Positions

Overview

  • S. Louis Bridges, Jr., MD, PhD is Anna Lois Waters Endowed Professor of Medicine at the University of Alabama at Birmingham and has served as Director of the UAB Division of Clinical Immunology and Rheumatology since 2009. He is also the Director of the UAB Comprehensive Arthritis, Musculoskeletal, Bone, and Autoimmunity Center. and Vice President of the Rheumatology Research Foundation.
    His research has been continuously funded by NIH and is focused largely on rheumatoid arthritis susceptibility, severity, and treatment response. He has authored more than 130 manuscripts, 20 book chapters, and served as Editor of Vasculitis, published by Oxford University Press. He serves as Director of the UAB T32 Training Program in Rheumatic and Musculoskeletal Diseases Research, PI of a Department of Defense research grant on the role of the interferon-gamma pathway in RA, and Associate Director of the UAB Investigations in Gout, Hyperuricemia, and Comorbidities (INSIGHT) Center of Research Translation (CORT). In addition, he serves as investigator on multiple research grants focused on arthritis and musculoskeletal diseases.
    He has been named to the Best Doctors in America list yearly since 2003, as well as to Castle Connolly Top Doctors. He was previously Co-Editor of Arthritis & Rheumatology (2010-17) and Chair of the NIH Arthritis, Musculoskeletal, and Skin Study Section (2013-16). In addition to membership on several committees of the American College of Rheumatology (ACR), Dr. Bridges served as Chair of the ACR Committee on Research and as a member of the Scientific Advisory Council and Board of Directors of the Rheumatology Research Foundation. He was named recipient of the 2008 Max Cooper Award for Research Excellence by the UAB Department of Medicine, and the 2012 Sam Brown Bridge Builder Award, UAB School of Public Health.
    As the Director of the UAB Comprehensive Arthritis, Musculoskeletal, Bone, and Autoimmunity Center, I work with the Executive Committee to lead strategic planning, training and research activities, outreach, and symposia, visiting professorships, and workshops.
  • Selected Publications

    Chapter

    Year Title Altmetric
    2018 Rheumatoid arthritis.  183-199. 2018
    2018 Spondyloarthritis.  201-220. 2018
    2017 Polymyalgia Rheumatica.  735-737. 2017
    2017 Seronegative Spondyloarthritis.  729-734. 2017
    2004 Therapeutic Dictionary of Rheumatology and Immunology 2004

    Research Overview

  • Dr. Bridges' research interests include the role of B lymphocytes and autoantibodies in rheumatoid arthritis (RA), particularly immunoglobulin gene expression and antibody repertoires. In addition, his research has focused on pathogenesis of RA, and genetic influences on RA susceptibility and severity, particularly in African-Americans, and on biomarkers of treatment response in RA.
    In his role as Associate Director of the INvestigationS In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (NIH/NIAMS P50 AR060772, K. Saag, PI), he is involved in strategic planning and execution of the projects, training and outreach, and pilot projects. He also serves on the Executive Committee and as Director of the Pilot Component of the UAB P2C National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation, called the Rehabilitation Research Resource to Enhance Clinical Trials (REACT) Center led by Dr. Marcas Bamman. He also serves as co-PI with Dr. Bamman on a clinical study of progressive resistance exercise training plus adjunctive functional mobility training after total hip or knee arthroplasty to restore muscle mass and mobility function in patients with osteoarthritis and TWEAK (TNF-like weak inducer of apoptosis)-mediated muscle inflammation.
  • Principal Investigator On

  • A Double-Blind, Placebo-Controlled, Phase II, Randomized Study of Lovastatin Therapy in the Treatment of Mildly Active Rheumatoid Arthritis  awarded by Duke University
  • A National Center for Digital Health Informatics Innovation  awarded by Oregon Health & Science University
  • ACE Protocol ARA08: Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis (StopRA)  awarded by University of California, San Francisco
  • ARA08 - Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis (StopRA)  awarded by Emory University
  • Continuation of the Consortium for the Longitudinal Evaluation of African-American with Early Rheumatoid Arthritis (CLEAR)  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Dissection of the ACPA Response in African-Americans with Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Does Aggressive Treatment in Early RA Reduce Biomarkers of Cardiovascular Risk?  awarded by University of California, Los Angeles
  • Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established Disease  awarded by Northwestern University
  • Genome Research in African American Scleroderma Patients (GRASP Study)  awarded by Scleroderma Research Foundation
  • Genome-Wide Association Study in African-Americans With Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Interferon Gamma in Pathogenesis of Rheumatoid Arthritis  awarded by RHEUMATOLOGY RESEARCH FOUNDATION
  • Lipids and Inflammation  awarded by VANDERBILT UNIVERSITY
  • Molecular, Functional and Structural Analyses of Anti-PAD Antibodies in Rheumatoid Arthritis  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Multi-Cytokine Profiling and Correlates with Outcome Measures and Treatment Responses in TETRAD  awarded by Stanford University
  • NIAMS Multidiscipllinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Pilot Projects Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Private Grant  awarded by AMGEN, INC.^
  • Private Grant  awarded by NODALITY, INC.
  • Private Grant  awarded by EXAGEN
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Private Grant  awarded by REGENERON GENETICS CENTER
  • Private Grant  awarded by BRISTOL-MYERS SQUIBB COMPANY
  • Rheumatoid Arthritis Consortium International (RACI)  awarded by FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
  • Serum Interferon Alpha/Beta Ratio as a Predictor of Response to Anti-TNF Alpha Therapy  awarded by MAYO CLINIC
  • The Rheumatoid Arthritis Responder Challenge  awarded by SAGE BIONETWORKS
  • The Rheumatoid Arthritis Synovial Tissue Network (REASON)  awarded by Northwestern University
  • The Role of the Interferon-Gamma-Jak/STAT Pathway in Rheumatoid Arthritis  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Training Program in Rheumatic Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Training Program in Rheumatic and Musculoskeletal Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository (TETRAD)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Autoimmunity Center for Excellence: Core B - Immunomodulatory Studies Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center - Core A (Administrative Core)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • UAHSF General Endowment Fund Scholar (HSF-GEF)  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Investigator On

  • Arthritis Patient Partnership With Comparative Effectiveness Researchers (AR-Power PPRN)  awarded by GLOBAL HEALTHY LIVING FOUNDATION
  • Building and InnovatinG: Digital heALTH Technology and Analytics (BIGDATA)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Building and InnovatinG: Digital heAlth Technology and Analytics (BIGDATA) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Centers of Research Translation (CoRT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Centers of Research Translation (CoRT) - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Control of B Cell Differentiation by IFNg Induced Transcription Factors  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Discovering Novel Genetic and Environmental Risk Factors for RA in African Americans  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Functional and Integrative Omics of Hyperuricemia to Gout and Recurrent Flares  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Genetic Architecture of Rheumatoid Arthritis in African-Americans  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Integrating Genomic Risk Assessment for Chronic Disease Management in a Diverse Population  awarded by National Human Genome Research Institute/NIH/DHHS
  • Molecular Mechanisms of Multiple Sclerosis Disease Severity in African Americans  awarded by NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES/NIH/DHHS
  • NIAMS Multidiscipllinary Clinical Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • NIAMS Multidiscipllinary Clinical Research Center - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • NIAMS Multidiscipllinary Clinical Research Center - Project 1  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • National Resource Center for High-Impact Clinical Trials in Medical Rehabilitation: Admin Oversight Component  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Overcoming TWEAK Signaling to Restore Muscle and Mobility after Joint Replacement  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group
  • Rehabilitation Research Resource to Enhance Clinical Trials (REACT)  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Rheumatic Diseases Research Core Centers (P30)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Rheumatic Diseases Research Core Centers - Core A: Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Safety and Effectiveness of Live Zoster Vaccine in Anti-TNF Users (VERVE Trial)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Skeletal Muscle in Rheumatoid Arthritis  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • TLR7 and TLR9-Directed Plasma Cell Formation: Dissecting the Molecular Basis for their Differential Dependence on IFN-Induced Signals  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Tissue and Organ Specific Human B Cell Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Tissue and Organ Specific Human B Cell Immunity - Project 1: Development and Maintenance of Human Glycan and Phospholipid Antibody Repertoires  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Tissue and Organ Specific Human B Cell Immunity - Core B: Human Tissue Collection, Processing and Repository Core  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Autoimmunity Center for Excellence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Teaching Overview

  • Dr. Bridges is highly committed to mentoring trainees in rheumatic and musculoskeletal diseases research through his role as PI of the Training Program in Rheumatic and Musculoskeletal Diseases Research (NIH/NIAMS T32 AR069516). This program brings together the expertise of faculty and staff in the Division of Clinical Immunology and Rheumatology, the Division of Pediatric Rheumatology, and multiple other Divisions, Departments, Schools, and Research Centers at UAB. He also provides clinical teaching in the outpatient rheumatology clinics at UAB, as well as didactic lectures on RA and other rheumatic diseases.
  • Education And Training

  • University of Texas Medical Branch Internal Medicine, Chief Resident
  • University of Texas Medical Branch Internal Medicine, Internship
  • University of Texas Medical Branch Internal Medicine, Residency
  • UAB Hospital, Postdoctoral Fellowship
  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Alabama at Birmingham 1995
  • Doctor of Medicine, Louisiana State University System : University of New Orleans 1984
  • Bachelor's Degree in Philosophy and Religious Studies, University of Notre Dame 1980
  • Full Name

  • S. Louis Bridges