• Dr. Matthews is an infectious disease trained clinician-scientist funded by NIMH and NICHD since 2011 to develop and test interventions that reduce HIV in the context of sexual and reproductive health for men and women in Uganda and South Africa. She has worked in South Africa and Uganda since 2007 and 2010, respectively. She started in a new role as an Associate Professor at the University of Alabama at Birmingham in 2019 where she has since expanded the scope of her research to address PrEP for Black adolescent girls and young women, HIV testing, and SARS-CoV2 in Alabama.

    She directs global health research for the UAB Division of Infectious Diseases and serves as Associate Director for Global Health Research and Partnerships for the UAB School of Medicine.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 A Multicomponent Intervention to Train and Support Family Medicine Providers to Promote Pre-exposure Prophylaxis (PrEP) for Adolescent Girls and Young Women in the Deep South: Protocol for the PrEP-Pro Study.JMIR Research Protocols.  12:e44908. 2023
    2023 Geospatial analysis of time to HIV diagnosis and adult HIV testing coverage highlights areas for intervention in the U.S. SoutheastOpen Forum Infectious Diseases2023
    2023 Evaluating the Feasibility, Acceptability, and Preliminary Efficacy of SupportMoms-Uganda, an mHealth-Based Patient-Centered Social Support Intervention to Improve the Use of Maternity Services Among Pregnant Women in Rural Southwestern Uganda: Randomized Controlled Trial.JMIR Formative Research.  7:e36619. 2023
    2023 High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort studyPLoS Medicine.  20. 2023
    2023 Using publicly available data to identify priority communities for a SARS-CoV-2 testing intervention in a southern U.S. state. 2023
    2023 Factors Associated With Changes in Alcohol Use During Pregnancy and the Postpartum Transition Among People With HIV in South Africa and Uganda.Journal of the International Association of Providers of AIDS Care.  22:23259582231161029. 2023
    2023 ‘I still desire to have a child’: a qualitative analysis of intersectional HIV- and childlessness-related stigma in rural southwestern UgandaCulture, Health and Sexuality.  25:143-158. 2023
    2022 Sexual and Relationship Benefits of a Safer Conception Intervention Among Men with HIV Who Seek to Have Children with Serodifferent Partners in UgandaAIDS and Behavior.  26:1841-1852. 2022
    2022 Demonstration and Acceptability of a Safer Conception Intervention for Men With HIV in South Africa: Pilot Cohort StudyJMIR Formative Research.  6. 2022
    2022 A qualitative exploration to understand barriers and facilitators to daily oral PrEP uptake and sustained adherence among HIV-negative women planning for or with pregnancy in rural Southwestern UgandaJournal of the International AIDS Society.  25. 2022
    2022 Acceptability of an Intervention to Promote Viral Suppression and Serostatus Disclosure for Men Living with HIV in South Africa: Qualitative FindingsAIDS and Behavior.  26. 2022
    2022 Client and Provider Experiences in Uganda Suggest Demand for and Highlight the Importance of Addressing HIV Stigma and Gender Norms Within Safer Conception CareAIDS and Behavior.  26:76-87. 2022
    2022 PrEP Prescription for Black Adolescent Girls and Young Women in Alabama: Findings from a Survey of Healthcare ProvidersJournal of the International Association of Providers of AIDS Care.  21. 2022
    2022 Understanding the Effect of a Healthcare Provider-Led Family Planning Support Intervention on Contraception use and Pregnancy Desires among Postpartum Women Living with HIV in Southwestern UgandaAIDS and Behavior.  26:266-276. 2022
    2021 Overcoming Ethical Challenges to Engaging Men Who Have Sex with Women in HIV ResearchAIDS and Behavior.  25:4055-4060. 2021
    2021 mhealth-based health promotion intervention to improve use of maternity care services among women in rural southwestern uganda: Iterative development studyJMIR Formative Research.  5. 2021
    2021 Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cARTInternational Journal of Obesity.  45:1855-1859. 2021
    2021 The Other U = U: Untested and Untreated Genital Tract Inflammation in People Living with and Exposed to Human Immunodeficiency VirusJournal of Infectious Diseases.  224:1-4. 2021
    2021 Changes in Immune Activation during Pregnancy and the Postpartum Period in Treated HIV InfectionOpen Forum Infectious Diseases.  8. 2021
    2021 "It really proves to us that we are still valuable": Qualitative research to inform a safer conception intervention for men living with HIV in South AfricaPLoS One.  16. 2021
    2021 Exploring adults as support persons for improved pre-exposure prophylaxis for HIV use among select adolescents and young adults in the Deep SouthPLoS One.  16. 2021
    2021 STI prevalence among men living with HIV engaged in safer conception care in rural, southwestern UgandaPLoS One.  16. 2021
    2021 Structured and Sustained Family Planning Support facilitates Effective Use of Postpartum Contraception amongst Women Living with Hiv in South Western uganda: A Randomized Controlled TrialJournal of Global Health.  11:1-14. 2021
    2021 “I did not plan … that is what hurts”: Pregnancy intentions and contraceptive use among pregnant young women in KwaZulu-Natal, South AfricaAfrican Journal of AIDS Research.  20:149-157. 2021
    2020 Adherence to HIV antiretroviral therapy among pregnant and postpartum women during the Option B+ era: 12-month cohort study in urban South Africa and rural UgandaJournal of the International AIDS Society.  23. 2020
    2020 Defining gaps in pre-exposure prophylaxis delivery for pregnant and post-partum women in high-burden settings using an implementation science frameworkLancet HIV.  7:e582-e592. 2020
    2020 Sexually Transmitted Infection Prevalence among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern UgandaSexually Transmitted Diseases.  47:E24-E28. 2020
    2020 Partner notification and treatment outcomes among South African adolescents and young adults diagnosed with a sexually transmitted infection via laboratory-based screeningInternational Journal of STD and AIDS.  31:627-636. 2020
    2020 Sexual Relationship Power and Periconception HIV-Risk Behavior Among HIV-Infected Men in Serodifferent RelationshipsAIDS and Behavior.  24:881-890. 2020
    2020 Protocol for a prospective evaluation of postpartum engagement in HIV care among women living with HIV in South AfricaBMJ Open.  10. 2020
    2020 Emerging evidence from a systematic review of safety of pre-exposure prophylaxis for pregnant and postpartum women: where are we now and where are we heading?Journal of the International AIDS Society.  23. 2020
    2020 When women deliver at home without a skilled birth attendant: A qualitative study on the role of health care systems in the increasing home births among rural women in southwestern ugandaInternational Journal of Women's Health.  12:423-434. 2020
    2020 Women's Choice to Deliver at Home: Understanding the Psychosocial and Cultural Factors Influencing Birthing Choices for Unskilled Home Delivery among Women in Southwestern UgandaJournal of Pregnancy.  2020. 2020
    2019 High Rates of Biomarker-Confirmed Alcohol Use among Pregnant Women Living with HIV in South Africa and Uganda 2019
    2019 A scoping review of interventions to address intimate partner violence in sub-Saharan African healthcareGlobal Public Health.  14:1335-1346. 2019
    2019 Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results from the META Longitudinal Cohort StudyJournal of Infectious Diseases.  220:1172-1177. 2019
    2019 High Incidence of Intended Partner Pregnancy Among Men Living With HIV in Rural Uganda: Implications for Safer Conception Services 2019
    2019 Protocol for a longitudinal study to evaluate the use of tenofovir-based PrEP for safer conception and pregnancy among women in South AfricaBMJ Open.  9:e027227. 2019
    2019 Calibration of ALMA as a Phased Array. ALMA Observations During the 2017 VLBI CampaignPublications of the Astronomical Society of the Pacific.  131. 2019
    2019 Safer conception care to eliminate transmission of HIVLancet HIV.  6:e413-e414. 2019
    2019 Biomarker-Measured Unhealthy Alcohol Use in Relation to CD4 Count Among Individuals Starting ART in Sub-Saharan AfricaAIDS and Behavior.  23:1656-1667. 2019
    2019 Factors Associated with Pregnancy Intentions Amongst Postpartum Women Living with HIV in Rural Southwestern UgandaAIDS and Behavior.  23:1552-1560. 2019
    2019 Provision of family planning vouchers and early initiation of postpartum contraceptive use among women living with HIV in southwestern Uganda: A randomized controlled trialPLoS Medicine.  16. 2019
    2019 ART adherence and viral suppression are high among most non-pregnant individuals with early-stage, asymptomatic HIV infection: an observational study from Uganda and South AfricaJournal of the International AIDS Society.  22. 2019
    2018 Contraceptive use following unintended pregnancy among Ugandan women living with HIVPLoS One.  13. 2018
    2018 HIV Prevention Among Young Women in South Africa: Understanding Multiple Layers of Risk 2018
    2018 Prevalence and correlates of physical and sexual intimate partner violence among women living with HIV in UgandaPLoS One.  13. 2018
    2018 Consensus statement: Supporting Safer Conception and Pregnancy For Men And Women Living with and Affected by HIVAIDS and Behavior.  22:1713-1724. 2018
    2018 Developing a Safer Conception Intervention for Men Living with HIV in South AfricaAIDS and Behavior.  22:1725-1735. 2018
    2018 Healthcare providers’ understanding of HIV serodiscordance in South Africa and Uganda: implications for HIV prevention in sub-Saharan AfricaAfrican Journal of AIDS Research.  17:137-144. 2018
    2018 "i beg you...breastfeed the baby, things changed": Infant feeding experiences among Ugandan mothers living with HIV in the context of evolving guidelines to prevent postnatal transmissionBMC Public Health.  18. 2018
    2017 Beyond HIV-serodiscordance: Partnership communication dynamics that affect engagement in safer conception carePLoS One.  12. 2017
    2017 Program Implementation of Option B+ at a President's Emergency Plan for AIDS Relief-Supported HIV Clinic Improves Clinical Indicators but Not Retention in Care in Mbarara, Uganda 2017
    2017 The Role of Relationship Dynamics and Gender Inequalities As Barriers to HIV-Serostatus Disclosure: Qualitative Study among Women and Men Living with HIV in Durban, South AfricaFrontiers in Public Health.  5. 2017
    2017 Understanding coping strategies during pregnancy and the postpartum period: A qualitative study of women living with HIV in rural UgandaBMC Pregnancy and Childbirth.  17. 2017
    2017 Psychosocial challenges facing women living with HIV during the perinatal period in rural UgandaPLoS One.  12. 2017
    2017 Supporting HIV prevention and reproductive goals in an HIV-endemic setting: Taking safer conception services from policy to practice in South AfricaJournal of the International AIDS Society.  20:36-42. 2017
    2017 HIV-affected couples and individuals who desire children should be offered options for safer conceptionJournal of the International AIDS Society.  20. 2017
    2017 Magnetic resonance elastography shear wave velocity correlates with liver fibrosis and hepatic venous pressure gradient in adults with advanced liver diseaseBioMed Research International.  2017. 2017
    2016 Simtuzumab treatment of advanced liver fibrosis in HIV and HCV-infected adults: results of a 6-month open-label safety trialLiver International.  36:1783-1792. 2016
    2016 Promises and pitfalls of data sharing in qualitative researchSocial Science and Medicine.  169:191-198. 2016
    2016 The Association Between Post-traumatic Stress Disorder and Markers of Inflammation and Immune Activation in HIV-Infected Individuals With Controlled ViremiaPsychosomatics.  57:423-430. 2016
    2016 PrEP as Peri-conception HIV Prevention for Women and MenCurrent HIV/AIDS Reports.  13:131-139. 2016
    2016 "i always worry about what might happen ahead": Implementing safer conception services in the current environment of reproductive counseling for HIV-affected men and women in UgandaBioMed Research International.  2016. 2016
    2016 HIV-infected ugandan women on antiretroviral therapy maintain HIV-1 RNA suppression across periconception, pregnancy, and postpartum periods 2016
    2015 Periconception HIV Risk Behavior Among Men and Women Reporting HIV-Serodiscordant Partners in KwaZulu-Natal, South AfricaAIDS and Behavior.  19:2291-2303. 2015
    2015 Safer conception strategies for HIV-serodiscordant couples: How safe is safe enough?Journal of Infectious Diseases.  212:1525-1528. 2015
    2015 Pioglitazone for Hepatic Steatosis in HIV/Hepatitis C Virus CoinfectionAIDS Research and Human Retroviruses.  31:961-966. 2015
    2015 “If I don’t use a condom … I would be stressed in my heart that I’ve done something wrong”: Routine Prevention Messages Preclude Safer Conception Counseling for HIV-Infected Men and Women in South AfricaAIDS and Behavior.  19:1666-1675. 2015
    2015 The influence of partnership on contraceptive use among HIV-infected women accessing antiretroviral therapy in rural UgandaContraception.  92:152-159. 2015
    2015 Inkwari: An Emerging High-Risk Place Potentiating HIV Spread Among Young Adults in a Hyper-Endemic South African Setting 2015
    2014 Depression during pregnancy and the postpartum among HIV-infected women on antiretroviral therapy in Uganda 2014
    2014 Lost opportunities to reduce periconception HIV transmission: Safer conception counseling by South African providers addresses perinatal but not sexual HIV transmission 2014
    2014 High medication adherence during periconception periods among HIV-1-uninfected women participating in a clinical trial of antiretroviral pre-exposure prophylaxis 2014
    2014 South Africans with recent pregnancy rarely know partner's HIV serostatus: Implications for serodiscordant couples interventionsBMC Public Health.  14. 2014
    2014 Pregnancy incidence and outcomes among women receiving preexposure prophylaxis for HIV prevention: A randomized clinical trialJournal of the American Medical Association.  312:362-371. 2014
    2014 Antiretroviral Therapy Helps HIV-Positive Women Navigate Social Expectations for and Clinical Recommendations against Childbearing in UgandaAIDS Research and Treatment.  2014. 2014
    2014 Whoonga: Potential recreational use of HIV antiretroviral medication in South AfricaAIDS and Behavior.  18:511-518. 2014
    2013 Reliability and validity of instruments for assessing perinatal depression in African settings: Systematic review and meta-analysisPLoS One.  8. 2013
    2013 HIV-infected women on antiretroviral treatment have increased mortality during pregnant and postpartum periodsAIDS.  27. 2013
    2013 Correction: Incidence and predictors of pregnancy among a cohort of HIV-positive women initiating antiretroviral therapy in Mbarara, Uganda (PLoS ONE)PLoS One.  8. 2013
    2013 Incidence and Predictors of Pregnancy among a Cohort of HIV-Positive Women Initiating Antiretroviral Therapy in Mbarara, UgandaPLoS One.  8. 2013
    2013 Women with Pregnancies Had Lower Adherence to 1% Tenofovir Vaginal Gel as HIV Preexposure Prophylaxis in CAPRISA 004, a Phase IIB Randomized-Controlled TrialPLoS One.  8. 2013
    2013 Dissemination of Research Findings to Research Participants Living with HIV in Rural Uganda: Challenges and RewardsPLoS Medicine.  10. 2013
    2013 Reproductive decision-making and periconception practices among HIV-positive men and women attending HIV services in Durban, South AfricaAIDS and Behavior.  17:461-470. 2013
    2013 Erratum: Antiretrovirals and safer conception for HIV-serodiscordant couples (Current Opinion in HIV and AIDS (2012) 7 (569-578)Current Opinion in HIV and AIDS.  8:86. 2013
    2012 A conceptual framework for understanding HIV risk behavior in the context of supporting fertility goals among HIV-serodiscordant couplesReproductive Health Matters.  20:50-60. 2012
    2012 Antiretrovirals and safer conception for HIV-serodiscordant couplesCurrent Opinion in HIV and AIDS.  7:569-578. 2012
    2012 Contraceptive use and associated factors among women enrolling into HIV care in southwestern UgandaInfectious Diseases in Obstetrics and Gynecology.  2012. 2012
    2012 Reproductive counseling by clinic healthcare workers in Durban, South Africa: Perspectives from HIV-infected men and women reporting serodiscordant partnersInfectious Diseases in Obstetrics and Gynecology.  2012. 2012
    2011 Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infantsBMC Pediatrics.  11. 2011
    2011 A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapyPLoS One.  6. 2011
    2010 Periconception pre-exposure prophylaxis to prevent HIV transmission: Benefits, risks, and challenges to implementationAIDS.  24:1975-1982. 2010
    2010 Outcomes after virologic failure of first-line ART in South AfricaAIDS.  24:1007-1012. 2010
    2009 Strategies for harm reduction among HIV-affected couples who want to conceiveAIDS and Behavior.  13. 2009
    2006 Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: Effects of highly active antiretroviral therapy provide insights into the mechanisms of naïve T-cell depletionJournal of Virology.  80:2665-2674. 2006
    2004 BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitroClinical Immunology.  113:248-255. 2004

    Research Overview

  • HIV prevention
    HIV treatment
    PrEP implementation
    Safer conception
    Reproductive health
    Global health
    Qualitative methods
    Mixed methods
    Implementation science
  • Principal Investigator On

  • Adherence to Periconception HIV Risk-Reduction Among HIV-Exposed Uninfected Women in Rural Uganda  awarded by Duke (Doris) Charitable Foundation
  • Falling off the HIV Treatment Cascade Cliff: Understanding Postpartum Attrition to HIV Care  awarded by MASSACHUSETTS GENERAL HOSPITAL
  • PrEP Pro: Adapting A Multi-Component Intervention to Train and Support Providers to Promote PrEP for Adolescent Girls and Young Women in the Deep South  awarded by National Institute of Mental Health/NIH/DHHS
  • PrEP Uptake/Adherence to Reduce Periconception HIV Risk for South African Women  awarded by National Institute of Mental Health/NIH/DHHS
  • PrEP Use During Periconception and Pregnancy Among Uninfected Women in Rural Uganda-Data Sharing  awarded by Duke (Doris) Charitable Foundation
  • Private Grant  awarded by Gilead Sciences ^
  • Private Grant  awarded by Gilead Sciences ^
  • UAB Center for AIDS Research (CFAR) - Mobile Testing to Increase HIV-testing Uptake in Rural Alabama: A Pilot Implementation Project (MOBILISE)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - CFAR Administrative Supplement - Promoting PrEP use among African-American AGYW in the Deep South at-risk for HIV: Provider and Client Perspectives  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - Exploring how intersectional stigmas among MWH in Uganda contribute to poor HIV outcomes for men and HIV incidence among women of reproductive age  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - Using Big Data to Estimate Undiagnosed HIV Infection and Inform Testing Interventions in Alabama  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Investigator On

  • A Type 2 Hybrid Effectiveness-Implementation Trial to Evaluate a Population Health Combination Intervention to Meet HIV Testing, Linkage, and Viral Suppression Goals in Coastal Alabama  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • CAMELLIA Cohort: A Longitudinal Study to Understand Sexual Health and Prevention Among Women in Alabama  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Center For AIDS Research - Implementation of HIV testing and linkage to PrEP at an HBCU in Alabama  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Effectiveness of a Smoking Cessation Algorithm Integrated into HIV Primary Care  awarded by National Institute on Drug Abuse/NIH/DHHS
  • Integration of Trusted Adult Supports into the Health MPowerment App to Improve Black Adolescent and Young Adult PrEP Use  awarded by National Institute of Mental Health/NIH/DHHS
  • PrEP 4 Her: Developing a Novel Strategy to Implement PrEP into Women's Healthcare  awarded by National Institute of Mental Health/NIH/DHHS
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research (CFAR) - A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Center for AIDS Research - Evaluating the Implementation of Sexual Health Education and STI/HIV Testing for Adolescents at a Community Based Center in Alabama  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Education And Training

  • Master of Public Health in Health Professions and Related Clinical Sciences, Harvard University 2011
  • Doctor of Medicine, Miami University 2004
  • Full Name

  • Lynn Matthews