Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout ratsNeurobiology of Disease.  150. 2021
2021 Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samplesAutophagy.  17:2613-2628. 2021
2020 Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein FibrilsNeuroscience.  437:64-75. 2020
2020 Formalin Versus Bouin Solution for Testis Biopsies: Which Is the Better Fixative? 2020
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytes.npj Parkinson's Disease.  5:29. 2019
2019 PINK1 phosphorylates ubiquitin predominantly in astrocytesnpj Parkinson's Disease.  5. 2019
2019 Precisely Control Mitochondria with Light to Manipulate Cell Fate DecisionBiophysical Journal.  117:631-645. 2019
2019 Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat StriatumNeuroscience.  409:169-179. 2019
2019 Analysis of α-synuclein pathology in PINK1 knockout rat brainsFrontiers in Neuroscience.  13. 2019
2018 Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenanceNeuro-Oncology.  20:1055-1067. 2018
2018 New Developments in Genetic rat models of Parkinson's DiseaseMovement Disorders.  33:717-729. 2018
2017 Parkin and PINK1 functions in oxidative stress and neurodegenerationBrain Research Bulletin.  133:51-59. 2017
2017 Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicityNeurobiology of Disease.  98:122-136. 2017
2015 The role of ventral striatal cAMP signaling in stress-induced behaviorsNature Neuroscience.  18:1094-1100. 2015
2014 Phenotypic characterization of recessive gene knockout rat models of Parkinson's diseaseNeurobiology of Disease.  70:190-203. 2014
2014 Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's diseaseNeurobiology of Disease.  62:113-123. 2014
2013 Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1Molecular and Cellular Biology.  33:3627-3643. 2013
2013 Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1-/- miceJournal of Neuroinflammation.  10. 2013
2012 A mutation in CLOCK leads to altered dopamine receptor functionJournal of Neurochemistry.  123:124-134. 2012
2012 Number and Brightness Analysis of LRRK2 Oligomerization in Live CellsBiophysical Journal.  102:L41-L43. 2012
2011 Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of maniaNeuropsychopharmacology.  36:1478-1488. 2011
2011 Alternative mitochondrial electron transfer as a novel strategy for neuroprotectionJournal of Biological Chemistry.  286:16504-16515. 2011
2010 Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35Biological Psychiatry.  68:1163-1171. 2010
2010 Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic interventionNeurobiology of Disease.  37:510-518. 2010
2010 Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6Cell Death and Differentiation.  17:158-169. 2010
2009 Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brainsMolecular Neurodegeneration.  4. 2009
2009 Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's diseaseNature Cell Biology.  11:1370-1375. 2009
2009 Parkin-mediated ubiquitination regulates phospholipase C-γ1Journal of Cellular and Molecular Medicine.  13:3061-3068. 2009
2006 Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle CellsJournal of Biological Chemistry.  281:12809-12816. 2006
2005 Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1Neuron.  45:489-496. 2005
2004 Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient MiceJournal of Biological Chemistry.  279:18614-18622. 2004
2003 Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic NeuronsJournal of Biological Chemistry.  278:43628-43635. 2003
2002 alpha-Synuclein is phosphorylated in synucleinopathy lesions.Nature Cell Biology.  4:160-164. 2002
2000 Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?Nature Cell Biology.  2:E115-E119. 2000
1992 NMR studies of structure and dynamics of isotope enriched proteinsBiopolymers.  32:381-390. 1992

Principal Investigator On

  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Advancing PINK1 KO Rat Animal Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Analysis of Parkin Activity in W403A Parkin Knockin Mice  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Characterization of the in Vivo Effects of aSyn PFFs on Mouse Brain Mitochondria  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Determining PINK1 and PRKN Enzyme Activities in Vivo  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Efficacy of Parkin Gene Delivery Towards Mitigation of A-Syn PFF-Induced Degeneration  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Immune Cell Dysfunction in PINK1 PD Animal Models  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • MOU - LRRK2 Consortium Memorandum of Understanding  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Mechanisms of Age-Dependent Nigral Neuron Loss in PINK1 Knockout Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Mechanisms of LRRK2 Membrane Association  awarded by Fox (Michael J.) Foundation for Parkinson's Research
  • Mechanisms of Protection Against Age-Dependent Nigral Neuron Loss in DJ-1 KO Rats  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Role of Alpha Synuclein in PINK1-linked Parkinson's Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Biophysics and Molecular Biology, Yale University 1998
  • Full Name

  • Matthew Goldberg