Positions

Overview

  • Scott M Wilson PhD
    Associated Professor
    Department of Neurobiology
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous systemJournal of Neurochemistry.  156:309-323. 2021
    2019 Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in miceJournal of Neurochemistry.  148:386-399. 2019
    2017 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's diseaseBBA: Molecular Basis of Disease.  1863:1157-1170. 2017
    2015 Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14Frontiers in Molecular Neuroscience.  8. 2015
    2013 Neuronal Ubiquitin HomeostasisCell Biochemistry and Biophysics.  67:67-73. 2013
    2012 Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14American Journal of Physiology: Cell Physiology.  302. 2012
    2009 Transgenic rescue of ataxia mice reveals a male-specific sterility defectDevelopmental Biology.  325:33-42. 2009
    2005 Loss of Usp14 results in reduced levels of ubiquitin in ataxia miceJournal of Neurochemistry.  95:724-731. 2005
    2001 Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer miceGenomics.  74:228-233. 2001
    2000 A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase IIGenetics: a periodical record of investigations bearing on heredity and variation.  154:557-571. 2000
    1992 Legionella pneumophila infection and cytokine production.Advances in Experimental Medicine and Biology.  319:97-104. 1992

    Research Overview

  • My long-term research interest is to identify genetic pathways that control the development and function of the nervous system in the context of developing strategies to treat neurodegenerative disorders. By positionally cloning genes responsible for spontaneously occurring neurological mouse mutations, my laboratory identified Ubiquitin specific protease 14 and components of the ubiquitin proteasome pathway as critical regulators of neuronal signaling during development. In addition to investigating the mechanisms of ubiquitin homeostasis in regulating synaptic formation and function, my current research uses conditional inactivation of genes in mice and primary cell culture to study the essential roles of endosomal sorting in Schwann cells during peripheral nerve myelination.
  • Teaching Overview

  • NBL433/633 Diseases of the Nervous System
  • Teaching Activities

  • CMB790 - CMB Laboratory Methods (Fall Term 2007)
  • CMB790 - CMB Laboratory Methods (Fall Term 2008)
  • CMB790 - CMB Laboratory Methods (Spring Term 2008)
  • CMB790 - CMB Laboratory Methods (Spring Term 2009)
  • GBS732 - GRADUATE NEUROSCIENCE DISCUSSION (Spring Term 2011)
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015)
  • GBS791 - Grad Neuro Discussion (Spring Term 2012)
  • NBL240 - Special Topics Neuroscience 3 (Spring Term 2017)
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2015)
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Fall Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017)
  • NBL398 - Rescg Prac in Neurobiology-RES (Spring Term 2017)
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2016)
  • NBL398 - Rescg Prac in Neurobiology-RES (Summer Term 2017)
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2015)
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016)
  • NBL399 - Senior Seminar in Neuroscience (Fall Term 2016)
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016)
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2016)
  • NBL399 - Senior Seminar in Neuroscience (Spring Term 2017)
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2016)
  • NBL401 - Collo in Basic Cog & Clin Neur (Fall Term 2017)
  • NBL401 - Collo in Basic Cog & Clin Neur (Spring Term 2017)
  • NBL433 - Diseases of the Nervous System (Fall Term 2019)
  • NBL433 - Diseases of the Nervous System (Fall Term 2020)
  • NBL433 - Diseases of the Nervous System (Fall Term 2021)
  • NBL633 - Diseases of the Nervous System (Fall Term 2019)
  • NBL633 - Diseases of the Nervous System (Fall Term 2020)
  • NBL633 - Diseases of the Nervous System (Fall Term 2021)
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2010)
  • NBL712 - Graduate Medical Neuroscience (Spring Term 2011)
  • NBL725 - Sem Practice in Cell Mol Neuro (Fall Term 2009)
  • NBL773 - Neuronal Signaling JC (Spring Term 2015)
  • NBL773 - Neuronal Signaling JC (Spring Term 2016)
  • NBL773 - Neuronal Signaling JC (Spring Term 2017)
  • NEUR708 - Laboratory Methods (Spring Term 2009)
  • NEUR725 - Grd Neur Dicussion (Spring Term 2010)
  • PY401 - Neuroscience Seminar (Spring Term 2017)
  • STH201 - Research Approaches (Spring Term 2017)
  • Education And Training

  • Doctor of Philosophy in Genetics, University of Florida 1996
  • Full Name

  • Scott Wilson