• Jiri Mestecky (b. 1941), Professor in the Department of Microbiology and Medicine, graduated from the School of Medicine, Charles University in Prague, Czechoslovakia in 1964. Postdoctoral studies were then performed at the Czechoslovak Academy of Sciences, Prague in the Department of Immunology headed by Professor J. Sterzl, and at UAB with Professor F.W. Kraus. A sabbatical was spent in 1976 at Rockefeller University, New York, in the laboratory of Professor H.G. Kunkel. Dr. Mestecky has served as a member of the editorial boards of the Journal of Immunology, Immunochemistry (Molecular Immunology), Infection and Immunity, Journal of Clinical Immunology, Oral Microbiology and Immunology, and International Archives of Allergy and Immunology. Outside interest include classical music and traveling.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmissionFrontiers in Immunology.  13. 2022
    2022 Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing ReceptorsJournal of the American Society of Nephrology.  33:908-917. 2022
    2022 Antibody-dependent passive protection of mucosal surfacesHuman Vaccines and Immunotherapeutics.  18. 2022
    2021 Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free pigletsMucosal Immunology.  14:511-522. 2021
    2020 Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 InfectionFrontiers in Immunology.  11. 2020
    2020 Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA NephropathyFrontiers in Immunology.  11. 2020
    2020 Multiparametric flow cytometry analysis of peripheral blood b cell trafficking differences among epstein-barr virus infected and uninfected subpopulations 2020
    2020 The Mammary Gland as an Integral Component of the Common Mucosal Immune SystemNestle Nutrition Institute workshop series.  94:27-37. 2020
    2019 Evaluation of mucosal humoral and cellular immune responses to hiv in external secretions and mucosal tissuesCurrent Immunology Reviews.  15:41-48. 2019
    2019 HIV-1/SIV humoral responses in external secretionsCurrent Immunology Reviews.  15:49-62. 2019
    2019 Mucosal immune system and HIV/SIVCurrent Immunology Reviews.  15:2-3. 2019
    2018 Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy PatientsKidney and Blood Pressure Research.  43:350-359. 2018
    2017 Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapyPLoS One.  12. 2017
    2017 Two cells, one antibody: The discovery of the cellular origins and transport of secretory igaJournal of Immunology.  198:1765-1767. 2017
    2017 An update on the treatment of IgA nephropathyAktuality V Nefrologii.  23:60-62. 2017
    2017 Current findings in the pathogenesis of IgA nephropathyAktuality V Nefrologii.  23:63-65. 2017
    2017 Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 InfectionPLoS Pathogens.  13. 2017
    2016 IgA nephropathy - research-generated questionsVnitrni lekarstvi.  62:67-77. 2016
    2016 IgA nephropathy enigmaClinical Immunology.  172:72-77. 2016
    2016 Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytesVaccine.  34:3171-3177. 2016
    2016 The origin and activities of IgA1-containing immune complexes in IGA nephropathyFrontiers in Immunology.  7. 2016
    2016 Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challengeMucosal Immunology.  9:13-23. 2016
    2016 Diminished cd103 (αeβ7) expression on resident t cells from the female genital tract of hiv-positive womenPathogens and Immunity.  1:371-389. 2016
    2015 IgA nephropathy. Facts, uncertainties, and potential causal therapy approachesCasopis lekaru ceskych.  154:168-173. 2015
    2014 Origin of galactose-deficient immunoglobulin G in gingival crevicular fluid in periodontitisJournal of Periodontology.  85:1779-1785. 2014
    2014 Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infectionAIDS Research and Therapy.  11. 2014
    2014 Cellular Signaling and Production of Galactose-Deficient IgA1 in IgA Nephropathy, an Autoimmune DiseaseJournal of Immunology Research.  2014. 2014
    2014 Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected WomenEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  71:600-607. 2014
    2013 The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial CellsPLoS Pathogens.  9. 2013
    2013 IgA nephropathy: Molecular mechanisms of the diseaseAnnual Review of Pathology: Mechanisms of Disease.  8:217-240. 2013
    2012 Comparative evaluation of HIV-1 neutralization in external secretions and sera of HIV-1-infected womenOpen AIDS Journal.  6:293-302. 2012
    2012 In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cellsResults in Immunology.  2:166-172. 2012
    2012 Role of the mucosal immune system and commensal bacteria in allergyAlergie -Praha-.  14:124-133. 2012
    2012 Glycosylation of IgA1 and pathogenesis of IgA nephropathy 2012
    2012 Naturally occurring structural isomers in serum IgA1 O -glycosylationJournal of Proteome Research.  11:692-702. 2012
    2011 Menstrual blood as a potential source of endometrial derived CD3+ T cellsPLoS One.  6. 2011
    2011 Current view of the pathogenesis of IgA nephropathy and possibilities for causal therapyAlergie -Praha-.  13:268-274. 2011
    2011 IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cellsNephrology Dialysis Transplantation.  26:3451-3457. 2011
    2011 Strategic dominance of the mucosal immune system in the defense and toleranceCasopis lekaru ceskych.  150:480-488. 2011
    2011 The pathophysiology of IgA nephropathyJournal of the American Society of Nephrology.  22:1795-1803. 2011
    2011 Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccinesJournal of Immunology Research.  2011. 2011
    2011 Aberrant glycosylation of iga1 and anti-glycan antibodies in iga nephropathy: Role of mucosal immune systemAdvances in oto-rhino-laryngology.  72:60-63. 2011
    2011 Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative womenAIDS Research and Human Retroviruses.  27:469-486. 2011
    2011 Systemic and mucosal differences in hiv burden, immune, and therapeutic responses 2011
    2011 Methods for Evaluation of Humoral Immune Responses in Human Genital Tract SecretionsEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  65:361-367. 2011
    2010 Clustered O-glycans of IgA1: Defining macro- and microheterogeneity by use of electron capture/transfer dissociationMolecular and Cellular Proteomics.  9:2545-2557. 2010
    2010 Enhancing oral vaccine potency by targeting intestinal M cellsPLoS Pathogens.  6. 2010
    2010 Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: A comparative binding study.Biochemistry.  49:5671-5682. 2010
    2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognitionJournal of Biological Chemistry.  285:20860-20869. 2010
    2010 Mucosal HIV vaccines: A holy grail or a dud?Vaccine.  28:4015-4026. 2010
    2010 Tolerance and protection against infection in the genital tract 2010
    2010 Antibody-mediated protection and the mucosal immune system of the genital tract: Relevance to vaccine designJournal of Reproductive Immunology.  85:81-85. 2010
    2010 Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluidsClinical and Vaccine Immunology.  17:393-401. 2010
    2010 Tissue distribution and biological activities of immune complexes are determined by their size and compositionNephrology Dialysis Transplantation.  25:1007. 2010
    2010 Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infectionEndocrine Reviews.  31:79-97. 2010
    2009 P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaquesRetrovirology.  6. 2009
    2009 Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfacesImmunology Letters.  124:57-62. 2009
    2009 Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneityJournal of Clinical Investigation.  119:1668-1677. 2009
    2009 Mucosal antibody responses to HIVMethods in Molecular Biology.  485:333-345. 2009
    2009 Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infectionJournal of Reproductive Immunology.  83:196-200. 2009
    2008 Oral immunization: An updateCurrent Opinion in Gastroenterology.  24:713-719. 2008
    2008 Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathyJournal of the American Society of Nephrology.  19:1008-1014. 2008
    2008 Treatment of IgA nephropathyVnitrni lekarstvi.  54:239-244. 2008
    2008 Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responsesVaccine.  26:1541-1551. 2008
    2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1Journal of Clinical Investigation.  118:629-639. 2008
    2008 Peyer's patches as the inductive site for IgA responsesJournal of Immunology.  180:1293-1294. 2008
    2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of iga nephropathyKidney and Blood Pressure Research.  31:29-37. 2008
    2008 IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA NephropathySeminars in Nephrology.  28:78-87. 2008
    2007 Mucosal immune system of genital tractModern Aspects of Immunobiology.  21:2. 2007
    2007 Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpuraPediatric Nephrology.  22:2067-2072. 2007
    2007 Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: Implications for IgA nephropathyAnalytical and Bioanalytical Chemistry.  389:1397-1407. 2007
    2007 Neutralizing antibodies in mucosal secretions: IgG or IgA?Current HIV Research.  5:588-593. 2007
    2007 Perspectives on mucosal vaccines: Is mucosal tolerance a barrier?Journal of Immunology.  179:5633-5638. 2007
    2007 Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoireJournal of Virology.  81:9331-9338. 2007
    2007 Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in miceVaccine.  25:6359-6366. 2007
    2007 Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levelsKidney International.  71:1148-1154. 2007
    2007 IgA nephropathy and henoch-schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cellsContributions to Nephrology.  157:134-138. 2007
    2007 IgA nephropathy: A clinical overviewContributions to Nephrology.  157:19-26. 2007
    2007 IgA nephropathy: Characterization of IgG antibodies specific for galactose-deficient IgA1Contributions to Nephrology.  157:129-133. 2007
    2007 IgA nephropathy: Current views of immune complex formationContributions to Nephrology.  157:56-63. 2007
    2007 Identification and Characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-Sialyltransferase in IgA1-producing CellsJournal of Molecular Biology.  369:69-78. 2007
    2007 Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteinsMolecular Immunology.  44:2598-2604. 2007
    2007 Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteinsVirology.  360:218-234. 2007
    2007 Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites (DOI:10.1016/j.jri.2006.05.006)Journal of Reproductive Immunology.  73:86-97. 2007
    2006 IgA-containing immune complexes in the urine of IgA nephropathy patientsNephrology Dialysis Transplantation.  21:2478-2484. 2006
    2006 HIV infection: first battle decides the warTrends in Immunology.  27:274-281. 2006
    2006 Immunoglobulin A and renal diseasesVnitrni lekarstvi.  52:256-262. 2006
    2006 Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sitesJournal of Reproductive Immunology.  72:1-17. 2006
    2006 Influenza virus infection of the murine uterus: A new model for antiviral immunity in the female reproductive tractViral Immunology.  19:613-622. 2006
    2006 Influenza virus infection of the murine uterus: a new model for antiviral immunity in the female reproductive tract.Viral Immunology.  19:613-622. 2006
    2006 University of Alabama at BirminghamAktuality V Nefrologii.  12:15-17. 2006
    2005 European Union and EDCTP strategy in the global context: Recommendations for preventive HIV/AIDS vaccines researchVaccine.  23:5551-5556. 2005
    2005 Urinary IgA in IgA nephropathy patients - A new finding which support diagnosis of IgA nephropathyAktuality V Nefrologii.  11:11-17. 2005
    2005 Heterogeneity of IgG glycosylation in adult periodontal disease 2005
    2005 Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunityJournal of Immunology.  175:4127-4136. 2005
    2005 Mucosal immunoglobulinsImmunological Reviews.  206:64-82. 2005
    2005 Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometryJournal of Biological Chemistry.  280:19136-19145. 2005
    2005 Immune response versus mucosal tolerance to mucosally administered antigensVaccine.  23:1800-1803. 2005
    2005 Increased levels of galactose-deficient IgG in sera of HIV-1-infected individualsAIDS.  19:381-389. 2005
    2005 Immune responses to human papillomavirus in genital tract of women with cervical cancerGynecologic Oncology.  96:452-461. 2005
    2005 IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cellsKidney International.  67:504-513. 2005
    2005 Immunologic uniqueness of the genital tract: Challenge for vaccine developmentEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  53:208-214. 2005
    2005 Interaction of mucosal microbiota with the innate immune systemScandinavian Journal of Immunology.  62:106-113. 2005
    2004 Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA LoadsJournal of Infectious Diseases.  190:1970-1978. 2004
    2004 Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individualsAIDS Research and Human Retroviruses.  20:972-988. 2004
    2004 Role for antibodies in heterosubtypic immunity: The link between innate and adaptive immunityInternational Congress Series.  1263:130-134. 2004
    2004 Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G proteinJournal of Infectious Diseases.  189:1221-1231. 2004
    2004 Oral tolerance in humans: Failure to suppress an existing immune response by oral antigen administrationAnnals of the New York Academy of Sciences.  1029:299-309. 2004
    2002 Detection of mucosal antibodies in HIV type 1-infected individualsAIDS Research and Human Retroviruses.  18:1291-1300. 2002
    2002 [IgA nephropathy. Significance of immunoglobulin A glycosylation in pathogenesis and clinical presentation].Casopis lekaru ceskych.  141:729-734. 2002
    2002 Cloning and expression of the turtle (Trachemys scripta) immunoglobulin joining (J)-chain cDNAImmunogenetics.  54:513-519. 2002
    2002 Cloning of the chicken immunoglobulin joining (J)-chain gene and characterization of its promoter regionDNA and Cell Biology.  21:81-90. 2002
    2002 Hydrostatic pressure induces the fusion-active state of enveloped virusesJournal of Biological Chemistry.  277:8433-8439. 2002
    2002 Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposureJournal of Infectious Diseases.  185:428-438. 2002
    2002 Humoral immune responses to microbial infections in the genital tract 2002
    2002 IgA nephropathy pathogenetic importance of immunoglobulin a glycosylation and clinical presentationCasopis lekaru ceskych.  141:729-734. 2002
    2002 Interactions of human mesangial cells with IgA and IgA-containing immune complexesKidney International.  62:465-475. 2002
    2002 Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cellsNature Medicine.  8:150-156. 2002
    2001 Progress in molecular and genetic studies of IgA nephropathyJournal of Clinical Immunology.  21:310-327. 2001
    2001 Urethral cytokine and immune responses in Chlamydia trachomatis-infected malesInfection and Immunity.  69:7178-7181. 2001
    2001 Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccineJournal of Reproductive Immunology.  52:61-75. 2001
    2001 Mechanism of heterosubtypic immunity to influenza A virus infectionInternational Congress Series.  1219:333-340. 2001
    2001 Biodegradable block copolymers for delivery of proteins and water-insoluble drugsJournal of Controlled Release.  72:203-215. 2001
    2001 A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjectsVaccine.  19:3033-3042. 2001
    2001 In Vitro exposure to highly cytopathic HIV-1 X4 strains increases expression of mucosa-associated integrins on CD4+ T CellsVirology.  280:262-272. 2001
    2001 Heterosubtypic immunity to influenza A virus infection requires B cells but not CD8+ cytotoxic T lymphocytesJournal of Infectious Diseases.  183:368-376. 2001
    2001 Homeostasis of the mucosal immune system: Human milk and lactationAdvances in Experimental Medicine and Biology.  501:197-205. 2001
    2001 Mechanisms of immune tolerance to food antigens in humansClinical Immunology.  101:158-168. 2001
    2000 Heterogeneity of O-glycosylation in the hinge region of human IgA1Molecular Immunology.  37:1047-1056. 2000
    2000 Strategies of immunization against mucosal infectionsVaccine.  19. 2000
    2000 Cytokine profiles in seronegative volunteers immunized with a recombinant canarypox and gp120 prime-boost HIV-1 vaccineAIDS.  14:1365-1374. 2000
    2000 Expression of the recombinant human immunoglobulin J chain in Escherichia coliMolecular Immunology.  37:133-140. 2000
    2000 Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in miceJournal of Virology.  74:5495-5501. 2000
    2000 False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigensAIDS Research and Human Retroviruses.  16:595-602. 2000
    2000 Production, distribution, and structure of human IgA moleculesNihon Jinzo Gakkai shi.  42. 2000
    2000 A method for quantification of absolute amounts of nucleic acids by (RT)-PCR and a new mathematical model for data analysis.Nucleic Acids Research.  28. 2000
    2000 Cloning and expression of the chicken immunoglobulin joining (J)-chain cDNAImmunogenetics.  51:85-91. 2000
    2000 IgA1 glycosylation and the pathogenesis of IgA nephropathyAmerican Journal of Kidney Diseases.  35:551-554. 2000
    2000 Induction of mucosal immune responses in the human genital tractFEMS Immunology and Medical Microbiology.  27:351-355. 2000
    2000 Invited Lecture 3:Production, distribution, and structure of human IgA moleculesNihon Jinzo Gakkai shi.  42:133-133. 2000
    2000 Role of nuclear factor-κB in the expression by tumor necrosis factor-α of the human polymeric immunoglobulin receptor (pIgR) geneImmunogenetics.  51:289-295. 2000
    1999 Induction of immune responses to SIV antigens by mucosally administered vaccinesAIDS Research and Human Retroviruses.  15:1469-1476. 1999
    1999 Mucosal immunity and tolerance: Relevance to vaccine developmentImmunological Reviews.  170:197-222. 1999
    1999 An IgA-binding peptide derived from a streptococcal surface proteinJournal of Biological Chemistry.  274:14521-14524. 1999
    1999 Mucosal immune system of the human genital tractJournal of Infectious Diseases.  179. 1999
    1999 Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humansJournal of Immunology.  162:5173-5177. 1999
    1999 Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8+ cytotoxic T lymphocyte responses induced in mucosa-associated tissuesVirology.  254:50-60. 1999
    1999 Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodiesJournal of Clinical Investigation.  104:73-81. 1999
    1999 Intestinal IgA: Novel views on its function in the defence of the largest mucosal surfaceGut.  44:2-5. 1999
    1999 Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infectionsInfection and Immunity.  67:3937-3946. 1999
    1999 Mucosal immunity in the genital tract: Prospects for vaccines against sexually transmitted diseases. A reviewEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  42:58-63. 1999
    1999 Progress in the pathogenesis of IgA nephropathy.Advances in nephrology from the Necker Hospital.  29:53-72. 1999
    1998 Nomenclature of immunoglobulin A and other proteins of the mucosal immune systemImmunologist.  6:24-25. 1998
    1998 Nomenclature of immunoglobulin A and other proteins of the mucosal immune systemBulletin of the World Health Organization.  76:427-428. 1998
    1998 Human and nonhuman primate lymphocytes engrafted into SCID mice reside in unique mesenteric lymphoid structuresJournal of Immunology.  161:1306-1312. 1998
    1998 Passive and active protection against disorders of the gut.Veterinary Quarterly.  20:83-87. 1998
    1998 Mucosal immunity in the female reproductive tract: Correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulationAIDS Research and Human Retroviruses.  14. 1998
    1998 HIV-1/simian immunodeficiency virus infection of human and nonhuman primate lymphocytes results in the migration of CD2+ T cells into the intestine of engrafted SCID miceJournal of Immunology.  160:2506-2513. 1998
    1998 In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgAJournal of Immunology.  160:1219-1223. 1998
    1998 Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: Evidence for compartmentalization within the common mucosal immune system in humansInfection and Immunity.  66:5630-5635. 1998
    1998 Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease- inhibitory activity in human female genital infection with Neisseria gonorrhoeaeInfection and Immunity.  66:5826-5832. 1998
    1998 Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1(MN) gp120, HIV-1(SF2) recombinant gp120, or both vaccines in seronegative adultsJournal of Infectious Diseases.  177:1230-1246. 1998
    1998 Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccinesJournal of Virology.  72:1552-1576. 1998
    1998 Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytesJournal of Virology.  72:4534-4536. 1998
    1998 Modulation of immunologic responses to HIV-1(MN) recombinant gp160 vaccine by dose and schedule of administrationVaccine.  16:493-506. 1998
    1998 Passive and active protection against disorders of the gutVeterinary Quarterly.  20:83-87. 1998
    1998 Vitamin A is required for regulation of polymeric immunoglobulin receptor (plgR) expression by interleukin-4 and interferon-γ in a human intestinal epithelial cell line 1998
    1997 Rectal immunization for induction of specific antibody in the genital tract of womenJournal of Clinical Immunology.  17:370-379. 1997
    1997 Current options for vaccine delivery systems by mucosal routesJournal of Controlled Release.  48:243-257. 1997
    1997 Structural differences among serum IgA proteins of chimpanzee, rhesus monkey and rat originMolecular Immunology.  34:557-565. 1997
    1997 Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgGKidney International.  52:509-516. 1997
    1997 Human peritoneal B-1 cells and the influence of continuous ambulatory peritoneal dialysis on peritoneal and peripheral blood mononuclear cell (PBMC) composition and immunoglobulin levelsClinical and Experimental Immunology.  109:356-361. 1997
    1997 IgA antibody as a non-inflammatory regulator of immunityBiochemical Society Transactions.  25:466-470. 1997
    1997 Immunoglobulin J chain. An early differentiation marker of human B cellsAnnals of the New York Academy of Sciences.  815:111-113. 1997
    1997 Mucosal immunoglobulins and their contribution to defence mechanisms: An overviewBiochemical Society Transactions.  25:457-462. 1997
    1997 Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.Behring Institute Mitteilungen.  33-43. 1997
    1996 Impaired mucosal iga responses in tcr6-/- mice 1996
    1996 In vitro HIV infection increases mucosal-associated adhesion molecules on CD4+ T CELLS 1996
    1996 Mucosally activated circulating human T-cells express the gut homing receptor α4β7 1996
    1996 Multiple mechanisms of oral tolerance to food antigens in humans 1996
    1996 Evaluation of monoclonal antibodies with specificity for human IgA, IgA subclasses and allotypes and secretory component. Results of an IUIS/WHO collaborative studyImmunotechnology : an international journal of immunological engineering.  193:103-148. 1996
    1996 gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.Journal of Experimental Medicine.  183:1929-1935. 1996
    1996 γ/δ T cell-deficient mice have impaired mucosal immunoglobulin a responsesJournal of Experimental Medicine.  183:1929-1935. 1996
    1996 The joining (J) chain is present in invertebrates that do not express immunoglobulins 1996
    1996 Comparative analysis of oral delivery systems for live rotavirus vaccinesJournal of Controlled Release.  41:237-247. 1996
    1996 Immunoglobulin-containing plasma cells recruited to cervical neoplasiaObstetrics and Gynecology.  87:520-526. 1996
    1996 Induction of tolerance in humans: Effectiveness of oral and nasal immunization routesAnnals of the New York Academy of Sciences.  778:194-201. 1996
    1996 Polyethylene glycol precipitates of serum contain a large proportion of uncomplexed immunoglobulins and C3 1996
    1996 Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunitInfection and Immunity.  64:1272-1283. 1996
    1996 Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulationClinical and Experimental Immunology.  104:538-542. 1996
    1995 A polarized human endometrial cell line that binds and transports polymeric IgA 1995
    1995 Alterations in the IgA carbohydrate chains influence the cellular distribution of IgA1.Contributions to Nephrology.  111. 1995
    1995 Antisperm antibodies in infertile women: Subclass distribution of immunoglobulin (Ig) A antibodies and removal of IgA sperm-bound antibodies with a specific IgA1 proteaseFertility and Sterility.  63:63-70. 1995
    1995 Characterization of IgA1, IgA2 and secretory IgA carbohydrate chains using plant lectinsAdvances in Experimental Medicine and Biology.  371:585-589. 1995
    1995 Clonal antibody dominance after influenza vaccination in IgA nephropathy patients and controlsAdvances in Experimental Medicine and Biology.  371:829-834. 1995
    1995 Compartmentalization within the common mucosal immune systemAdvances in Experimental Medicine and Biology.  371:97-101. 1995
    1995 Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeysAdvances in Experimental Medicine and Biology.  371:1035-1038. 1995
    1995 Human immune responses to influenza virus vaccines administered by systemic or mucosal routesVaccine.  13:1006-1012. 1995
    1995 Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virusAdvances in Experimental Medicine and Biology.  371:1587-1590. 1995
    1995 IgA nephropathy: A disease of incomplete IgA 1 glycosylation?Advances in Experimental Medicine and Biology.  376:221-222. 1995
    1995 IgA production and transport in the murine liver after mucosal immunizationAdvances in Experimental Medicine and Biology.  371:1061-1066. 1995
    1995 Intestinal Immune Function Is Unaffected By Parenteral Nutrition In ManJournal of the American College of Nutrition.  14:656-661. 1995
    1995 Intraperitoneal administration of tetanus toxoid elicits a specific responses of antibody-secreting cells in the peritoneal cavityAdvances in Experimental Medicine and Biology.  371:103-106. 1995
    1995 Normal Uterine Cervix: Characterization of Isolated Lymphocyte Phenotypes and Immunoglobulin SecretionEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  34:241-247. 1995
    1995 Oral immunization studies with streptococcus mutans and influenza vaccines in rhesus macaque monkeysAdvances in Experimental Medicine and Biology.  371:1423-1429. 1995
    1995 Oral tolerance in humans: T cell but not B cell tolerance to a soluble protein antigenAdvances in Experimental Medicine and Biology.  371:1225-1228. 1995
    1995 Phylogeny of the immunoglobulin joining (J) chainAdvances in Experimental Medicine and Biology.  371:353-356. 1995
    1995 T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8‐positive cells are recruited to invasionCancer.  76:1411-1415. 1995
    1994 Antispermatozoal antibodies in human colostrum and milkGeburtshilfe und Frauenheilkunde.  116:636-638. 1994
    1994 Mucosal immunity in the female genital tract: Relevance to vaccination efforts against the human immunodeficiency virusAIDS Research and Human Retroviruses.  10. 1994
    1994 Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccinesJournal of Clinical Immunology.  14:259-272. 1994
    1994 HIV Infection in Vaccinated VolunteersJournal of the American Medical Association.  272:431. 1994
    1994 Molecular characterization of protein Sir, a streptococcal cell surface protein that binds both immunoglobulin A and immunoglobulin GJournal of Biological Chemistry.  269:13458-13464. 1994
    1994 Oral tolerance in humans: T cell but not B cell tolerance after antigen feedingJournal of Immunology.  152:4663-4670. 1994
    1994 Antisperm Antibodies (ASAs) in Infertile Males: Subclass Distribution of IgA Antibodies and the Effect of an IgA1 Protease on Sperm‐Bound AntibodiesEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  31:77-83. 1994
    1994 Biodegradable microspheres for the delivery of oral vaccinesJournal of Controlled Release.  28:131-141. 1994
    1994 Carbohydrate heterogeneity of human myeloma proteins of the IgA1 and IgA2 subclassesMolecular Immunology.  31:1415-1422. 1994
    1994 Conference on advances in AIDS vaccine development - 1993 summary: Cytotoxic T-cell immunity workshopAIDS Research and Human Retroviruses.  10. 1994
    1994 Conference on advances in AIDS vaccine development - 1993 summary: Mucosal immunity workshopAIDS Research and Human Retroviruses.  10. 1994
    1994 Effects of total parenteral nutrition on intestinal morphology and function in humansTransplantation Proceedings.  26:1457. 1994
    1994 Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA responseClinical and Experimental Immunology.  96:356-363. 1994
    1994 Lectin Receptors on IgA IsotypesScandinavian Journal of Immunology.  39:195-201. 1994
    1994 Mucosal immunity and strategies for novel microbial vaccines 1994
    1994 Secretory immunity in the female reproductive tractEarly pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy.  31:40-46. 1994
    1994 Suppression of the immune response by nasal immunizationClinical Immunology.  72:30-34. 1994
    1993 Surface expression of secretory component and HLA class II DR antigen on glandular epithelial cells from human endometrium and two endometrial adenocarcinoma cell linesJournal of Clinical Immunology.  13:259-264. 1993
    1993 Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.Journal of Periodontology.  64:400-406. 1993
    1993 Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy.Contributions to Nephrology.  104:172-182. 1993
    1993 Early Expression of Human J Chain and μ Chain Gene in the Fetal LiverCell Structure and Function.  18:297-302. 1993
    1993 Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunitInfection and Immunity.  61:2162-2171. 1993
    1993 Interactions of cell-surface galactosyltransferase with immunoglobulinsMolecular Immunology.  30:265-275. 1993
    1993 Interactions of galactosyltransferase with serum and secretory immunoglobulins and their component chainsMolecular Immunology.  30:277-286. 1993
    1993 Murine model for evaluation of protective immunity to influenza virusVaccine.  11:55-60. 1993
    1993 Oral immunization with influenza virus in biodegradable microspheresJournal of Infectious Diseases.  167:84-90. 1993
    1993 Saliva as a Manifestation of the Common Mucosal Immune SystemAnnals of the New York Academy of Sciences.  694:184-194. 1993
    1993 Serum IgG and IgM levels to bacterial antigens in necrotizing ulcerative gingivitis.Journal of Periodontology.  64:195-201. 1993
    1993 Shared idiotypes in mesangial deposits in IgA nephropathy are not disease-specificKidney International.  44:65-74. 1993
    1992 Transforming growth factor-β inhibits the production of IgG, IgM, and IgA in human lymphocyte culturesCellular Immunology.  144:417-428. 1992
    1992 Antisperm antibodies: Current knowledge and new horizonsMolecular Andrology.  4:183-193. 1992
    1992 Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infectionKidney International.  42:374-382. 1992
    1992 Cytokine-Induced Immunoglobulin Production in Primary IgA NephropathyAmerican Journal of Kidney Diseases.  20:611-617. 1992
    1992 Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: A comparison between intravenously and genitally inoculated Rhesus macaquesClinical and Experimental Immunology.  88:520-526. 1992
    1992 IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathyClinical and Experimental Immunology.  89:315-320. 1992
    1992 Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routesAIDS Research and Human Retroviruses.  8:1389. 1992
    1992 Liposomes and conjugate vaccines for antigen delivery and induction of mucosal immune responsesAdvances in Experimental Medicine and Biology.  327:191-198. 1992
    1992 Molecular heterogeneity of human IgA antibodies during an immune responseClinical and Experimental Immunology.  87:1-6. 1992
    1992 Properties of IgA‐Binding Receptors on Murine T Cells: Relative Importance of FcαR, β‐Galactosyltransferase and Anti‐Secretory Component Reactive Proteins (ASCP)Scandinavian Journal of Immunology.  35:469-486. 1992
    1992 Prospects for human mucosal vaccinesAdvances in Experimental Medicine and Biology.  327:13-21. 1992
    1992 The mucosal immune system: from fundamental concepts to vaccine developmentVaccine.  10:75-88. 1992
    1992 The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigensRegional immunology.  4:86-90. 1992
    1991 Anti-adhesive molecules in human milkAdvances in Experimental Medicine and Biology.  310:167-171. 1991
    1991 Cellular origins of human polymeric and monomeric IgA: enumeration of single cells secreting polymeric IgA1 and IgA2 in peripheral blood, bone marrow, spleen, gingiva and synovial tissueClinical and Experimental Immunology.  85:341-348. 1991
    1991 Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesisJournal of Clinical Investigation.  88:248-252. 1991
    1991 IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical courseKidney International.  39:1218-1224. 1991
    1991 Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis: Relationship to periodontal treatmentJournal of Clinical Periodontology.  18:703-707. 1991
    1991 Immunological properties and differentiation potential of human colostral lymphocytes of B cell lineageAdvances in Experimental Medicine and Biology.  310:123-129. 1991
    1991 Local iga and igm rheumatoid factor production in autoimmune MRL/ipr miceAutoimmunity.  10:7-14. 1991
    1991 Peyer's patch B cells with memory cell characteristics undergo terminal differentiation within 24 hours in response to interleukin-6Cytokine.  3:107-116. 1991
    1991 Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cellsCellular Immunology.  132:423-432. 1991
    1991 Regulation of mucosal responses by cd4+ t lymphocytes: Effects of anti-l3t4 treatment on the gastrointestinal immune systemInternational Immunology.  3:793-805. 1991
    1991 Role of IL-6 in human antigen-specific and polyclonal IgA responsesAdvances in Experimental Medicine and Biology.  310:113-121. 1991
    1991 Selective transport of IgA: Cellular and molecular aspectsGastroenterology Clinics of North America.  20:441-471. 1991
    1991 Targeting and controlled release of antigens for the effective induction of secretory antibody responsesCurrent Opinion in Immunology.  3:492-495. 1991
    1991 Transforming growth factor-β enhances secretory component and major histocompatibility complex class I antigen expression on rat IEC-6 intestinal epithelial cellsCytokine.  3:543-550. 1991
    1990 Antibody-secreting peripheral blood lymphocytes induced by immunization with a conjugate consisting of Streptococcus pneumoniae type 12F polysaccharide and diphtheria toxoidInfection and Immunity.  58:2547-2554. 1990
    1990 In defense of mucosal surfaces. Development of novel vaccines for IgA responses protective at the portals of entry of microbial pathogens.Infectious Disease Clinics of North America.  4:315-341. 1990
    1990 Degradation of IgA proteins by Pseudomonas aeruginosa elastaseJournal of Immunology.  144:2253-2257. 1990
    1990 Immunization of humans with polysaccharide vaccines induces systemic, predominantly polymeric IgA2-subclass antibody responsesJournal of Immunology.  144:3770-3778. 1990
    1990 Immunoglobulin A (IgA) Polymerization Sites in Human Immunocytes: Immunoelectron Microscopic StudyCell Structure and Function.  15:85-91. 1990
    1990 J chain disease: A novel form of plasma cell dyscrasiaAmerican Journal of Medicine.  88:411-416. 1990
    1990 Liposomes containing anti-idiotypic antibodies: An oral vaccine to induce protective secretory immune response specific for pathogens of mucosal surfacesInfection and Immunity.  58:1932-1936. 1990
    1990 Secretory immune system of the female reproductive tract. II. Local immune system in normal and infected fallopian tubeFertility and Sterility.  54:51-55. 1990
    1990 Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectinInfection and Immunity.  58:3073-3077. 1990
    1990 Serum antibody response in adult volunteers elicited by injection of Streptococcus pneumoniae type 12F polysaccharide alone or conjugated to diphtheria toxoidInfection and Immunity.  58:2309-2312. 1990
    1990 Site of Catabolism of Autologous and Heterologous IgA in Non‐Human PrimatesScandinavian Journal of Immunology.  32:577-583. 1990
    1990 Synergistic effect of IL-4 and IFN-γ on the expression of polymeric Ig receptor (secretory component) and IgA binding by human epithelial cellsJournal of Immunology.  145:1740-1744. 1990
    1989 Local production of IgA- and IgM-rheumatoid factors in adult periodontal diseaseJournal of Clinical Immunology.  9:273-278. 1989
    1989 Regulation of IgA synthesis and immune response by T cells and interleukinsJournal of Clinical Immunology.  9:175-199. 1989
    1989 Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissueJournal of Immunology.  142:1150-1158. 1989
    1989 Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissuesClinical and Experimental Immunology.  76:103-110. 1989
    1989 Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue.Regional immunology.  2:103-110. 1989
    1989 Distribution of immunoglobulin isotypes including IgA subclasses in adult, juvenile, and rapidly progressive periodontitisJournal of Clinical Periodontology.  16:179-184. 1989
    1989 IgA subclasses of human colostral antibodies specific for microbial and food antigensClinical and Experimental Immunology.  78:85-90. 1989
    1989 IgA-induced eosinophil degranulationJournal of Immunology.  142:2393-2400. 1989
    1989 Immune responses to influenza virus in orally and systemically immunized mice.Current Topics in Microbiology and Immunology.  146:91-99. 1989
    1989 Non-specific mesangial staining with antibodies against cytomegalovirus in immunoglobulin-A nephropathy 1989
    1989 Oral immunization: past and present.Current Topics in Microbiology and Immunology.  146:3-11. 1989
    1989 Systemic immunization for the induction of IgA responses.Current Topics in Microbiology and Immunology.  146:161-168. 1989
    1989 The role of the liver in catabolism of mouse and human iga 1989
    1988 A novel two colour ELISPOT assay. I. Simultaneous detection of distinct types of antibody-secreting cellsImmunotechnology : an international journal of immunological engineering.  115:31-37. 1988
    1988 Immunobiology of IgA.American Journal of Kidney Diseases.  12:378-383. 1988
    1988 Agglutination of E. coli by secretory IgA--a result of interaction between bacterial mannose-specific adhesins and immunoglobulin carbohydrate?Monographs in allergy.  24:307-309. 1988
    1988 Autoimmunity to collagen in adult periodontal diseaseJournal Of Oral Pathology and Medicine.  17:456-459. 1988
    1988 Binding of IgA to erythrocytes from patients with IgA nephropathyClinical Immunology.  48:1-9. 1988
    1988 Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteasesMicrobiology and Molecular Biology Reviews.  52:296-303. 1988
    1988 EditorialJournal Of Oral Pathology and Medicine.  17:443-444. 1988
    1988 HNK‐1+ (Leu‐7) cells and natural killer cell activity in inflamed human gingival tissueJournal Of Oral Pathology and Medicine.  17:118-123. 1988
    1988 IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States?American Journal of Medicine.  84:129-132. 1988
    1988 IgA-mediated clearance and tissue deposition of dinitrophenylated human serum albumin at various DNP:HSA ratiosMolecular Immunology.  25:731-738. 1988
    1988 Immunobiology of IgAAmerican Journal of Kidney Diseases.  12:378-383. 1988
    1988 Induction of the mucosal immune response.Clinical Infectious Diseases.  10 Suppl 2. 1988
    1988 Interaction of lymphoid cells with epithelial cells: selectivity of the expression of IgA in mucosal plasma cells and of the transport of polymeric IgA.Monographs in allergy.  24:83-90. 1988
    1988 Intestinal IgA systemImmunology and Allergy Clinics of North America.  8:349-368. 1988
    1988 Receptor-mediated binding and uptake of immunoglobulin a by human liverGastroenterology.  94:762-770. 1988
    1988 Role of hepatocytes in the uptake of IgA and IgA-containing immune complexes in miceMolecular Immunology.  25:873-879. 1988
    1988 Secretory immune system of the female reproductive tract: I. immunoglobulin and secretory component-containing cellsObstetrics and Gynecology.  71:56-60. 1988
    1988 Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodiesJournal of Immunology.  140:3793-3800. 1988
    1988 The sites of catabolism of murine monomeric IgAJournal of Immunology.  141:208-213. 1988
    1988 precursor B cells transformed by Epstein-Barr virus undergo sterile plasma-cell differentiation: J-chain expression without immunoglobulin 1988
    1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigensAnnals of allergy.  59:54-59. 1987
    1987 Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune system 1987
    1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigens. 1987
    1987 IgA antibody-producing cells in peripheral blood after antigen ingestion: Evidence for a common mucosal immune system in humans 1987
    1987 The common mucosal immune system and current strategies for induction of immune responses in external secretionsJournal of Clinical Immunology.  7:265-276. 1987
    1987 Analysis of paraprotein transport into the saliva by using anti-idiotype antibodiesJournal of Immunology.  138:435-439. 1987
    1987 Antibodies directed at Fab of IgA in the sera of normal individuals and IgA nephropathy patients.Advances in Experimental Medicine and Biology.  216 B:1537-1544. 1987
    1987 Binding, uptake and processing of various molecular forms of IgA by human hepatoma cell line (HepG2).Advances in Experimental Medicine and Biology.  216 B:1117-1123. 1987
    1987 Detection of food antigen-specific IgA immune complexes in human sera.Advances in Experimental Medicine and Biology.  216 A:813-820. 1987
    1987 Glycoconjugate receptors for bacteria attaching to mucosal sites: examples for Escherichia coli and Streptococcus pneumoniae.Advances in Experimental Medicine and Biology.  216 B:931-939. 1987
    1987 Heterogeneity of binding of monoclonal IgA to staphylococcal protein A is related to the IgA polymerization stateImmunology Letters.  16:11-14. 1987
    1987 IgA on the surface of erythrocytes from IgA nephropathy patients.Advances in Experimental Medicine and Biology.  216 B:1577-1581. 1987
    1987 IgA subclass responses to lipopolysaccharide in humans.Advances in Experimental Medicine and Biology.  216 B:1199-1205. 1987
    1987 IgA-associated renal diseases: immunochemical studies of IgA1 proteins, circulating immune complexes, and cellular interactions.Seminars in Nephrology.  7:332-335. 1987
    1987 Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune ResponseAdvances in Immunology.  40:153-245. 1987
    1987 Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. 1987
    1987 Immunohistochemical study of the ontogeny of the secretory immune system.Advances in Experimental Medicine and Biology.  216 B:1359-1368. 1987
    1987 Immunological studies of IgA nephropathy: familial and racial aspects.Advances in Experimental Medicine and Biology.  216 B:1489-1498. 1987
    1987 Influence of IgA on carbohydrate-mediated clearance of antigen.Advances in Experimental Medicine and Biology.  216 B:1125-1131. 1987
    1987 Inhibition of natural killer (NK) activity by human colostral and serum IgA.Advances in Experimental Medicine and Biology.  216 A:539-542. 1987
    1987 Molecular form and subclass distribution of IgA antibodies after immunization with live and inactivated influenza A vaccines.Advances in Experimental Medicine and Biology.  216 B:1691-1700. 1987
    1987 Normal human sera contain antibodies directed at Fab of IgAJournal of Immunology.  138:2244-2248. 1987
    1987 Novel oral vaccines: the effectiveness of cloned gene products on inducing secretory immune responses.Advances in Experimental Medicine and Biology.  216 B:1741-1747. 1987
    1987 Oral immunization with bacterial antigen induces IgA-secreting cells in peripheral blood in humans.Advances in Experimental Medicine and Biology.  216 B:1709-1719. 1987
    1987 Secretory component binding: immunofluorescence and ultrastructural studies.Advances in Experimental Medicine and Biology.  216 B:1085-1094. 1987
    1987 Striking Elevation of Serum IgA, IgA-Containing Immune Complexes, and IgA Rheumatoid Factor in Clinically Silent Dermatitis HerpetiformisAmerican Journal of Kidney Diseases.  10:378-384. 1987
    1986 Potential for immunological intervention against dental caries.Journal de biologie buccale.  14:159-175. 1986
    1986 Isotype-specific immunoregulation; characterization and function of Fc receptors on T-T hybridomas which produce murine IgA-binding factorJournal of Immunology.  136:3953-3960. 1986
    1986 Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodiesImmunotechnology : an international journal of immunological engineering.  87:87-93. 1986
    1986 Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodiesMolecular Immunology.  23:339-346. 1986
    1986 Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathiesJournal of Clinical Investigation.  77:1931-1938. 1986
    1986 IgA subclasses.Monographs in allergy.  19:277-301. 1986
    1986 IgA-associated renal diseases: Antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruliJournal of Clinical Immunology.  6:74-86. 1986
    1986 Inhibition of natural killer cell activity by IgACellular Immunology.  101:143-155. 1986
    1986 The human IgA system: A reassessmentClinical Immunology.  40:105-114. 1986
    1986 The stoichiometry of J chain in human secretory dimeric IgAMolecular Immunology.  23:541-544. 1986
    1985 Secondary structure of the immunoglobulin J chain. (circular dichroism/hydrophobicity profile/tertiary structure/antiparallel β-barrel) 1985
    1985 Secondary structure of the immunoglobulin J chain. 1985
    1985 Urinary IgA in IgA nephropathy and Henoch-Schoenlein purpuraJournal of Clinical Immunology.  5:298-306. 1985
    1985 J-chain expression in human cells producing IgG subclassesCellular Immunology.  91:515-519. 1985
    1985 Analysis of the hepatobiliary transport of polymeric IgA with monoclonal anti-allotypic antibodies 1985
    1985 Carbohydrate-mediated clearance of secretory IgA from the circulationMolecular Immunology.  22:887-892. 1985
    1985 Electronmicroscopic and cytofluorographic analysis of Fcα receptor bearing T-T hybridomas 1985
    1985 Enumeration of antibody-secreting cells in mice immunized with Streptococcus mutans 1985
    1985 IgA rheumatoid factor synthesis by dissociated synovial cells. Characterization and relationship to IgM rheumatoid factor synthesisArthritis and Rheumatism.  28:1219-1227. 1985
    1985 Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigensInfection and Immunity.  49:459-462. 1985
    1985 Major site(s) of mIgA catabolism in BALB/c mice 1985
    1985 Molecular forms of tear IgA and distribution of IgA subclasses in human lacrimal glandsJournal of Allergy and Clinical Immunology.  76:569-576. 1985
    1985 Natural killer cells in human colostrumCellular Immunology.  93:467-474. 1985
    1985 Ontogeny of J chain expression in pig lymphocytesImmunology Letters.  10:287-291. 1985
    1985 Prevention of Streptococcus mutans colonization by salivary IgA antibodiesJournal of Clinical Immunology.  5:55-62. 1985
    1985 Subclass distribution and molecular form of immunoglobulin A hemagglutinin antibodies in sera and nasal secretions after experimental secondary infection with influenza A virus in humansJournal of Clinical Microbiology.  22:259-264. 1985
    1985 Subclass distribution of human serum and salivary IgA antibodies to lipopolysaccharides 1985
    1985 Urinary Immunoglobulins in Healthy Individuals and Children with Acute PyelonephritisScandinavian Journal of Immunology.  21:305-313. 1985
    1985 [3] Immunoglobulin A (IgA)Methods in Enzymology.  116:37-75. 1985
    1984 Cellular origins of human polymeric and monomeric IgA: Intracellular and secreted forms of IgAJournal of Immunology.  133:3156-3162. 1984
    1984 Racial difference in the prevalence of IgA-associated nephropathies. 1984
    1984 Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissuesJournal of Immunology.  132:16-18. 1984
    1984 Characterization of a monoclonal antibody to human J chain 1984
    1984 Effect of IgA on natural killer cells 1984
    1984 Elimination of intestinally absorbed antigen into the bile by IgAJournal of Immunology.  132:780-782. 1984
    1984 Human colostral cells. II. Response to mitogensCellular Immunology.  86:222-229. 1984
    1984 Immunohistochemical distribution of immunoglobulins, lactoferrin, and lysozyme in human minor salivary glandsJournal Of Oral Pathology and Medicine.  13:97-104. 1984
    1984 J chain expression in human cells producing IgG subclasses 1984
    1984 Receptors for secretory and serum IgA in human liver 1984
    1984 Selective hepatobiliary transport of human polymeric IgA in miceMolecular Immunology.  21:907-914. 1984
    1984 Serum IgA antibodies to environmental antigens in patients with IgA nephropathy 1984
    1984 Workshop Report: The Periodontium as a Watershed Between Mucosal and Systemic Immunology 1984
    1983 IgA-mediated elimination of antigens by the hepatobiliary route 1983
    1983 Ultrastructural studies of human lymphoid cells: µ and J chain expression as a function of B cell differentiationJournal of Experimental Medicine.  158:1993-2006. 1983
    1983 Localization of IgA and IgM in human colostral elements using immunoelectron microscopyJournal of Clinical Immunology.  3:382-391. 1983
    1983 Immunoinhibitory elements in human colostrumSurvey of immunologic research.  2:164-169. 1983
    1983 ANTIBACTERIAL PROPERTIES OF MILK: IgA‐PEROXIDASE‐LACTOFERRIN INTERACTIONSAnnals of the New York Academy of Sciences.  409:848-850. 1983
    1983 Biosynthesis of J-chain in human lymphoid cells producing immunoglobulins of various isotypesMolecular Immunology.  20:967-976. 1983
    1983 DISTRIBUTION OF IgA1 AND IgA2 SUBCLASSES IN HUMAN TISSUE: CORRELATION WITH THE PRESENCE OF J‐CHAINAnnals of the New York Academy of Sciences.  409:803-805. 1983
    1983 FUNCTION AND BIOSYNTHESIS OF POLYMERIC IgAAnnals of the New York Academy of Sciences.  409:292-306. 1983
    1983 IgA‐MEDIATED HEPATOBILIARY CLEARANCE OF BACTERIAL ANTIGENSAnnals of the New York Academy of Sciences.  409:871-872. 1983
    1983 Immunoglobulin A-mediated hepatobiliary transport constitutes an natural pathway for disposing of bacterial antigensInfection and Immunity.  42:1041-1048. 1983
    1982 Human milk peroxidase is derived from milk leukocytes 1982
    1982 Interaction of specific and innate factors of immunity: IgA enhances the antimicrobial effect of the lactoperoxidase system against Streptococcus mutansJournal of Immunology.  128:726-731. 1982
    1982 Hepatobiliary transport of IgA immune complexes: Molecular and cellular aspectsJournal of Immunology.  128:2183-2186. 1982
    1982 Preferential transport of IgA and IgA-immune complexes to bile compared with other external secretionsMolecular Immunology.  19:677-682. 1982
    1982 Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bileGastroenterology.  82:184-193. 1982
    1982 Tissue origins of human polymeric and monomeric IgAJournal of Immunology.  128:990-995. 1982
    1981 Oral-parenteral immunization leads to the appearance of IgG auto-anti-idiotypic cells in mucosal tissuesCellular Immunology.  60:498-502. 1981
    1981 Antibodies to mouse mammary tumor virus‐related antigen in sera of patients with breast carcinomaCancer.  47:2696-2703. 1981
    1981 Hemolytic plaque formation by cellular and noncellular elements of human colostrumJournal of Immunology.  127:1967-1972. 1981
    1981 Immunoblastic lymphoma: An immunologic studyCancer.  47:2312-2318. 1981
    1981 Immunodeficiency disease and dental caries in manArchives of Oral Biology.  26:905-910. 1981
    1981 Inhibition of the pokeweed mitogen-induced response of normal peripheral blood lymphocytes by humoral components of colostrumClinical and Experimental Immunology.  45:386-392. 1981
    1981 Interference of secretory immunoglobulin A with sorption of oral bacteria to hydroxyapatiteInfection and Immunity.  31:942-951. 1981
    1981 Nanosecond Fluorescence Spectroscopy of Human Immunoglobulin ABiochemistry.  20:1997-2003. 1981
    1981 Role of serum IgA. Hepatobiliary transport of circulating antigenJournal of Experimental Medicine.  153:968-976. 1981
    1981 Shared Idiotypes Among Anti‐Albumin Antibodies of Different SpeciesScandinavian Journal of Immunology.  14:31-38. 1981
    1980 Molecular-cellular interactions in the secretory IgA response.Journal of Leukocyte Biology.  28. 1980
    1980 Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogensJournal of Experimental Medicine.  152:1424-1429. 1980
    1980 IgA1 proteases from Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, and Streptococcus sanguis: Comparative immunochemical studiesJournal of Immunology.  124:2596-2600. 1980
    1980 Presence of J chain in human lymphoid cellsClinical and Experimental Immunology.  39:371-385. 1980
    1979 Human colostral cells. I. Separation and characterizationClinical and Experimental Immunology.  38:585-597. 1979
    1979 Secretory component: Interactions with intracellular and surface imunoglobulins of human lymphoid cellsJournal of Immunology.  122:906-911. 1979
    1979 Presence of plasma cells binding autologous antibody during an immune responseJournal of Experimental Medicine.  150:1265-1270. 1979
    1979 Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 proteaseInfection and Immunity.  26:143-149. 1979
    1978 Secretory component on epithelial cells is a surface receptor for polymeric immunoglobulins*Journal of Experimental Medicine.  147:1832-1837. 1978
    1978 Concept of the local and common mucosal immune response.Advances in Experimental Medicine and Biology.  107:185-192. 1978
    1978 Effective immunity to dental caries: selective induction of secretory immunity by oral administration of Streptococcus mutans in rodents.Advances in Experimental Medicine and Biology.  107:261-269. 1978
    1978 Induction of secretory antibodies in humans following ingestion of Streptococcus mutans.Advances in Experimental Medicine and Biology.  107:177-184. 1978
    1978 Molecular-cellular interactions in the secretory IgA system.Advances in Experimental Medicine and Biology.  107:209-217. 1978
    1978 Report of the summation committee: recommended areas for future research.Advances in Experimental Medicine and Biology.  107:883-888. 1978
    1978 Secretory immunity and immunodeficiency.Advances in Experimental Medicine and Biology.  107:401-410. 1978
    1978 Secretory immunity and infection 1978
    1978 Selective induction of an immune response in human external secretions by ingestion of bacterial antigen.Journal of Clinical Investigation.  61:731-737. 1978
    1977 Monoclonal IgG3 kappa and IgG1 λ proteins with different iodiotypic determinants present in a single patientClinical and Experimental Immunology.  29:67-74. 1977
    1977 Parallel synthesis of immunoglobulins and J chain in pokeweed mitogen-stimulated normal cells and in lymphoblastoid cell lines*Journal of Experimental Medicine.  145:760-765. 1977
    1977 Properties of IgA myeloma proteins isolated from sera of patients with the hyperviscosity syndrome 1977
    1976 Caries immunization through ingestion of Streptococcus mutans.Dental Abstracts.  21:522-523. 1976
    1976 Affinity chromatography of glycopeptides using Concanavalin AAnalytical Biochemistry.  72:389-399. 1976
    1976 Affinity chromatography of glycopeptides using Concanavalin AAnalytical Biochemistry.  72:389-399. 1976
    1976 Antibodies to human native and denatured collagens in synovial fluids of patients with rheumatoid arthritisClinical Immunology.  6:209-212. 1976
    1976 Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritisArthritis and Rheumatism.  19:613-617. 1976
    1976 Characterization of antibodies to the native human collagens and to their component α chains in the sera and the joint fluids of patients with rheumatoid arthritisImmunochemistry.  13:709-712. 1976
    1976 Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunityScience.  192:1238-1240. 1976
    1976 Introduction to the structural and cellular aspects of the secretory IgA system 1976
    1976 Naturally occurring secretory immunoglobulin A antibodies to Streptococcus mutans in human colostrum and salivaInfection and Immunity.  14:355-362. 1976
    1976 Salivary proteins and the development of dental plaque 1976
    1976 The differences in carbohydrate composition between the subclasses of IgA immunoglobulinsImmunochemistry.  13:325-328. 1976
    1975 Identification and properties of J chain isolated from catfish macroglobulinJournal of Immunology.  115:993-997. 1975
    1975 Presence of antibodies specific to cartilage type collagen in rheumatoid synovial tissueClinical and Experimental Immunology.  22:453-456. 1975
    1975 Carbohydrate composition of IgA glycopeptides 1975
    1975 J chain: Occurrence and characteristics in bony fishes 1975
    1975 Studies on human dental plaque: 2. Immunochemical characteristicsJournal Of Oral Pathology and Medicine.  4:86-95. 1975
    1975 The Nature of the Polymeric Serum IgA in ManExperimental Biology and Medicine.  150:482-484. 1975
    1974 Site of attachment of J chain to human immunoglobulin MNature.  249:650-652. 1974
    1974 Studies on human secretory immunoglobulin A. VI. Cyanogen bromide cleavageJournal of Immunology.  113:404-412. 1974
    1974 Association of S-IgA subunits.Advances in Experimental Medicine and Biology.  45:99-109. 1974
    1974 Site of J chain attachment to human polymeric IgA 1974
    1974 The J chain of polymeric immunoglobulins.Contemporary topics in molecular immunology.  3:111-141. 1974
    1974 The carbohydrate composition of glycopeptides isolated from IgA2 immunoglobulin.Advances in Experimental Medicine and Biology.  45:219-222. 1974
    1974 The interactions of human complement with interfacially aggregated preparations of human secretory IgAImmunochemistry.  11:543-548. 1974
    1974 The origin of monomeric and polymeric forms of IgA in man.Advances in Experimental Medicine and Biology.  45:57-65. 1974
    1973 Recombination of the polypeptide chains of a Waldenstrom's IgM that binds IgGJournal of Immunology.  111:1699-1711. 1973
    1973 Molecular weight of a human J chain 1973
    1972 Studies on human secretory immunoglobulin A. IV. Carbohydrate composition.Journal of Immunology.  108:1631-1636. 1972
    1972 Studies on human secretory immunoglobulin A. II. Subunit structure.Journal of Immunology.  108:738-747. 1972
    1972 The carbohydrate composition of J chain from human serum and secretory IgA 1972
    1972 Immune Response to Clostridial Collagenase in Gingiva and other Tissues of the Rabbit 1972
    1972 Structure of antibodiesJournal Of Oral Pathology and Medicine.  1:288-300. 1972
    1972 Studies on human secretory immunoglobulin A-III. J chainImmunochemistry.  9. 1972
    1972 Studies on human secretory immunoglobulin a V. Trypsin hydrolysis at elevated temperaturesImmunochemistry.  9. 1972
    1972 The carbohydrate composition of human myeloma IgAImmunochemistry.  9. 1972
    1971 Species distribution of J chain.Journal of Immunology.  107:1211-1212. 1971
    1971 Method of serum IgA isolation.Journal of Immunology.  107:605-607. 1971
    1971 Immunoglobulin M and secretory immunoglobulin A: Presence of a common polypeptide chain different from light chainsScience.  171:1163-1165. 1971
    1971 Immunohistochemical localization of amylase, lysozyme and immunoglobulins in the human parotid glandArchives of Oral Biology.  16. 1971
    1970 Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant.Immunology.  18:237-243. 1970
    1969 Immunofluorescent localization of lysozyme in human leukocytes.The Alabama journal of medical sciences.  6:417-421. 1969
    1969 Rivanol-ethanol fractionation of parotid fluid and colostrumCellular and Molecular Life Sciences.  25:892-893. 1969
    1969 A simple quantitative method for α-amylase determinationsAnalytical Biochemistry.  30:190-198. 1969
    1967 Role of lysozyme and character of antibodies in experimental viral infection. 1967
    1967 Detection of lysozyme production in individual cells by the plaque techniqueFolia Microbiologica.  12:175-176. 1967
    1966 Primary antibody response studied by using inhibitors of nucleic acid synthesisFolia Microbiologica.  11:102-111. 1966
    1966 Variances in the levels of serum lysozyme in X-irradiated miceFolia Microbiologica.  11:179-183. 1966


    Year Title Altmetric
    2015 Mucosal immunology: Fourth edition.  Ed. 1-2.  2015
    2015 Preface to the First Edition.  Ed. 1-2.  2015
    2015 Preface to the Fourth Edition.  Ed. 1-2.  2015
    2015 Preface to the Second Edition.  Ed. 1-2.  2015
    2015 Preface to the Third Edition.  Ed. 1-2.  2015
    2005 Mucosal Immunology, Two-Volume set 2005
    2005 Preface to the first edition 2005
    2005 Preface to the second edition 2005
    2005 Preface to the third edition 2005
    2005 Historical aspects of mucosal immunology 2005
    2005 Mucosal Immunology, Two-Volume set 2005


    Year Title Altmetric
    2019 Protective activities of mucosal antibodies.  71-84. 2019
    2016 Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy.  53-68. 2016
    2015 Historical Aspects of Mucosal Immunology.  xxxi-lvii. 2015
    2015 IgA Nephropathy and Related Diseases.  2023-2038. 2015
    2015 Immunity to Sexually Transmitted Infections.  2183-2214. 2015
    2015 Mucosal Immunity in the Human Female Reproductive Tract.  2097-2124. 2015
    2015 Mucosal Immunoglobulins.  287-324. 2015
    2015 Mucosal Vaccines: An Overview.  1039-1046. 2015
    2015 Overview: The Mucosal Immune System. The Mucosal Immune System.  3-8. 2015
    2015 Urogenital Tract and Mammary Gland: Overview.  2019-2022. 2015
    2009 IgA immune-complex.  177-191. 2009
    2007 IgA-associated diseases.  321-344. 2007
    2005 IgA nephropathy and related diseases.  1579-1600. 2005
    2005 Immunology and immunopathology of the genitourinary tract: An overview.  1575-1577. 2005
    2005 Mucosal immunity in the human female reproductive tract.  1631-1646. 2005
    2005 Mucosal immunoglobulins.  153-181. 2005
    2005 Mucosal immunology of sexually transmitted diseases.  1693-1720. 2005
    2005 Mucosal vaccines: An overview.  855-874. 2005
    2005 Collection and processing of human mucosal secretions.  1829-1839. 2005
    2003 Absolute quantification of specific nucleic acids by RT-PCR using a nonlinear mathematical model for data analysis.  235-244. 2003

    Research Overview

  • Dr. Mestecky's area of interest includes various aspects of Mucosal Immunology, including the delivery of antigens through the mucosal route and induction of humoral and cellular immune responses in various compartments of the mucosal immune system, induction of mucosal tolerance, and mucosal and systemic responses to HIV-1 either in vaccinated or infected individuals. In addition Dr. Mestecky is involved in studies of the most common glomerulonephritis in the world, IgA nephropathy. In this field, he and his co-workers determined the composition of immune complexes which contained IgA1 molecules altered glycans as antigen and IgG antibodies specific to IgA1 molecules.
  • Education And Training

  • Doctor of Philosophy Level Degree in Cell Physiology, 1999
  • Doctor of Medicine, Charles University in Prague 1964
  • Full Name

  • Jiri Mestecky