Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Helicobacter pylori infection is associated with an altered gastric microbiota in children.  Mucosal Immunology.  10:1169-1177. 2017
2017 Differential regulation of CD103 (αE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands.  Journal of Leukocyte Biology.  101:1169-1180. 2017
2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages.  Virology.  504:79-87. 2017
2015 Mother-to-child HIV-1 transmission events are differentially impacted by breast milk and its components from HIV-1-infected women.  PLoS One.  10. 2015
2015 Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells.  Mucosal Immunology.  8:533-544. 2015
2015 Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F.  Biochemical Journal.  467:517-527. 2015
2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses.  Journal of Immunology.  193:5604-5612. 2014
2014 Microbiota, the immune system, black moods and the brain—melancholia updated.  Frontiers in Human Neuroscience.  8:1-4. 2014
2014 Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells 2014
2014 Exosomes in the gut.  Frontiers in Immunology.  5. 2014
2014 Vaginal myeloid dendritic cells transmit founder HIV-1.  Journal of Virology.  88:7683-7688. 2014
2013 Role of childhood infection in the sequelae of H. Pylori disease.  Gut Microbes.  4. 2013
2013 Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.  Mucosal Immunology.  6:950-959. 2013
2013 Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.  Journal of Immunology.  190:6626-6634. 2013
2013 Renal macrophages in autosomal recessive polycystic kidney disease.  Nephrology.  18:746. 2013
2012 Regulation of pattern recognition receptors by the apolipoprotein A-I mimetic peptide 4F 2012
2011 Extracellular matrix-associated cytokines regulate CD4+ effector T-cell responses in the human intestinal mucosa.  Mucosal Immunology.  4:420-427. 2011
2011 Stromal down-regulation of macrophage CD4/CCR5 expression and NF-κB activation mediates HIV-1 non-permissiveness in intestinal macrophages.  PLoS Pathogens.  7. 2011
2011 Intestinal macrophages and response to microbial encroachment.  Mucosal Immunology.  4:31-42. 2011
2011 Stromal regulation of human gastric dendritic cells restricts the Th1 response to helicobacter pylori.  Gastroenterology.  141:929-938. 2011
2010 Inflammation anergy in human intestinal macrophages is due to Smad-induced IκBα expression and NF-κB inactivation.  Journal of Biological Chemistry.  285:19593-19604. 2010
2010 Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages 2010
2010 Human primary gastric dendritic cells induce a Th1 response to H. pylori.  Mucosal Immunology.  3:260-269. 2010
2010 Dendritic cells transmit HIV-1 through human small intestinal mucosa.  Journal of Leukocyte Biology.  87:663-670. 2010
2010 GP41-specific antibody blocks cell-free HIV type 1 transcytosis through human rectal mucosa and model colonic epithelium.  Journal of Immunology.  184:3648-3655. 2010
2010 IL-17 activates the canonical NF-κB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.  Journal of Immunology.  184:2289-2296. 2010
2010 Renal CD14 expression correlates with the progression of cystic kidney disease.  Kidney International.  78:550-560. 2010
2009 Macrophages in vaginal but not intestinal mucosa are monocyte-like and permissive to human immunodeficiency virus type 1 infection.  Journal of Virology.  83:3258-3267. 2009
2009 Selective advantage of inflammation anergy in gut macrophages.  Mucosal Immunology.  2:378-9. 2009
2008 Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell Response.  Gastroenterology.  134:491-499. 2008
2007 Gliadin peptides activate blood monocytes from patients with celiac disease.  Journal of Clinical Immunology.  27:201-209. 2007
2006 Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease.  Advances in Experimental Medicine and Biology.  579:117-132. 2006
2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infection.  Journal of Leukocyte Biology.  80:1111-1117. 2006
2006 Mucosal IL-8 and TGF-β recruit blood monocytes: Evidence for cross-talk between the lamina propria stroma and myeloid cells.  Journal of Leukocyte Biology.  80:492-499. 2006
2006 Isolation and purification of human intestinal macrophages..  Current protocols in immunology / edited by John E. Coligan ... [et al.].  Chapter 7. 2006
2006 Isolation of human monocyte populations..  Current protocols in immunology / edited by John E. Coligan ... [et al.].  Chapter 7. 2006
2005 Intestinal macrophages: Unique effector cells of the innate immune system.  Immunological Reviews.  206:149-159. 2005
2005 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection.  Vaccine.  23:901-909. 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity.  Journal of Clinical Investigation.  115:66-75. 2005
2005 Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity..  Journal of Clinical Investigation.  115:66-75. 2005
2001 Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities.  Journal of Immunology.  167:2651-2656. 2001
2000 Quantitative analysis of Helicobacter pylori infection in a mouse model.  Immunotechnology : an international journal of immunological engineering.  242:67-78. 2000
2000 Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-γ, gene-deficient mice.  Journal of Immunology.  165:1022-1029. 2000
2000 Inflammatory cytokine mRNA expression during early and persistent Helicobacter pylori infection in nonhuman primates.  Journal of Infectious Diseases.  181:783-786. 2000
1999 Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response.  Vaccine.  17:2384-2391. 1999
1998 African trypanosome infections in mice that lack the interferon-γ receptor gene: Nitric oxide-dependent and -independent suppression of T-cell proliferative responses and the development of anaemia.  Immunology.  94:476-480. 1998
1998 Nitric oxide produced in the lungs of mice immunized with the radiation- attenuated schistosome vaccine is not the major agent causing challenge parasite elimination.  Immunology.  93:55-63. 1998
1996 Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-γ receptor gene exposed to the irradiated Schistosoma mansoni vaccine.  Immunology.  87:275-282. 1996
1996 Kinetics and mechanism of effector focus formation in the lungs of mice vaccinated with irradiated cercariae of Schistosoma mansoni.  Parasite Immunology.  18:359-369. 1996
1993 Pulmonary granulomatous hypersensitivity: Cell-mediated responses to embolized schistosome larvae and eggs.  Regional immunology.  5:165-173. 1993
1993 Functional and phenotypic properties of the CD4+ T cell population in a murine pulmonary delayed-type hypersensitivity response..  Chest.  103:138S. 1993
1993 Immunity to Schistosoma mansoni in mice vaccinated with irradiated cercariae: Cytokine interactions in the pulmonary protective response.  Pathogens and Global Health.  87:653-657. 1993
1993 Phenotypic and functional properties of Th lines and clones recognizing larval antigens of Schistosoma mansoni.  Parasite Immunology.  15:373-382. 1993
1992 T cell-derived cytokines associated with pulmonary immune mechanisms in mice vaccinated with irradiated cercariae of Schistosoma mansoni.  Journal of Immunology.  148:1512-1518. 1992
1992 Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae.  Journal of Immunology.  149:3654-3658. 1992
1992 The generation of interferon-gamma-producing T lymphocytes in skin-draining lymph nodes, and their recruitment to the lungs, is associated with protective immunity to Schistosoma mansoni.  Immunology.  75:250-256. 1992
1991 Patterns of cytokine production and proliferation by T lymphocytes differ in mice vaccinated or infected with Schistosoma mansoni.  Immunology.  73:327-333. 1991

Chapter

Year Title Altmetric
2015 Mucosal Macrophages in Defense and Regulation.  543-556. 2015
2012 Intestinal macrophages in defense of the mucosa.  159-70. 2012
2005 Antigen handling and presentation by mucosal dendritic cells and macrophages.  451-485. 2005
2005 Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease.  117-33. 2005
2001 Macrophage effector function.  19.1-19.9. 2001

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Plant Physiology, University of London 1982
  • Bachelor of Science or Mathematics in Biology, University of London 1976

    • Awards And Honors

    Full Name

  • Lesley Smythies