Selected Publications

Academic Article

Year Title Altmetric
2022 Red blood cell exosome hemoglobin content increases after cardiopulmonary bypass and mediates acute kidney injury in an animal modelJournal of Thoracic and Cardiovascular Surgery.  164:e289-e308. 2022
2022 IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patientClinical Immunology.  244. 2022
2022 Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral RegurgitationJACC: Basic to Translational Science.  7:973-981. 2022
2022 Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant HypertensionHypertension.  79:775-784. 2022
2022 Diastolic function: Modeling left ventricular untwisting as a damped harmonic oscillatorPhysiological Measurement.  43. 2022
2022 Plasma Exosome Hemoglobin Released During Surgery Is Associated With Cardiac Injury in Animal ModelAnnals of Thoracic Surgery2022
2020 Circulating and tissue biomarkers as predictors of bromine gas inhalationAnnals of the New York Academy of Sciences.  1480:104-115. 2020
2020 Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research PracticesHypertension.  76:1350-1367. 2020
2020 DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologiesHuman Molecular Genetics.  29:2855-2871. 2020
2020 Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic DysfunctionAntioxidants and Redox Signaling.  32:1293-1312. 2020
2020 Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral RegurgitationJACC: Basic to Translational Science.  5:109-122. 2020
2020 Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage CellsHypertension.  500-509. 2020
2019 Angiotensin-(1–12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogenInternational Journal of Cardiology.  297:104-110. 2019
2019 Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene TranscriptsFrontiers in Cardiovascular Medicine.  6. 2019
2019 Intracardiac administration of neutrophil protease cathepsin G activates noncanonical inflammasome pathway and promotes inflammation and pathological remodeling in non-injured heartJournal of Molecular and Cellular Cardiology.  134:29-39. 2019
2019 Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overloadVaccine Reports.  5. 2019
2019 Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertensionFree Radical Biology and Medicine.  134:343-349. 2019
2019 Bromine inhalation mimics ischemia-reperfusion Cardiomyocyte injury and Calpain activation in rats 2019
2019 Primary endothelial-specific regulation of hypoxiainducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia 2019
2018 AKT-independent activation of p38 MAP kinase promotes vascular calcificationRedox Biology.  16:97-103. 2018
2018 Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)American Journal of Cardiology.  121:1162-1168. 2018
2018 DASH score and subsequent risk of coronary artery disease: The findings from million veteran programJournal of the American Heart Association.  7. 2018
2018 Left ventricular torsion shear angle volume approach for noninvasive evaluation of diastolic dysfunction in preserved ejection fractionJournal of the American Heart Association.  7. 2018
2018 Multifunctional role of chymase in acute and chronic tissue injury and remodelingCirculation Research.  122:319-336. 2018
2017 Increased Inflammation in Pericardial Fluid Persists 48 Hours after Cardiac SurgeryCirculation.  136:2284-2286. 2017
2017 Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophyExperimental Gerontology.  99:98-109. 2017
2017 Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in miceNature Communications.  8. 2017
2017 Dietary potassium regulates vascular calcification and arterial stiffnessJCI Insight.  2. 2017
2017 Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant MiceHypertension.  70:390-400. 2017
2017 Impact of VA Research on Health Care for All: Contributions over Nine Decades and CountingCirculation Research.  121:16-18. 2017
2017 Novel paradigms of salt and hypertensionJournal of the American Society of Nephrology.  28:1362-1369. 2017
2017 Estimation of Left Ventricular Motion from Cardiac Gated Tagged MRI Using an Image-Matching Deformable Mesh ModelIEEE Transactions on Radiation and Plasma Medical Sciences.  1:147-157. 2017
2017 Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart DiseaseCurrent Hypertension Reports.  19. 2017
2017 A graph theoretic approach for computing 3D+time biventricular cardiac strain from tagged MRI dataMedical Image Analysis.  35:46-57. 2017
2017 Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure 2017
2016 Catheter-directed treatment for acute pulmonary embolism: Systematic review and single-arm meta-analysesInternational Journal of Cardiology.  225:128-139. 2016
2016 Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular functionJournal of Thoracic and Cardiovascular Surgery.  152:1059-1070.e2. 2016
2016 Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzymeBiochemical and Biophysical Research Communications.  478:559-564. 2016
2016 Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overloadJournal of Molecular and Cellular Cardiology.  92:1-9. 2016
2016 Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal AncestryCirculation: Cardiovascular Genetics.  9:26-36. 2016
2016 Impaired mitochondrial network excitability in failing Guinea-pig cardiomyocytesCardioscience.  109:79-89. 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signalingFrontiers in Bioscience-Landmark.  21:397-409. 2016
2015 Volume overload induces autophagic degradation of procollagen in cardiac fibroblastsJournal of Molecular and Cellular Cardiology.  89:241-250. 2015
2015 Left ventricular twist and shear in patients with primary mitral regurgitationJournal of Magnetic Resonance Imaging.  42:400-406. 2015
2015 Early exposure to hyperoxia or hypoxia adversely impacts cardiopulmonary developmentAmerican Journal of Respiratory Cell and Molecular Biology.  52:594-602. 2015
2015 Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary diseaseCirculation: Cardiovascular Imaging.  8. 2015
2015 Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophyJournal of Human Hypertension.  29:241-246. 2015
2015 Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload 2015
2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
2015 Decreased Bioenergetic Health Index in monocytes isolated from the pericardial fluid and blood of post-operative cardiac surgery patients 2015
2014 Left ventricular torsion shear angle volume analysis in patients with hypertension: A global approach for LV diastolic functionCritical Reviews in Computed Tomography.  16. 2014
2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats 2014
2014 Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculatureToxicology.  321:96-102. 2014
2014 Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dogPLoS One.  9. 2014
2014 An evolving story of angiotensin-II-forming pathways in rodents and humansClinical Science.  126:461-469. 2014
2014 Activation of AKT by O-linked N-Acetylglucosamine induces vascular calcification in diabetes mellitusCirculation Research.  114:1094-1102. 2014
2014 3D+time left ventricular strain by unwrapping harmonic phase with graph cutsLecture Notes in Artificial Intelligence.  8674 LNCS:578-585. 2014
2014 Angiotensin-(1-12): A chymase-mediated cellular angiotensin II substrateCurrent Hypertension Reports.  16. 2014
2014 Increased sarcolipin expression and adrenergic drive in humans with preserved left ventricular ejection fraction and chronic isolated mitral regurgitationCirculation: Heart Failure.  7:194-202. 2014
2014 The multiple mechanistic faces of a pure volume overload: Implications for therapyAmerican Journal of the Medical Sciences.  348:337-346. 2014
2014 Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophyTherapeutic Advances in Cardiovascular Disease.  8:97-118. 2014
2013 Erratum: Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload (Biochemical Journal (2013) 455 (157-167))Biochemical Journal.  456:147. 2013
2013 Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload 2013
2013 Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overloadBiochemical Journal.  455:157-167. 2013
2013 Volume overload induces differential spatiotemporal regulation of myocardial soluble guanylyl cyclase in eccentric hypertrophy and heart failureJournal of Molecular and Cellular Cardiology.  60:72-83. 2013
2013 Submassive pulmonary embolism where's the tipping point?Circulation.  127:2458-2464. 2013
2013 Changes in lipoproteins associated with methotrexate or combination therapy in early rheumatoid arthritis: Results from the treatment of early rheumatoid arthritis trialArthritis and Rheumatism.  65:1430-1438. 2013
2013 The never-ending story of angiotensin peptides: Beyond angiotensin i and IICirculation Research.  112:1086-1087. 2013
2013 Importance of three-dimensional geometric analysis in the assessment of the athlete's heartAmerican Journal of Cardiology.  111:1067-1072. 2013
2013 Chymase mediates angiotensin-(1-12) metabolism in normal human heartsJournal of the American Society of Hypertension.  7:128-136. 2013
2013 Response to letter regarding article, magnetic resonance imaging with 3-dimensional analysis of left ventricular remodeling in isolated mitral regurgitation: Implications beyond dimensionsCirculation.  127. 2013
2013 Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heartLife Sciences.  92:648-656. 2013
2013 Quercetin prevents left ventricular hypertrophy in the Apo E knockout mouseRedox Biology.  1:381-386. 2013
2013 Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation productsFree Radical Biology and Medicine.  59:56-68. 2013
2012 Integration of cellular bioenergetics with mitochondrial quality control and autophagy 2012
2012 A randomized controlled phase IIb trial of Beta 1-receptor blockade for chronic degenerative mitral regurgitationJournal of the American College of Cardiology.  60:833-838. 2012
2012 An argument for reviving the disappearing skill of cardiac auscultationCleveland Clinic Journal of Medicine.  79. 2012
2012 Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overloadJournal of Molecular and Cellular Cardiology.  53:240-249. 2012
2012 Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney diseaseJournal of Human Hypertension.  26:502-506. 2012
2012 Cardiac Kallikrein-Kinin system is upregulated in chronic volume overload and mediates an inflammatory induced Collagen lossPLoS One.  7. 2012
2012 The human story of aortic stenosis: A time for new surrogate markers in clinical decision making 2012
2012 Magnetic resonance imaging with 3-dimensional analysis of left ventricular remodeling in isolated mitral regurgitation: Implications beyond dimensionsCirculation.  125:2334-2342. 2012
2012 Anatomy and Physiology of the Right VentricleCardiology Clinics.  30:167-187. 2012
2012 Renin-angiotensin inhibition in systolic heart failure and chronic kidney diseaseAmerican Journal of Medicine.  125:399-410. 2012
2012 Relation of torsion and myocardial strains to LV ejection fraction in hypertensionJACC: Cardiovascular Imaging.  5:273-281. 2012
2012 Left ventricular remodeling in preclinical experimental mitral regurgitation of dogsJournal of Veterinary Cardiology.  14:73-92. 2012
2012 Refractory hypertension: Definition, prevalence, and patient characteristicsJournal of the CardioMetabolic Syndrome.  14:7-12. 2012
2011 Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overloadFree Radical Biology and Medicine.  51:1975-1984. 2011
2011 Three-dimensional plus time biventricular strain from tagged MR images by phase-unwrapped harmonic phaseJournal of Magnetic Resonance Imaging.  34:799-810. 2011
2011 Translational success stories: Angiotensin receptor 1 antagonists in heart failureCirculation Research.  109:437-452. 2011
2011 Oxidative stress and myocardial remodeling in chronic mitral regurgitationAmerican Journal of the Medical Sciences.  342:114-119. 2011
2011 Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload 2011
2011 Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulate hypertrophic and cell signaling pathways in cardiomyocytes from diabetic miceAmino Acids.  40:819-828. 2011
2011 The forgotten left ventricle in right ventricular pressure overloadJournal of the American College of Cardiology.  57:929-930. 2011
2011 Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overloadJournal of Molecular and Cellular Cardiology.  50:147-156. 2011
2010 Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitationCirculation.  122:1488-1495. 2010
2010 Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitationJournal of Cardiac Failure.  16:769-776. 2010
2010 Association between hyperuricemia and incident heart failure among older adults: A propensity-matched studyInternational Journal of Cardiology.  142:279-287. 2010
2010 Tumor necrosis factor-α produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overloadJournal of Molecular and Cellular Cardiology.  49:70-78. 2010
2010 Rapid reversal of left ventricular hypertrophy and intracardiac volume overload in patients with resistant hypertension and hyperaldosteronism: A prospective clinical studyHypertension.  55:1137-1142. 2010
2010 Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodentsJournal of Clinical Investigation.  120:1229-1239. 2010
2010 Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction >60%Journal of the American College of Cardiology.  55:671-679. 2010
2010 Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loadingPhysiological Genomics.  40:141-149. 2010
2010 3D left ventricular strain from unwrapped harmonic phase measurementsJournal of Magnetic Resonance Imaging.  31:854-862. 2010
2010 Effects of right ventricular ejection fraction on outcomes in chronic systolic heart failureCirculation.  121:252-258. 2010
2010 How much alcohol should we infuse in the coronary artery of hypertrophic cardiomyopathy patients? 2010
2009 A dual propagation contours technique for semi-automated assessment of systolic and diastolic cardiac function by CMRCritical Reviews in Computed Tomography.  11. 2009
2009 Pleiotropic effects of neutrophils on myocyte apoptosis and left ventricular remodeling during early volume overloadJournal of Molecular and Cellular Cardiology.  47:634-645. 2009
2009 Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: Results from a randomized trialHypertension.  54:475-481. 2009
2009 Molecular cardiology microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dogCirculation.  119:2086-2095. 2009
2009 Mitral RegurgitationCurrent Problems in Cardiology.  34:93-136. 2009
2009 Interaction of diet and diabetes on cardiovascular function in rats 2009
2009 Mitral valve prolapse with a late-systolic regurgitant murmur may be associated with significant hemodynamic consequencesAmerican Journal of the Medical Sciences.  338:113-115. 2009
2008 Dissociation between cardiomyocyte function and remodeling with β-adrenergic receptor blockade in isolated canine mitral regurgitation 2008
2008 Hemodynamic evaluation of coronary artery bypass graft lesions using fractional flow reserveCatheterization and Cardiovascular Interventions.  72:479-485. 2008
2008 Marked regional left ventricular heterogeneity in hypertensive left ventricular hypertrophy patients: A losartan intervention for endpoint reduction in hypertension (LIFE) cardiovascular magnetic resonance and echocardiographic substudyHypertension.  52:279-286. 2008
2008 Feasibility of primary clot extraction prior to percutaneous coronary intervention in acute myocardial infarctionCatheterization and Cardiovascular Interventions.  71:870-876. 2008
2008 Three-dimensional balloon catheter sizing identifies significant underdeployed stents using conventional methods in renal artery interventions 2008
2008 Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dogCirculation Research.  102:1127-1136. 2008
2008 Incident Heart Failure Hospitalization and Subsequent Mortality in Chronic Heart Failure: A Propensity-Matched Study*Journal of Cardiac Failure.  14:211-218. 2008
2008 c-kit is required for cardiomyocyte terminal differentiationCirculation Research.  102:677-685. 2008
2007 A propensity-matched study of the effect of diabetes on the natural history of heart failure: Variations by sex and ageHeart.  93:1584-1590. 2007
2007 Effect of Primary Mitral Regurgitation on Left Ventricular SynchronyAmerican Journal of Cardiology.  100:707-711. 2007
2007 Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: Role of hydronephrosis 2007
2007 Left Ventricular Eccentric Remodeling and Matrix Loss Are Mediated by Bradykinin and Precede Cardiomyocyte Elongation in Rats With Volume OverloadJournal of the American College of Cardiology.  49:811-821. 2007
2007 Hospitalizations Due to Unstable Angina Pectoris in Diastolic and Systolic Heart FailureAmerican Journal of Cardiology.  99:460-464. 2007
2007 A thrombospondin-1 antagonist of transforming growth factor-β activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin IIAmerican Journal of Pathology.  171:777-789. 2007
2006 Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failureCardioscience.  72:262-270. 2006
2006 Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikisJournal of Biological Chemistry.  281:19781-19792. 2006
2006 β1-Adrenoceptor blockade mitigates excessive norepinephrine release into cardiac interstitium in mitral regurgitation in dog 2006
2006 Heart failure, chronic diuretic use, and increase in mortality and hospitalization: An observational study using propensity score methodsEuropean Heart Journal.  27:1431-1439. 2006
2004 Involvement of chymase-mediated angiotensin II generation in blood pressure regulationJournal of Clinical Investigation.  114:112-120. 2004
2004 Short-acting β-adrenergic antagonist esmolol given at reperfusion improves survival after prolonged ventricular fibrillationCirculation.  109:2469-2474. 2004
2004 Use of beta-blockers in older adults with chronic heart failureAmerican Journal of the Medical Sciences.  328:100-111. 2004
2003 Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factorCirculation.  108:598-604. 2003
2003 Cardiac interstitial bradykinin and mast cells modulate pattern of LV remodeling in volume overload in rats 2003
2003 β1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitationCirculation.  108:225-230. 2003
2003 Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dogJournal of Molecular and Cellular Cardiology.  35:311-319. 2003
2003 Intrinsic cardiac nervous system in tachycardia induced heart failure 2003
2002 The renin-angiotensin system in mitral regurgitation: A typical example of tissue activationCurrent Cardiology Reports.  4:97-103. 2002
2002 Angiotensin II receptor blockade does not improve left ventricular function and remodeling in subacute mitral regurgitation in the dogJournal of the American College of Cardiology.  39:1374-1379. 2002
2002 Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivoJournal of Pharmacology and Experimental Therapeutics.  300:324-329. 2002
2002 Differential ANG II generation in plasma and tissue of mice with decreased expression of the ACE gene 2002
2002 Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseasesCurrent Opinion in Cardiology.  17:374-379. 2002
2002 Downregulation of ANG II receptor is associated with compensated pressure-overload hypertrophy in the young dog 2002
2002 Use of angiotensin-converting enzyme inhibitors in patients with diabetes and coronary artery diseaseCurrent Problems in Cardiology.  27:6-36. 2002
2001 Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistulaCirculation.  103:1012-1016. 2001
2001 Angiotensin II modulates catecholamine release into interstitial fluid of canine myocardium in vivo 2001
2001 Differential MAP kinase activation and Na+/H+ exchanger phosphorylation by H2O2 in rat cardiac myocytes 2001
2001 Enalaprilat blunts reflexive increases in cardiac interstitial norepinephrine in conscious ratsJournal of Hypertension.  19:2025-2029. 2001
2000 Left ventricular mass and volume: Fast calculation with guide-point modeling on MR imagesRadiology.  216:597-602. 2000
1999 Bradykinin in the heart: Friend or foe?Circulation.  100:2305-2307. 1999
1999 Evidence for angiotensin-converting enzyme- and chymase-mediated angiotensin II formation in the interstitial fluid space of the dog heart in vivoCirculation.  99:2583-2589. 1999
1999 Consensus recommendations for the management of chronic heart failure: IntroductionAmerican Journal of Cardiology.  83. 1999
1999 2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptorJournal of Molecular and Cellular Cardiology.  31:1405-1412. 1999
1999 ACE inhibitors in HF restore canine pulmonary endothelial function and ANG II vasoconstriction 1999
1999 Differential expression of angiotensin-converting enzyme and chymase in dogs with chronic mitral regurgitationJournal of Molecular and Cellular Cardiology.  31:1033-1045. 1999
1999 Differential expression of natriuretic peptides and their receptors in volume overload cardiac hypertrophy in the ratJournal of Molecular and Cellular Cardiology.  31:1927-1936. 1999
1999 Hypertrophic response to hemodynamic overload: Role of load vs. renin- angiotensin system activationAmerican Journal of Physiology.  276. 1999
1998 Handgrip increases endothelin-1 secretion in normotensive young male offspring of hypertensive parentsJournal of the American College of Cardiology.  31:1362-1366. 1998
1998 Reperfusion for right ventricular infarctionNew England Journal of Medicine.  338:978-980. 1998
1998 Can indices of left ventricular function be applied to the right ventricle?Progress in Cardiovascular Diseases.  40:309-324. 1998
1998 Changes in left ventricular mass and volumes in patients receiving angiotensin-converting enzyme inhibitor therapy for left ventricular dysfunction after Q-wave myocardial infarctionAmerican Heart Journal.  136:269-275. 1998
1998 Ventricular interdependence: Significant left ventricular contributions to right ventricular systolic functionProgress in Cardiovascular Diseases.  40:289-308. 1998
1997 Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs 1997
1997 Compartmentalization of angiotensin II generation in the dog heart: Evidence for independent mechanisms in intravascular and interstitial spacesJournal of Clinical Investigation.  100:253-258. 1997
1997 Angiotensin-converting enzyme inhibitor therapy affects left ventricular mass in patients with ejection fraction >40% after acute myocardial infarctionJournal of the American College of Cardiology.  29:49-54. 1997
1997 Angiotensin II formation from ACE and chymase in human and animal hearts: Methods and species considerations 1997
1997 Selective induction of the creatine kinase-B gene in chronic volume overload hypertrophy is not affected by ACE-inhibitor therapyJournal of Molecular and Cellular Cardiology.  29:2665-2673. 1997
1997 Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs 1997
1996 Angiotensin II formation in dog heart is mediated by different pathways in vivo and in vitro 1996
1996 Cardiac hypertrophy and failure in hypertensionCurrent Opinion in Nephrology and Hypertension.  5:186-191. 1996
1996 Accuracy of biplane long-axis left ventricular volume determined by cine magnetic resonance imaging in patients with regional and global dysfunctionAmerican Journal of Cardiology.  77:1098-1104. 1996
1996 Slow coronary flow: Clinical and histopathological features in patients with otherwise normal epicardial coronary arteriesCatheterization and Cardiovascular Interventions.  37:375-381. 1996
1996 Angiotensin II formation in dog heart is mediated by different pathways in vivo and in vitro 1996
1996 Cardiac renin angiotensin system in hypertrophy and the progression to heart failureHeart Failure Reviews.  1:63-72. 1996
1996 Three-dimensional changes in left and right ventricular geometry in chronic mitral regurgitationAmerican Journal of Physiology.  271. 1996
1995 Sensitive method for quantitation of angiotensin-converting enzyme (ACE) activity in tissueBiochemical Pharmacology.  50:1445-1450. 1995
1995 Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation 1995
1995 Optimizing the method to calculate right ventricular ejection fraction from first-pass data acquired with a multicrystal cameraJournal of Nuclear Cardiology.  2:372-379. 1995
1995 Right and left ventricular volumes and function after acute pulmonary hypertension in intact dogsJournal of Applied Physiology.  78:2320-2327. 1995
1995 The canine model of mitral regurgitationHeart failure.  11:208-218. 1995
1994 Assessment of ventricular volumes using cine magnetic resonance in the intact dog: A comparison of measurement methodsInvestigative Radiology.  29:162-167. 1994
1993 A stable model of left ventricular dysfunction in an intact animal assessed with high fidelity pressure and cinemagnetic resonance imagingCardiovascular Research.  27:974-979. 1993
1993 A stable model of left ventricular dysfunction in an intact animal assessed with high fidelity pressure and cinemagnetic resonance imagingCardioscience.  27:974-979. 1993
1993 Cardiac function and functional capacity: Implications for the failing heartCurrent Problems in Cardiology.  18:710-758. 1993
1993 Relationship between shortening load, contractility, and myocardial energetics in intact dogAmerican Journal of Physiology.  264. 1993
1993 Ventricular coupling via the pericardium: Normal versus tamponadeCardioscience.  27:1470-1476. 1993
1992 Time-varying wall stress: An index of ventricular vascular couplingAmerican Journal of Physiology.  263. 1992
1991 Development of a micromanometer‐tip catheter to record high‐fidelity pressures during cine‐gated NMR without significant image distortionMagnetic Resonance in Medicine.  17:119-125. 1991
1991 The right ventricle: anatomy, physiology, and clinical importanceCurrent Problems in Cardiology.  16:658-720. 1991
1990 Mechanism of postextrasystolic potentiation in the right ventricleAmerican Journal of Cardiology.  65:736-741. 1990
1989 Effect of intravenous metoprolol on left ventricular performance in Q-wave acute myocardial infarctionAmerican Journal of Cardiology.  63:166-171. 1989
1989 Hemodynamic effects of the Valsalva maneuver in pregnant womenJournal of applied cardiology.  4:315-322. 1989
1988 Bedside Diagnosis of Systolic MurmursNew England Journal of Medicine.  318:1572-1578. 1988
1988 Acute determinants of the hangout interval in the pulmonary circulationAmerican Heart Journal.  116:1289-1297. 1988
1988 Application of a time varying elastance model to right ventricular performance in manCardioscience.  22:864-874. 1988
1988 Assessment of the radionuclide angiographic left ventricular maximum time-varying elastance calculation in manJournal of Nuclear Medicine.  29:1368-1381. 1988
1988 Mitral valve prolapse in patients with prior rheumatic feverCirculation.  77:830-836. 1988
1988 Right ventricular diastolic pressure-volume relations and regional dimensions during acute alterations in loading conditionsCirculation.  77:1276-1282. 1988
1987 Usefulness of two-dimensional echocardiography during low-level exercise testing early after uncomplicated acute myocardial infarctionAmerican Journal of Cardiology.  60:10-14. 1987
1987 Hemodynamically important right ventricular infarction: Follow-up evaluation of right ventricular systolic function at rest and during exercise with radionuclide ventriculography and respiratory gas exchangeCirculation.  75:996-1003. 1987
1987 Systemic lupus erythematosus: A consideration for antimicrobial prophylaxisOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.  64:30-34. 1987
1987 The relationship of various measures of end-systole to left ventricular maximum time-varying elastance in manCirculation.  76:32-43. 1987
1986 Clinical and prognostic importance of persistent precordial (V1-V4) electrocardiographic ST segment depression in patients with inferior transmural myocardial infarctionCirculation.  74:56-63. 1986
1986 Diagnosis of left-sided regurgitant murmurs by transient arterial occlusion: A new maneuver using blood pressure cuffsACP journal club.  105:368-370. 1986
1986 Right Ventricular InfarctionJournal of Intensive Care Medicine.  1:246-256. 1986
1985 Comparative effects of volume loading, dobutamine, and nitroprusside in patients with predominant right ventricular infarctionCirculation.  72:1327-1335. 1985
1985 Validation of attenuation-corrected equilibrium radionuclide angiographic determinations of right ventricular volume: Comparison with cast-validated biplane cineventriculographyCirculation.  72:317-326. 1985
1984 Estimates of left-ventricular volumes by equilibrium radionuclide angiography: Importance of attenuation correctionJournal of Nuclear Medicine.  25:14-20. 1984
1984 Accurate estimates of absolute left ventricular volumes from equilibrium radionuclide angiographic count data using a simple geometric attenuation correctionJournal of the American College of Cardiology.  3:789-798. 1984
1984 Hemodynamic profile of constrictive pericarditis produced by a massive right pleural effusionCatheterization and Cardiovascular Interventions.  10:471-477. 1984
1984 Right ventricular infarction: An important clinical entityCurrent Problems in Cardiology.  9:6-57. 1984
1983 Physical examination for exclusion of hemodynamically important right ventricular infarctionACP journal club.  99:608-611. 1983


Year Title Altmetric
2021 Electrons and protons.  545-550. 2021
2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
2013 Role of chymase in matrix and myocardial remodeling due to mitral regurgitation: Implications for therapy.  201-214. 2013

Investigator On

  • ACES - ACE Inhibitors Combined with Exercise for Hypertensive Seniors  awarded by National Institute on Aging/NIH/DHHS
  • CIALIS® Reverses Halogen Induced Injury to Pregnant Animals and Their Offspring  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Mitochondrial Genetic Background Influences Susceptibility to Atherosclerosis  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • O-GlcNAcylation Regulates Vascular Smooth Muscle Cells in Diabetic Vasculopathy  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Post-Baccalaureate Research Experience in Cardiovascular Sciences at UAB  awarded by American Heart Association
  • Precision High Intensity Training through Epigenetics (PHITE)  awarded by Wright State University
  • Private Grant  awarded by HEART BIOTECH HOLDINGS, LLC
  • Reductive Stress Induces Proteotoxic Cardiac Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Resveratrol and Exercise to Treat Functional Limitations in Late Life  awarded by National Institute on Aging/NIH/DHHS
  • Targeting Cardiopulmonary Calpains to Mitigate Toxicity of Halogen Gases.  awarded by National Institute of Environmental Health Sciences/NIH/DHHS
  • The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical Center  awarded by BALL STATE UNIVERSITY
  • The Exercise and Physical Activity Collaborative Team (ExPact): A Proposed MoTrPAC Clinical Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • UAB Statistical Genetics Post-Doctoral Training Program  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Education And Training

  • Doctor of Medicine, Georgetown University 1978
  • Bachelor's Degree in Biology, Holy Cross College 1974
  • Full Name

  • Louis Dell'Italia