Selected Publications

Academic Article

Year Title Altmetric
2022 Regulation of glucose responsive protein (GRP) gene expression by insulinCell Stress and Chaperones.  27:27-35. 2022
2017 Polytrauma-induced hepatic stress response and the development of liver insulin resistance 2017
2017 Insulin attenuates TNFα-induced hemopexin mRNA: An anti-inflammatory action of insulin in rat H4IIE hepatoma cellsBiochemistry and Biophysics Reports.  9:211-216. 2017
2016 Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expressionBiochemical and Biophysical Research Communications.  474:594-598. 2016
2016 Skeletal muscle atrogene expression and insulin resistance in a rat model of polytraumaPhysiological Reports.  4. 2016
2015 A rat model of concurrent combined injuries (polytrauma)International Journal of Clinical and Experimental Medicine.  8:20097-20110. 2015
2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
2014 Regulation of hepatic insulin receptor activity following injury 2014
2013 Acute psychological stress results in the rapid development of insulin resistanceJournal of Endocrinology.  217:175-184. 2013
2013 Hepatic growth hormone resistance after acute injury 2013
2012 Injury-induced insulin resistance in adipose tissueBiochemical and Biophysical Research Communications.  421:442-448. 2012
2012 Role of tissue macrophages in the development of critical illness diabetesShock.  37:70-76. 2012
2011 Role of inhibitory κB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes 2011
2011 Role of reactive oxygen species in injury-induced insulin resistance 2011
2010 Adenovirus infection results in alterations of insulin signaling and glucose homeostasis 2010
2010 Anti-Inflammatory Action of Insulin via Induction of Gadd45-β Transcription by the mTOR Signaling Pathway.Hepatic Medicine: Evidence and Research.  2001:79-85. 2010
2010 Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: Role in glucose-induced insulin resistance 2010
2009 Age and tissue specific differences in the development of acute insulin resistance following injuryJournal of Endocrinology.  203:365-374. 2009
2009 Acute insulin resistance following injuryTrends in Endocrinology and Metabolism.  20:429-435. 2009
2009 Chapter 6 Crosstalk Between Growth Hormone and Insulin Signaling 2009
2009 Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury 2009
2008 Acute, muscle-type specific insulin resistance following injuryMolecular Medicine.  14:715-723. 2008
2008 Trauma and hemorrhage-induced acute hepatic insulin resistance: Dominant role of tumor necrosis factor-α 2008
2007 Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and actionJournal of Biological Chemistry.  282:25649-25658. 2007
2007 Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cellsMolecular and Cellular Endocrinology.  274:53-59. 2007
2007 Insulin regulation of growth hormone receptor gene expression: Involvement of both the PI-3 kinase and MEK/ERK signaling pathwaysEndocrine.  32:219-226. 2007
2006 Insulin reverses growth hormone-induced homologous desensitizationJournal of Biological Chemistry.  281:21594-21606. 2006
2006 Insulin enhances growth hormone induction of the MEK/ERK signaling pathwayJournal of Biological Chemistry.  281:982-992. 2006
2005 Blockade of rapid versus prolonged extracellularly regulated kinase 1/2 activation has differential effects on insulin-induced gene expression 2005
2005 Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expressionBreast Cancer Research and Treatment.  91:207-215. 2005
2005 Modulation of Elk-dependent-transcription by gene33Journal of Cellular Biochemistry.  94:1190-1198. 2005
2005 Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1Journal of Endocrinology.  184:481-492. 2005
2005 Genetic variability in the immune-inflammatory response after major burn injuryShock.  23:123-128. 2005
2004 Mechanism of cardiac depression after trauma-hemorrhage: Increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function 2004
2004 Regulation of Gene33 expression by insulin requires MEK-ERK activation 2004
2004 Mechanisms of hemorrhage-induced hepatic insulin resistance: Role of tumor necrosis factor-α 2004
2003 Insulin-Regulated Expression of Egr-1 and Krox20: Dependence on ERK1/2 and Interaction with p38 and PI3-Kinase Pathways 2003
2003 Identification of hemopexin as a GH-regulated geneMolecular and Cellular Endocrinology.  204:101-110. 2003
2003 Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cellsMolecular and Cellular Endocrinology.  204:111-116. 2003
2002 Insulin signal transduction pathways and insulin-induced gene expressionJournal of Biological Chemistry.  277:48565-48573. 2002
2002 Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylationJournal of Biological Chemistry.  277:28384-28393. 2002
1999 Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathwayJournal of Biological Chemistry.  274:13434-13442. 1999
1998 Nitric oxide-dependent induction of glutathione synthesis through increased expression of γ-glutamylcysteine synthetaseMolecular cell biology research communications : MCBRC.  358:74-82. 1998
1998 Translocation of PKC delta by insulin in a rat hepatoma cell lineEndocrine.  8:161-167. 1998
1997 Insulin induction of pip 92, CL-6, and novel mRNAs in rat hepatoma cellsEndocrine.  7:199-207. 1997
1997 Pioglitazone: In vitro effects on rat hepatoma cells and in vivo liver hypertrophy in kkay micePharmacology.  54:169-178. 1997
1995 One of three CCArGG box/serum response elements of the β-actin gene is an insulin-responsive element 1995
1994 Evidence for diverse roles of protein kinase-C in the inhibition of gene expression by insulin: the tyrosine aminotransferase, albumin, and phosphoenolpyruvate carboxykinase genes. 1994
1994 Identification of β-actin sequences necessary for induction by phorbol esters and calcium ionophoresOncogene.  9:1713-1722. 1994
1994 Synergistic induction of gene 33 expression by retinoic acid and insulin. 1994
1994 Regulation of γ‐actin gene expression by insulinJournal of Cellular Physiology.  160:287-294. 1994
1993 Role of cytosolic calcium in regulation of cytoskeletal gene expression by insulin.American Journal of Physiology.  264:E519-E525. 1993
1992 Vanadate and insulin stimulate gene 33 expressionBiochemical and Biophysical Research Communications.  189:931-937. 1992
1992 Rapid regulation of albumin transcription by insulin and phorbol esters in rat hepatoma cells 1992
1992 Induction of cytoskeletal gene expression by insulin. 1992
1992 Protein synthesis and insulin regulation of p33 and PEPCK gene expressionMolecular and Cellular Endocrinology.  84:39-46. 1992
1992 Regulation of β-actin gene transcription by insulin and phorbol estersExperimental Cell Research.  200:532-535. 1992
1992 Role of protein kinase C in insulin's regulation of c-fos transcriptionJournal of Biological Chemistry.  267:9223-9228. 1992
1992 Short- and long-term effects of insulin on tyrosine aminotransferase gene expressionMolecular cell biology research communications : MCBRC.  298:56-62. 1992
1991 Inhibition and stimulation of c-myc gene transcription by insulin in rat hepatoma cells: Insulin alters the intragenic pausing of c-myc transcriptionJournal of Biological Chemistry.  266:17995-18001. 1991
1990 Interaction of insulin and phorbol esters on the regulation of DNA synthesis in rat hepatome cellsBiochemical and Biophysical Research Communications.  172:759-766. 1990
1990 Decreased induction of an hepatic mRNA by phorbol esters after insulin desensitizationMolecular and Cellular Endocrinology.  72:121-129. 1990
1990 Insulin's regulation of c-fos gene transcription in hepatoma cellsJournal of Biological Chemistry.  265:11700-11705. 1990
1989 Insulin and dexamethasone regulation of a rat hepatoma messenger ribonucleic acid: Insulin has a transcriptional and a posttranscriptional effect 1989
1988 Transcriptional regulation of a rat hepatoma gene by insulin and protein kinase-c 1988
1987 Positive interaction between insulin and phorbol esters on the regulation of a specific messenger ribonucleic acid in rat hepatoma cells 1987
1985 Effects of insulin alone on the accumulation of a specific mRNA in rat hepatoma cellsJournal of Biological Chemistry.  260:16418-16423. 1985

Education And Training

  • Doctor of Philosophy in Physiology, University of Michigan System : Ann Arbor 1982
  • Full Name

  • Joseph Messina