Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Selective Response to Bacterial Infection by Regulating Siglec-E ExpressioniScience.  23. 2020
2020 Fibrinogen alpha chain knockout promotes tumor growth and metastasis through integrin-akt signaling pathway in lung cancer 2020
2020 A CD24-p53 axis contributes to African American prostate cancer disparities 2020
2019 MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancerOncogene.  38:4820-4834. 2019
2019 Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c-MycCancer Research.  79:1413-1425. 2019
2018 Bioprocess development of antibody-drug conjugate production for cancer treatmentPLoS ONE.  13. 2018
2018 FOXP3 activates SUMO-conjugating UBC9 gene in MCF7 breast cancer cellsInternational Journal of Molecular Sciences.  19. 2018
2018 Integrated oncogenomic profiling of copy numbers and gene expression in lung adenocarcinomas without EGFR mutations or ALK fusionJournal of Cancer.  9:1096-1105. 2018
2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancerBreast Cancer Research.  19. 2017
2017 CD24 is a genetic modifier for risk and progression of prostate cancerMolecular Carcinogenesis.  56:641-650. 2017
2017 MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancerOncotarget.  8:41451-41464. 2017
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in miceCardiovascular Research.  112:532-542. 2016
2016 Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.Cardiovascular Research.  112:532-542. 2016
2016 Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cellsOncotarget.  7:28935-28946. 2016
2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cellsClinical Cancer Research.  22:2545-2554. 2016
2016 CD24 genetic variants contribute to overall survival in patients with gastric cancerWorld Journal of Gastroenterology.  22:2373-2382. 2016
2016 The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylationJournal of Cellular Biochemistry.  117:426-438. 2016
2015 FOXP3 controls an MIR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cellsCancer Research.  75:1703-1713. 2015
2015 FOXP3-MIR-146-NF-κB axis and therapy for precancerous lesions in prostateCancer Research.  75:1714-1724. 2015
2015 Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivationNature Communications.  6. 2015
2015 FOXP3-microRNA-146-NF-κB as oncotargetOncoscience.  2:839-840. 2015
2015 SEMA6D expression and patient survival in breast invasive carcinomaInternational Journal of Breast Cancer.  2015. 2015
2014 SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cellsInternational Journal of Molecular Sciences.  15:10233-10251. 2014
2014 The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell line 2014
2013 Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1International Journal of Molecular Sciences.  14:22331-22345. 2013
2013 IPEX Syndrome, FOXP3 and Cancer.J Syndr.  1. 2013
2013 FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1Cancer Research.  73:2170-2180. 2013
2013 SUMOylation of ATF3 alters its transcriptional activity on regulation of TP53 geneJournal of Cellular Biochemistry.  114:589-598. 2013
2012 Inactivation of X-linked tumor suppressor genes in human cancerFuture Oncology.  8:463-481. 2012
2012 A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosisAmerican Journal of Translational Research.  4:347-356. 2012
2011 FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1Molecular Cell.  44:770-784. 2011
2011 Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancersCancer Research.  71:2162-2171. 2011
2010 Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 geneJournal of Clinical Immunology.  30:855-860. 2010
2010 Signalling through FOXP3 as an X-linked tumor suppressor 2010
2010 Synergistic activation of the Mc2r promoter by FOXL2 and NR5A1 in miceBiology of Reproduction.  83:842-851. 2010
2010 X-linked tumor suppressors: Perplexing inheritance, a unique therapeutic opportunityTrends in Genetics.  26:260-265. 2010
2009 CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infectionHepatology.  50:735-742. 2009
2009 Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the ProstateCancer Cell.  16:336-346. 2009
2009 Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition 2009
2009 F0XP3 Up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locusCancer Research.  69:2252-2259. 2009
2008 Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3β-dependent mechanismsMolecular and Cellular Biology.  28:7236-7244. 2008
2007 FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2Journal of Clinical Investigation.  117:3765-3773. 2007
2007 FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 OncogeneCell.  129:1275-1286. 2007
2007 A dinucleotide deletion in CD24 confers protection against autoimmune diseasesPLoS Genetics.  3:0508-0517. 2007
2006 Impact of IGF-I and CYP19 gene polymorphisms on the survival of patients with metastatic prostate cancerJournal of Clinical Oncology.  24:1982-1989. 2006
2005 An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancerBiochemical and Biophysical Research Communications.  331:958-963. 2005
2005 CA repeat polymorphism in the insulin-like growth factor-I gene is associated with increased risk of prostate cancer and benign prostatic hyperplasia.International Journal of Oncology.  26:225-231. 2005
2004 Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: Implication for prostate cancer riskProstate Cancer and Prostatic Diseases.  7:333-337. 2004
2004 Clinical characteristics of normotensive renal transplant recipients with microalbuminuria and effects of angiotensin II type I receptor antagonist on urinary albumin excretionInternational Journal of Urology.  11:585-591. 2004
2004 Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancerUrology.  64:74-78. 2004
2004 Increased risk of prostate cancer and benign prostatic hyperplasia associated with transforming growth factor-beta 1 gene polymorphism at codon10Carcinogenesis.  25:237-240. 2004
2004 Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant 2004
2003 Polymorphisms in prostate-specific antigen (PSA) gene, risk of prostate cancer, and serum PSA levels in Japanese populationCancer Letters.  202:53-59. 2003
2002 Single nucleotide polymorphisms in the 3′ untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinomaTohoku Journal of Experimental Medicine.  198:181-190. 2002
2002 Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancerCarcinogenesis.  23:257-264. 2002

Education And Training

  • Doctor of Science in Urology Residency Program, Akita University 2002
  • Full Name

  • Lizhong Wang