Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Insulin controls cytoskeleton reorganization and filtration barrier permeability via the PKGIα-Rac1-RhoA crosstalk in cultured rat podocytes 2022
2022 Endothelin-1 via ETA receptor activation promotes renal iron deposition in murine models of iron overload 2022
2022 Peroxiredoxin-2 recycling is slower in denser and pediatric sickle cell red cells 2022
2022 Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice.  Canadian Journal of Physiology and Pharmacology.  100:637-650. 2022
2021 Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice 2021
2021 Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure.  Function.  2. 2021
2020 Role for ovarian hormones in purinoceptor-dependent natriuresis.  Biology of Sex Differences.  11. 2020
2020 High molecular weight kininogen contributes to early mortality and kidney dysfunction in a mouse model of sickle cell disease.  Journal of Thrombosis and Haemostasis.  18:2329-2340. 2020
2020 Diurnal Control of Blood Pressure Is Uncoupled from Sodium Excretion.  Hypertension.  75:1624-1634. 2020
2020 Sex differences in the trajectory of glomerular filtration rate in pediatric and murine sickle cell anemia.  Blood Advances.  4:263-265. 2020
2020 Loss of endothelin type B receptor function improves insulin sensitivity in rats.  Canadian Journal of Physiology and Pharmacology.  98:604-610. 2020
2019 Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice.  Clinical Science.  133:1475-1486. 2019
2019 Dynamic changes in histone deacetylases following kidney ischemia-reperfusion injury are critical for promoting proximal tubule proliferation 2019
2019 Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.  Acta Physiologica.  226. 2019
2019 Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy.  American Journal of Hematology.  94:417-423. 2019
2019 Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse.  Acta Physiologica.  225. 2019
2019 Hyperfiltration predicts long-term renal outcomes in humanized sickle cell mice.  Blood Advances.  3:1460-1475. 2019
2018 A more direct way to measure glomerular albumin permeability—even in human glomeruli!.  Kidney International.  93:1035-1037. 2018
2018 Diurnal pattern in skin Na+and water content is associated with salt-sensitive hypertension in ETBreceptor-deficient rats 2018
2018 High dietary sodium causes dyssynchrony of the renal molecular clock in rats 2018
2017 Renal denervation attenuates hypertension but not salt sensitivity in ETB receptor-deficient rats 2017
2017 Interplay between renal endothelin and purinergic signaling systems 2017
2017 Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice.  Journal of the American Society of Nephrology.  28:2443-2458. 2017
2017 Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis 2017
2017 Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways 2017
2016 Endothelin receptor antagonists in sickle cell disease: A promising new therapeutic approach.  Life Sciences.  159:15-19. 2016
2016 Activation of purinergic receptors (P2) in the renal medulla promotes endothelin-dependent natriuresis in male rats 2016
2016 Extracellular purines’ action on glomerular albumin permeability in isolated rat glomeruli: Insights into the pathogenesis of albuminuria 2016
2016 Intracellular calcium signaling regulates glomerular filtration barrier permeability: the role of the PKGIα-dependent pathway.  FEBS Letters.  1739-1748. 2016
2016 Involvement of P2 receptors in regulation of glomerular permeability to albumin by extracellular nucleotides of intra-/extra-glomerular origins 2016
2016 Endothelin-1 and the kidney: New perspectives and recent findings.  Current Opinion in Nephrology and Hypertension.  25:35-41. 2016
2015 Insulin increases glomerular filtration barrier permeability through PKGIα-dependent mobilization of BKCa channels in cultured rat podocytes 2015
2013 Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Iα subunits 2013
2012 Chronic renal denervation increases renal tubular response to P2X receptor agonists in rats: Implication for renal sympathetic nerve ablation.  Nephrology Dialysis Transplantation.  27:3443-3448. 2012

Education And Training

  • Doctor of Philosophy Level Degree in Medical Scientist, Medical University of Gda?sk 2014

    • Full Name

  • Malgorzata Kasztan