• Dr. Mark R. Harrigan grew up in Minnesota and received a B.S. degree in Economics from the University of Minnesota. He received an M.D. degree from the University of Washington in Seattle, Washington, in 1995. During medical school, he was the recipient of the American Federation for Clinical Research E.E. Osgood Award, the Roche Laboratories Award in Basic Science, and the American Medical Association Award for Outstanding Clinical Research.

    Dr. Harrigan then did his general surgery internship and neurological surgery residency at the University of Michigan Medical Center under the direction of Dr. Julian Hoff from 1995 to 2002. During his residency, he spent 18 months in the laboratory of Dr. Richard Keep studying cerebral blood flow and the effects of angiogenic factors on cerebral blood flow and ischemia. During this time he also participated in the introduction of clinical cerebral blood flow measurement techniques at the University of Michigan Medical Center, including xenon-CT and CT perfusion. He was the recipient of the Pharmacia Upjohn Research Fellowship in Cerebrovascular Disease, the Michigan Association of Neurological Surgeons Resident Award, and the Fifth International Conference on Xenon CT-CBF Young Investigator Award.

    Upon completion of his residency, he did a fellowship in Neuroendovascular Surgery at SUNY Buffalo under the direction of Dr. Nick Hopkins from 2002 to 2004. During this time he received the Sean Mullen Neuroendovascular Fellowship. Upon completion of his fellowship, Dr. Harrigan joined the faculty of the University of Alabama at Birmingham as an Assistant Professor of Neurosurgery and Radiology. There, under the mentorship of Dr. Winfield Fisher, he did a fellowship in Cerebrovascular Neurosurgery.

    Dr. Harrigan is the co-author, along with Dr. John Deveikis, of the Handbook of Cerebrovascular Disease and Neurointerventional Technique (Springer), which is in the 3rd edition. He is a regular speaker and panelist at the International Stroke Conference, the Congress of Neurological Surgeons and the American Associations of Neurological Surgeons meetings, among other. He has more than 140 peer-reviewed publications. He has served as the UAB site principal investigator in an array of NIH- and industry-sponsored clinical trials. His scientific focus is on stroke due to blunt cerebrovascular injury (BCVI), and he is the Co-Principal Investigator, along with Dr. Jan Jansen, of a proposal for a multicenter randomized trial for prevention of stroke in patients with BCVI currently being prepared for submission to the NIH. In addition, he is the Director of Neurointervention at UAB and also the Neurointerventional Fellowship Director.

    Dr. Harrigan's clinical practice includes the operative and endovascular treatment of cerebrovascular disease, as well as general neurosurgery and neurosurgical critical care. His clinical and research interests focus on cerebrovascular disorders. He is the UAB Site Principal Investigator for five multicenter clinical studies. He is active in resident education and was a recipient of a Top Ten Award for Excellence in Resident Education from the Department of Radiology. He is also the co-author, with Dr. John Deveikis, of the Handbook of Cerebrovascular Disease and Neurointerventional Technique.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Morphological characteristics of symptomatic and asymptomatic carotid websJournal of Neurosurgery.  137:1727-1732. 2022
    2022 Learning Curve for Flow Diversion of Posterior Circulation Aneurysms: A Long-Term International Multicenter Cohort StudyAmerican Journal of Neuroradiology.  43:1615-1620. 2022
    2022 The Pipeline Embolization Device: a decade of lessons learned in the treatment of posterior circulation aneurysms in a multicenter cohortJournal of Neurosurgery.  137:1454-1461. 2022
    2022 Flossing technique for endovascular repair of a penetrating cerebrovascular injury: illustrative case. 2022
    2022 Educational Intervention in the Emergency Department to Address Disparities in Stroke KnowledgeJournal of Stroke and Cerebrovascular Diseases.  31. 2022
    2022 Imaging analysis of ischemic strokes due to blunt cerebrovascular injuryJournal of Trauma and Acute Care Surgery.  92:990-996. 2022
    2022 Repeat Flow Diversion for Cerebral Aneurysms Failing Prior Flow Diversion: Safety and Feasibility From Multicenter ExperienceStroke.  53:1178-1189. 2022
    2021 Existence of knowledge silos in the adult blunt cerebrovascular injury literature 2021
    2021 “Seizure Prophylaxis in Unruptured Aneurysm Repair: A randomized controlled trial” by Daou et al. journal of stroke and cerebrovascular diseases, Vol. 29, No. 10 (October), 2020: 105171Journal of Stroke and Cerebrovascular Diseases.  30. 2021
    2021 Adaptive Approach to Endovascular Management of Large Vessel Occlusion During the COVID-19 PandemicJournal of Stroke and Cerebrovascular Diseases.  30. 2021
    2021 Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH TrialsNeurosurgery.  88:961-970. 2021
    2021 Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversionJournal of Neurosurgery.  134:961-970. 2021
    2021 Posterior communicating artery injury and symptomatic vasospasm after high-energy blunt head injury: illustrative case. 2021
    2021 Comparison of PED and FRED flow diverters for posterior circulation aneurysms: A propensity score matched cohort studyJournal of NeuroInterventional Surgery.  13:153-158. 2021
    2021 Knowledge silos in pediatric blunt cerebrovascular injuryJournal of Neurosurgery: Pediatrics.  27:239-240. 2021
    2021 Universal screening for blunt cerebrovascular injuryJournal of Trauma and Acute Care Surgery.  90:224-231. 2021
    2021 Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH TrialsNeurosurgery.  89:s125-s125. 2021
    2021 Rapid Evolution and Rupture of an Incidental Aneurysm During Hyperdynamic Therapy for Cerebral VasospasmWorld Neurosurgery.  145:205-209. 2021
    2021 Thrombolysis for evacuation of intracerebral and intraventricular hemorrhage: A guide to surgical protocols with practical lessons learned from the MISTIE and CLEAR trialsOperative Neurosurgery.  20:98-108. 2021
    2020 Propensity Score Matched Analysis of Functional Outcomes Post Mechanical Thrombectomy of the Anterior Circulation Alone or Combined with Preoperative Intravenous ThrombolysisNeurosurgery.  67. 2020
    2020 Repeat Flow Diversion for Previously Failed Flow DiversionNeurosurgery.  67. 2020
    2020 The Benefits Seen with Mechanical Thrombectomy for Anterior Circulation Ischemic Stroke are Independent of Occlusion LocationNeurosurgery.  67. 2020
    2020 Intraventricular metastatic melanoma: A case report and review of the literatureClinical Case Reports.  8:1757-1764. 2020
    2020 Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patientsNeurosurgical Review.  43:1173-1178. 2020
    2020 New ischemic lesions on brain magnetic resonance imaging in patients with blunt traumatic cerebrovascular injuryJournal of Trauma and Acute Care Surgery.  88:796-802. 2020
    2020 Commentary: Side-to-side superficial temporal artery to middle cerebral artery bypass technique: Application of fourth generation bypass in a case of adult moyamoya diseaseOperative Neurosurgery.  18:E142. 2020
    2020 Abstract TP335: Comparative Impact of Timing From Ictus to Intracerebral Hemorrhage Evacuation on Outcome in MISTIE III, STICH I & II TrialsStroke.  51. 2020
    2020 Abstract TP444: New Ischemic Lesions on Brain MRI in Patients With Blunt Traumatic Cerebrovascular InjuryStroke.  51. 2020
    2020 Abstract WMP103: Comparative Impact of Extent of Lobar Intracerebral Hemorrhage Removal on Outcome in the MISTIE III and STICH II TrialsStroke.  51. 2020
    2020 The Pipeline Embolization Device: Changes in Practice and Reduction of Complications in the Treatment of Anterior Circulation Aneurysms in a Multicenter CohortNeurosurgery.  86:266-271. 2020
    2020 Ischemic Stroke due to Blunt Traumatic Cerebrovascular InjuryStroke.  51:353-360. 2020
    2020 Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid HemorrhageStroke.  1142-1149. 2020
    2019 Commentary: Novel Hemicraniectomy Technique for Malignant Middle Cerebral Artery Infarction: Technical NoteOperative Neurosurgery.  17:E96-E97. 2019
    2019 The Effect of Epsilon-Aminocaproic Acid on the Development of Shunt-Dependent Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage: a Case-Control Study 2019
    2019 Haplotype analysis of SERPINE1 gene: Risk for aneurysmal subarachnoid hemorrhage and clinical outcomesMolecular Genetics and Genomic Medicine.  7. 2019
    2019 Report of Spontaneous Internal Carotid Dissection in a Patient with Turner Syndrome with a Systematic Review of the LiteratureWorld Neurosurgery.  128:340-346. 2019
    2019 A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III)International Journal of Stroke.  14:548-554. 2019
    2019 Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) ProcedureNeurosurgery.  84:1157-1168. 2019
    2019 Aspirin for primary prevention of stroke in traumatic cerebrovascular injury: Association with increased risk of transfusionJournal of Neurosurgery.  130:1520-1527. 2019
    2019 Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial 2019
    2019 Le Coup de Poignard Rachidien: A Historical Perspective.Cureus.  11:e4175. 2019
    2019 Pipeline embolization of posterior circulation aneurysms: A multicenter study of 131 aneurysmsJournal of Neurosurgery.  130:923-935. 2019
    2019 Abstract TP149: The Effects of Intravenous Thrombolysis on Distal Migration of Clots and Recanalization in Acute Ischemic Strokes Also Treated With Endovascular TherapiesStroke.  50. 2019
    2019 Whole blood aggregometry prior to Pipeline embolization device treatment of intracranial aneurysms: Defining an optimal platelet inhibition cutoff value for clopidogrelJournal of Neurosurgery.  131:1437-1444. 2019
    2018 Flow diversion for the treatment of basilar apex aneurysmsNeurosurgery.  83:1298-1304. 2018
    2018 PHASES score applied to a prospective cohort of aneurysmal subarachnoid hemorrhage patientsJournal of Clinical Neuroscience.  53:69-73. 2018
    2018 Risk of branch occlusion and ischemic complications with the pipeline embolization device in the treatment of posterior circulation aneurysmsAmerican Journal of Neuroradiology.  39:1303-1309. 2018
    2018 Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  128:1771-1777. 2018
    2018 Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcomeJournal of Neurosurgery.  128:1311-1317. 2018
    2018 The use of single stent-assisted coiling in treatment of bifurcation aneurysms: A multicenter cohort study with proposal of a scoring system to predict complete occlusionNeurosurgery.  82:710-718. 2018
    2018 Intra-Arterial vasodilators for vasospasm following aneurysmal subarachnoid hemorrhage: A meta-AnalysisJournal of NeuroInterventional Surgery.  10:380-386. 2018
    2018 Abstract TMP90: Prevention of Stroke in Traumatic Cerebrovascular Injury With Aspirin Carries an Increased Risk of TransfusionStroke.  49. 2018
    2018 Abstract WP77: Effect of Concurrent Coil Embolization on Delayed Spontaneous Aneurysm Rupture Following Flow Diverter PlacementStroke.  49. 2018
    2018 Admission Systolic Blood Pressure Predicts the Number of Blood Pressure Medications at Discharge in Patients with Primary Intracerebral HemorrhageNeurologist.  23:60-64. 2018
    2018 Association of renin-angiotensin system genetic polymorphisms and aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  128:86-93. 2018
    2018 Suboccipital Craniotomy Versus Craniectomy: A Survey of Practice PatternsWorld Neurosurgery.  109:e731-e738. 2018
    2017 Predictors of incomplete occlusion following pipeline embolization of intracranial aneurysms: Is It less effective in older patients?American Journal of Neuroradiology.  38:2295-2300. 2017
    2017 The role of endothelial nitric oxide synthase −786 T/C polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhageNitric Oxide: Biology and Chemistry.  71:52-56. 2017
    2017 Dr. Norman Chater and Chater's PointWorld Neurosurgery.  106:281-284. 2017
    2017 Association of Plasminogen Activator Inhibitor 1 (SERPINE1) Polymorphisms and Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  105:672-677. 2017
    2017 Comparison of Stent-Assisted Coil Embolization and the Pipeline Embolization Device for Endovascular Treatment of Ophthalmic Segment Aneurysms: A Multicenter Cohort StudyWorld Neurosurgery.  105:206-212. 2017
    2017 In Reply to the Letter to the Editor Regarding “Safety and Efficacy of Noncompliant Balloon Angioplasty for the Treatment of Subarachnoid Hemorrhage-Induced Vasospasm: A Multicenter Study”World Neurosurgery.  105:1023. 2017
    2017 Pipeline Embolization Device in Treatment of 50 Unruptured Large and Giant AneurysmsWorld Neurosurgery.  105:232-237. 2017
    2017 ResponseJournal of Neurosurgery.  127:708. 2017
    2017 Corrigendum to ‘Predictors of Shunt Insertion in Aneurysmal Subarachnoid Hemorrhage’ [World Neurosurgery 98 (2017) 421-426] (S1878875016312402) (10.1016/j.wneu.2016.11.092))World Neurosurgery.  104:1043. 2017
    2017 Treatment of tandem internal carotid artery aneurysms using a single pipeline embolization device: Evaluation of safety and efficacyAmerican Journal of Neuroradiology.  38:1605-1609. 2017
    2017 Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trialNeurology.  89:355-362. 2017
    2017 Reliability assessment of the Biffl Scale for blunt traumatic cerebrovascular injury as detected on computer tomography angiographyJournal of Neurosurgery.  127:32-35. 2017
    2017 Associations of Endothelin Polymorphisms and Aneurysm Size at Time of RuptureWorld Neurosurgery.  102:253-257. 2017
    2017 Endothelin polymorphisms as a risk factor for cerebral aneurysm rebleeding following aneurysmal subarachnoid hemorrhageClinical Neurology and Neurosurgery.  157:65-69. 2017
    2017 Associations of renin-angiotensin system genetic polymorphisms and clinical course after aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  126:1585-1597. 2017
    2017 Endothelial Nitric Oxide Synthase Polymorphism Is Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  101:514-519. 2017
    2017 External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  126:1530-1536. 2017
    2017 Impact of High-Mobility Group Box 1 Polymorphism on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  101:325-330. 2017
    2017 Recrudescence of Symptoms of Remote Ischemic Stroke After a Cerebral AngiogramWorld Neurosurgery.  101:814.e15-814.e17. 2017
    2017 Use of Platelet Function Testing before Pipeline Embolization Device Placement: A Multicenter Cohort StudyStroke.  48:1322-1330. 2017
    2017 Ischemic Stroke after Treatment of Intraprocedural Thrombosis during Stent-Assisted Coiling and Flow DiversionStroke.  48:1098-1100. 2017
    2017 Pipeline Embolization Device for Small Intracranial Aneurysms: Evaluation of Safety and Efficacy in a Multicenter CohortNeurosurgery.  80:579-587. 2017
    2017 Ryanodine Receptor 1 Polymorphism Is Not Associated with Aneurysmal Subarachnoid Hemorrhage or its Clinical SequelaeWorld Neurosurgery.  100:190-194. 2017
    2017 Trends in Transcranial Doppler Monitoring in Aneurysmal Subarachnoid Hemorrhage: A 10-Year Analysis of the Nationwide Inpatient SampleJournal of Stroke and Cerebrovascular Diseases.  26:851-857. 2017
    2017 Seizure outcomes after stereotactic radiosurgery for the treatment of cerebral arteriovenous malformationsJournal of Neurosurgery.  126:845-851. 2017
    2017 Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial 2017
    2017 Predictors of Shunt Insertion in Aneurysmal Subarachnoid HemorrhageWorld Neurosurgery.  98:421-426. 2017
    2017 Safety and Efficacy of Noncompliant Balloon Angioplasty for the Treatment of Subarachnoid Hemorrhage–Induced Vasospasm: A Multicenter StudyWorld Neurosurgery.  98:189-197. 2017
    2017 Blunt Traumatic Extracranial Cerebrovascular Injury and Ischemic StrokeCerebrovascular Diseases Extra.  7:72-83. 2017
    2017 A safe and effective management strategy for BCVIJournal of Trauma and Acute Care Surgery.  82:228. 2017
    2017 Carotid artery angioplasty and stenting without distal embolic protection devicesNeurosurgery.  80:66. 2017
    2016 Association of nosocomial infections with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhageJournal of Neurosurgery.  125:1383-1389. 2016
    2016 Pipeline Embolization Device for small paraophthalmic artery aneurysms with an emphasis on the anatomical relationship of ophthalmic artery origin and aneurysmJournal of Neurosurgery.  125:1352-1359. 2016
    2016 In reference to what is the optimal perioperative management of antiplatelet therapy? 2016
    2016 114 Treatment of Bifurcation Aneurysms Using Single Stent-Coiling With Relation to Aneurysm Configuration: A Cohort Study of Two Academic Institutions in the United States.Neurosurgery.  63 Suppl 1:148. 2016
    2016 Systemic Inflammatory Response Syndrome and Outcomes in Intracerebral HemorrhageNeurocritical Care.  25:133-140. 2016
    2016 Aneurysm study of pipeline in an observational registry (ASPIRe)Interventional Neurology.  5:89-99. 2016
    2016 Early trauma-induced coagulopathy is associated with increased ventilator-associated pneumonia in spinal cord injury patientsShock.  45:502-505. 2016
    2016 Vasospasm on transcranial Doppler is predictive of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysisJournal of Neurosurgery.  124:1257-1264. 2016
    2016 Abstract 148: Age Disparities in Acute Stroke Treatment: An Analysis of Six Years of US Hospital DischargesStroke.  47. 2016
    2016 Abstract 195: Nosocomial Infections are Associated with Delayed Cerebral Ischemia in Aneurysmal Subarachnoid HemorrhageStroke.  47. 2016
    2016 Abstract TMP104: Prevalence of Transcranial Doppler Monitoring in Aneurysmal Subarachnoid Hemorrhage: An Analysis of the Nationwide Inpatient SampleStroke.  47. 2016
    2016 Abstract TMP107: Intra-arterial Vasodilators Treat Vasospasm in Aneurysmal Subarachnoid Hemorrhage With Fair Angiographic & Neurological Response, but the Impact on Outcome is Unknown: a Meta-analysis of Observational StudiesStroke.  47. 2016
    2016 Abstract TP30: Risks and Benefits of Bypassing the Emergency Department for Ischemic Stroke Transferred in for Acute Endovascular TherapyStroke.  47. 2016
    2016 Optical coherence tomography of traumatic aneurysms of the internal carotid artery: Report of 2 casesJournal of Neurosurgery.  124:305-309. 2016
    2015 Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control studyClinical Neurology and Neurosurgery.  139:66-69. 2015
    2015 Access to the carotid artery bifurcation: Cadaveric study with application to nasotracheal intubation as a technique to improve access to a high carotid artery bifurcationBritish Journal of Neurosurgery.  29:865-867. 2015
    2015 Corrective spinal surgery may be protective against stroke in patients with blunt traumatic vertebral artery occlusionJournal of Neurosurgery: Spine.  23:665-670. 2015
    2015 Proposal of venous drainage-based classification system for carotid cavernous fistulae with validity assessment in a multicenter cohortNeurosurgery.  77:380-385. 2015
    2015 Validation of a System to Predict Recanalization after Endovascular Treatment of Intracranial AneurysmsNeurosurgery.  77:168-173. 2015
    2015 Temporal Changes in Periprocedural Events in the Carotid Revascularization Endarterectomy Versus Stenting TrialStroke.  46:2183-2189. 2015
    2015 The clinical significance and reliability of self-reported smoking status in patients with intracranial aneurysms: A reviewClinical Neurology and Neurosurgery.  137:44-49. 2015
    2015 Clinical presentation, imaging, and management of complications due to neurointerventional proceduresSeminars in Interventional Radiology.  32:98-107. 2015
    2015 Carotid and vertebral injury study (CAVIS) technique for characterization of blunt traumatic aneurysms with reliability assessmentInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.  21:255-262. 2015
    2015 Abstract 68: Palliative Care Is Underutilized in Patients with Severe Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract T MP91: A Simple Systemic Inflammatory Response Syndrome Prediction Score for Patients with Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract T P325: The Role Of A History Of Coronary Artery Disease, The Need For Transfusion And Outcomes In Patients With Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract T P326: The Utility of Charlson Comorbidity Index in Predicting Short-term Outcomes in Patients with Primary Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract T P404: The Influence Of Systemic Inflammatory Response Syndrome, In The Absence Of Infection, On The Relationship Between Intracerebral Hemorrhage Score And OutcomesStroke.  46. 2015
    2015 Abstract W P309: Serum Albumin Predicts Outcome In Primary Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract W P324: The Influence Of Low Density Lipoprotein On Intracerebral Hemorrhage VolumeStroke.  46. 2015
    2015 Abstract W P328: Elevated Systolic Blood Pressure on Arrival is Not Associated with Higher Early Mortality in Intracerebral Hemorrhage PatientsStroke.  46. 2015
    2015 Abstract W P329: Systemic Inflammatory Response Syndrome during Hospitalization for Intracerebral Hemorrhage Drives Poor Functional Outcome at DischargeStroke.  46. 2015
    2015 Abstract W P332: Ratio of Blood Urea Nitrogen to Serum Creatinine Predicts Primary Intracerebral Hemorrhage VolumeStroke.  46. 2015
    2015 Abstract W P333: Seizure as the Presenting Symptom of ICH Patient Characteristics and EEG UtilizationStroke.  46. 2015
    2015 Abstract W P334: Admission Blood Pressure Predicts The Number Of Medications Upon Discharge In Patients With Primary Intracerebral HemorrhageStroke.  46. 2015
    2015 Abstract W P335: The Impact of Electrolyte Abnormalities in Primary Intracerebral HemorrhageStroke.  46. 2015
    2015 CommentNeurosurgery.  76:164. 2015
    2015 External ventricular drain placement in the intensive care unit versus operating room: Evaluation of complications and accuracyClinical Neurology and Neurosurgery.  128:94-100. 2015
    2014 Investigating the utility of previously developed prediction scores in acute ischemic stroke patients in the stroke beltJournal of Stroke and Cerebrovascular Diseases.  23:2001-2006. 2014
    2014 Maxillary Artery Embolization for the Treatment of Intractable Epistaxis 2014
    2014 Incidence and trends in the diagnosis of traumatic extracranial cerebrovascular injury in the nationwide inpatient sample database, 2003-2010Journal of Neurotrauma.  31:1056-1062. 2014
    2014 Abstract T P52: Technique for Measurement of Traumatic Aneurysms of the Cervical Internal Carotid Artery and Assessment of ReproducibilityStroke.  45. 2014
    2014 Abstract W MP6: Pre-treatment Neuroimaging Is Critical to Identify Acute Stroke Patients With Large Infarcts Unlikely to Respond to Endovascular TherapyStroke.  45. 2014
    2014 Abstract W P53: Extracranial Traumatic Aneurysms Due to Blunt Cerebrovascular InjuryStroke.  45. 2014
    2014 Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): The final results of a randomised trial 2014
    2014 CommentNeurosurgery.  75:116. 2014
    2014 Endovascular tools available for the treatment of cerebrovascular diseaseNeurosurgery Clinics of North America.  25:387-394. 2014
    2014 Extracranial traumatic aneurysms due to blunt cerebrovascular injury: Clinical articleJournal of Neurosurgery.  120:1437-1445. 2014
    2014 N-acetylcysteine (NAC) in neurological disorders: Mechanisms of action and therapeutic opportunitiesBrain and Behavior.  4:108-122. 2014
    2014 Resolution of diminished olfactory sensation after treatment of bilateral ophthalmic segment aneurysms with flow diversion: Case reportNeurosurgery.  74. 2014
    2013 Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 updateNeurosurgery.  60:82-91. 2013
    2013 Neurosurgical injuries resulting from the 2011 tornados in Alabama: The experience at the University of Alabama at Birmingham Medical CenterJournal of Neurosurgery.  118:1356-1362. 2013
    2013 Infection risk in neurointervention and cerebral angiographyNeurosurgery.  72:327-331. 2013
    2013 Management of vertebral artery injuries following non-penetrating cervical traumaNeurosurgery.  72:234-243. 2013
    2013 Abstract WMP78: Investigating the Utility of Previously Developed Prediction Scores in AIS patients in the Stroke BeltStroke.  44. 2013
    2013 Real-time validation of transcranial doppler criteria in assessing recanalization during intra-arterial procedures for acute ischemic stroke an international, multicenter studyStroke.  44:394-400. 2013
    2013 Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury ; Clinical articleJournal of Neurosurgery.  118:397-404. 2013
    2013 Rare case of bilateral vertebral artery stenosis caused by C4-5 spondylotic changes manifesting with bilateral bow hunter's syndromeWorld Neurosurgery.  79:799.e1-799.e5. 2013
    2012 CommentNeurosurgery.  71. 2012
    2012 Detailed analysis of periprocedural strokes in patients undergoing intracranial stenting in stenting and aggressive medical management for preventing recurrent stroke in intracranial stenosis (SAMMPRIS)Stroke.  43:2682-2688. 2012
    2012 Safety and cost effectiveness of step-down unit admission following elective neurointerventional proceduresJournal of NeuroInterventional Surgery.  4:390-392. 2012
    2012 O-001 Pre-treatment CTA ASPECTS as a predictor of clinical outcome in endovascular stroke therapy (EVT): results from the penumbra START trialJournal of NeuroInterventional Surgery.  4:a1. 2012
    2012 Did Carotid Stenting and Endarterectomy Outcomes Change over Time in the Carotid Revascularization Endarterectomy Versus Stenting Trial? (S09.005)Neurology.  78:s09.005-s09.005. 2012
    2012 Abstract 121: Symptomatic Intracranial Atherosclerotic Disease in Acute Cerebral Ischemia: Frequency, Clinical Course and Short-Term Outcome in a Tertiary Care Hospital in the Southeastern United StatesStroke.  43. 2012
    2012 Abstract 1: Did Carotid Stenting and Endarterectomy Outcomes Change Over Time in the Carotid Revascularization Endarterectomy versus Stenting Trial?Stroke.  43. 2012
    2012 Arterial ReOcclusion and Persistent Distal Occlusion after Thrombus AspirationJournal of Neuroimaging.  22:92-94. 2012
    2012 CommentsNeurosurgery.  70:149. 2012
    2012 Diagnosis and Management of an Intraorbital Vascular FistulaOphthalmic Plastic and Reconstructive Surgery.  28:e39-e41. 2012
    2011 CommentsNeurosurgery.  69:1271. 2011
    2011 Computed tomography perfusion prognostic maps do not predict reversible and irreversible neurological dysfunction following reperfusion therapiesInternational Journal of Stroke.  6:544-546. 2011
    2011 Pediatric traumatic carotid, vertebral and cerebral artery dissections: A reviewChild's Nervous System.  27:2045-2056. 2011
    2011 Velocity criteria for intracranial stenosis revisited: An international multicenter study of transcranial Doppler and digital subtraction angiographyStroke.  42:3429-3434. 2011
    2011 Stenting versus aggressive medical therapy for intracranial arterial stenosisNew England Journal of Medicine.  365:993-1003. 2011
    2011 In replyNeurosurgery.  69. 2011
    2011 Laparoscopic versus open insertion of the peritoneal catheter in ventriculoperitoneal shunt placement: Review of 810 consecutive cases - Clinical articleJournal of Neurosurgery.  115:151-158. 2011
    2011 In ReplyNeurosurgery.  68. 2011
    2011 Rebleeding risk after treatment of ruptured intracranial aneurysmsJournal of Neurosurgery.  114:1778-1784. 2011
    2011 Management of blunt extracranial traumatic cerebrovascular injury: A multidisciplinary survey of current practiceWorld Journal of Emergency Surgery.  6. 2011
    2011 Safety and tolerability of early noninvasive ventilatory correction using bilevel positive airway pressure in acute ischemic strokeStroke.  42:1030-1034. 2011
    2011 Cerebrovascular dissections: A review. Part II: Blunt cerebrovascular injuryNeurosurgery.  68:517-530. 2011
    2011 Cerebrovascular dissections - A review part I: Spontaneous dissectionsNeurosurgery.  68:242-257. 2011
    2010 CommentsNeurosurgery.  67:1443. 2010
    2010 Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: Effects on rehemorrhage, cerebral ischemia, and hydrocephalusNeurosurgery.  67:935-939. 2010
    2010 Hypertension may be the most important component of hyperdynamic therapy in cerebral vasospasm 2010
    2010 Diagnostic criteria and yield of real-time transcranial doppler monitoring of intra-arterial reperfusion proceduresStroke.  41:695-699. 2010
    2010 A. Diagnostic Criteria and Yield of Real Time Transcranial Doppler (TCD) Monitoring of Intra-Arterial (IA) Reperfusion Procedures 2010
    2010 X-Configuration Stent-Assisted CoilingWorld Neurosurgery.  74:143-144. 2010
    2009 Legacy and current understanding of the often-misunderstood Foix-Alajouanine syndrome: Historical vignetteJournal of Neurosurgery.  111:902-906. 2009
    2009 ResponseJournal of Neurosurgery.  111:901. 2009
    2009 Clinical experience with Matrix2 360° coils in the treatment of 100 intracranial aneurysmsWorld Neurosurgery.  72:41-47. 2009
    2009 Laparoscopic versus open approach for implantation of the peritoneal catheter during ventriculoperitoneal shunt placement 2009
    2008 Intraluminal septation of the basilar artery: Incidence and potential clinical significanceFolia Morphologica.  67:193-195. 2008
    2007 Coil extrusion after endovascular treatment. Case illustrationJournal of Neurosurgery.  106:512. 2007
    2006 Advancements in carotid stenting leading to reductions in perioperative morbidity among patients 80 years and olderNeurosurgery.  58:233-239. 2006
    2005 Monorail snare technique for the recovery of stretched platinum coils: Technical case reportNeurosurgery.  57. 2005
    2005 CT perfusion cerebral blood flow imaging in neurological critical careNeurocritical Care.  2:352-366. 2005
    2005 Accelerated embolization healing of aneurysms by polyethylene terephthalate coils seeded with autologous fibroblasts: CommentsNeurosurgery.  56:1080-1081. 2005
    2005 Carotid tissue levels of argatroban after direct local delivery during carotid endarterectomy to prevent perioperative cerebral embolism: CommentsNeurosurgery.  56:917-918. 2005
    2005 Deep brain stimulation for refractory obsessive-compulsive disorderBiological Psychiatry.  57:510-516. 2005
    2005 Computed tomographic perfusion in the management of aneurysmal subarachnoid hemorrhage: New application of an existent techniqueNeurosurgery.  56:304-316. 2005
    2005 Endovascular treatment of acute strokeNeurosurgery Clinics of North America.  16:433-444. 2005
    2004 Comparison of endovascular and surface cooling during unruptured cerebral aneurysm repair: CommentsNeurosurgery.  55:314-315. 2004
    2004 Giant vertebrobasilar aneurysms: Endovascular treatment and long-term follow-up: CommentsNeurosurgery.  55:323-326. 2004
    2004 Carotid perfusion CT with balloon occlusion and acetazolamide challenge test: FeasibilityRadiology.  231:906-913. 2004
    2004 Cerebral perfusion CT: Technique and clinical applicationsRadiology.  231:632-644. 2004
    2004 Haemorrhagic tracheal necrosis as a lethal complication of an aneurysm model in rabbits via endoluminal incubation with elastase 2004
    2004 Bivalirudin for Endovascular Intervention in Acute Ischemic Stroke: Case ReportNeurosurgery.  54:218-223. 2004
    2004 Carotid Angioplasty and Stenting versus Carotid Endarterectomy for Treatment of Asymptomatic Carotid Stenosis: A Randomized Trial in a Community HospitalNeurosurgery.  54:318-325. 2004
    2004 Endovascular Coil Occlusion of 1811 Intracranial Aneurysms: Early Angiographic and Clinical ResultsNeurosurgery.  54:268-285. 2004
    2004 Patient selection for revascularization in cervical carotid artery disease: angioplasty and stenting vs. endarterectomy.American Heart Hospital Journal.  2:8-15. 2004
    2004 Study of Magnetic Resonance Imaging-based Arteriovenous Malformation Delineation without Conventional AngiographyNeurosurgery.  54:1104-1110. 2004
    2004 The Neuroform Stent, the First Microcatheter-delivered Stent for Use in the Intracranial CirculationNeurosurgery.  54:2-5. 2004
    2003 Transvenous treatment of carotid cavernous and dural arteriovenous fistulae: Results for 31 patients and review of the literatureNeurosurgery.  53:836-857. 2003
    2003 A reappraisal of angioplasty and stenting for the treatment of vertebral origin stenosisNeurosurgery.  53:607-616. 2003
    2003 Angiogenic factors in the central nervous systemNeurosurgery.  53:639-661. 2003
    2003 Results of endovascular treatment of internal carotid artery stenoses with a newly developed balloon protection catheterNeurosurgery.  53:617-625. 2003
    2003 Acceleration of aneurysm healing by controlled release of basic fibroblast growth factor with the use of polyethylene terephthalate fiber coils coated with gelatin hydrogelNeurosurgery.  53:393-401. 2003
    2003 Endovascular treatment of paraclinoid aneurysms: Experience with 73 patientsNeurosurgery.  53:14-24. 2003
    2003 Alcohol embolization of carotid-cavernous indirect fistulaeNeurosurgery.  52:1111-1116. 2003
    2003 Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume 2003
    2003 Occlusion of Experimental Aneurysms with Heparin-loaded, Microporous Stent GraftsNeurosurgery.  53:1397-1405. 2003
    2002 Should interventional cardiologists treat ischemic strokes? A global perspective 2002
    2002 Intraventricular Infusion of Vascular Endothelial Growth Factor Promotes Cerebral Angiogenesis with Minimal Brain EdemaNeurosurgery.  50:589-598. 2002
    2002 Intraventricular infusion of vascular endothelial growth factor promotes cerebral angiogenesis with minimal brain edemaNeurosurgery.  50:589-598. 2002
    2002 Persistent autoregulatory disturbance after angioplasty for cerebral vasospasm: A case reportInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.  8:409-415. 2002
    2001 Cerebral salt wasting syndromeCritical Care Clinics.  17:125-138. 2001
    2000 Effect of hematocrit on calculation of cerebral blood flow and lambda in xenon CT 2000
    2000 Meralgia parestheticaTechniques in Neurosurgery.  6:50-56. 2000
    1999 Adenoid cystic carcinoma metastatic to the dura: Report of two casesJournal of Neuro-Oncology.  44:267-273. 1999
    1999 Metastatic adenocarcinoma to the brain mimicking hemorrhage: Case reportWorld Neurosurgery.  52:46-49. 1999
    1998 Abducens nerve palsy after radiofrequency rhizolysis for trigeminal neuralgia: Case reportNeurosurgery.  43:623-625. 1998
    1997 Indomethacin in the management of elevated intracranial pressure: A reviewJournal of Neurotrauma.  14:637-650. 1997
    1996 Cerebral salt wasting syndrome: A reviewNeurosurgery.  38:152-160. 1996
    1995 Beta amyloid is neurotoxic in hippocampal slice culturesNeurobiology of Aging.  16:779-789. 1995
    1994 Somatostatin‐containing neurons in rat organotypic hippocampal slice cultures: Light and electron microscopic immunocytochemistry 1994


    Year Title Altmetric
    2018 Handbook of Cerebrovascular Disease and Neurointerventional Technique 2018
    2018 Handbook of Cerebrovascular Disease and Neurointerventional Technique 2018
    2013 Handbook of Cerebrovascular Disease and Neurointerventional Technique: Second Edition 2013
    2009 Handbook of Cerebrovascular Disease and Neurointerventional Technique 2009


    Year Title Altmetric
    2021 Vascular Malformations of the Spine.  143-157. 2021
    2016 Internal Carotid Artery and the Anterior Cerebral Circulation.  449-460. 2016
    2015 Review of Current Literature and Occlusion Results 2015
    2013 Acute Ischaemic Stroke Agnieszka Anna Ardelt.  655-735. 2013
    2013 Acute ischemic stroke.  757-769. 2013
    2013 Cerebral angiography.  303-314. 2013
    2013 Dural Arteriovenous Fistulas.  603-625. 2013
    2013 General Considerations for Neurointerventional Procedures.  153-185. 2013
    2013 Intracranial Aneurysm Treatment.  189-241. 2013
    2013 Treatment of Acute Ischaemic Stroke.  343-398. 2013
    2011 Cerebral Vasospasm after Subarachnoid Hemorrhage.  207-213. 2011
    2009 Arteriovenous Malformations.  511-537. 2009
    2009 Cavernous Malformations and Venous Angiomas.  561-570. 2009
    2009 Diagnostic Cerebral Angiography.  87-115. 2009
    2009 Dural Arteriovenous Fistulas.  539-560. 2009
    2009 Endovascular Treatment of Intracranial Stenosis and Vasospasm.  365-380. 2009
    2009 Extracranial Angioplasty and Stenting.  347-364. 2009
    2009 Extracranial Embolization.  259-300. 2009
    2009 Intracranial Aneurysm Treatment.  143-177. 2009
    2009 Intracranial Cerebrovascular Occlusive Disease.  679-700. 2009
    2009 Intracranial Embolization Procedures.  205-257. 2009
    2009 Neuroendovascular Suite.  135-142. 2009
    2009 Provocative Testining.  179-204. 2009
    2009 Spinal Angiography.  117-134. 2009
    2009 Thrombolysis for Acute Ischemic Stroke.  301-346. 2009
    2009 Venous Procedures.  381-432. 2009
    2007 Carotid Endarterectomy Compared with Carotid Angioplasty and Stenting.  575-586. 2007
    2005 Intracranial Stenting.  70-84. 2005

    Research Overview

  • Cerebrovascular neurosurgery and stroke
  • Education And Training

  • University of Michigan Hospitals & Health Centers, Internship
  • University of Michigan Hospitals & Health Centers, Residency
  • The University of Rochester School of Medicine and Dentistry, Postdoctoral Fellowship
  • Doctor of Medicine, University of Washington 1995
  • Bachelor of Science or Mathematics in Economics, University of Minnesota-Twin Cities 1988
  • Awards And Honors

    Full Name

  • Mark Harrigan