• Dr. Maddox is a clinical cardiac electrophysiologist committed to delivering exceptional healthcare through dedication to patients and their families. He strives to provide compassionate care, through personalized education and open communication, wishing to inspire hope and well-being in all his patients.

    His specific clinical expertise includes catheter ablation of complex atrial and ventricular arrhythmias, implantation of pacemakers, defibrillators, and cardiac resynchronization devices, and extraction of implanted cardiac devices.

    His research interests involve the development of tools and technologies to better treat cardiac arrhythmias with higher degrees of efficacy and safety. Specifically, this includes development of new catheters for delivery of RF energy to cardiac tissues, development of novel energy sources for ablation, and development of better mapping tools for complex arrhythmias.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trialThe Lancet.  397:2476-2486. 2021
    2021 Atrial arrhythmia related outcomes in critically ill COVID-19 patientsPacing and Clinical Electrophysiology.  44:814-823. 2021
    2021 A Novel Temperature-Controlled Radiofrequency Catheter Ablation System Used to Treat Patients With Paroxysmal Atrial FibrillationJACC: Clinical Electrophysiology.  7:352-363. 2021
    2020 Atrial Arrhythmias in COVID-19 PatientsJACC: Clinical Electrophysiology.  6:1189-1190. 2020
    2019 Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control After Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO TrialCirculation.  139:2542-2553. 2019
    2019 Acute safety, effectiveness, and real-world clinical usage of ultra-high density mapping for ablation of cardiac arrhythmias: Results of the TRUE HD studyEuropace.  21:655-661. 2019
    2018 Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist DeviceJournal of Cardiac Failure.  24:716-718. 2018
    2017 Safety and Efficacy of Uninterrupted Apixaban Therapy Versus Warfarin During Atrial Fibrillation AblationAmerican Journal of Cardiology.  120:404-407. 2017
    2017 Significant Discrepancy Between Estimated and Actual Longevity in St. Jude Medical Implantable Cardioverter-DefibrillatorsJournal of Cardiovascular Electrophysiology.  28:552-558. 2017
    2016 Prevalence and Electrocardiographic and Electrophysiological Characteristics of Idiopathic Ventricular Arrhythmias Originating from Intramural Foci in the Left Ventricular Outflow TractCirculation: Arrhythmia and Electrophysiology.  9. 2016
    2015 Cardiac implantable electronic device infection in patients with end-stage renal diseaseHeart Rhythm.  12:2395-2401. 2015
    2015 Education of Physicians and Implementation of a Formal Referral System Can Improve Cardiac Rehabilitation Referral and Participation Rates after Percutaneous Coronary InterventionHeart Lung and Circulation.  24:806-816. 2015
    2015 Radiofrequency catheter ablation of idiopathic ventricular arrhythmias originating from intramural foci in the left ventricular outflow tractCirculation: Arrhythmia and Electrophysiology.  8:344-352. 2015
    2015 The Gaps in Cardiac Rehabilitation Referral: The Elephant in the RoomJournal of the American College of Cardiology.  66:2574. 2015
    2013 Dabigatran versus warfarin therapy for uninterrupted oral anticoagulation during atrial fibrillation ablationJournal of Cardiovascular Electrophysiology.  24:861-865. 2013
    2012 Iatrogenic Aortocoronary Arteriovenous Fistula following Coronary Artery Bypass Surgery: A Case Report and Complete Review of the Literature.Case Reports in Cardiology.  2012:652086. 2012
    2007 Implementation of a statewide system for coronary reperfusion for ST-segment elevation myocardial infarctionJAMA: Journal of the American Medical Association.  298:2371-2380. 2007
    2000 Intravenous NPA for the treatment of infarcting myocardium early: InTIME-II, a double-blind comparison on of single-bolus lanoteplase vs accelerated alteplase for the treatment of patients with acute myocardial infarctionEuropean Heart Journal.  21:2005-2013. 2000
    1996 A randomized factorial trial of reperfusion strategies and aspirin dosing in acute myocardial infarctionAmerican Journal of Cardiology.  77:791-797. 1996
    1992 Evaluation of a prolonged infusion of recombinant tissue-type plasminogen activator (Duteplase) in preventing reocclusion following successful thrombolysis in acute myocardial infarctionAmerican Journal of Cardiology.  69:1120-1127. 1992
    1983 Platelet function abnormalities in response to arachidonic acid in the acute phase of myocardial infarctionAmerican Journal of Cardiology.  52:965-968. 1983
    1983 The financial pain of chest discomfort.The Alabama journal of medical sciences.  20:171-173. 1983
    1981 Comparison of electrophysiologic and antiarrhythmic effects of intravenous versus oral quinidineClinical research.  29. 1981
    1981 Electrophysiologic properties of intravenous quinidine in manClinical research.  29. 1981
    1981 Serial platelet responsiveness to arachidonic acid in acute myocardial infarctionClinical research.  29. 1981

    Research Overview

  • Emerging technologies in catheter ablation of complex arrhythmias
    Improvement techniques for catheter ablation in complex arrhythmias
    Stroke prevention in atrial fibrillation
  • Education And Training

  • Georgia Health Sciences University, Residency
  • Georgia Regents University, Postdoctoral Fellowship
  • University of Alabama - Birmingham, Postdoctoral Fellowship
  • Doctor of Medicine, Medical College of Georgia 2004
  • Full Name

  • William Maddox