Positions

Overview

  • Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015.

    Dr. Lapi is currently an Professor of Radiology and Chemistry and Cyclotron Facility Director where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies.

    Dr. Lapi has over 100 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is a Board Member of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and past Board member of the Nuclear Division of the American Chemical Society (ACS). She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 A General Design Strategy Enabling the Synthesis of Hydrolysis‐Resistant, Water‐Stable Titanium(IV) Complexes 2022
    2022 Meet the advisors - Suzy LapiJournal of Labelled Compounds and Radiopharmaceuticals.  65:25-27. 2022
    2022 Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast CancerCancers.  14. 2022
    2022 β-eye: A benchtop system for in vivo molecular screening of labeled compoundsApplied Radiation and Isotopes.  180. 2022
    2022 A General Design Strategy Enabling the Synthesis of Hydrolysis-Resistant, Water-Stable Titanium(IV) Complexes 2022
    2021 A heavy-ion production channel of 149Tb via 63Cu bombardment of 89YApplied Radiation and Isotopes.  178. 2021
    2021 Production of 52Mn using a semi-automated moduleApplied Radiation and Isotopes.  174. 2021
    2021 Homologous Structural, Chemical, and Biological Behavior of Sc and Lu Complexes of the Picaga Bifunctional Chelator: Toward Development of Matched Theranostic Pairs for Radiopharmaceutical ApplicationsBioconjugate Chemistry.  32:1232-1241. 2021
    2021 Production, purification, and applications of a potential theranostic pair: Cobalt-55 and cobalt-58mDiagnostics.  11. 2021
    2021 Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteriaJCI insight.  6. 2021
    2021 Production of [89Zr]Oxinate4 and cell radiolabeling for human useJournal of Labelled Compounds and Radiopharmaceuticals.  64:209-216. 2021
    2021 Positron emission tomography imaging of macrophages in cancerCancers.  13. 2021
    2021 Accelerator Production of Scandium Radioisotopes: Sc-43, Sc-44, and Sc-47Current Radiopharmaceuticals.  14:359-373. 2021
    2021 IAEA Activities on 67Cu, 186Re, 47Sc Theranostic Radionuclides and RadiopharmaceuticalsCurrent Radiopharmaceuticals.  14:306-314. 2021
    2021 Real-Time Gain Control of PET Detectors and Evaluation with Challenging RadionuclidesIEEE Transactions on Medical Imaging.  40:71-80. 2021
    2020 Multilayer Microcapsules with Shell-Chelated 89Zr for PET Imaging and Controlled DeliveryACS Applied Materials and Interfaces.  12:56792-56804. 2020
    2020 Optimized methods for production and purification of Titanium-45Applied Radiation and Isotopes.  166. 2020
    2020 Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in miceBrain Research Bulletin.  164:339-349. 2020
    2020 Comparative Uptake and Biological Distribution of [18F]-Labeled C6 and C8 Perfluorinated Alkyl Substances in Pregnant Mice via Different Routes of AdministrationEnvironmental Science and Technology Letters.  7:665-671. 2020
    2020 Harvesting 48V at the National Superconducting Cyclotron LaboratoryApplied Radiation and Isotopes.  157. 2020
    2020 64Cu-ATSM positron emission tomography/ magnetic resonance imaging of hypoxia in human atherosclerosisCirculation: Cardiovascular Imaging2020
    2019 Radiometals for imaging and theranostics, current production, and future perspectivesJournal of Labelled Compounds and Radiopharmaceuticals.  62:615-634. 2019
    2019 The Cu(II) reductase RclA protectsEscherichia coliagainst the combination of hypochlorous acid and intracellular copper 2019
    2019 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell CarcinomaCancer Biotherapy and Radiopharmaceuticals.  34:288-296. 2019
    2019 Pulmonary carcinoid surface receptor modulation using histone deacetylase inhibitorsCancers.  11. 2019
    2019 Imaging of HER2 with [ 89 Zr]pertuzumab in response to T-DM1 therapyCancer Biotherapy and Radiopharmaceuticals.  34:209-217. 2019
    2019 Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeVApplied Radiation and Isotopes.  147:165-170. 2019
    2019 Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47ScEJNMMI Research.  9. 2019
    2019 Radiolabeled Cationic Peptides for Targeted Imaging of InfectionContrast Media and Molecular Imaging.  2019. 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumoniaAmerican Journal of Respiratory and Critical Care Medicine.  198:1288-1301. 2018
    2018 Evaluation of [ 89 Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancerBreast Cancer Research and Treatment.  169:523-530. 2018
    2017 Radiosynthesis and Biological Distribution of 18F-Labeled Perfluorinated Alkyl SubstancesEnvironmental Science and Technology Letters.  4:211-215. 2017
    2016 New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of ConceptACS Chemical Biology.  11:2829-2837. 2016
    2016 Calibration setting numbers for dose calibrators for the PET isotopes 52Mn, 64Cu, 76Br, 86Y, 89Zr, 124IApplied Radiation and Isotopes.  113:89-95. 2016
    2015 Harvesting 67Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron LaboratoryAnalytical Chemistry.  87:10323-10329. 2015
    2015 Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[76Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor ImagingJournal of Medicinal Chemistry.  58:8542-8552. 2015
    2015 Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracerJournal of Labelled Compounds and Radiopharmaceuticals.  58:234-241. 2015
    2015 Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54 Mn radioisotopesApplied Radiation and Isotopes.  96:154-161. 2015
    2014 Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imagingArchaeological and Anthropological Sciences.  4. 2014
    2014 Investigation of a vitamin B12 conjugate as a PET imaging probe 2014
    2014 Specific activity measurement of 64Cu: A comparison of methodsApplied Radiation and Isotopes.  90:117-121. 2014
    2013 Routine production of 89Zr using an automated moduleApplied Sciences.  3:593-613. 2013
    2013 Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions 2013
    2012 Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesisApplied Radiation and Isotopes.  70:2539-2544. 2012
    2012 A semi-automated system for the routine production of copper-64Applied Radiation and Isotopes.  70:1803-1806. 2012
    2011 The rise of metal radionuclides in medical imaging: Copper-64, zirconium-89 and yttrium-86Future Medicinal Chemistry.  3:599-621. 2011
    2011 A new and simple calibration-independent method for measuring the beam energy of a cyclotronApplied Radiation and Isotopes.  69:247-253. 2011
    2007 55Cobalt complexes with pendant carbohydrates as potential PET imaging agentsApplied Radiation and Isotopes.  65:1303-1308. 2007
    2007 Production cross-sections of 181-186Re isotopes from proton bombardment of natural tungstenApplied Radiation and Isotopes.  65:345-349. 2007
    2007 Visualization of the flow of a fiber suspension through a sudden expansion using PETAIChE Journal.  53:327-334. 2007
    2006 Production of intense radioactive beams using low energy protons 2006
    2006 Production of intense radioactive beams at ISAC using low-energy protonsCanadian Journal of Physics.  84:325-333. 2006
    2005 Printed sources for Positron Emission Tomography (PET)IEEE Transactions on Nuclear Science.  52:114-118. 2005
    Radiolabelled Bacterial Metallophores as Targeted PET Imaging Contrast Agents for Accurate Identification of Bacteria and Outer Membrane Vesicles in vivo

    Chapter

    Year Title Altmetric
    2014 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals.  47-79. 2014

    Principal Investigator On

  • A Plant Origined PET Probe (ENL-PLGA-PEG-DOTA-64Cu): Investigation of Prostate Cancer Imaging Potential by In Vitro Methods  awarded by EGE UNIVERSITY
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Dermal Absorption of PFAS  awarded by LAST CALL FOUNDATION
  • Development of Novel Tataniu-45 PET Imaging Agents for PSMA  awarded by SOCIETY OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Direct Production of 99mTc Using a Small Medical Cyclotron  awarded by Department of Energy
  • Expansion of UAB Isotope Production Capabilities to Enable Participation in the DOE UIN  awarded by Department of Energy
  • GE FASTLab2 for the UAB Cyclotron Facility  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Imaging for Assessment and Prediction of Response to Therapy for Triple Negative Breast Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Infrastructure for Investigator Initiated Molecular Imaging Trials  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
  • Integrated Placental Imaging: Novel Methods for Probing Function and Metabolism  awarded by Washington University
  • Preparing for Harvesting Radioisotopes from FRIB  awarded by Department of Energy
  • Private Grant  awarded by ABBVIE INC
  • Private Grant  awarded by CELLDEX THERAPEUTICS, INC.
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC.
  • Private Grant  awarded by IMAGINAB^
  • Private Grant  awarded by PROTEOGENOMICS RESEARCH INSTITUTE FOR SYSTEMS MEDICINE
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC.
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC.
  • Private Grant  awarded by APPLIED DIAMOND INC
  • Private Grant  awarded by BRISTOL-MYERS SQUIBB COMPANY
  • Private Grant  awarded by CLOVIS ONCOLOGY
  • Private Grant  awarded by CLOVIS ONCOLOGY
  • Private Grant  awarded by Genzyme Corporation
  • Private Grant  awarded by NAVIDEA BIOPHARMACEUTICALS, INC.
  • Production of Radiohalogens: Bromine and Astatine for Imaging and Therapy  awarded by Department of Energy
  • Production of Radioisotopes of Scandium for Imaging and Therapy  awarded by Department of Energy
  • Production of the Medically Important Radionuclides: 52Mn and 90Nb  awarded by Department of Energy
  • Production, Purification and Characterization of Radioisotopes via Neutron Spallation  awarded by Department of Energy
  • Radiolabeled Antibodies Targeting LAT1 for Imaging and Therapy of Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Support for Students, Postdoctoral Fellows and Trainees to Attend Nuclear and Radiochemistry Symposia at the Spring 2018 ACS Meeting  awarded by Department of Energy
  • Synthra MeIPlus Research with HCN/CO Options and Radchrom Plus for the UAB Cyclotron Facility  awarded by NIH - OFFICE OF THE DIRECTOR
  • Therapeutic Radiopharmaceuticals Labelled with New Emerging Radionuclides (67Cu,186Re, 47Sc)  awarded by International Atomic Energy Agency
  • University Network IP Basic Ordering Agreement  awarded by UT-Battelle
  • Zr-89 Production, Optimized Antibody Labeling and Imaging Studies  awarded by International Atomic Energy Agency
  • Investigator On

  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Preclinical Imaging Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Detecting Neuroinflammation in Fibromyalgia with the Positron Emission Tomography (PET) Radioligand [18] DPA-714  awarded by American Fibromyalgia Syndrome Association
  • FET-PET/MRI for Surgical Assessment of Pediatric Brain Tumors  awarded by St. Baldrick's Foundation
  • Measuring Neuroinflammation in Chronic Fatigue Syndrome with Whole-brain Magnetic Resonance Spectroscopy  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Non-Invasive Imaging of Ameloblastomas  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Pharmacological Upregulation of SSTR2 For Imaging and Therapy of Medullary Thyroid Cancer  awarded by INTERNATIONAL THYROID ONCOLOGY GROUP (ITOG)
  • Private Grant  awarded by IMAGINAB^
  • Private Grant  awarded by CYTOSITE BIOPHARMA INC
  • Private Grant  awarded by CLOVIS ONCOLOGY
  • Private Grant  awarded by CYTOSITE BIOPHARMA INC
  • Risk of Hospital-acquired Pneumonia is Increased by Cigarette Smoke-induced Impaired Host Defense  awarded by American Lung Association
  • Site-Specific Immune Cell Activation Detection for Improving Individualized Cancer Immunotherapy  awarded by NIH - OFFICE OF THE DIRECTOR
  • Viability Testing of Immune Cells Extracted from Human Blood Samples  awarded by ME RESEARCH UK
  • [18F] Fluoroestradiol (FES) PET as a Predictive Measure for Endocrine Therapy in Women with Newly Diagnosed Metastatic Breast Cancer (R20-146)  awarded by ECOG-ACRIN CANCER RESEARCH GROUP
  • Education And Training

  • Doctor of Philosophy in Chemistry, Simon Fraser University 2007
  • Full Name

  • Suzanne Lapi