Positions

Overview

  • Martin Young received his Bachelors, Masters, PhD degrees in Biochemistry from the University of Oxford. Following postdoctoral training at Boston University and the University of Texas-Houston, Dr. Young held faculty appointments at the University of Texas-Houston and Baylor College of Medicine, before joining the University of Alabama at Birmingham (UAB). Dr. Young is currently a Professor of Medicine, Vice-Director for Research in the Division of Cardiovascular Disease, and Section Chief for Basic and Translational Research in the Division of Cardiovascular Disease. He is also the Jeanne V. Marks Endowed Chair of Cardiovascular Disease. Dr. Young has published over 160 peer-reviewed manuscripts in top tier journals, such as Circulation Research and Journal of Biological Chemistry, and has been commissioned by numerous journals (including Nature Reviews Endocrinology) for the completion of invited reviews.

    Research in Dr. Young’s laboratory is focused on understanding how environmental factors, such as time-of-day and nutrition, influence cardiovascular health and disease. Regarding time-of-day, the laboratory is actively seeking to understand how an intrinsic time-keeping mechanism, known as the circadian clock, affects the function of the heart. More specifically, a broad objective of the laboratory has been to test the hypothesis that the circadian clock synchronizes responsiveness of the heart to diurnal fluctuations in the environment. Impairment of this molecular mechanism would therefore result in an inability of the heart to respond appropriately to the onset of normal stimuli/stresses, thereby leading to contractile dysfunction and cardiac disease.
  • Selected Publications

    Chapter

    Year Title Altmetric
    2012 Relationship between myocardial ischemia/reperfusion and time of day.  1-38. 2012

    Investigator On

  • Alcohol-Induced Mitochondrial Dysfunction and the Hepatocyte Clock  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Anti-Obesity Effect Of No-Releasing Nanomatrix  awarded by National Institute on Aging/NIH/DHHS
  • Basic and Translational Science in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Cardioprotective Effects of Autophagy Are Dependent on Mitochondrial Biogenesis during Ischemia/Reperfusion  awarded by American Heart Association
  • Circadian Dysfunction and GSK3 in Neurodegenerative Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Circadian Regulation of Vascular Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Delineate the Pathophysiological Effect of Cardiomyocyte-Specific Mitochondrial Stress  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Disruption of the Clock O-GlcNAc Axis in Diabetic Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Energetics, Disparities, & Lifespan: A Unified Hypothesis  awarded by National Institute on Aging/NIH/DHHS
  • Genomic Classification of the Heart Transplant Endomyocardial Biopsy  awarded by University of California, Los Angeles
  • Hepatocyte Clock and Alcoholic Fatty Liver Injury  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Improving Mitochondrial Function to Protect Against Myocardial Ischemia/Reperfusion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Macrophage Circadian Clock Disruption and Inflammation in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Protein O-GlcNAcylation and the Regulation of Cardiac Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Regulation of Skeletal Muscle Mitochondrial Quality Control Parameters and Systemic Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • STIM1 and its Role in Regulating Cardiac Metabolism  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Saturated Fatty Acid-Induced Autophagy in Vascular Endothelium  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Tissue Chip Models for Cardiovascular Development and Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC) - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Oxford 1999
  • Master of Life Sciences in Biochemistry, University of Oxford 1995
  • Full Name

  • Martin Young