Scott Wilson Ph.D.

Scott Wilson Ph.D.
Associate Professor

Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology
Investigator (C), Evelyn F. McKnight Brain Institute , Neurology
Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments
Associate Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments
Associate Professor (S), Biochemistry & Molecular Genetics , Academic Joint Departments
Associate Professor (P), Neurobiology , Academic Joint Departments
Assistant Professor (S), Genetic & Translational Medicine , Genetics

Overview

Scott M Wilson PhD
Associated Professor
Department of Neurobiology

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation. Life Science Alliance. 5. 2022
2022	Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease 2022
2021	Examination of genetic and pharmacological tools to study the proteasomal deubiquitinating enzyme ubiquitin-specific protease 14 in the nervous system. Journal of Neurochemistry. 156:309-323. 2021
2019	Chronic over-expression of ubiquitin impairs learning, reduces synaptic plasticity, and enhances GRIA receptor turnover in mice. Journal of Neurochemistry. 148:386-399. 2019
2017	Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease 2017
2015	Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genetics. 11. 2015
2015	Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14. Frontiers in Molecular Neuroscience. 8. 2015
2015	Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction. Molecular Neurodegeneration. 10. 2015
2014	A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number 2014
2014	The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation. Learning and Memory. 21:9-13. 2014
2013	Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (Usp14). PLoS One. 8. 2013
2013	Neuronal Ubiquitin Homeostasis. Cell Biochemistry and Biophysics. 67:67-73. 2013
2012	Usp14 Deficiency Increases Tau Phosphorylation without Altering Tau Degradation or Causing Tau-Dependent Deficits. PLoS One. 7. 2012
2012	Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14 2012
2011	Ubiquitin homeostasis is critical for synaptic development and function 2011
2010	Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 467:179-184. 2010
2009	The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions 2009
2009	Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1 2009
2009	The ataxia (ax^J) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genetics. 5. 2009
2009	Transgenic rescue of ataxia mice reveals a male-specific sterility defect. Developmental Biology. 325:33-42. 2009
2008	Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Molecular and Cellular Neuroscience. 39:539-548. 2008
2008	Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.. Molecular Brain. 1:17. 2008
2006	Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14 2006
2005	Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. Journal of Neurochemistry. 95:724-731. 2005
2003	Neurological disease: UPS stops delivering!. Trends in Pharmacological Sciences. 24:18-23. 2003
2002	Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nature Genetics. 32:420-425. 2002
2002	Dual requirement for yeast hnRNP Nab2p in mRNA poly(A) tail length control and nuclear export 2002
2001	Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics. 74:228-233. 2001
2001	Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. 2001
2000	The status of voltage-dependent calcium channels in α(1E) knock-out mice 2000
2000	A mutation in Rab27a causes the vesicle transport defects observed in ashen mice 2000
2000	A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II 2000
1994	Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. 1994
1993	NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.. Molecular and Cellular Biology. 13:2730-2741. 1993
1992	Legionella pneumophila infection and cytokine production.. Advances in Experimental Medicine and Biology. 319:97-104. 1992

Research Overview

My long-term research interest is to identify genetic pathways that control the development and function of the nervous system in the context of developing strategies to treat neurodegenerative disorders. By positionally cloning genes responsible for spontaneously occurring neurological mouse mutations, my laboratory identified Ubiquitin specific protease 14 and components of the ubiquitin proteasome pathway as critical regulators of neuronal signaling during development. In addition to investigating the mechanisms of ubiquitin homeostasis in regulating synaptic formation and function, my current research uses conditional inactivation of genes in mice and primary cell culture to study the essential roles of endosomal sorting in Schwann cells during peripheral nerve myelination.