Matthew Goldberg

Matthew Goldberg
Associate Professor

Associate Professor (P), Neurology , School of Medicine
Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Associate Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology
Investigator (C), Evelyn F. McKnight Brain Institute , Neurology
Scientist (C), Civitan International Research Center , Academic Joint Departments
Associate Professor (S), Neurobiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Bace1 inhibition increases susceptibility to oxidative stress by promoting mitochondrial damage. Antioxidants. 10. 2021
2021	Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats. Frontiers in Neuroscience. 15. 2021
2021	Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats. Neurobiology of Disease. 150. 2021
2021	Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples. Autophagy. 17:2613-2628. 2021
2020	Enhanced Susceptibility of PINK1 Knockout Rats to α-Synuclein Fibrils. Neuroscience. 437:64-75. 2020
2020	Formalin Versus Bouin Solution for Testis Biopsies: Which Is the Better Fixative?. Clinical Pathology. 13. 2020
2019	PINK1 phosphorylates ubiquitin predominantly in astrocytes.. npj Parkinson's Disease. 5:29. 2019
2019	PINK1 phosphorylates ubiquitin predominantly in astrocytes. npj Parkinson's Disease. 5. 2019
2019	Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision. Biophysical Journal. 117:631-645. 2019
2019	Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum. Neuroscience. 409:169-179. 2019
2019	Analysis of α-synuclein pathology in PINK1 knockout rat brains. Frontiers in Neuroscience. 13. 2019
2018	Reactive species balance via GTP cyclohydrolase i regulates glioblastoma growth and tumor initiating cell maintenance. Neuro-Oncology. 20:1055-1067. 2018
2018	New Developments in Genetic rat models of Parkinson's Disease. Movement Disorders. 33:717-729. 2018
2017	Parkin and PINK1 functions in oxidative stress and neurodegeneration. Brain Research Bulletin. 133:51-59. 2017
2017	Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Neurobiology of Disease. 98:122-136. 2017
2015	The role of ventral striatal cAMP signaling in stress-induced behaviors. Nature Neuroscience. 18:1094-1100. 2015
2014	Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Neurobiology of Disease. 70:190-203. 2014
2014	Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease. Neurobiology of Disease. 62:113-123. 2014
2013	Parkin-Dependent Degradation of the F-Box Protein Fbw7β Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1. Molecular and Cellular Biology. 33:3627-3643. 2013
2013	Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1^-/- mice. Journal of Neuroinflammation. 10. 2013
2013	Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PLoS One. 8. 2013
2012	A mutation in CLOCK leads to altered dopamine receptor function. Journal of Neurochemistry. 123:124-134. 2012
2012	Number and brightness analysis of LRRK2 oligomerization in live cells. Biophysical Journal. 102. 2012
2012	Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One. 7. 2012
2011	Lipopolysaccharide and tumor necrosis factor regulate parkin expression via Nuclear factor-kappa B. PLoS One. 6. 2011
2011	Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the clockδ19 mouse model of mania. Neuropsychopharmacology. 36:1478-1488. 2011
2011	Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. Journal of Biological Chemistry. 286:16504-16515. 2011
2010	Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35. Biological Psychiatry. 68:1163-1171. 2010
2010	Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention. Neurobiology of Disease. 37:510-518. 2010
2010	Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death and Differentiation. 17:158-169. 2010
2009	Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nature Cell Biology. 11:1370-1375. 2009
2009	Parkin-mediated ubiquitination regulates phospholipase C-γ1. Journal of Cellular and Molecular Medicine. 13:3061-3068. 2009
2009	Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLoS One. 4. 2009
2009	Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains. Molecular Neurodegeneration. 4. 2009
2008	Parkin deficiency increases vulnerability to inflammation-related nigral degeneration. The Journal of Neuroscience. 28:10825-10834. 2008
2006	Parkin protects against mitochondrial toxins and β-amyloid accumulation in skeletal muscle cells. Journal of Biological Chemistry. 281:12809-12816. 2006
2005	Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron. 45:489-496. 2005
2004	Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice. Journal of Biological Chemistry. 279:18614-18622. 2004
2003	Parkin-deficient Mice Exhibit Nigrostriatal Deficits but not Loss of Dopaminergic Neurons. Journal of Biological Chemistry. 278:43628-43635. 2003
2002	α-synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology. 4:160-164. 2002
2001	α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proceedings of the National Academy of Sciences of USA. 98:9110-9115. 2001
2000	Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson's disease?. Nature Cell Biology. 2. 2000
1997	Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL. Proceedings of the National Academy of Sciences of USA. 94:1080-1085. 1997
1992	NMR studies of structure and dynamics of isotope enriched proteins. Biopolymers. 32:381-390. 1992
1992	The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X‐ray structures. Protein Science. 1:736-751. 1992