• Dr. Lalita Shevde-Samant is Professor in the Department of Pathology and and the Associate Director of Cancer Research Training and Education Coordination (CRTEC) at the O’Neal Comprehensive Cancer at UAB.

    Following a Ph.D. in Cancer Immunology at the Cancer Research Institute, University of Bombay (India), Dr. Shevde-Samant completed her postdoctoral training in the area of cancer metastasis at the Hershey Medical Center, Penn State University. She was on the faculty at the University of South Alabama before being recruited to UAB in the Department of Pathology in 2012.

    Research Program leadership: Since 2004, her lab has been continuously funded to interrogate dynamics of interactions between breast tumor cells and their microenvironment. Investigations led by her group have uncovered a novel role of Hedgehog signaling in regulating tumor cell resistance to chemotherapeutics and the tumor microclimate; more recently having identified that Hedgehog activity sculpts the immune portfolio of breast tumors. She has a well-documented record of accomplishments, with 108 peer-reviewed research publications and book chapters. These discoveries have been enabled with intramural support and extramural funding from the NCI and the Department of Defense.

    Leadership in Cancer Research Training, Education, and Career Enhancement: Dr. Shevde-Samant is the Associate Director of O’Neal Cancer Research Training and Education Coordination (CRTEC) at the O’Neal Comprehensive Cancer at UAB. This role leverages her experience (14+ years) in the leadership of the Cancer Biology Ph.D. program at two institutions. She continues to serve in this capacity, while also playing an important role in the curriculum management and admissions process. She has trained and provided mentorship at all levels – undergraduate students, graduate students, MD, PhD students, postdoctoral fellows, clinical fellows, and early-stage investigators. Her trainees honored her with the UAB Graduate Dean’s mentoring Award. Dr. Shevde-Samant is the MPI of the NCI R25 YES Grant “Roadmap for America’s Cancer Explorers for the 21st Century (RACE21)” to build an innovative and effective pipeline to cancer research careers, especially for students underrepresented in cancer research.
    Dr. Shevde-Samant is an elected Board member of Cancer Biology Training Consortium (CABTRAC), the national consortium that interfaces with institutions in the United States and the NCI’s Cancer Training Branch to develop innovative and multidisciplinary training mechanisms needed to produce the highest quality cancer scientists. This underscores national recognition of her leadership in cancer education and training and positioning her to engage in discussions with the NCI and other Cancer Centers .
    In 2011 Dr. Shevde-Samant initiated an organized development of a program in the Metastasis Research Society (MRS) to train and mentor the next generation of metastasis investigators. This legacy continues even 10 years after the establishment of the Early Career Ambassadors of Metastasis Research (ECAM) program and fills a much-needed gap to foster the development of young investigators in the area of metastasis research.

    Importantly, Dr. Shevde-Samant is dedicated to education and career development of diverse trainees and junior faculty. She enjoys mentoring trainees and junior faculty. She is of the opinion that broadening an inclusive scientific workforce is essential to successful interdisciplinary research.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2023 A Biomimetic Hyaluronic Acid Hydrogel Models Mass Dormancy in Brain Metastatic Breast Cancer Spheroids 2023
    2022 Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinoma.Laboratory Investigation.  102:1236-1244. 2022
    2022 Hedgehog blockade remodels the gut microbiota and the intestinal effector CD8+ T cells in a mouse model of mammary carcinomaLaboratory Investigation.  102:1236-1244. 2022
    2022 Ribosome Biogenesis: A Central Player in Cancer Metastasis and Therapeutic ResistanceCancer Research.  82:2344-2353. 2022
    2022 Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor LandscapeMolecular Cancer Research.  20:150-160. 2022
    2021 Hedgehog signaling regulates metabolism and polarization of mammary tumor-associated macrophagesCancer Research.  81:5425-5437. 2021
    2021 Novel role of the dietary flavonoid fisetin in suppressing rRNA biogenesisLaboratory Investigation.  101:1439-1448. 2021
    2021 Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seedingCancer Letters.  517:24-34. 2021
    2021 Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumorsOncogenesis.  10. 2021
    2021 Informing the new developments and future of cancer immunotherapy: Future of cancer immunotherapyCancer and Metastasis Reviews.  40:549-562. 2021
    2021 Merlin deficiency alters the redox management program in breast cancerMolecular Oncology.  15:942-956. 2021
    2021 Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancerCell Death and Disease.  12. 2021
    2021 Hypoxia re-programs 2′-O-Me modifications on ribosomal RNAiScience.  24. 2021
    2020 Hedgehog signaling enables repair of ribosomal DNA double-strand breaksNucleic Acids Research.  48:10342-10352. 2020
    2020 Merlin regulates signaling events at the nexus of development and cancerCell Communication and Signaling.  18. 2020
    2020 An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cellsActa Biomaterialia.  107:65-77. 2020
    2020 An emerging regulatory role for the tumor microenvironment in the DNA damage response to double-strand breaksMolecular Cancer Research.  18:185-193. 2020
    2019 The tumor microenvironment innately modulates cancer progressionCancer Research.  79:4557-4567. 2019
    2019 Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancerOncoImmunology.  8. 2019
    2019 O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activityLaboratory Investigation.  99:260-270. 2019
    2018 Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancerCarcinogenesis.  39:1165-1175. 2018
    2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumorsOncogene.  37:1610-1623. 2018
    2017 Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasisInternational Journal of Cancer.  141:1091-1109. 2017
    2017 BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cellsOncotarget.  8:8670-8678. 2017
    2017 Genomic regulation of invasion by STAT3 in triple negative breast cancerOncotarget.  8:8226-8238. 2017
    2016 Tamoxifen induces cytotoxic autophagy in glioblastomaJournal of Neuropathology and Experimental Neurology.  75:946-954. 2016
    2016 Emerging roles and underlying molecular mechanisms of DNAJB6 in cancerOncotarget.  7:53984-53996. 2016
    2016 Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancerBioorganic and Medicinal Chemistry Letters.  26:1237-1244. 2016
    2016 Erratum to: 'Hedgehog signaling: Modulation of cancer properties and tumor microenvironment' [Hanna and Shevde Molecular Cancer (2016) 15:35] DOI: 10.1186/s12943-016-0522-6Molecular Cancer.  15. 2016
    2016 Hedgehog signaling: Modulation of cancer properies and tumor mircroenvironmentMolecular Cancer.  15. 2016
    2016 Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancerOncotarget.  7:17991-18005. 2016
    2015 The impact of hedgehog signaling pathway on DNA repair mechanisms in human cancerCancers.  7:1333-1348. 2015
    2014 MicroRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancerMolecular Cancer.  13. 2014
    2014 Nonclassical HEDGEHOG-GLI signaling and its clinical implicationsInternational Journal of Cancer.  135:1-6. 2014
    2014 Role of osteopontin in the pathophysiology of cancerMatrix Biology.  37:131-141. 2014
    2014 Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signalingOncogene.  33:2620-2628. 2014
    2014 GLI1 upregulates C-JUN through a specific 130-kDa isoform.International Journal of Oncology.  44:655-661. 2014
    2014 GLI1 upregulates C-JUN through a specific 130-kDa isoformInternational Journal of Oncology.  44:655-661. 2014
    2014 NMI and EMTOncoscience.  1:476-477. 2014
    2013 Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to smoothened-targeting Hedgehog inhibitionJournal of Biological Chemistry.  288:11824-11833. 2013
    2012 CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell properties and correlate to survivalClinical and Experimental Metastasis.  29:939-948. 2012
    2012 Merlin: The wizard requires protein stability to function as a tumor suppressor 2012
    2012 Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAsOncogene.  31:4979-4986. 2012
    2012 Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repairOncogene.  31:4718-4724. 2012
    2012 DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontinOncogene.  31:4472-4483. 2012
    2012 Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistanceFEBS Letters.  586:3429-3434. 2012
    2012 Micro-RNA-632 downregulates DNAJB6 in breast cancerLaboratory Investigation.  92:1310-1317. 2012
    2012 Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61Oncogene.  31:3370-3380. 2012
    2012 DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activityBiochemical Journal.  444:573-580. 2012
    2012 Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJExperimental Cell Research.  318:1086-1093. 2012
    2012 Dickkopf1: A tumor suppressor or metastasis promoter?International Journal of Cancer.  130:1477-1483. 2012
    2012 Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastasesPLoS One.  7. 2012
    2012 Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cellsGynecologic Oncology.  124:598-605. 2012
    2012 CD44+/CD24- ovarian cancer cells demonstrate cancer stem cell-like properties and correlate to survival.Clinical and Experimental Metastasis.  28:400-406. 2012
    2012 The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer.International Journal of Breast Cancer.  2012:298623. 2012
    2012 The influence of the cancer microenvironment on the process of metastasis.International Journal of Breast Cancer.  2012:756257. 2012
    2011 Loss of tumor suppressor merlin in advanced breast cancer is due to post-translational regulationJournal of Biological Chemistry.  286:40376-40385. 2011
    2011 Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cellsInternational Journal of Oncology.  39:797-804. 2011
    2011 Hedgehog signaling: Networking to nurture a promalignant tumor microenvironmentMolecular Cancer Research.  9:1165-1174. 2011
    2011 Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysisJournal of Biological Chemistry.  286:9612-9622. 2011
    2011 Recent advances in anti-angiogenic therapy of cancerOncotarget.  2:122-134. 2011
    2010 Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancerMolecular Cancer.  9. 2010
    2010 DNAJB6 induces degradation of β-catenin and causes partial reversal of mesenchymal phenotypeJournal of Biological Chemistry.  285:24686-24694. 2010
    2010 Functional characterization of the progestagen-associated endometrial protein gene in human melanomaJournal of Cellular and Molecular Medicine.  14:1432-1442. 2010
    2010 Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontinJournal of Cellular and Molecular Medicine.  14:1693-1706. 2010
    2010 Osteopontin: An effector and an effect of tumor metastasisCurrent Molecular Medicine.  10:71-81. 2010
    2010 Elevated osteopontin levels in metastatic melanoma correlate with epigenetic silencing of breast cancer metastasis suppressor 1 2010
    2009 Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanomaClinical and Experimental Metastasis.  26:739-749. 2009
    2009 The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontinJournal of Biological Chemistry.  284:22888-22897. 2009
    2009 Multi-faceted role of HSP40 in cancerClinical and Experimental Metastasis.  26:559-567. 2009
    2009 Nmi (N-Myc interactor) inhibits Wnt/β-catenin signaling and retards tumor growthInternational Journal of Cancer.  125:556-564. 2009
    2009 Current concepts in biobanking: Development and implementation of a tissue repository 2009
    2009 Microparticles/Exosomes: Isolation and TEM AnalysisMicroscopy Today.  17:42-45. 2009
    2009 Emerging role of nuclear protein 1 (NUPR1) in cancer biologyCancer and Metastasis Reviews.  28:225-232. 2009
    2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancerClinical and Experimental Metastasis.  25:753-763. 2008
    2008 Lung endothelial cells express ALCAM on released exosomes/microparticlesMicroscopy and Microanalysis.  14:1520-1521. 2008
    2008 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stressCurrent Cancer Drug Targets.  8:421-430. 2008
    2008 Quantum dots - Utilization in TEMMicroscopy and Microanalysis.  14:702-703. 2008
    2008 The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.BMC Medical Genomics.  1:13. 2008
    2008 Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer 2008
    2008 Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancerBreast Cancer Research.  10. 2008
    2008 Global comparative gene expression analysis of melanoma patient samples, derived cell lines and corresponding tumor xenograftsCancer Genomics and Proteomics.  5:1-35. 2008
    2007 Rac1 activity regulates proliferation of aggressive metastatic melanomaExperimental Cell Research.  313:3832-3839. 2007
    2007 Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancerJournal of Proteome Research.  6:2993-3002. 2007
    2007 Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activationMolecular Cancer.  6. 2007
    2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperoneBiochemical and Biophysical Research Communications.  348:1429-1435. 2006
    2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1)Cancer Letters.  235:260-265. 2006
    2006 Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435Clinical and Experimental Metastasis.  23:123-133. 2006
    2004 A small molecule antagonist of the αυβ 3 integrin suppresses MDA-MB-435 skeletal metastasisClinical and Experimental Metastasis.  21:119-128. 2004
    2004 Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses TranscriptionJournal of Biological Chemistry.  279:1562-1569. 2004
    2003 Metastasis suppressor pathways - An evolving paradigmCancer Letters.  198:1-20. 2003
    2002 Cu/Zn superoxide dismutase plays a role in angiogenesisInternational Journal of Cancer.  97:34-41. 2002
    2002 Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1).International Journal of Cancer.  97:15-20. 2002
    2002 Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1Experimental Cell Research.  273:229-239. 2002
    2001 Analysis of mechanisms underlying BRMS1 suppression of metastasisClinical and Experimental Metastasis.  18:683-693. 2001
    1999 Immune functions, clinical parameters and hormone receptor status in breast cancer patientsJournal of Cancer Research and Clinical Oncology.  125:313-320. 1999
    1998 Impaired T lymphocyte function and differential cytokine response pattern in members from cancer familiesNatural immunity.  16:146-156. 1998
    1998 Studies on functional status of circulating lymphocytes in unaffected members from cancer familiesHuman Immunology.  59:373-381. 1998
    1998 Natural killer cell function and genetic instability in unaffected individuals from breast cancer familiesEuropean Journal of Cancer Prevention.  7:141-148. 1998


    Year Title Altmetric
    2018 Hedgehog Signaling in Carcinogenesis.  297-304. 2018

    Teaching Activities

  • GBS746 - Special Topics (Fall Term 2014)
  • GBS747 - Special Topics (Spring Term 2017)
  • GBS769 - Carcinogenesis (Fall Term 2014)
  • GBS769 - Carcinogenesis (Spring Term 2016)
  • GBS769 - Carcinogenesis (Spring Term 2018)
  • GBS769 - Carcinogenesis (Spring Term 2019)
  • GBS769 - Carcinogenesis (Spring Term 2020)
  • GBS769 - Carcinogenesis (Spring Term 2021)
  • GBS769 - Carcinogenesis (Spring Term 2022)
  • GBS769 - Carcinogenesis (Spring Term 2023)
  • GBS777 - Cancer Biology Seminar (Fall Term 2014)
  • GBS777 - Cancer Biology Seminar (Fall Term 2015)
  • GBS777 - Cancer Biology Seminar (Fall Term 2016)
  • GBS777 - Cancer Biology Seminar (Fall Term 2017)
  • GBS777 - Cancer Biology Seminar (Fall Term 2018)
  • GBS777 - Cancer Biology Seminar (Fall Term 2019)
  • GBS777 - Cancer Biology Seminar (Fall Term 2020)
  • GBS777 - Cancer Biology Seminar (Fall Term 2021)
  • GBS777 - Cancer Biology Seminar (Fall Term 2022)
  • GBS777 - Cancer Biology Seminar (Spring Term 2015)
  • GBS777 - Cancer Biology Seminar (Spring Term 2016)
  • GBS777 - Cancer Biology Seminar (Spring Term 2017)
  • GBS777 - Cancer Biology Seminar (Spring Term 2018)
  • GBS777 - Cancer Biology Seminar (Spring Term 2019)
  • GBS777 - Cancer Biology Seminar (Spring Term 2020)
  • GBS777 - Cancer Biology Seminar (Spring Term 2021)
  • GBS777 - Cancer Biology Seminar (Spring Term 2022)
  • GBS777 - Cancer Biology Seminar (Spring Term 2023)
  • GBS787 - Special Topics (Spring Term 2017)
  • GBSC701 - Seminars (Fall Term 2015)
  • GBSC701 - Seminars (Fall Term 2016)
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018)
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019)
  • Education And Training

  • Doctor of Philosophy Level Degree in Biology, University of Mumbai 1999
  • Full Name

  • Lalita Samant