Positions

Overview

  • Martin Young received his Bachelors, Masters, PhD degrees in Biochemistry from the University of Oxford. Following postdoctoral training at Boston University and the University of Texas-Houston, Dr. Young held faculty appointments at the University of Texas-Houston and Baylor College of Medicine, before joining the University of Alabama at Birmingham (UAB). Dr. Young is currently a Professor of Medicine, Vice-Director for Research in the Division of Cardiovascular Disease, and Section Chief for Basic and Translational Research in the Division of Cardiovascular Disease. He is also the Jeanne V. Marks Endowed Chair of Cardiovascular Disease. Dr. Young has published over 160 peer-reviewed manuscripts in top tier journals, such as Circulation Research and Journal of Biological Chemistry, and has been commissioned by numerous journals (including Nature Reviews Endocrinology) for the completion of invited reviews.

    Research in Dr. Young’s laboratory is focused on understanding how environmental factors, such as time-of-day and nutrition, influence cardiovascular health and disease. Regarding time-of-day, the laboratory is actively seeking to understand how an intrinsic time-keeping mechanism, known as the circadian clock, affects the function of the heart. More specifically, a broad objective of the laboratory has been to test the hypothesis that the circadian clock synchronizes responsiveness of the heart to diurnal fluctuations in the environment. Impairment of this molecular mechanism would therefore result in an inability of the heart to respond appropriately to the onset of normal stimuli/stresses, thereby leading to contractile dysfunction and cardiac disease.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heartCardioscience.  118:2566-2581. 2022
    2022 Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion InjuryCells.  11. 2022
    2022 Circadian disruption of hippocampus in an early senescence male mouse model 2022
    2022 Subcutaneous Administration of a Nitric Oxide-Releasing Nanomatrix Gel Ameliorates Obesity and Insulin Resistance in High-Fat Diet-Induced Obese MiceACS Applied Materials and Interfaces.  14:19104-19115. 2022
    2022 Circadian Governance of Cardiac GrowthCells.  11. 2022
    2022 Islet transplantation into brown adipose tissue can delay immune rejectionJCI Insight.  7. 2022
    2022 Augmented Cardiac Growth Hormone Signaling Contributes to Cardiomyopathy Following Genetic Disruption of the Cardiomyocyte Circadian ClockFrontiers in Pharmacology.  13. 2022
    2021 The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER StressFrontiers in Molecular Biosciences.  8. 2021
    2021 The transcriptional co-regulator LDB1 is required for brown adipose functionMolecular Metabolism.  53. 2021
    2021 Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational AspectsCirculation: Arrhythmia and Electrophysiology.  14:e010181. 2021
    2021 Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical ConsiderationsCirculation: Arrhythmia and Electrophysiology.  14:e010190. 2021
    2021 Prolonged QT intervals in mice with cardiomyocyte-specific deficiency of the molecular clockActa Physiologica.  233. 2021
    2021 Branched chain amino acids selectively promote cardiac growth at the end of the awake periodJournal of Molecular and Cellular Cardiology.  157:31-44. 2021
    2021 Cardiac surgery in the morning or not in the morning:“When?” is the questionThe Lancet Regional Health. Europe.  7. 2021
    2021 Editorial overview: Circadian rhythms in the cardiovascular systemCurrent Opinion in Pharmacology.  59:1-2. 2021
    2021 Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complicationsCurrent Opinion in Pharmacology.  57:1-12. 2021
    2021 Impact of obesity on day-night differences in cardiac metabolism 2021
    2021 Glucagon receptor signaling regulates weight loss via central KLB receptor complexesJCI Insight.  6. 2021
    2021 Circadian rhythms in cardiac metabolic flexibility 2021
    2021 Guidelines for the design and conduct of human clinical trials on ingestion-time differences–chronopharmacology and chronotherapy–of hypertension medications 2021
    2020 Circadian influence on the microbiome improves heart failure outcomesJournal of Molecular and Cellular Cardiology.  149:54-72. 2020
    2020 Reprint of: Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complicationsCurrent Opinion in Pharmacology.  54:209-220. 2020
    2020 A small molecule, UAB126, reverses diet-induced obesity and its associated metabolic disordersDiabetes.  69:2003-2016. 2020
    2020 Nuclear receptor binding factor 2 (NRBF2) is required for learning and memoryLaboratory Investigation.  100:1238-1251. 2020
    2020 Diurnal, metabolic and thermogenic alterations in a murine model of accelerated aging 2020
    2020 SHVM-2018 Charleston 2020
    2020 Differential effects of REV-ERB/ agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption 2020
    2020 Re-balancing cellular energy substrate metabolism to mend the failing heart 2020
    2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
    2020 Chronobiological influence over cardiovascular function the good, the bad, and the uglyCirculation Research.  258-279. 2020
    2020 Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart BeatingAnnual Review of Physiology.  82:79-101. 2020
    2020 Empagliflozin Blunts Worsening Cardiac Dysfunction Associated with Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart FailureCirculation: Heart Failure.  13:E006277. 2020
    2020 Increased glucose availability attenuates myocardial ketone body utilizationJournal of the American Heart Association.  9. 2020
    2019 Metabolic Coupling as a Therapeutic Strategy for Heart FailureJACC: Basic to Translational Science.  4:401-403. 2019
    2019 Promoting Cardiovascular Health in Early Childhood and Transitions in Childhood through Adolescence: A Workshop ReportJournal of Pediatrics.  209:240-251.e1. 2019
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism 2019
    2019 Shift Work Disrupts Circadian Regulation of the Transcriptome in Hospital NursesJournal of Biological Rhythms.  34:167-177. 2019
    2018 Editorial overview: Circadian rhythms 2018
    2018 Mitochondrial – nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivoEBioMedicine.  36:316-328. 2018
    2018 Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21Diabetes.  67:1773-1782. 2018
    2018 Differential tissue response to growth hormone in miceFEBS Open Bio.  8:1146-1154. 2018
    2018 The circadian clock in cardiovascular regulation and disease: Lessons from the Nobel Prize in Physiology or Medicine 2017European Heart Journal.  39:2326-2329. 2018
    2018 An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clockFree Radical Biology and Medicine.  119:75-84. 2018
    2018 Introduction to special issue: Circadian regulation of metabolism, redox signaling and function in health and diseaseFree Radical Biology and Medicine.  119:1-2. 2018
    2018 Temporal partitioning of adaptive responses of the murine heart to fastingLife Sciences.  197:30-39. 2018
    2018 Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice 2018
    2018 Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation 2018
    2018 Repercussions of hypo and hyperthyroidism on the heart circadian clock 2018
    2018 High dietary sodium causes dyssynchrony of the renal molecular clock in rats 2018
    2018 Normative Values of Muscle Power using Force Plate Jump Tests in Men Aged 77-101 Years: The Osteoporotic Fractures in Men (MrOS) StudyJournal of Nutrition, Health and Aging.  22:1167-1175. 2018
    2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
    2017 Metabolic Origins of Heart FailureJACC: Basic to Translational Science.  2:297-310. 2017
    2017 LDB1 regulates energy homeostasis during diet-induced obesity 2017
    2017 Myocardial ischemia/reperfusion impairs neurogenesis and hippocampal-dependent learning and memoryBrain, Behavior, and Immunity.  61:266-273. 2017
    2017 Circadian Control of Cardiac Metabolism: Physiologic Roles and Pathologic ImplicationsMethodist DeBakey cardiovascular journal.  13:15-19. 2017
    2017 VEGF-B: Friend or foe to the heart in times of nutrient excess? 2017
    2016 Interrelationship between 3,5,3´-triiodothyronine and the circadian clock in the rodent heart 2016
    2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
    2016 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant mice 2016
    2016 The acute effects of time-of-day-dependent high fat feeding on whole body metabolic flexibility in miceInternational Journal of Obesity.  40:1444-1451. 2016
    2016 Temporal partitioning of cardiac metabolism by the cardiomyocyte circadian clockExperimental Physiology.  101:1035-1039. 2016
    2016 TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling 2016
    2016 Biotinylation: A novel posttranslational modification linking cell autonomous circadian clocks with metabolism 2016
    2016 Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regressionCardioscience.  110:249-257. 2016
    2016 Assessing Cardiac MetabolismCirculation Research.  118:1659-1701. 2016
    2016 Circadian regulation of metabolic homeostasis: Causes and consequencesNature and Science of Sleep.  8:163-180. 2016
    2015 AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolismCardioscience.  107:235-245. 2015
    2015 Influence of the cardiomyocyte circadian clock on cardiac physiology and pathophysiologyJournal of Biological Rhythms.  30:183-205. 2015
    2015 Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice 2015
    2015 Erratum: MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo [J Bioenerg Biomembr, 46, (2014), (173-187), DOI 10.1007/s10863-014-9549-9]Journal of Bioenergetics and Biomembranes.  47:281. 2015
    2015 Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleusJournal of Biological Rhythms.  30:155-160. 2015
    2015 Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation 2015
    2015 Circadian biology: The early bird catches the morning shiftCurrent Biology.  25:R269-R271. 2015
    2014 Morning surge of ventricular arrhythmias in a new arrhythmogenic canine model of chronic heart failure is associated with attenuation of time-of-day dependence of heart rate and autonomic adaptation, and reduced cardiac chaosPLoS One.  9. 2014
    2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heartJournal of Biological Rhythms.  29:257-276. 2014
    2014 The day/night proteome in the murine heart 2014
    2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
    2014 Carnitine Palmitoyltransferase 1b Deficiency Protects Mice from Diet-Induced Insulin Resistance.Journal of Diabetes and Metabolism.  5:361. 2014
    2014 Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesityInternational Journal of Obesity.  38:205-215. 2014
    2014 PAI at breakfast (whether you like it or not)Blood.  123:466-468. 2014
    2014 Circadian clock control of endocrine factorsNature Reviews Endocrinology.  10:466-475. 2014
    2014 Circadian regulation of metabolismJournal of Endocrinology.  222. 2014
    2014 Circadian rhythms in cell maturationPhysiology.  29:72-83. 2014
    2014 MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivoJournal of Bioenergetics and Biomembranes.  46:173-187. 2014
    2013 APpEaLINg therapeutic target for obesity cardiomyopathy?Journal of Molecular and Cellular Cardiology.  63:165-168. 2013
    2013 Chronic Ethanol Consumption Disrupts the Core Molecular Clock and Diurnal Rhythms of Metabolic Genes in the Liver without Affecting the Suprachiasmatic NucleusPLoS One.  8. 2013
    2013 Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablationCardioscience.  99:442-451. 2013
    2013 Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice 2013
    2013 Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female miceHeart.  99:1041-1047. 2013
    2013 Metabolism as an integral cog in the mammalian circadian clockworkCritical Reviews in Biochemistry and Molecular Biology.  48:317-331. 2013
    2013 Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in miceInternational Journal of Obesity.  37:843-852. 2013
    2013 Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathyDiabetes.  62:1464-1477. 2013
    2013 Influence of dark phase restricted high fat feeding on myocardial adaptation in miceJournal of Molecular and Cellular Cardiology.  55:147-155. 2013
    2013 Regulation of myocardial metabolism by the cardiomyocyte circadian clockJournal of Molecular and Cellular Cardiology.  55:139-146. 2013
    2012 Heat from calcium cycling melts fatNature Medicine.  18:1458-1459. 2012
    2012 Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genesMolecular Pharmacology.  82:541-549. 2012
    2012 Metabolic remodeling in the hypertrophic heart: Fuel for thoughtCirculation Research.  111:666-668. 2012
    2012 Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancerJournal of Applied Physiology.  113:263-272. 2012
    2012 Normalizing the metabolic phenotype after myocardial infarction: Impact of subchronic high fat feedingJournal of Molecular and Cellular Cardiology.  53:125-133. 2012
    2012 Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunctionMolecular and Cellular Biology.  32:740-750. 2012
    2012 Chronobiological Effects on ObesityCurrent Obesity Reports.  1:9-15. 2012
    2011 O-glcnacylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clockJournal of Biological Chemistry.  286:44606-44619. 2011
    2011 Cardiac-specific mutation of clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythmsJournal of Biological Rhythms.  26:412-422. 2011
    2011 Regulation of fatty acid metabolism by cell autonomous circadian clocks: Time to fatten up on information?Journal of Biological Chemistry.  286:11883-11889. 2011
    2011 Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice 2011
    2010 Time-of-day-dependent dietary fat consumption influences multiple cardiometabolic syndrome parameters in miceInternational Journal of Obesity.  34:1589-1598. 2010
    2010 Metabolic adaptation follows contractile dysfunction in the heart of obese Zucker rats fed a high-fat western dietObesity.  18:1895-1901. 2010
    2010 The myocardial contractile response to physiological stress improves with high saturated fat feeding in heart failure 2010
    2010 The cardiomyocyte circadian clock: Emerging roles in health and diseaseCirculation Research.  106:647-658. 2010
    2010 Short communication: Ischemia/reperfusion tolerance is time-of-day- dependent: Mediation by the cardiomyocyte circadian clockCirculation Research.  106:546-550. 2010
    2010 Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clockJournal of Biological Chemistry.  285:2918-2929. 2010
    2009 Diurnal variations in myocardial metabolismHeart and metabolism : management of the coronary patient.  5-9. 2009
    2009 The role of cell-specific circadian clocks in metabolism and diseaseObesity Reviews.  10:6-13. 2009
    2009 Anticipating anticipation: Pursuing identification of cardiomyocyte circadian clock functionJournal of Applied Physiology.  107:1339-1347. 2009
    2009 Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesityCirculation.  119:2818-2828. 2009
    2009 Chronic treatment with the peroxisome proliferator-activated receptor α agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function 2009
    2009 The role of clock genes in cardiometabolic diseaseJournal of Applied Physiology.  107:1316-1317. 2009
    2008 Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acidsJournal of Lipid Research.  49:1395-1408. 2008
    2008 Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulationJournal of Molecular and Cellular Cardiology.  45:230-239. 2008
    2008 Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy 2008
    2008 Diurnal variations in myocardial metabolismCardioscience.  79:228-237. 2008
    2008 Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failureCardioscience.  79:331-340. 2008
    2008 Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency 2008
    2008 Linking the cardiomyocyte circadian clock to myocardial metabolismCardiovascular Drugs and Therapy.  22:115-124. 2008
    2008 Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression 2008
    2008 Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal glandLife Sciences.  82:108-114. 2008
    2008 Alterations in carbohydrate metabolism and its regulation in PPARα null mouse hearts 2008
    2007 Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesityDiabetes.  56:2863-2871. 2007
    2007 Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusionJournal of Molecular and Cellular Cardiology.  43:744-753. 2007
    2007 The AMPK γ1 R70Q mutant regulates multiple metabolic and growth pathways in neonatal cardiac myocytes 2007
    2007 Proposed regulation of gene expression by glucose in rodent heart.Gene Regulation and Systems Biology.  1:251-262. 2007
    2007 CD36 expression contributes to age-induced cardiomyopathy in miceCirculation.  116:2139-2147. 2007
    2007 Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function 2007
    2007 Circadian rhythms in myocardial metabolism and contractile function: Influence of workload and oleate 2007
    2007 Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar ratsBiochemical Journal.  406:457-467. 2007
    2007 Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats 2007
    2007 Potential role for peripheral circadian clock dyssynchrony in the pathogenesis of cardiovascular dysfunctionSleep Medicine.  8:656-667. 2007
    2007 Metabolic and signaling alterations in dystrophin-deficient hearts precede overt cardiomyopathyJournal of Molecular and Cellular Cardiology.  43:119-129. 2007
    2007 Diabetes or peroxisome proliferator-activated receptor α agonist increases mitochondrial thioesterase I activity in heartJournal of Lipid Research.  48:1511-1517. 2007
    2007 Chronic activation of peroxisome proliferator-activated receptor-α with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failureJournal of Pharmacology and Experimental Therapeutics.  321:165-171. 2007
    2007 Circadian rhythms in the development of obesity: Potential role for the circadian clock within the adipocyteObesity Reviews.  8:169-181. 2007
    2007 The dominant negative thyroid hormone receptor β-mutant Δ337T alters PPARα signaling in heart 2007
    2007 Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat dietClinical and Experimental Pharmacology and Physiology.  34:113-119. 2007
    2006 Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertensionHypertension.  48:1116-1123. 2006
    2006 Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failureEuropean Journal of Heart Failure.  8:687-693. 2006
    2006 Participation of β-adrenergic activity in modulation of GLUT4 expression during fasting and refeeding in rats 2006
    2006 Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart 2006
    2006 Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injuryCirculation.  114:1721-1728. 2006
    2006 Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failureFundamental and Clinical Pharmacology.  20:503-505. 2006
    2006 The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acidsJournal of Biological Chemistry.  281:24254-24269. 2006
    2006 Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heartJournal of Molecular and Cellular Cardiology.  41:340-349. 2006
    2006 Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin 2006
    2006 Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin 2006
    2006 Effects of chronic activation of peroxisome proliferator-activated receptor-α or high-fat feeding in a rat infarct model of heart failure 2006
    2006 Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heartBiochemical and Biophysical Research Communications.  342:361-364. 2006
    2006 Reducing unnecessary right ventricular pacing with the managed ventricular pacing mode in patients with sinus node disease and AV blockPacing and Clinical Electrophysiology.  29:697-705. 2006
    2006 The circadian clock within the heart: Potential influence on myocardial gene expression, metabolism, and function 2006
    2005 Thyroid hormone interacts with PPARα and PGC-1 during mitochondrial maturation in sheep heart 2005
    2005 Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesityCirculation.  112:2686-2695. 2005
    2005 The intrinsic circadian clock within the cardiomyocyte 2005
    2005 Activation of PPARγ enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats 2005
    2005 Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failureCardioscience.  66:454-461. 2005
    2004 Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids 2004
    2004 Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-α-regulated gene in cardiac and skeletal muscle 2004
    2004 Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyteJournal of Biological Chemistry.  279:32771-32779. 2004
    2004 Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failureJournal of Molecular and Cellular Cardiology.  36:567-576. 2004
    2004 Hypoxia-induced decrease of UCP3 gene expression in rat heart parallels metabolic gene switching but fails to affect mitochondrial respiratory couplingBiochemical and Biophysical Research Communications.  314:561-564. 2004
    2003 Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamineJournal of Biological Chemistry.  278:13143-13150. 2003
    2003 Circadian rhythms in cardiac gene expressionCurrent Hypertension Reports.  5:445-453. 2003
    2002 Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failureCirculation.  106:407-411. 2002
    2002 Adaptation and maladaptation of the heart in diabetes: Part II: Potential mechanismsCirculation.  105:1861-1870. 2002
    2002 Adaptation and maladaptation of the heart in diabetes: Part I. General conceptsCirculation.  105:1727-1733. 2002
    2002 Mitochondrial proteins in hypertrophy and atrophy: A transcript analysis in rat heartClinical and Experimental Pharmacology and Physiology.  29:346-350. 2002
    2002 Alterations of the circadian clock in the heart by streptozotocin-induced diabetesJournal of Molecular and Cellular Cardiology.  34:223-231. 2002
    2002 Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading. 2002
    2002 Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heartDiabetes.  51:2587-2595. 2002
    2002 Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expressionJournal of Clinical Investigation.  109:629-639. 2002
    2002 The adenylosuccinate synthetase-1 gene is activated in the hypertrophied heartJournal of Cellular and Molecular Medicine.  6:235-243. 2002
    2001 Metabolic gene expression in fetal and failing human heartCirculation.  104:2923-2931. 2001
    2001 Intrinsic diurnal variations in cardiac metabolism and contractile functionCirculation Research.  89:1199-1208. 2001
    2001 Reactivation of Peroxisome Proliferator-activated Receptor α Is Associated with Contractile Dysfunction in Hypertrophied Rat HeartJournal of Biological Chemistry.  276:44390-44395. 2001
    2001 Calcitonin gene-related peptide is not essential for the development of pressure overload-induced hypertrophy in vivo 2001
    2001 Hypoxia in vivo decreases peroxisome proliferator-activated receptor α-regulated gene expression in rat heartBiochemical and Biophysical Research Communications.  287:5-10. 2001
    2001 Calcitonin gene-related peptide is not essential for the development of pressure overload-induced hypertrophy in vivo. 2001
    2001 Clock genes in the heart: Characterization and attenuation with hypertrophyCirculation Research.  88:1142-1150. 2001
    2001 Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor α in the adult rodent heart 2001
    2001 Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. 2001
    2001 Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids 2001
    2001 Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: Effects of AICAR 2001
    2000 Anaplerosis of the citric acid cycle: Role in energy metabolism of heart and skeletal muscleActa Physiologica.  168:657-665. 2000
    2000 Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cellsToxicological Sciences.  53:48-55. 2000
    2000 Exercise diminishes the activity of acetyl-CoA carboxylase in human muscleDiabetes.  49:1295-1300. 2000
    2000 Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunctionJournal of Molecular and Cellular Cardiology.  32:985-996. 2000
    1999 Creatine uptake in isolated soleus muscle: Kinetics and dependence on sodium, but not on insulinActa Physiologica.  166:99-104. 1999
    1999 Effectiveness of brief counseling in reducing HIV risk behavior in injecting drug users: Final results of randomized trials of counseling with and without HIV testingAIDS and Behavior.  3:3-12. 1999
    1999 Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of duchenne muscular dystrophyJournal of Molecular and Cellular Cardiology.  31:1857-1862. 1999
    1998 Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxideBiochemical and Biophysical Research Communications.  249:512-516. 1998
    1998 Fuel oxidation in skeletal muscle is increased by nitric oxide/cGMP - evidence for involvement of cGMP-dependent protein kinaseFEBS Letters.  424:79-83. 1998
    1998 Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscleBiochemical Journal.  329:73-79. 1998
    1997 Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitroBiochemical Journal.  322:223-228. 1997
    1997 Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscleBiochemical Journal.  321:707-712. 1997
    1997 NOS activity in skeletal muscle from hypertensive ratsBiochemical Society Transactions.  25. 1997
    1997 Zaprmast raises glucose utilisation in SHR skeletal muscleBiochemical Society Transactions.  25. 1997
    1996 Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR - An activator of AMP-activated protein kinaseFEBS Letters.  382:43-47. 1996
    1996 A survey of physician use of treatment methods for functional enuresisJournal of Developmental and Behavioral Pediatrics.  17:90-93. 1996
    1996 Effects of treatment of spontaneously hypertensive rats with the angiotensin-converting enzyme inhibitor trandolapril and the calcium antagonist verapamil on the sensitivity of glucose metabolism to insulin in rat soleus muscle in vitroDiabetes.  45. 1996
    1996 Glycogen phosphorylase may be activated by AMP-kinase in skeletal muscleBiochemical Society Transactions.  24. 1996
    1981 Biomass energy from crop and forest residuesScience.  212:1110-1115. 1981

    Chapter

    Year Title Altmetric
    2015 Diurnal Variation in Cardiac Metabolism.  123-137. 2015
    2012 Relationship between myocardial ischemia/reperfusion and time of day.  1-38. 2012

    Principal Investigator On

  • Aberrant Circadian Regulation Of Autophagy In The Heart During Diabetes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Aerobic Training During or After Adjuvant Therapy: A Randomized Trial  awarded by Duke University
  • Basic and Translational Science in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Circadian Influence on Protein Synthesis and Hypertrophic Growth of the Heart  awarded by American Heart Association
  • Circadian Regulation of Myocardial Insulin Signaling  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Circadian Regulation of mTOR Signaling in the Failing Heart  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Delineate the Pathophysiological Effect of Cardiomyocyte-Specific Mitochondrial Stress  awarded by Ohio State University
  • HEAL Data Analysis  awarded by HEAL ALABAMA
  • Influence of the Cardiomyocyte Circadian Clock on Cardiac Hypertrophy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Macrophage Circadian Clock Disruption and Inflammation in Heart  awarded by Washington University
  • Metabolic Rhythm Alterations as a Cause for Obesity Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Molecular Genetics of Thermogenesis  awarded by PENNINGTON BIOMEDICAL RESEARCH CENTER
  • Prolactin Receptor Signaling Regulates Adaptation of the Heart during Pregnancy and Postpartum  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Role of the Molecular Circadian Clock Within the Heart  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Time-of-Day-Dependent Feeding Influences Myocardial Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Investigator On

  • Alcohol-Induced Mitochondrial Dysfunction and the Hepatocyte Clock  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Anti-Obesity Effect Of No-Releasing Nanomatrix  awarded by National Institute on Aging/NIH/DHHS
  • Basic and Translational Science in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Cardioprotective Effects of Autophagy Are Dependent on Mitochondrial Biogenesis during Ischemia/Reperfusion  awarded by American Heart Association
  • Circadian Dysfunction and GSK3 in Neurodegenerative Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Circadian Regulation of Vascular Aging  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Delineate the Pathophysiological Effect of Cardiomyocyte-Specific Mitochondrial Stress  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Disruption of the Clock O-GlcNAc Axis in Diabetic Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Energetics, Disparities, & Lifespan: A Unified Hypothesis  awarded by National Institute on Aging/NIH/DHHS
  • Epitranscriptomic Regulation of Fibrotic gene in the Progress of Heart Failure  awarded by American Heart Association
  • Genomic Classification of the Heart Transplant Endomyocardial Biopsy  awarded by University of California, Los Angeles
  • Hepatocyte Clock and Alcoholic Fatty Liver Injury  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS
  • Improving Mitochondrial Function to Protect Against Myocardial Ischemia/Reperfusion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 1 = Circadian Control of Sodium Excretion  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Macrophage Circadian Clock Disruption and Inflammation in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Protein O-GlcNAcylation and the Regulation of Cardiac Function  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Regulation of Skeletal Muscle Mitochondrial Quality Control Parameters and Systemic Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • STIM1 and its Role in Regulating Cardiac Metabolism  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Saturated Fatty Acid-Induced Autophagy in Vascular Endothelium  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Targeting Cardiomyocyte Mitochondria In Vivo with an Innovative Luminoptogenetic Approach  awarded by American Heart Association
  • Tissue Chip Models for Cardiovascular Development and Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center (NORC) - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB Nutrition Obesity Research Center - P&F Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center  awarded by American Heart Association
  • University of Alabama at Birmingham Strategically Focused Hypertension Research Center - Novel Mechanisms of Salt-Sensitivity and Diurnal Blood Pressure Rhythm - Project 3  awarded by American Heart Association
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Oxford 1999
  • Master of Life Sciences in Biochemistry, University of Oxford 1995
  • Full Name

  • Martin Young