen Structural and Compositional Heterogeneity to Tissue Mechanical Properties: A Chemical PerspectiveACS Nano.  11:10665-10671. 2017
    2017 Conjugation Dependent Interaction of Folic Acid with Folate Binding ProteinBioconjugate Chemistry.  28:2350-2360. 2017
    2017 Atomic Force Microscopy-Infrared Spectroscopy of Individual Atmospheric Aerosol Particles: Subdiffraction Limit Vibrational Spectroscopy and Morphological AnalysisAnalytical Chemistry.  89:8594-8598. 2017
    2017 Folate-binding protein self-aggregation drives agglomeration of folic acid targeted iron oxide nanoparticlesBioconjugate Chemistry.  28:81-87. 2017
    2017 Dendrimer and dendrimer-conjugate protein complexes and protein coronasCanadian Journal of Chemistry.  95:903-906. 2017
    2016 Estrogen depletion and drug treatment alter the microstructure of type I collagen in boneBone Reports.  5:243-251. 2016
    2016 Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex NanoassembliesACS Macro Letters.  5:1104-1108. 2016
    2016 In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxideClinical materials.  104:361-371. 2016
    2016 Increase in Dye:Dendrimer Ratio Decreases Cellular Uptake of Neutral Dendrimers in RAW CellsACS Biomaterials Science and Engineering.  2:1540-1545. 2016
    2016 Role of Cell Membrane-Vector Interactions in Successful Gene DeliveryAccounts of Chemical Research.  49:1486-1493. 2016
    2016 Substrate-Triggered Exosite Binding: Synergistic Dendrimer/Folic Acid Action for Achieving Specific, Tight-Binding to Folate Binding ProteinBiomacromolecules.  17:922-927. 2016
    2016 Rapid exchange between free and bound states in RNA-dendrimer polyplexes: Implications on the mechanism of delivery and releaseBiomacromolecules.  17:154-164. 2016
    2015 Quantitative Measurement of Cationic Polymer Vector and Polymer-pDNA Polyplex Intercalation into the Cell Plasma MembraneACS Nano.  9:6097-6109. 2015
    2015 Folate binding protein - Outlook for drug delivery applicationsChinese Chemical Letters.  26:426-430. 2015
    2015 Fluorophore:Dendrimer ratio impacts cellular uptake and intracellular fluorescence lifetimeBioconjugate Chemistry.  26:304-315. 2015
    2014 Hyperspectral imaging and characterization of live cells by broadband coherent anti-stokes raman scattering (CARS) microscopy with singular value decomposition (SVD) analysisApplied Spectroscopy.  68:1116-1122. 2014
    2014 Multivalent polymers for drug delivery and imaging: The challenges of conjugationBiomacromolecules.  15:3215-3234. 2014
    2014 Isolation and characterization of precise dye/dendrimer ratios 2014
    2014 The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cellsEuropean Journal of Pharmaceutics and Biopharmaceutics.  88:658-663. 2014
    2013 Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticlesACS Chemical Biology.  8:2063-2071. 2013
    2013 Variation in type I collagen fibril nanomorphology: the significance and origin.BoneKEy Reports.  2:394. 2013
    2013 Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer 2013
    2013 Dendrimer-based multivalent vancomycin nanoplatform for targeting the drug-resistant bacterial surfaceACS Nano.  7:214-228. 2013
    2013 Nanoscale structure of type I collagen fibrils: Quantitative measurement of D-spacingBiotechnology Journal.  8:117-126. 2013
    2012 Type i collagen D-spacing in fibril bundles of dermis, tendon, and bone: Bridging between nano- and micro-level tissue hierarchyACS Nano.  6:9503-9514. 2012
    2012 Bifunctional PAMAM dendrimer conjugates of folic acid and methotrexate with defined ratioBiomacromolecules.  13:982-991. 2012
    2012 Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug deliveryBiomacromolecules.  13:507-516. 2012
    2012 Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targetingEuropean Journal of Medicinal Chemistry.  47:560-572. 2012
    2011 Heterogeneous ligand-nanoparticle distributions: A major obstacle to scientific understanding and commercial translationAccounts of Chemical Research.  44:1135-1145. 2011
    2011 Effect of osteogenesis imperfecta mutations on free energy of collagen model peptides: A molecular dynamics simulationBiophysical Chemistry.  156:146-152. 2011
    2011 Free energy simulation to investigate the effect of amino acid sequence environment on the severity of osteogenesis imperfecta by glycine mutations in collagenBiospectroscopy.  95:401-409. 2011
    2011 Bioanalytical screening of riboflavin antagonists for targeted drug delivery - A thermodynamic and kinetic studyACS Medicinal Chemistry Letters.  2:363-367. 2011
    2011 Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platformBioconjugate Chemistry.  22:679-689. 2011
    2011 Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer-methotrexate conjugate as a potential anticancer agentBioorganic and Medicinal Chemistry.  19:2557-2564. 2011
    2011 The severity of osteogenesis imperfecta: A comparison to the relative free energy differences of collagen model peptidesBiospectroscopy.  95:182-193. 2011
    2011 Contributions of Ordered Solvent to Long-Range DNA-Dendrimer InteractionsBiophysical Journal.  100:356a-357a. 2011
    2011 Acetonitrile shortage: Use of isopropanol as an alternative elution system for ultra/high performance liquid chromatography 2011
    2010 Isolation and characterization of dendrimers with precise numbers of functional groups 2010
    2010 Distribution of type I collagen morphologies in bone: Relation to estrogen depletionBone.  46:1349-1354. 2010
    2010 Microscopic basis for the mesoscopic extensibility of dendrimer-compacted DNABiophysical Journal.  98:834-842. 2010
    2009 Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrationsBiomacromolecules.  10:3207-3214. 2009
    2009 RGD dendron bodies; synthetic avidity agents with defined and potentially interchangeable effector sites that can substitute for antibodiesBioconjugate Chemistry.  20:1853-1859. 2009
    2009 Stoichiometry and structure of poly(amidoamine) dendrimer- Lipid complexesACS Nano.  3:1886-1896. 2009
    2009 Stoichiometries and Energetics of Cationic Nanoparticle-Membrane ComplexesBiophysical Journal.  96:19a. 2009
    2009 The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimersBioconjugate Chemistry.  20:1503-1513. 2009
    2008 Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimersACS Nano.  2:773-783. 2008
    2008 The implications of stochastic synthesis for the conjugation of functional groups to nanoparticlesBioconjugate Chemistry.  19:1748-1752. 2008
    2007 Closing the gap between interdisciplinary research and disciplinary teachingACS Chemical Biology.  2:518-520. 2007
    2007 Nanoparticle interaction with biological membranes: Does nanotechnology present a janus face?Accounts of Chemical Research.  40:335-342. 2007
    2007 The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery PlatformCell chemical biology.  14:107-115. 2007
    2006 HPLC analysis of functionalized poly(amidoamine) dendrimers and the interaction between a folate-dendrimer conjugate and folate binding protein 2006
    2006 Interaction of polycationic polymers with supported lipid bilayers and cells: Nanoscale hole formation and enhanced membrane permeabilityBioconjugate Chemistry.  17:728-734. 2006
    2005 Membrane thinning due to antimicrobial peptide binding: An atomic force microscopy study of MSI-78 in lipid bilayersBiophysical Journal.  89:4043-4050. 2005
    2004 Direct observation of lipid bilayer disruption by poly(amidoamine) dendrimersChemistry and Physics of Lipids.  132:3-14. 2004
    2004 Deformability of poly(amidoamine) dendrimers 2004
    2004 Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: Hole formation and the relation to transportBioconjugate Chemistry.  15:774-782. 2004
    2003 The Case of the Disappearing Monolayer: Alkylsilane Monolayer Formation, Oxidation, and Subsequent Transparency to Scanning Tunneling Microscopy 2003
    2003 Interaction of dendrimers (Artificial Proteins) with biological hydroxyapatite crystals 2003
    1999 Nucleation of chemical vapor deposited silicon nitride on silicon dioxideApplied Physics Letters.  74:1830-1832. 1999
    1999 The reaction of H8Si8O12 with a chromium oxide surface: A model for stainless steel surface modificationApplied Organometallic Chemistry.  13:279-285. 1999
    1998 The role of second-neighbor effects in photoemission: Are silicon surfaces and interfaces special?Applied Physics Letters.  72:46-48. 1998
    1997 Intermediates in the catalytic dehydrogenative coupling of arylgermanes 1997
    1997 Transition Metal Germylene Complexes as Hydrogenation Catalysts: The Synthesis of a Rare Bis(amino)germaneAngewandte Chemie International Edition.  36:496-498. 1997
    1996 Photoemission assignments of HxSiO4-x fragments at the Si/SiOx interfaceApplied Physics Letters.  68:1081-1083. 1996
    1996 Conversion of [(tBuCH2)2TaN]5 to Cubic TaN: Related Syntheses, EHMO Calculations, and MAS and Spin Echo 15N NMR SpectroscopiesChemistry of Materials.  8:2468-2480. 1996
    1995 Photoemission assignments of HxSiO4-x fragments at the Si/SiOx interfaceApplied Physics Letters.  1081. 1995
    1994 Core-level photoemission and the structure of the Si/SiO2 interface: A reappraisalApplied Physics Letters.  65:1097-1099. 1994
    1993 Low-temperature selective-area deposition of metals: Chemical vapor deposition of gold from ethyl(trimethylphosphine)gold(I)Applied Physics Letters.  62:1475-1477. 1993
    1990 Tantalum amide preparation [1]Chemical and engineering news.  68:2. 1990


    Year Title Altmetric
    2012 Dendrimer-Based Nanoparticle Therapies: Can Uniform Multifunctional Therapeutics Be Made with Current Chemical Approaches?.  295-313. 2012
    2009 Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications.  177-193. 2009
    2008 Nanoparticle - membrane interactions: Mechanism for enhanced permeability.  289-329. 2008
    2008 Nanoparticle — Membrane Interactions: Mechanism for Enhanced Permeability.  289-329. 2008

    Research Overview

  • The Banaszak Holl lab has a major focus on biological structure and function, particular at the nano and micro scales. We are particularly interested in bone and ligaments. We also have a major focus on nanomaterials, including aerosol formulations and transport proteins, for drug and gene delivery. In addition to our biological work, the group has a long history in synthesis of new materials and polymer science and engineering. We currently have a focus on green and sustainable polymers including developing new methods to depolymerize major industrial polymers that are currently land filled at the end of their useful lifetime. We are also continuing our studies of the environmental and biological interactions of nanoplastics.
    Specific projects currently active in the group include: the mechanism of anterior cruciate ligament (ACL) failure; serum protein for drug delivery; aerosol formulations for drug delivery; and environmental nanoplastics.
  • Education And Training

  • Doctor of Philosophy in Inorganic Chemistry, Cornell University 1991
  • Bachelor of Science or Mathematics in Chemistry, University of Chicago 1986
  • Full Name

  • Mark Banaszak Holl