Positions

Selected Publications

Academic Article

Year Title Altmetric
2014 Changing the academic culture: Valuing patents and commercialization toward tenure and career advancement 2014
2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
2014 O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses 2014
2013 STIM1/Orai1-mediated SOCE: Current perspectives and potential roles in cardiac function and pathology 2013
2012 Modification of STIM1 by O-linked N-Acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytesJournal of Biological Chemistry.  287:39094-39106. 2012
2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependentJournal of Biological Chemistry.  287:34419-34431. 2012
2011 Better regulation for research universities 2011
2010 The role of protein O-linked β-N-acetylglucosamine in mediating cardiac stress responses 2010
2010 Increased O-linked β-N-acetylglucosamine levels on proteins improves survival, reduces inflammation and organ damage 24 hours after trauma-hemorrhage in ratsCritical Care Medicine.  38:562-571. 2010
2010 Protein O-GlcNAcylation: A critical regulator of the cellular response to stressCurrent Signal Transduction Therapy.  5:49-59. 2010
2009 Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-κB signaling 2009
2008 Erratum: Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin (Transplantation (1999) 68:11 (1660-1673))Transplantation.  86:482. 2008
2008 Erratum: Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients (Transplantation (1999) 68:2 (215-219))Transplantation.  86:482. 2008
2008 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2 2008
2008 Hexosamine biosynthesis and protein O-glycosylation: The first line of defense against stress, ischemia, and traumaShock.  29:431-440. 2008
2008 Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes 2008
2008 Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway ratsBiogerontology.  9:139-151. 2008
2007 Glucosamine administration improves survival rate after severe hemorrhagic shock combined with trauma in ratsShock.  28:345-352. 2007
2007 Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis 2007
2007 Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation 2007
2007 Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart 2007
2007 The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levelsShock.  27:402-408. 2007
2007 Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular systemCardiovascular Research.  73:288-297. 2007
2007 Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc 2007
2007 Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levelsJournal of Molecular and Cellular Cardiology.  42:177-185. 2007
2006 Glucosamine administration during resuscitation improves organ function after trauma hemorrhageShock.  25:600-607. 2006
2006 Increased hexosamine biosynthesis and protein O-GlcNAc levels associated with myocardial protection against calcium paradox and ischemiaJournal of Molecular and Cellular Cardiology.  40:303-312. 2006
2006 Glucosamine inhibits angiotensin II-induced cytoplasmic Ca2+ elevation in neonatal cardiomyocytes via protein-associated O-linked N-acetylglucosamine 2006
2005 A store-operated nonselective cation channel in human lymphocytesCellular and Molecular Neurobiology.  25:625-647. 2005
2005 Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophilsJournal of Biological Chemistry.  280:14579-14585. 2005
2004 Neutrophils exhibit rapid agonist-induced increases in protein-associated O-GlcNAcJournal of Biological Chemistry.  279:45759-45765. 2004
2004 Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced InotropyDiabetes.  53:1074-1081. 2004
2004 Adult rat cardiomyocytes exhibit capacitative calcium entry 2004
2004 Ca2+ Modulation of Ca2+ Release-Activated Ca 2+ Channels Is Responsible for the Inactivation of Its Monovalent Cation CurrentBiophysical Journal.  86:805-814. 2004
2003 Regulation of Ca2+ release-activated Ca2+ channels by INAD and Ca2+ influx factor 2003
2002 Hyperglycemia inhibits capacitative calcium entry and hypertrophy in neonatal cardiomyocytesDiabetes.  51:3461-3467. 2002
2002 Calnexin is associated with and induced by overexpressed human complement protein C2Anatomical Record.  267:7-16. 2002
2002 Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytesJournal of Biological Chemistry.  277:14266-14273. 2002
2001 A store-operated nonselective cation channel in lymphocytes is activated directly by CA2+ influx factor and diacylglycerol 2001
2000 Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cellsJournal of Biological Chemistry.  275:26158-26163. 2000
2000 Preparation and use of a photoactivatable glucose-6-phosphate analogueBioorganic and Medicinal Chemistry Letters.  10:535-539. 2000
2000 Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiaeJournal of Biological Chemistry.  275:5431-5440. 2000
2000 Measuring Contributions to the Research Mission of Medical SchoolsAcademic Medicine.  75:304-313. 2000
1999 The inhibition of capacitative calcium entry due to ATP depletion but not due to glucosamine is reversed by staurosporineJournal of Biological Chemistry.  274:20165-20170. 1999
1999 Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signalJournal of Biological Chemistry.  274:3602-3609. 1999
1999 Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores 1999
1998 Glucose-6-phosphate and Ca2+ sequestration are mutually enhanced in microsomes from liver, brain, and heartDiabetes.  47:874-881. 1998
1997 Inhibition of capacitative Ca2+ entry by monosaccharides in J774 macrophagesThe FASEB Journal.  11. 1997
1996 A role for the glucose-6-phosphatase system in intracellular regulation of Ca2+ in J774 macrophagesThe FASEB Journal.  10. 1996
1996 Permeability to multivalent anions enhances calcuim (Ca2+) sequestration by rat cardiac microsomesThe FASEB Journal.  10. 1996
1996 Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNAJournal of Immunology.  156:4901-4908. 1996
1996 Regulation of intracellular calcium is closely linked to glucose metabolism in J774 macrophagesCell Calcium.  20:361-371. 1996
1995 Hyperglycemia alters cytoplasmic Ca2+ responses to capacitative Ca2+ influx in rat aortic smooth muscle cells 1995
1995 The posttranslational modification of phosphoglucomutase is regulated by galactose induction and glucose repression in Saccharomyces cerevisiaeJournal of Bacteriology.  177:3087-3094. 1995
1994 The glycosylation of phosphoglucomutase is modulated by carbon source and heat shock in Saccharomyces cerevisiaeJournal of Biological Chemistry.  269:27143-27148. 1994
1994 Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel 1994
1994 Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortexScience.  263:973-977. 1994
1994 The Addition of Glucose‐1‐Phosphate to the Cytoplasmic Glycoprotein Phosphoglucomutase Is Modulated by Intracellular Calcium in PC12 Cells and Rat Cortical SynaptosomesJournal of Neurochemistry.  62:456-464. 1994
1993 Isolation and expression of a rat liver cDNA encoding phosphoglucomutaseGene.  133:261-266. 1993
1993 Glycogen contains phosphodiester groups that can be introduced by UDPglucose:glycogen glucose 1-phosphotransferaseFEBS Letters.  329:263-267. 1993
1993 Cell surface labeling of CFTR in T84 cellsAmerican Journal of Physiology.  264. 1993
1993 Phosphoglucomutase in Saccharomyces cerevisiae is a cytoplasmic glycoprotein and the acceptor for a Glc-phosphotransferaseJournal of Biological Chemistry.  268:8341-8349. 1993
1992 Gangliosides as modulators of cell functionAmerican Journal of Physiology.  262. 1992
1992 Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptideAmerican Journal of Physiology.  262. 1992
1991 β-phosphorothioate analogs of nucleotide sugars are resistant to hydrolytic degradation and utilized efficiently by glycosyltransferasesAnalytical Biochemistry.  197:40-46. 1991
1991 Receptor synthesis and routing to the plasma membraneAmerican Journal of the Medical Sciences.  302:238-243. 1991
1990 Parafusin, an exocytic-sensitive phosphoprotein, is the primary acceptor for the glucosylphosphotransferase in Paramecium tetraurelia and rat liver 1990
1990 Relative accessibility of N-acetylglucosamine in trimers of the adenovirus types 2 and 5 fiber proteinsJournal of Virology.  64:5317-5323. 1990
1990 Resolution of phosphoglucomutase and the 62-kDA acceptor for the glucosylphosphotransferaseArchives of Biochemistry and Biophysics.  280:122-129. 1990
1989 An α-glucose-1-phosphate phosphodiesterase is present in rat liver cytosolJournal of Biological Chemistry.  264:20540-20546. 1989
1988 Cell surface expression of 4β‐galactosyltransferase accompanies rat parotid gland acinar cell transition to growthJournal of Cellular Biochemistry.  36:453-465. 1988
1988 Localization of the glucose phosphotransferase to a cytoplasmically accessible site on intracellular membranes.Journal of Biological Chemistry.  263:17792-17797. 1988
1987 Glucose-1-phosphate containing glycoproteins and interneuronal adhesion 1987
1987 The β-phosphoro[35S]thioate analogue of UDP-Glc is efficiently utilized by the glucose phosphotransferase and is relatively resistant to hydrolytic degradation 1987
1987 Glucose-1-phosphotransferase and N-acetylglucosamine-1-phosphotransferase have distinct acceptor specificitiesJournal of Biological Chemistry.  262:4377-4381. 1987
1987 Isoproterenol-mediated parotid gland hypertrophy is inhibited by effectors of 4β-galactosyltransferaseJournal of Biological Chemistry.  262:11706-11713. 1987
1986 Glucose phosphotransferase and intracelular trafficking 1986
1984 Ontogeny of the basal lamina in the sea urchin embryoDevelopmental Biology.  103:235-245. 1984
1984 Phosphoglucose-containing glycoproteins in intracellular trafficking and neuronal recognition.Advances in Experimental Medicine and Biology.  181:161-173. 1984
1984 Three peptides recognizing mannose-6-phosphate-α1-glucoseThe FASEB Journal.  43. 1984
1982 A Possible Role for Ligatin and the Phosphoglycoproteins It Binds in Calcium‐Dependent Retinal Cell AdhesionJournal of Cellular Biochemistry.  18:461-468. 1982
1982 A UDP-glucose:Glycoprotein glucose-1-phosphotransferase in embryonic chicken neural retinaCell.  31:739-748. 1982
1982 Brain Ligatin: A Membrane Lectin That Binds AcetylcholinesteraseJournal of Cellular Biochemistry.  18:447-459. 1982
1982 Calcium‐Dependent and Calcium‐Independent Adhesive Mechanisms Are Present During Initial Binding Events of Neural Retina CellsJournal of Cellular Biochemistry.  18:469-478. 1982
1982 Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucoseCell.  28:813-820. 1982
1981 Distribution of anionic sites on surfaces of retinal cells: A study using cationized ferritin 1981
1981 Intercellular recognition: Quantitation of initial binding events 1981
1981 Ligatin from embryonic chick neural retina inhibits retinal cell adhesionDevelopmental Biology.  86:250-255. 1981
1979 Ligatin from embryonic chick neural retina 1979
1979 Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigensDevelopmental Biology.  71:289-296. 1979
1978 Glycosyltransferase activities in developing chick embryos: potential roles in cell recognition and migrationBirth defects original article series.  14:317-326. 1978
1978 The potential roles for ganglioside GM2 and GM1 synthetase in retinotectal specificity. 1978
1978 Properties of a double gradient model for retinotectal specificityProgress in clinical and biological research.  VOL.23:637-645. 1978
1977 Biochemical investigations of retinotectal specificity.Progress in clinical and biological research.  15:73-79. 1977
1977 Biochemical investigations of retinotectal adhesive specificity 1977
1976 Intercellular adhesive specificity 1976
1975 A molecular approach to retinotectal specificity 1975
1975 A molecular approach to retinotectal specificity.Ciba Foundation symposium.  0:315-341. 1975
1973 Adhesive recognition and retinotectal specificity 1973

Chapter

Year Title Altmetric
2013 Phosphoglucomutase Is a Cytoplasmic Glycoprotein Implicated in the Regulated Secretory Pathway.  289-292. 2013
1984 Gene Expression and Cell-Cell Interactions in the Developing Nervous System 1984
1984 Receptor for Glycoproteins with Phosphorylated Oligosaccharides.  261-313. 1984

Education And Training

  • Doctor of Philosophy in Biophysics, Johns Hopkins University 1976
  • Awards And Honors

  • Charter Fellow, National Academy of Inventors, 2012
  • Fellow, American Association of Anatomists, 2010
  • A.J. Ladman Exemplary Service Award of the American Association of Anatomists, 2010
  • Mary Jane Kugle Award, Juvenile Diabetes Foundation International, 1999
  • National Science Foundation Presidential Young Investigator Award, 1989
  • National Science Foundation Presidential Young Investigator Award, 1988
  • National Science Foundation Presidential Young Investigator Award, 1987
  • National Science Foundation Presidential Young Investigator Award, 1986
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1986
  • National Science Foundation Presidential Young Investigator Award, 1985
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1985
  • National Science Foundation Presidential Young Investigator Award, 1984
  • Exxon Education Foundation Presidential Young Investigator Matching Funds, 1984
  • 1982-1985 Nanaline H. Duke Scholarship (Junior Faculty Research Award, Duke)
  • 1978 - Present Sigma Xi
  • 1977-1978 National Institutes of Health, Postdoctoral Fellowship
  • 1976-1977 Muscular Dystrophy Association, Postdoctoral Fellowship
  • 1975 Danforth Foundation Supplemental Grant for the Improvement of Undergraduate Education
  • 1972-1975 Danforth Foundation Graduate Fellowship
  • 1970-1972 National Science Foundation Graduate Fellowship
  • 1970 Cornell University Hamilton Watch Award (Outstanding Graduate in Science and Engineering)
  • 1970 First in class, Cornell University College of Engineering
  • 1969 Tau Beta Pi
  • Full Name

  • Richard Marchase