Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.  Neuron.  110:1173-1192.e7. 2022
2021 BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease.  Frontiers in Neuroanatomy.  15. 2021
2020 Differential effects of SNARE-dependent gliotransmission on behavioral phenotypes in a mouse model of Huntington's disease.  Experimental Neurology.  330. 2020
2020 Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model.  Human Molecular Genetics.  29:369-381. 2020
2019 Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington’s disease mouse model.  Human Molecular Genetics.  28:487-500. 2019
2019 Astrocytes in huntington’s disease.  Advances in Experimental Medicine and Biology.  1175:355-381. 2019
2014 Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.  Nature Medicine.  20:536-541. 2014
2013 α-synuclein overexpression represses 14-3-3θ transcription.  Journal of Molecular Neuroscience.  51:1000-1009. 2013
2013 Enhanced Ca2+-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model.  Neurobiology of Disease.  58:192-199. 2013
2012 Network organization of the huntingtin proteomic interactome in mammalian brain.  Neuron.  75:41-57. 2012
2011 Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in HPSA/TAUP301L double-transgenic mice.  Human Molecular Genetics.  20:1820-1833. 2011
2011 Identifying polyglutamine protein species in situ that best predict neurodegeneration.  Nature Chemical Biology.  7:925-934. 2011
2010 Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. 2010
2008 Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. 2008
2006 FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains..  Nature Neuroscience.  9:443-452. 2006
2003 Mutations in deadly seven/notch1a reveal developmental plasticity in the escape response circuit. 2003
2001 Zebrafish deadly seven functions in neurogenesis..  Developmental Biology.  237:306-323. 2001

Chapter

Year Title Altmetric
2014 Basal Ganglia Disorders 2014
2014 The role of astrocytes in Huntington's disease.  213-229. 2014
2013 Basal Ganglia Disorders.  1-39. 2013

Education And Training

  • University of California Los Angeles Semel Institute of Neuroscience and Human Behavior, Postdoctoral Fellowship
  • Doctor of Philosophy in Molecular Biology, Ohio State University System : Columbus 2003

    • Full Name

  • Michelle Gray