Selected Publications

Academic Article

Year Title Altmetric
2023 Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 DiabetesCirculation Research.  132:E1-E21. 2023
2022 Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal NeovascularizationInternational Journal of Molecular Sciences.  23. 2022
2022 PRMT5 is a therapeutic target in choroidal neovascularization 2022
2022 Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic miceScience Advances.  8. 2022
2021 Supplemental nitrite increases choroidal neovascularization in miceNitric Oxide: Biology and Chemistry.  117:7-15. 2021
2021 Bace1 inhibition increases susceptibility to oxidative stress by promoting mitochondrial damageAntioxidants.  10. 2021
2021 Characterizing temporal and spatial recruitment of systemically administered RPE65-programmed bone marrow-derived cells to the retina in a mouse model of age-related macular degenerationGerman journal of ophthalmology.  259:2987-2994. 2021
2021 Tribbles Homolog 3 Mediates the Development and Progression of Diabetic RetinopathyDiabetes.  70:1738-1753. 2021
2021 Potential role for age as a modulator of oral nitrate reductase activityNitric Oxide: Biology and Chemistry.  108:1-7. 2021
2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy.  17:1-382. 2021
2020 Human Induced Pluripotent Stem Cell Derived Mesoderm Subset Ameliorates Diabetic Retinopathy by Reestablishing Retinal Function and Restoring Protective Signaling Cascades in Type 2 Diabetes 2020
2020 Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic RetinaCells.  9. 2020
2020 LXRs regulate features of age-related macular degeneration and may be a potential therapeutic targetJCI Insight.  5. 2020
2020 Sars-cov-2 infections and ace2: Clinical outcomes linked with increased morbidity and mortality in individuals with diabetesDiabetes.  69:1875-1886. 2020
2019 Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy (OIR) modelJCI Insight.  4. 2019
2019 Role of translational attenuation in inherited retinal degeneration 2019
2018 Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow DysfunctionStem Cells.  36:1430-1440. 2018
2018 Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularizationPLoS One.  13. 2018
2018 Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db miceDiabetes.  67:1867-1879. 2018
2018 Enteral arg-gln dipeptide administration increases retinal docosahexaenoic acid and neuroprotectin D1 in a murine model of retinopathy of prematurity 2018
2018 Improving the Transduction of Bone Marrow-Derived Cells with an Integrase-Defective Lentiviral VectorHuman gene therapy. Clinical development.  29:44-59. 2018
2018 Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular NeovascularizationACS Chemical Biology.  13:45-52. 2018
2017 Ferrochelatase is a therapeutic target for ocular neovascularizationEMBO Molecular Medicine.  9:786-801. 2017
2017 Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem CellsStem Cells.  35:1303-1315. 2017
2017 Erratum to: CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes (Journal of Molecular Medicine, (2016), 94, 11, (1255-1265), 10.1007/s00109-016-1433-0)Journal of Molecular Medicine.  95:565-566. 2017
2017 Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal DegenerationMolecular Therapy.  25:917-927. 2017
2017 Oxidative stress-mediated NFeκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagyPLoS One.  12. 2017
2016 CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetesJournal of Molecular Medicine.  94:1255-1265. 2016
2016 A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapyScientific Reports.  6. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
2016 PPARβ/δ selectively regulates phenotypic features of age-related macular degenerationAging.  8:1952-1978. 2016
2015 Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus after Intravenous InjectionHuman gene therapy. Clinical development.  26:767-776. 2015
2015 A simple optical coherence tomography quantification method for choroidal neovascularizationJournal of Ocular Pharmacology and Therapeutics.  31:447-454. 2015
2015 Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epitheliumAutophagy.  11:939-953. 2015
2014 Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMDAutophagy.  10:1989-2005. 2014
2014 Regulation of retinal inflammation by rhythmic expression of miR-146a in diabetic Retina 2014
2014 Changes in the daily rhythm of lipid metabolism in the diabetic retinaPLoS One.  9. 2014
2014 Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanismsPLoS One.  9. 2014
2014 CD82 restrains pathological Angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cellsCirculation.  130:1493-1504. 2014
2014 Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytesJournal of Lipid Research.  55:860-869. 2014
2014 Studying melanin and lipofuscin in RPE cell culture modelsExperimental Eye Research.  126:61-67. 2014
2013 Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetesPLoS One.  8. 2013
2013 CNS inflammation and bone marrow neuropathy in type 1 diabetesAmerican Journal of Pathology.  183:1608-1620. 2013
2013 Enhancing the function of CD34+ cells by targeting plasminogen activator inhibitor-1PLoS One.  8. 2013
2013 Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology 2013
2013 Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction 2013
2013 Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature developmentCancer Letters.  332:120-129. 2013
2013 Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularizationAmerican Journal of Pathology.  182:1412-1424. 2013
2013 Non-dimensional analysis of retinal microaneurysms: Critical threshold for treatment 2013
2013 Assessment of mitochondrial damage in retinal cells and tissues using quantitative polymerase chain reaction for mitochondrial DNA damage and extracellular flux assay for mitochondrial respiration activityMethods in Molecular Biology.  935:227-243. 2013
2013 Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationAutophagy.  9:973-984. 2013
2013 Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrowDiabetes.  62:273-282. 2013
2012 Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiationMolecular Vision.  18:2758-2769. 2012
2012 Concentration dependence of vitamin C in combinations with vitamin e and zeaxanthin on light-induced toxicity to retinal pigment epithelial cellsPhotochemistry and Photobiology.  88:1408-1417. 2012
2012 Cytotoxicity of all-trans-retinal increases upon photodegradationPhotochemistry and Photobiology.  88:1362-1372. 2012
2012 β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigmentEMBO Molecular Medicine.  4:980-991. 2012
2012 Consequences of oxidative stress in age-related macular degenerationMolecular Aspects of Medicine.  33:399-417. 2012
2012 Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3PLoS One.  7. 2012
2012 The 5HT 1a receptor agonist 8-OH DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epitheliumPLoS One.  7. 2012
2012 Proteomic profiling of human retinal pigment epithelium exposed to an advanced glycation-modified substrateGerman journal of ophthalmology.  250:349-359. 2012
2012 γ-secretase inhibition of murine choroidal neovascularization is associated with reduction of superoxide and proinflammatory cytokines 2012
2012 Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses. 2012
2011 γ-secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1Journal of Biological Chemistry.  286:42514-42523. 2011
2011 Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase) 2011
2011 Epidermal growth factor: The driving force in initiation of RPE cell proliferationGerman journal of ophthalmology.  249:1195-1200. 2011
2011 PEDF regulates vascular permeability by a γ-secretase-mediated pathwayPLoS One.  6. 2011
2011 Involvement of the CD200 receptor complex in microglia activation in experimental glaucomaExperimental Eye Research.  92:338-343. 2011
2011 Mitochondrial DNA damage and repair in rpe associated with aging and age-related macular degeneration 2011
2011 Transretinal degeneration in ageing human retina: A multiphoton microscopy analysisBritish Journal of Ophthalmology.  95:727-730. 2011
2011 Tear film volume and protein analysis in full-term newborn infantsCornea.  30:400-404. 2011
2011 A role for Notch signaling in corneal wound healingWound Repair and Regeneration.  19:98-106. 2011
2011 Adhesion of laser in situ keratomileusis-like flaps in the cornea: Effects of crosslinking, stromal fibroblasts, and cytokine treatmentJournal of Cataract and Refractive Surgery.  37:166-172. 2011
2011 In pursuit of new anti-angiogenic therapies for cancer treatmentFrontiers in Bioscience-Landmark.  16:803-814. 2011
2011 Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeabilityPLoS One.  6. 2011
2011 αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cellsMolecular Cancer Research.  9:1632-1643. 2011
2010 Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane 2010
2010 The importance of Mitochondria in age-related and inherited eye disorders 2010
2009 Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clockJournal of Experimental Medicine.  206:2897-2906. 2009
2009 Activation of the β-catenin signaling pathway and its impact on RPE cell cycle 2009
2009 Topography of neuron loss in the retinal ganglion cell layer in human glaucomaBritish Journal of Ophthalmology.  93:1676-1679. 2009
2009 Using LC3 to monitor autophagy flux in the retinal pigment epitheliumAutophagy.  5:1190-1193. 2009
2009 Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generationCirculation Research.  105:897-905. 2009
2009 Erratum: "Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair" (Molecular Theraphy (2009) 10.1038/mt.2009.145)Molecular Therapy.  17:1832. 2009
2009 Lipofuscin phototoxicity: Reality or myth?Journal of Cataract and Refractive Surgery.  35:1479. 2009
2009 Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens developmentExperimental Eye Research.  88:1137-1151. 2009
2009 Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneasExperimental Eye Research.  88:953-959. 2009
2009 Effect of signal intensity normalization on the multivariate analysis of spectral data in complex 'real-world' datasetsJournal of Raman Spectroscopy.  40:429-435. 2009
2009 Effects on collagen orientation in the cornea after trephine injuryMolecular Vision.  15:378-385. 2009
2009 Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal modelsAmerican Journal of Pathology.  175:2676-2685. 2009
2009 Advanced glycation end product (AGE) accumulation on Bruch's membrane: Links to age-related RPE dysfunction 2009
2009 Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repairMolecular Therapy.  17:1594-1604. 2009
2008 Mitochondrial DNA damage and its potential role in retinal degenerationProgress in Retinal and Eye Research.  27:596-607. 2008
2008 Tear sample collection using cellulose acetate absorbent filtersOphthalmic and Physiological Optics.  28:577-583. 2008
2008 Carbomer and sodium hyaluronate eyedrops for moderate dry eye treatmentOptometry and Vision Science.  85:750-757. 2008
2008 Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation 2008
2008 Retinal pigment epithelium lipofuscin proteomicsMolecular and Cellular Proteomics.  7:1397-1405. 2008
2008 Intraretinal leakage and oxidation of LDL in diabetic retinopathy 2008
2008 γ-Secretase: A multifaceted regulator of angiogenesis: Angiogenesis Review SeriesJournal of Cellular and Molecular Medicine.  12:781-795. 2008
2008 The phototoxicity of aged human retinal melanosomesPhotochemistry and Photobiology.  84:650-657. 2008
2008 Quantification of retinal transneuronal degeneration in human glaucoma: A novel multiphoton-DAPI approach 2008
2008 The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy 2008
2008 A missense mutation in the murine Opa3 gene models human Costeff syndrome 2008
2008 Erythropoietin: When liability becomes asset in neurovascular repairJournal of Clinical Investigation.  118:467-470. 2008
2007 Retinal and choroidal microangiopathies: Therapeutic opportunitiesMicrovascular Research.  74:131-144. 2007
2007 A role for notch signaling in human corneal epithelial cell differentiation and proliferation 2007
2007 Choroidal neovascularization: New dynamics of the VEGF signaling systemExpert Review of Ophthalmology.  2:551-556. 2007
2007 Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium 2007
2007 L-carnitine protects human retinal pigment epithelial cells from oxidative damageCurrent Eye Research.  32:575-584. 2007
2007 Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual functionHuman Molecular Genetics.  16:1307-1318. 2007
2007 Connective tissue structure of the tree shrew optic nerve and associated ageing changes 2007
2007 Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2British Journal of Ophthalmology.  91:538-545. 2007
2007 Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging 2007
2006 Protein quality control by the ubiquitin proteolytic pathway: Roles in resistance to oxidative stress and diseaseIsrael Journal of Chemistry.  46:145-158. 2006
2006 The contribution of DNA repair and antioxidants in determining cell type-specific resistance to oxidative stress 2006
2006 Dietary antioxidants provide differential subcellular protection in epithelial cellsRedox Report.  11:144-152. 2006
2006 VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cellsBritish Journal of Ophthalmology.  90:1052-1059. 2006
2006 Decreased pigment epithelium-derived factor expression in human breast cancer progressionClinical Cancer Research.  12:3510-3517. 2006
2006 Differential regulation of key stages in early corneal wound healing by TGF-β isoforms and their inhibitors 2006
2006 Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1Journal of Biological Chemistry.  281:3604-3613. 2006
2006 Effects of VEGFR-1, VEGFR-2, and IGF-IR hammerhead ribozymes on glucose-mediated tight junction expression in cultured human retinal endothelial cellsMolecular Vision.  12:32-42. 2006
2006 Effectiveness of sodium hyaluronate eyedrops in the treatment of dry eyeGerman journal of ophthalmology.  244:109-112. 2006
2006 Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOSMicrovascular Research.  71:20-31. 2006
2005 Evidence of a distinct lipid fraction in historical parchments: A potential role in degradation?Journal of Lipid Research.  46:2726-2734. 2005
2005 Placenta growth factor is over-expressed and has prognostic value in human breast cancerEuropean Journal of Cancer.  41:2819-2827. 2005
2005 Blue light induces mitochondrial DNA damage and free radical production in epithelial cellsJournal of Biological Chemistry.  280:21061-21066. 2005
2005 Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cellsFree Radical Biology and Medicine.  38:1382-1391. 2005
2005 Angiopoietin concentrations in diabetic retinopathyBritish Journal of Ophthalmology.  89:480-483. 2005
2005 Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healingJournal of Cataract and Refractive Surgery.  31:412-423. 2005
2005 RPE lipofuscin and its role in retinal pathobiologyExperimental Eye Research.  80:595-606. 2005
2004 Do blue light filters confer protection against age-related macular degeneration?Progress in Retinal and Eye Research.  23:523-531. 2004
2004 The photoreactivity of ocular lipofuscin 2004
2004 Age-related changes in the photoreactivity of retinal lipofuscin granules: Role of chloroform-insoluble components 2004
2004 Stem cells in the eye 2004
2004 Ageing of the retinal pigment epithelium: Implications for transplantationGerman journal of ophthalmology.  242:76-84. 2004
2004 Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2Microvascular Research.  68:239-246. 2004
2004 RPE transplantation: The challenges and the futureOphthalmologe.  101:877-881. 2004
2003 Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial CellsDiabetes.  52:2959-2968. 2003
2002 Photoreactivity of aged human RPE melanosomes: A comparison with lipofuscin 2002
2002 The pathogenesis of diabetic retinopathy: Old concepts and new questionsEye.  16:242-260. 2002
2001 Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin 2001
2001 Retinal photodamage 2001
2001 Photocytotoxicity of lipofuscin in human retinal pigment epithelial cellsFree Radical Biology and Medicine.  31:256-265. 2001
2001 Oxygen modulates the release of urokinase and plasminogen activator inhibitor-1 by retinal pigment epithelial cells 2001
2001 Macular pigment and risk for age-related macular degeneration in subjects from a northern European population 2001
2001 Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye diseaseDiabetes.  50:2641-2645. 2001
2001 The role of the retinal pigment epithelium: Topographical variation and ageing changesEye.  15:384-389. 2001
2000 Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cellsPigment Cell and Melanoma Research.  13:436-441. 2000
2000 Apoptosis in the endothelium of human corneas for transplantation 2000
2000 Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin 2000
2000 Adenovirus-mediated gene transfer to human lens epithelial cells in organ cultureJournal of Cataract and Refractive Surgery.  26:887-892. 2000
2000 IL-10 and antibodies to TGF-β2 and PDGF inhibit RPE-mediated retinal contraction 2000
2000 Expression of a single pair of desmosomal glycoproteins renders the corneal epithelium unique amongst stratified epithelia 2000
2000 A fluorescent compound of lipofuscin, A2-E, is a photosensitizer in human retinal pigment epithelial cellsOphthalmologe.  97:682-687. 2000
2000 Centration of donor trephination in human corneal transplantationCornea.  19:325-328. 2000
2000 Influence of pigment content, intracellular calcium and cyclic AMP on the ability of human retinal pigment epithelial cells to contract collagen gelsCurrent Eye Research.  21:518-529. 2000
2000 Optimization of non-viral gene transfer to human primary retinal pigment epithelial cellsCurrent Eye Research.  20:361-366. 2000
2000 Protein kinase C isoenzyme expression in retinal cells 2000
2000 The role of oxidative stress in the pathogenesis of age-related macular degenerationSurvey of Ophthalmology.  45:115-134. 2000
1999 The photoreactivity of the retinal age pigment lipofuscinJournal of Biological Chemistry.  274:23828-23832. 1999
1999 Positive correlation between mammalian life span and cellular resistance to stressFree Radical Biology and Medicine.  26:495-500. 1999
1999 A role for hepatocyte growth factor in diabetic retinopathy?British Journal of Ophthalmology.  83:763-764. 1999
1999 Growth factor staining patterns in the pig retina following retinal laser photocoagulationBritish Journal of Ophthalmology.  83:728-736. 1999
1999 Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathyBritish Journal of Ophthalmology.  83:486-494. 1999
1999 Lipofuscin turnover [1] (multiple letters) 1999
1999 Macular pigment and age related macular degenerationBritish Journal of Ophthalmology.  83:867-877. 1999
1999 Ophthalmology in the post-genomic eraBritish Journal of Ophthalmology.  83:1215-1218. 1999
1999 Oxidative damage and age-related macular degeneration.Molecular Vision.  5:32. 1999
1999 Three dimensional analysis of microaneurysms in the human diabetic retinaJournal of Anatomy.  194:89-100. 1999
1998 Involvement of calcium in retinal pigment epithelial cell proliferation and pigmentationCurrent Eye Research.  17:813-822. 1998
1998 Fluorescence properties of autofluorescent granules generated by cultured human RPE cells 1998
1998 Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar mediaFree Radical Biology and Medicine.  24:1107-1112. 1998
1998 Adhesion of IOLs to the posterior capsule.British Journal of Ophthalmology.  82:468. 1998
1998 Endothelial viability of organ-cultured corneas following penetrating keratoplastyEye.  12:834-838. 1998
1998 Increased expression of placenta growth factor in proliferative diabetic retinopathyLaboratory Investigation.  78:109-116. 1998
1998 Lens epithelial cell proliferation, migration, and metaplasia following capsulorhexisBritish Journal of Ophthalmology.  82:945-952. 1998
1998 The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytesGerman journal of ophthalmology.  236:1-8. 1998
1998 VEGF localisation in diabetic retinopathyBritish Journal of Ophthalmology.  82:561-568. 1998
1997 Melanogenesis in cultured canine RPE cells 1997
1997 Cell attachment to, and contraction of, the retina in vitro 1997
1997 A role for vitamin A in the formation of ocular lipofuscinBritish Journal of Ophthalmology.  81:911-918. 1997
1997 Intravitreal growth factors in proliferative diabetic retinopathy: Correlation with neovascular activity and glycaemic managementBritish Journal of Ophthalmology.  81:228-233. 1997
1996 Oxygen modulates the response of the retinal pigment epithelium to basic fibroblast growth factor and epidermal growth factor by receptor regulation 1996
1996 Aerobic photoreactions of retinal pigment granules with aging 1996
1996 The effect of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes 1996
1996 The potential phototoxicity of retinal lipofuscin 1996
1996 VEGF distribution in proliferative diabetic retinopathy 1996
1996 A simple organ culture model for assessing the effects of growth factors on corneal re-epithelializationExperimental Eye Research.  62:555-564. 1996
1996 Diurnal variations in human corneal thicknessBritish Journal of Ophthalmology.  80:1068-1072. 1996
1996 Dual immunodetection and hybridisation in situ of opsin mrna and rhodopsin protein in retinal sections 1996
1996 Immunocytochemical study of retinal diode laser photocoagulation in the ratBritish Journal of Ophthalmology.  80:1092-1098. 1996
1996 Retinal pigment epithelial dystrophy in Briard dogsResearch in Veterinary Science.  60:17-23. 1996
1996 The effect of scatter laser photocoagulation on intravitreal levels of growth factors in the miniature pigCurrent Eye Research.  15:923-931. 1996
1996 Three dimensional analysis of the retinal vasculature using immunofluorescent staining and confocal laser scanning microscopyBritish Journal of Ophthalmology.  80:246-251. 1996
1995 Hypoxia induces HSP 70 gene expression in human hepatoma (HEP G2) cellsIUBMB Life.  36:907-912. 1995
1995 Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive speciesJournal of Biological Chemistry.  270:18825-18830. 1995
1995 Massive proliferation of lens epithelial remnants after Nd-YAG laser capsulotomyBritish Journal of Ophthalmology.  79:261-263. 1995
1995 Oxygen modulates production of bFGF and TGF-β by retinal cells in vitroExperimental Eye Research.  60:415-423. 1995
1994 Effect of 'Hypoxia' on the Proliferation of Microvascular Cells in VitroExperimental Eye Research.  59:243-246. 1994
1994 Cell attachment to standard and surface-modified intraocular lensesEuropean Journal of Implant and Refractive Surgery.  6:190-194. 1994
1994 Membrane-bound carbonic anhydrase in human retinal pigment epithelium 1994
1994 Oxygen regulation of TGF-β1 mRNA in human hepatoma (HEP G2) cellsIUBMB Life.  34:639-644. 1994
1994 Production of IGF-I and IGF binding proteins by retinal cells in vitroBritish Journal of Ophthalmology.  78:638-642. 1994
1994 Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epitheliumBritish Journal of Ophthalmology.  78:125-129. 1994
1994 Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathyBritish Journal of Ophthalmology.  78:714-718. 1994
1993 Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segmentsGlycobiology.  3:403-412. 1993
1993 Lipofuscin is a photoinducible free radical generator 1993
1992 Biological activities of vitreous gel, retrohyaloid fluid and subretinal fluid from diabetic and non-diabetic eyesBritish Journal of Ophthalmology.  76:79-83. 1992
1992 Modulators and milieu in preretinal neovascularisationEye.  6:560-565. 1992
1991 Chapter 6 Ageing of the retinal pigment epitheliumProgress in Retinal and Eye Research.  11:125-151. 1991
1991 Effect of varying oxygen concentrations on the proliferation of retinal microvascular cells in vitroExperimental Eye Research.  53:597-601. 1991
1991 Temporal variations in the ionic transport across rabbit retinal pigment epitheliumCurrent Eye Research.  10:513-522. 1991
1990 Age-related changes in the morphology, absorption and fluorescence of melanosomes and lipofuscin granules of the retinal pigment epitheliumVision Research.  30:1291-1303. 1990
1990 Cell cultureEye.  4:622-631. 1990
1990 Formation of "vessel-like" structures by retinal capillary endothelial cells in cultureGerman journal of ophthalmology.  228:377-381. 1990
1990 Inhibition of microvascular endothelial cell proliferation by vitreous following retinal scatter photocoagulationBritish Journal of Ophthalmology.  74:328-332. 1990
1990 Regional distribution of lysosomal enzymes in the canine retinal pigment epithelium 1990
1990 Time-Resolved Fluorescence Spectroscopy of the Retinal Pigment Epithelium: Age-Related StudiesIEEE Journal of Quantum Electronics.  26:2218-2225. 1990
1989 Inherited retinal dystrophies: Cell biology and interacting co-factors 1989
1989 Growth characteristics of central and peripheral bovine corneal epithelial cells in vitroGerman journal of ophthalmology.  227:263-270. 1989
1989 The formation of autofluorescent granules in cultured human RPE 1989
1989 Assessment of corneal wound repair in vitroCurrent Eye Research.  8:713-719. 1989
1989 Effect of the fluorinated gases SF6 and C3F8 on ocular tissues following laser treatmentLasers and Light in Ophthalmology.  2:183-191. 1989
1989 Transplantation of retinal pigment epithelium using a pars plana approachEye.  3:27-32. 1989
1988 A microsystem to assay lysosomal enzyme activities in cultured retinal pigment epithelial cellsCurrent Eye Research.  7:1097-1104. 1988
1988 Editorial: Research reviews from the institute of ophthalmologyEye.  2:Vii. 1988
1988 Effects of vitreous from photocoagulated eyes on retinal micro vascular cells in culture: A preliminary reportCurrent Eye Research.  7:465-470. 1988
1988 Growth of pure cultures of retinal pigment epithelial cells using chorioretinal biopsies from the pigExperimental Eye Research.  46:813-817. 1988
1988 The cytoskeletal elements of human retinal pigment epithelium: in vitro and in vivo.Journal of Cell Science.  91 ( Pt 2):303-312. 1988
1988 Vasoproliferative retinopathies: Clinical, morphogenetic and modulatory aspectsEye.  2:S124-S139. 1988
1987 Growth of retinal capillary endothelia using pericyte conditioned medium 1987
1987 Retinal pigment epithelial cells produce mitogenic factors for retinal microvascular cells in culture: A preliminary reportEye.  1:754-756. 1987
1986 Investigations of cytoskeletal elements in cultured bovine meshwork cells 1986
1986 The generation of dense granules within cultured human retinal pigment epithelial cells at senescenceGerman journal of ophthalmology.  224:106-109. 1986
1986 Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: A model for agingBritish Journal of Ophthalmology.  70:808-815. 1986
1986 He-Ne laser stimulation of human fibroblast proliferation and attachment in vitroLasers in the life sciences.  1:125-134. 1986
1986 Human retinal pigment epithelial cells in the vitreous of the owl monkeyExperimental Eye Research.  43:491-502. 1986
1985 An analysis of some behavioural characteristics of normal and dystrophic human RPE cells in tissue cultureOphthalmic Genetics.  6:157-162. 1985
1985 Repigmentation of human retinal pigment epithelial cells in vitroExperimental Eye Research.  41:209-218. 1985
1984 Retinitis pigmentosa: a quantitative study of the apical membrane of normal and dystrophic human retinal pigment epithelial cells in tissue culture in relation to phagocytosisGerman journal of ophthalmology.  221:214-229. 1984
1983 Retinitis pigmentosa: A preliminary report on tissue culture studies of retinal pigment epithelial cells from eight affected human eyesExperimental Eye Research.  37:307-314. 1983
1982 Human retinal pigment epithelial cells in tissue culture: A means of studying inherited retinal diseasesBirth defects original article series.  18:101-118. 1982


Year Title Altmetric
2016 A non-canonical role for β-secretase in the retina.  333-339. 2016
2013 Ageing of the Retina and Retinal Pigment Epithelium.  45-63. 2013
2013 Stem Cells in the Eye.  1399-1412. 2013
2012 Cell Death, Apoptosis, and Autophagy in Retinal Injury.  537-552. 2012
2012 The role of mitochondrial oxidative stress in retinal dysfunction.  203-239. 2012
2012 Transformation of progenitor cells for treatment of retinal disease.  419-435. 2012
2010 The vascular stem cell.  289-299. 2010
2010 The vascular stem cell.  289-299. 2010
2008 Macular degeneration: The role of reactive oxygen species.  171-180. 2008
2007 Hematopoietic stem cells in vascular development and ocular neovascularization.  78-96. 2007
2007 Stem cells in the eye.  1011-1023. 2007

Education And Training

  • Doctor of Philosophy in Engineering Science, 1982
  • Full Name

  • Michael Boulton