Selected Publications

Academic Article

Year Title Altmetric
2021 Bace1 inhibition increases susceptibility to oxidative stress by promoting mitochondrial damageAntioxidants.  10. 2021
2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy.  17:1-382. 2021
2020 Human Induced Pluripotent Stem Cell Derived Mesoderm Subset Ameliorates Diabetic Retinopathy by Reestablishing Retinal Function and Restoring Protective Signaling Cascades in Type 2 Diabetes 2020
2020 Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic RetinaCells.  9. 2020
2018 Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular NeovascularizationACS Chemical Biology.  13:45-52. 2018
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
2016 PPARβ/δ selectively regulates phenotypic features of age-related macular degenerationAging.  8:1952-1978. 2016
2015 Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epitheliumAutophagy.  11:939-953. 2015
2014 Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMDAutophagy.  10:1989-2005. 2014
2014 CD82 restrains pathological Angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cellsCirculation.  130:1493-1504. 2014
2013 CNS inflammation and bone marrow neuropathy in type 1 diabetesAmerican Journal of Pathology.  183:1608-1620. 2013
2013 Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature developmentCancer Letters.  332:120-129. 2013
2013 Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularizationAmerican Journal of Pathology.  182:1412-1424. 2013
2013 Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationAutophagy.  9:973-984. 2013
2011 Transretinal degeneration in ageing human retina: A multiphoton microscopy analysisBritish Journal of Ophthalmology.  95:727-730. 2011
2011 Tear film volume and protein analysis in full-term newborn infantsCornea.  30:400-404. 2011
2009 Topography of neuron loss in the retinal ganglion cell layer in human glaucomaBritish Journal of Ophthalmology.  93:1676-1679. 2009
2009 Using LC3 to monitor autophagy flux in the retinal pigment epitheliumAutophagy.  5:1190-1193. 2009
2009 Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generationCirculation Research.  105:897-905. 2009
2009 Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal modelsAmerican Journal of Pathology.  175:2676-2685. 2009
2008 A missense mutation in the murine Opa3 gene models human Costeff syndrome 2008
2007 L-carnitine protects human retinal pigment epithelial cells from oxidative damageCurrent Eye Research.  32:575-584. 2007
2007 Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2British Journal of Ophthalmology.  91:538-545. 2007
2006 VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cellsBritish Journal of Ophthalmology.  90:1052-1059. 2006
2006 Decreased pigment epithelium-derived factor expression in human breast cancer progressionClinical Cancer Research.  12:3510-3517. 2006
2005 Angiopoietin concentrations in diabetic retinopathyBritish Journal of Ophthalmology.  89:480-483. 2005
2000 Centration of donor trephination in human corneal transplantationCornea.  19:325-328. 2000
2000 Influence of pigment content, intracellular calcium and cyclic AMP on the ability of human retinal pigment epithelial cells to contract collagen gelsCurrent Eye Research.  21:518-529. 2000
2000 Optimization of non-viral gene transfer to human primary retinal pigment epithelial cellsCurrent Eye Research.  20:361-366. 2000
1999 A role for hepatocyte growth factor in diabetic retinopathy?British Journal of Ophthalmology.  83:763-764. 1999
1999 Growth factor staining patterns in the pig retina following retinal laser photocoagulationBritish Journal of Ophthalmology.  83:728-736. 1999
1999 Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathyBritish Journal of Ophthalmology.  83:486-494. 1999
1999 Macular pigment and age related macular degenerationBritish Journal of Ophthalmology.  83:867-877. 1999
1999 Ophthalmology in the post-genomic eraBritish Journal of Ophthalmology.  83:1215-1218. 1999
1998 Involvement of calcium in retinal pigment epithelial cell proliferation and pigmentationCurrent Eye Research.  17:813-822. 1998
1998 Adhesion of IOLs to the posterior capsule.British Journal of Ophthalmology.  82:468. 1998
1998 Lens epithelial cell proliferation, migration, and metaplasia following capsulorhexisBritish Journal of Ophthalmology.  82:945-952. 1998
1998 VEGF localisation in diabetic retinopathyBritish Journal of Ophthalmology.  82:561-568. 1998
1997 A role for vitamin A in the formation of ocular lipofuscinBritish Journal of Ophthalmology.  81:911-918. 1997
1997 Intravitreal growth factors in proliferative diabetic retinopathy: Correlation with neovascular activity and glycaemic managementBritish Journal of Ophthalmology.  81:228-233. 1997
1996 Diurnal variations in human corneal thicknessBritish Journal of Ophthalmology.  80:1068-1072. 1996
1996 Immunocytochemical study of retinal diode laser photocoagulation in the ratBritish Journal of Ophthalmology.  80:1092-1098. 1996
1996 The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pigCurrent Eye Research.  15:923-931. 1996
1996 Three dimensional analysis of the retinal vasculature using immunofluorescent staining and confocal laser scanning microscopyBritish Journal of Ophthalmology.  80:246-251. 1996
1995 Massive proliferation of lens epithelial remnants after Nd-YAG laser capsulotomyBritish Journal of Ophthalmology.  79:261-263. 1995
1994 Production of IGF-I and IGF binding proteins by retinal cells in vitroBritish Journal of Ophthalmology.  78:638-642. 1994
1994 Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epitheliumBritish Journal of Ophthalmology.  78:125-129. 1994
1994 Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathyBritish Journal of Ophthalmology.  78:714-718. 1994
1992 Biological activities of vitreous gel, retrohyaloid fluid and subretinal fluid from diabetic and non-diabetic eyesBritish Journal of Ophthalmology.  76:79-83. 1992
1991 Temporal variations in the ionic transport across rabbit retinal pigment epitheliumCurrent Eye Research.  10:513-522. 1991
1990 Inhibition of microvascular endothelial cell proliferation by vitreous following retinal scatter photocoagulationBritish Journal of Ophthalmology.  74:328-332. 1990
1989 Inherited retinal dystrophies: Cell biology and interacting co-factorsChibret International Journal of Ophthalmology.  6:29-39. 1989
1989 Assessment of corneal wound repair in vitroCurrent Eye Research.  8:713-719. 1989
1988 A microsystem to assay lysosomal enzyme activities in cultured retinal pigment epithelial cellsCurrent Eye Research.  7:1097-1104. 1988
1988 Effects of vitreous from photocoagulated eyes on retinal micro vascular cells in culture: A preliminary reportCurrent Eye Research.  7:465-470. 1988
1986 Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: A model for agingBritish Journal of Ophthalmology.  70:808-815. 1986
1982 Human retinal pigment epithelial cells in tissue culture: A means of studying inherited retinal diseasesBirth defects original article series.  18:101-118. 1982
PRMT5 is a therapeutic target in choroidal neovascularization


Year Title Altmetric
2016 A non-canonical role for β-secretase in the retina.  333-339. 2016
2013 Ageing of the Retina and Retinal Pigment Epithelium.  45-63. 2013
2013 Stem Cells in the Eye.  1399-1412. 2013
2012 Cell Death, Apoptosis, and Autophagy in Retinal Injury.  537-552. 2012
2012 The role of mitochondrial oxidative stress in retinal dysfunction.  203-239. 2012
2012 Transformation of progenitor cells for treatment of retinal disease.  419-435. 2012
2010 The vascular stem cell.  289-299. 2010
2010 The vascular stem cell.  289-299. 2010
2008 Macular degeneration: The role of reactive oxygen species.  171-180. 2008
2007 Hematopoietic stem cells in vascular development and ocular neovascularization.  78-96. 2007
2007 Stem cells in the eye.  1011-1023. 2007

Education And Training

  • Doctor of Philosophy in Engineering Science, 1982
  • Full Name

  • Michael Boulton